Cm In Women Research Articles

Composite dietary antioxidant index and obesity among U.S. adults in NHANES 2007–2018

Antioxidant-rich diets serve as protective factors in preventing obesity. The composite dietary antioxidant index (CDAI) represents a novel, comprehensive metric for assessing the antioxidant capacity of diets. Our objective is to investigate the relationship between the CDAI and obesity prevalence among adults in the United States. Dietary and anthropometric information about adults aged 20 years and older were obtained from the National Health and Nutrition Examination Survey (NHANES) 2007–2018. The CDAI was derived from six dietary antioxidants. Obesity is defined as a body mass index (BMI, kg/m2) ≥ 30 kg/m2, and abdominal obesity as a waist circumference (WC, cm) ≥ 102 cm for men and ≥ 88 cm for women. The relationship between CDAI and obesity, including abdominal obesity, was analyzed using logistic regression and subgroup analyses. A total of 25,553 participants were analyzed. With higher tertiles of the CDAI, both obesity (41.28% vs. 38.62 vs. 35.09%, P < 0.001) and abdominal obesity (63.75% vs. 59.54 vs. 52.09%, P < 0.001) prevalence notably declined. Adjusting for multiple confounders, the CDAI was found to be independently linked to obesity (OR = 0.980, 95%CI = 0.971–0.989, P < 0.001) and abdominal obesity (OR = 0.972, 95%CI = 0.963–0.982, P < 0.001) risks. Subgroup analyses revealed a stronger relationship between CDAI and obesity in non-hypertensive individuals and a more significant association with abdominal obesity in women and those without hypertension. Our findings reveal a negative relationship between CDAI levels and both general and abdominal obesity. Additional extensive research is necessary to investigate CDAI’s contribution to obesity.

Association between subjective walking speed and metabolic diseases in individuals with obesity: a cross-sectional analysis

The association between subjective walking speed and metabolic diseases has received limited attention, particularly in individuals with obesity. We aimed to clarify this association using comprehensive health checkup data of participants with obesity. In total, 8578 individuals with a body mass index ≥ 25.0 kg/m2, 9626 individuals with waist circumference ≥ 85 cm in men and ≥ 90 cm in women, and 6742 individuals who met both criteria of body mass index and waist circumference were included in this cross-sectional analysis. Subjective walking speed was investigated using the question “Is your walking speed faster than the speed of those of your age and sex?” in a health examination questionnaire. Metabolic diseases were defined according to the guidelines for each disease, and modified Poisson regression analyses were performed. In the model adjusted for age and sex, individuals with obesity based on body mass index and fast subjective walking speed showed significantly lower risk of diabetes mellitus (risk ratio [RR] 0.70; 95% CI 0.63–0.77) and dyslipidemia (RR 0.97; 95% CI 0.94–1.00). Similarly, among those with obesity based on waist circumference and both body mass index and waist circumference, fast subjective walking speed showed a significant negative association with hypertension (RR 0.94; 95% CI 0.90–0.97 and RR 0.95; 95% CI 0.92–0.99, respectively), diabetes mellitus (RR 0.70; 95% CI 0.64–0.77 and RR 0.70; 95% CI 0.63–0.77, respectively), and dyslipidemia (RR 0.96; 95% CI 0.94–0.99 and RR 0.96; 95% CI 0.94–0.99, respectively). Thus, among individuals with obesity, the odds of metabolic diseases were lower if their subjective walking speed was fast. This study contributes to earlier prevention of the cascade of diseases that begin with obesity.

Abstract 4136677: High Visceral-to-Subcutaneous Fat Ratio is Correlated with Increased Cardiovascular Events in Patients with Low Waist Circumference Suspected of Coronary Artery Disease

Introduction: Waist circumference (WC) has been recognized as an appropriate index of obesity and is closely associated with the amount of abdominal fat. Although abdominal fat distribution (AFD), which is represented by the ratio of visceral adipose tissue (VAT) to subcutaneous adipose tissue (SAT) area (V/S ratio), is possibly related to an increased risk of cardiovascular disease (CVD), few studies have explored the relationship between AFD and CVD outcomes. This study aimed to assess the influence of AFD based on the V/S ratio and physique categorized by WC on long-term clinical results in patients with suspected coronary artery disease (CAD). Methods: We evaluated 931 consecutive patients (mean age, 67 years; 42.4% women) with suspected CAD who underwent computed tomography (CT) angiography. The patients also underwent plain abdominal CT to assess and measure VAT and SAT areas; V/S ratio was calculated to assess AFD. The patients were divided into four groups based on the median V/S ratio (0.624) and reference values of WC for metabolic syndrome in Japan (85 cm for men, 90 cm for women). We assessed the relationship between the V/S ratio and long-term clinical outcomes in each WC group. The main outcome was major adverse cardiac events (MACEs, including cardiac death, any coronary revascularization, acute coronary syndrome, and emergency hospitalization due to cardiac cause). Results: Over a median follow-up of 1869 days, although the incidence of any cardiovascular event was not related to the V/S ratio among patients with high WC, a higher incidence of MACE and cardiac death was noted among patients with low WC in the high V/S ratio group than in the low V/S ratio group. Furthermore, Kaplan–Meier analysis revealed a significantly lower MACE-free survival rate among patients with low WC in the high V/S ratio group than in the low V/S ratio group, despite of no differences being noted among high WC patients in both the V/S ratio groups (Figure). Conclusion: Only in patients with low WC, a high V/S ratio was linked to increased risks of MACE. Thus, high V/S ratio may be an essential risk factor for CVD, specifically in patients with low WC. However, AFD did not influence CVD prognosis in patients with high WC.

Margin of safety for needle puncture of a radial artery in children: Recommendation for ultrasound-guided cannulation.

The radial artery is commonly selected for arterial puncture and cannulation, but radial nerve palsy may occur. To minimize possible damage to the nerve, needle puncture should be made within the margin of safety (between the wrist to the distal end of the radial artery and the radial nerve running in parallel). In adults, the margin of safety for radial artery puncture is approximately 6.8cm from the wrist in men and approximately 5.4cm in women, but the margin of safety is not known in children of different age groups. Using an ultrasound device, we measured the margin of safety in 100 anesthetized patients aged 0months to 15yr. Polynomial quadratic regression models were made, and the lower limit of the prediction interval was regarded as the margin of safety. These results were then compared with the results obtained in adults. The margin of safety became wider as a child grows older, and the height, weight, and age were all suitable explanatory variables to predict the margin of safety, providing fairly a constant predicted margin of safety from a few millimeters in neonates to approximately 4cm in adolescents (much narrower than in adults). In children and adolescents, the margin of safety for radial artery puncture is much narrower than in adults, and these findings support the recommendation to use ultrasound guidance during radial artery puncture in children and adolescents, to minimize the risk of associated complications. jRCT1032230243.

Characteristics of the Medallists of the World Masters Orienteering Championships

This research aimed to investigate morphological parameters (body mass, height, BMI) of medallists at the World Masters Orienteering Championships (WMOC), alongside their sports achievements and results. Fifty medallists from the 2022 WMOC, aged 35 to 80, were surveyed using a questionnaire, with non-parametric statistics (Mann–Whitney U test and ρ-Spearman test) applied for analysis. The average height was 179 cm for men and 165 cm for women, with average weights of 70 kg for men and 54 kg for women. BMI was 21.5 (SD = 1.43) for men and 20.4 (SD = 1.74) for women, with significantly lower BMI values in women (Z = 2.054, p = 0.04). Men’s BMI decreased with age (R = −0.534, p &lt; 0.01). The BMI value of masters foot orienteers is typical for middle-distance runners. Women are closer to the somatotype of 1500 m athletes and men to 800 m athletes. Lack of earlier elite success does not preclude being on the podium at the WMOC (only 3 of the 50 medallists surveyed had won a medal in elite competition in the past).

Anthropometric Indices of Obstructive Sleep Apnea Patients in Mauritius.

Background Obstructive sleep apnea (OSA) is the most prevalent sleep-related breathing disorder, affecting a significant number of individuals globally.It is associated with poor quality of life and an increased risk of all-cause mortality. It is estimated that most of the patients suffering from OSA are obese. Anthropometric indices can help guide doctors towardthe diagnosis. Objectives This study aimed to establish specific anthropometric thresholds associated with OSA risk, allowing clinicians to identify individuals more likely to have OSA and who may need further evaluation, such as polysomnography. This targeted screening approach would enable better resource allocation to those at higher risk, potentially enhancing the efficiency of OSA diagnosis and management. Methods We conducted a descriptive study using data from the sole private sleep clinic in Mauritius. We analyzed case files of consecutive patients diagnosed with OSA over a 3.5-year period from January 2015 to June 2018. Results The study population comprised 170 patients (79.4% males) diagnosed with OSA by a polygraphy test.The mean age of OSA diagnosis in men and women was 51.7 ± 14.0 years and 53.8 ± 12.5 years, respectively.The mean neck circumference (NC) for males and females was 41.9 ± 3.9 cm and 38.2 ± 3.9 cm, while the mean waist circumference (WC) was 105.6 ± 12.2 cm for men and 103.4 ± 14.5 cm for women. The body mass index (BMI) was 29.1± 5.0 kg/m2 and 31.4± 6.8 kg/m2 for males and females, respectively. The apnea-hypopnea index (AHI) averaged to 42.1 ± 19.7 events/hour for men and 33.3 ± 16.4 events/hour for women.In male patients, we found a positive significant correlation (p<0.001) between AHI and the following parameters: BMI (r=0.443), WC(r=0.337), WC-to-height ratio (WHr) (r=0.378), NC(r =0.274), and neck-to-height ratio (NHr) (r =0.321).In women, we observed a positive significant correlation between apnea severity and the following: BMI (r=0.396, p=0.029), WC (r=0.462, p=0.005), and WHr (r=0.494, p=0.003).No significant relationships were observed between AHI and the following parameters in women: NC (r=0.317, p=0.064) and NHr (r=0.311, p=0.069). A total of 83.5% of patients had a Mallampati score of 3-4. Conclusion This study represents a pioneering effort on the island. While further research is necessary to establish exact anthropometric cutoff values, the findings offer crucial insights for physicians to identify high-risk individuals. With just a scale, measuring tape, and calculator, healthcare professionals can detect important health markers that extend beyond diagnosing OSA. These simple measurements not only help in predicting OSA but also provide a broader view of an individual's overall health, identifying risks that go beyond sleep issues. This research sets an important foundation for future OSA studies within the Mauritian population.

Morphometric analysis and tortuosity typing of the large intestine segments on computed tomography colonography with artificial intelligence.

Morphological properties such as length and tortuosity of the large intestine segments play important roles, especially in interventional procedures like colonoscopy. Using computed tomography (CT) colonoscopy images, this study aimed to examine the morphological features of the colon's anatomical sections and investigate the relationship of these sections with each other or with age groups. The shapes of the transverse colon were analyzed using artificial intelligence. The study was conducted as a two- and three-dimensional examination of CT colonography images of people between 40 and 80 years old, which were obtained retrospectively. An artificial intelligence algorithm (YOLOv8) was used for shape detection on 3D colon images. 160 people with a mean age of 89 men and 71 women included in the study were 57.79±8.55 and 56.55±6.60, respectively, and there was no statistically significant difference (p= 0.24). The total colon length was 166.11±25.07 cm for men and 158.73±21.92 cm for women, with no significant difference between groups (p=0.12). As a result of the training of the model Precision, Recall, and Mean Average Precision (mAP) were found to be 0.8578, 0.7940, and 0.9142, respectively. The study highlights the importance of understanding the type and morphology of the large intestine for accurate interpretation of CT colonography results and effective clinical management of patients with suspected large intestine abnormalities. Furthermore, this study showed that 88.57% of the images in the test data set were detected correctly and that AI can play an important role in colon typing.

Stress in individuals with noncommunicable diseases: ESSE-RF and ESSE-RF2 data

Aim. To determine the level and prevalence of stress in individuals with noncommunicable diseases (NCDs).Material and methods. Representative samples of the population aged 25-64 years from 17 regions of the Russian Federation (n=27950) were included, examined within the ESSE-RF and ESSE-RF2 studies. To assess stress, the Perceived Stress Scale-10 was used. Stress levels were defined as follows: low — 0-11, moderate — 12-19, high — 20-40. The presence of diseases was recorded by a positive answer to the question: "Has a doctor ever told you that you have/had the following diseases?". Hypertension was defined as systolic blood pressure (BP) ≥140 mm Hg, and/or diastolic BP ≥90 mm Hg, and/or taking antihypertensive drugs. Obesity was defined as a body mass index ≥30,0 kg/m2, while abdominal obesity — as a waist circumference ≥102 cm in men and ≥88 cm in women. Blood biochemical tests included lipid profile assessment.Results. The stress level in the entire sample varied from 15,0 (myo­cardial infarction) to 16,6 (rheumatoid arthritis). When analyzing by sex, the highest stress score in women was observed in coronary artery disease — 17,6, while in men — in rheumatoid arthritis (15,1), cerebrovascular accident (15,1). More than a quarter of men with coronary artery disease (25,8%), prior cerebrovascular accidents (26,4%) had a high level of stress, while women with these diseases — 40,6%. Among the entire sample, the presence of each NCD, except for myocardial infarction, was characterized by a significantly higher stress level compared to participants without the corresponding disease.Conclusion. In the Russian population, individuals with NCDs are cha­racterized by higher stress rates compared to individuals without the corresponding disease. Among women, both the level and prevalence of stress are higher, and the list of diseases affecting the mental well-being is wider compared to men.

Exploring the association between hypertension and atherosclerotic cardiovascular disease in adults with familial hypercholesterolemia: insights from the HELLAS-FH registry

Abstract Aim While the link between hypertension and atherosclerotic cardiovascular disease (ASCVD) is well-established, its impact on patients with familial hypercholesterolemia (FH) remains less explored. This study aims to assess the association between hypertension and ASCVD in adult FH patients. Material-Methods: Participants from the HELLAS-FH registry were divided into two groups based on the presence or absence of hypertension. We compared demographic information, lipid profile and history of ASCVD between the two groups. Results The study included 2367 FH patients, of whom 602 (25.4%) had a diagnosis of hypertension. Hypertensive patients were generally older and exhibited higher rates of ASCVD risk factors such as increased body mass index (28.6 vs 26.3 kg/m2), waist circumference (98 cm in men and 97 cm in women compared with 95 cm and 88 cm in non-hypertensive counterparts), and more prevalent history of smoking (44.2% vs 35.8%) (p&amp;lt;0.01 for all comparisons). Patients with hypertension had higher triglyceride levels (148 vs 123 mg/dL; p&amp;lt;0.05), lower high-density lipoprotein cholesterol (HDL-C) levels (48 vs 53 mg/dL; p&amp;lt;0.05) while total cholesterol and non-HDL-C levels were not significantly different. When adjusted for age, sex, and major ASCVD risk factors, hypertension was significantly associated with prevalent coronary artery disease (CAD) (adjusted odds ratio [OR] 3.10; 95% CI 2.29-4.19; p&amp;lt;0.001), ischemic stroke (OR 1.89; 95% CI 1.02-3.49; p=0.04), and peripheral arterial disease (PAD) (OR 3.15; 95% CI 1.62-6.13; p&amp;lt;0.001). Conclusions Hypertension is frequent and is independently associated with an increased risk of CAD, stroke, and PAD in patients with FH.

Modifying effect of obesity status on the association between low-density lipoprotein cholesterol with incident hemorrhagic stroke: evidence from a community-based longitudinal cohort study in China

Abstract Background Previous results on the association between lipids and hemorrhagic stroke were controversial. Modifying effect of obesity on the association between low-density lipoprotein cholesterol (LDL-C) and hemorrhagic stroke risk in the Chinese community-based population remains unclear. Objectives We aimed to investigate the association between LDL-C and hemorrhagic stroke risk in the Chinese community-based population. In addition, we aimed to explore the potential modifying effect of obesity status, particularly abdominal obesity, on this relationship. Methods A total of 7899 eligible subjects, without history of stroke and myocardial infarction, and any use of lipid-lowering medication at baseline, were enrolled in this study. Levels of LDL-C, total cholesterol (TC), triglyceride (TG), and high-density lipoprotein cholesterol (HDL-C) were assessed at baseline. The primary endpoint was the hemorrhagic stroke. Abdominal obesity was defined as waist circumference &amp;gt; 90 cm in men and &amp;gt; 85 cm in women. Results Of all participants, the mean age was 56.13 ± 8.87 years, 2848 (36.1%) were male. During a mean 9.71-year follow-up, 66 hemorrhagic strokes occurred. After multivariable adjustment (Figure 1), compared to participants with LDL-C levels 2.6 – 3.4 mmol/L, those with LDL-C levels &amp;lt; 1.8 mmol/L had 3.32 times the risk (hazard ratio [HR]: 3.32; 95% confidence interval [CI]: 1.24, 8.84) of incident hemorrhagic stroke. Compared with participants with TC levels 3.1 – 5.2 mmol/L, HR (95% CI) was 7.82 (2.36, 25.90) for hemorrhagic stroke in those with TC &amp;lt; 3.1 mmol/L. We observed no significant associations between TG or HDL-C levels and hemorrhagic stroke risk. Interaction effects were found between obesity and LDL-C for incident hemorrhagic stroke. Accordingly, significant associations between low LDL-C level (&amp;lt; 1.8 mmol/L) and the risk of incident hemorrhagic stroke were found only among abdominal obesity participants (HR: 3.76; 95% CI: 1.01, 13.97), or those with body mass index (BMI) &amp;gt; = 24 kg/m2 (HR: 3.74; 95% CI: 1.24, 11.34) (Figure 2). Conclusions LDL-C levels &amp;lt; 1.8mmol/L and TC levels &amp;lt; 3.1mmol/L were associated with increased risk of hemorrhagic stroke. Modifying effect of obesity status on the association between low LDL-C level and hemorrhagic stroke was observed in our study.

Dynapenic abdominal obesity and activities of daily living disability among older adults residing in low- and middle-income countries

BackgroundDynapenic abdominal obesity (DAO) may be associated with an increased risk of disability. However, to date, this has not been investigated in low- and middle-income countries (LMICs), while the mediators are largely unknown.AimsTherefore, we aimed to investigate the association between DAO and activities of daily living (ADL) disability, and to identify potential mediators among older adults from six LMICs.MethodsCross-sectional, nationally representative data from the WHO Study on global AGEing and adult health were analyzed. Data on 20,198 adults aged ≥ 60 years were analyzed [mean (SD) age 69.3 (13.1) years; 54.1% females]. Dynapenia was defined as handgrip strength of < 26 kg for men and < 16 kg for women. Abdominal obesity was defined as waist circumference of > 88 cm for women and > 102 cm for men. DAO was defined as having both dynapenia and abdominal obesity. Disability was defined as severe or extreme difficulty in conducting at least one of six types of ADL. Multivariable logistic regression and mediation analysis were conducted.ResultsCompared to no dynapenia and no abdominal obesity, DAO was significantly associated with 2.08 (95%CI = 1.37–3.17) times higher odds for ADL disability Mediation analysis showed that diabetes (mediated percentage 4.7%), hypertension (7.2%), and angina (7.7%) were significant mediators in the association between DAO and ADL disability.ConclusionsDAO was associated with increased odds for ADL disability among older adults from LMICs. Future longitudinal studies are warranted to assess temporal associations, and whether addressing or preventing DAO can impact on future occurrence of disability.

Challenge of cardiovascular prevention in primary care: achievement of lifestyle, blood pressure, lipids and diabetes targets for primary prevention in England – results from ASPIRE-3-PREVENT cross-sectional survey

BackgroundImplementation of the cardiovascular disease (CVD) prevention guidelines in the UK has been repeatedly evaluated under the auspices of the British Cardiovascular Society in three Action on Secondary and Primary...

Association of obesity status and the risk of long-COVID: Isfahan COVID cohort study.

People with COVID-19 infection continue to have their symptoms or develop new ones after recovery. This is called long-COVID syndrome. We aimed to examine the association of general and abdominal obesity with long COVID. This study was conducted using Isfahan COVID Cohort (ICC). Totally 4008 including 3213 hospitalized and 795 non-hospitalized patients with positive RT-PCR were included. Body mass index (BMI) and waist circumference (WC) were calculated. BMI >25 kg/m2 and WC >88 cm in women and 102 cm in men were considered generally and abdominally obese, respectively. By using an open-ended questionnaire, subjects were asked whether they had any new or persistent symptom. Reported symptoms were categorized in three different fields including general, cardiac, and respiratory symptoms. Higher BMI and WC tended to increase general symptoms (odds ratio [OR] for BMI = 1.16, 95 % confidence interval (95% CI): 0.97, 1.38, and OR for WC = 1.14, 95% CI: 0.99, 1.32). Higher BMI significantly increased cardiovascular (OR = 1.38, 95% CI: 1.14, 1.67) and respiratory symptoms (OR = 1.43, 95% CI: 1.15, 1.78). Compared with patients with normal WC, the risk of cardiovascular (OR = 1.44, 95% CI: 1.24, 1.69) and respiratory symptoms was significantly higher in subjects with abdominal obesity (OR = 1.31, 95% CI: 1.10, 1.56). We found that general and abdominal obesity were associated with increased risk of cardiovascular and respiratory symptoms in patients with long-COVID symptoms. However, only general obesity was associated with increased risk of general symptoms.

Osteometric characteristics of the Medieval population of Northern Sudan (based on materials from the Deraheib monument)

Introduction. Paleoanthropological studies of Medieval North African materials are extremely few. Despite the large number of international expeditions working in the region, very few results of craniometric and osteometric data are presented. This is partly due to the loss of practical measurement skills in European anthropological schools in the second half of the 20th century, partly due to the difficulties of studying the graves of the Islamic period. Several seasons of work of the Nubian Archaeological and Anthropological Expedition of the Research Institute and the Museum of Anthropology of Lomonosov Moscow State University on the Southern Necropolis of the medieval site Derakheyb (Republic of Sudan) were devoted to the study of this population. The purpose of the publication is characteristics of the medieval population buried in the Southern Necropolis of the Derakheyb site due to osteological features and introducing the new data. Materials and methods. The material is the bones of the postcranial skeleton of adult individuals (14 men and 9 women). The technique corresponds to the classical program in the modification of V.P. Alekseev (a total of 74 signs and 16 pointers). The reconstruction of the body length was carried out, the total body dimensions were described, and the proportion indicators were calculated. For intra-group analysis, the principal component method was used, which was carried out using individual data using the R language. Results and discussion. The male population is characterized by average total body size and shoulder width, while the female series is relatively narrow-shouldered. In the male series, the distal parts of the arms and legs are elongated relative to the proximal ones, and the lower limbs are elongated relative to the upper ones. The women's series featured a more graceful physique. The distal part of the leg is elongated relative to the proximal one, as in the male group; there is also some shortening of the upper limbs relative to the lower ones. Body length varies between 166 cm for men and 156 cm for women. Conclusion. According to osteometry data, the medieval population of the city of Derakheyb can be characterized as heterogeneous, the individuals that stand out mainly correspond to those that stood out according to craniological data. The male part of the population is medium-massive, and the female part is graceful. The entire sample is characterized by shortened lower limbs relative to the arms, as well as elongated distal parts of the arms and legs relative to the proximal ones, which reflects one of the features of the tropical adaptive type.

Waist circumference-years and cancer risk: a prospective study of the association and comparison of predictive performance with waist circumference and body mass index

BackgroundAssociations of waist circumferences (WC) and body mass index (BMI) measured once or over time, with cancer incidence were studied. WC is associated with some cancers independent of BMI. Analyses of cumulative central adiposity and cancer are lacking. We investigated associations between waist circumference-years, incorporating exposure time to WC ≥ 102 cm in men or ≥88 cm in women, and cancer, and compared this with single WC or BMI.MethodsSerial WC measurements taken over 9 years in the prospective Atherosclerosis Risk in Communities Study (ARIC) predicted yearly WC. Cox proportional hazards regression estimated hazard ratios (HRs) of cancer incidence for waist circumference-years, WC or BMI, measured in Visit 4. Harrell’s C-statistic quantified metric predictive performances.Results10,172 participants were followed up from Visit 4 for cancer over a median 13.7 for men and 15.8 years for women. For obesity-related cancers, HRs per standard deviation waist circumference-years were 1.14 (95%CI:1.04,1.25) and 1.19 (95%CI:1.12,1.27), respectively. Differences in metric predictive performances were marginal.DiscussionThis is the first study to identify positive associations between waist circumference-years and cancer. Waist circumference-years did not provide additional information on cancer risk beyond that of WC and BMI. BMI is routinely measured in clinic so it may be preferred over WC.

Triglyceride levels and remnant cholesterol triglyceride-rich lipoproteins in metabolic syndrome and diabetes

In recent years, new epidemiological and genetic data have been obtained on the role of triglycerides (TG) and remnant cholesterol (RC) triglyceride-rich lipoproteins in increasing the residual risk of atherosclerosis-associated cardiovascular diseases (ACCD) in metabolic disorders. The aim of the study was to study the associations of different levels of triglycerides and RC triglyceriderich lipoproteins with metabolic syndrome (MS) and type 2 diabetes mellitus (TDM2) in the Siberian population.Material and methods. The research was carried out on the materials of the international epidemiological project HAPIEE (n = 9360 people) in people aged 45–69 years. In accordance with the protocol, a questionnaire, anthropometry, and biochemical research were conducted. Abdominal obesity (AO) was found with a waist circumference of ≥ 94 cm in men and ≥ 80 cm in women. MS was diagnosed according to the criteria of the IDF (2005), TDM2 – at fasting glucose levels ≥ 7.0 mmol/l (WHO, 1999, ADA, 2013), hypertriglyceridemia (hyperTG) – according to the definitions of NCEP ATP III, 2002 and the Russian Clinical Guidelines on lipid metabolism disorders, 2023. RC levels are calculated using the formula: total cholesterol (TC) – HDL cholesterol – LDL cholesterol mmol/L. The triglyceride-glucose index (TyG) was determined by the formula: TyG = ln [Fasting triglycerides (mg/dl) x Fasting glucose (mg/dl)/2].Results. Median values and prevalence of various levels of TG have been determined (&lt;1.7; ≥ 1.7 &lt; 2.3; ≥ 2.3 &lt; 5.6; ≥ 5.6 mmol/l). An increase in the prevalence of MS and TDM2 has been shown depending on the levels of hyperTG. High values of RC in AO, MS, and TDM2 were revealed in men and women: 0.68; 0.76; 0.90 and 0.68; 0.79 and 0.93, respectively. In 60 % of men and 80 % of women, RC was ≥ 0.5 mmol/l. An increase in RC was shown from values of 0.51–0.54 mmol/l at TG &lt; 1.7 mmol/l to higher values of 1.26–1.29 at TG ≥ 2.3 &lt; 5.6 mmol/l. The frequency of AO, MS, TDM2 in quintiles (Q) of RC increases linearly from Q1 to Q5. It is shown that from Q1 to Q5 TyG, the levels of RC increase in each subsequent quintile: from 0.36–0.38 in Q1 to 1.1–1.12 mmol/l in Q5.Conclusions. The medians and prevalence of various levels of TG and RC in MS and TDM2 and without metabolic disorders were determined. RC values increase from mild to moderate and high hypertriglyceridemia.

Trans-Vaginal Cervical Length and Amniotic Fluid Index in Prediction of Delivery Latency Following Preterm Pre-Labor Rupture of Membranes

Abstract Background After premature pre-labor rupture of membranes (PPROM), it is challenging to forecast with precision the time to delivery (latency). Predicting delivery delay may be useful in determining when to recommend hospitalization, close observation, prenatal steroid use, and magnesium sulfate for neuroprotection. In women who report with preterm pre-labor rupture of membranes (PPROM), our goal is to ascertain if transvaginal cervical length (TVCL), amniotic fluid index (AFI), or a combination of both can predict delivery latency. Methods 70 pregnant women presented with PPROM between the gestational age of 28 weeks and 36 weeks +6 days were enrolled. Transvaginal ultrasound measurement of cervical length and amniotic fluid index was performed within 24 hours of admission, to assess number of women reached latency period of 7 days or more and assess other maternal and fetal parameters as number of women reached 36 +6 weeks, mode of delivery, development of chorioamnionitis, gestational age at PPROM and delivery, birthweight at delivery, presence of neonatal sepsis, Apgar score at 1 and 5 minutes and need for NICU admission and indication. Results The best sensitivity of TVCL in prediction of delivery latency was 100 % at TVCL&amp;gt;3 cm in women with AFI &amp;gt;5 cm. On the other hand, the best specificity was 80.5% at TVCL&amp;gt;3 cm in women with AFI ≤5 cm. Conclusion When a woman presents with preterm pre-labor rupture of the membranes, it is recommended to employ either transvaginal cervical length, amniotic fluid index, or both to forecast delivery delay.

Interevaluator reliability of a tool for measuring body height in adult intensive care patients

BackgroundThe calculation of body height in the intensive care unit is essential for obtaining the ideal body weight, which is used to program the tidal volume and establish objective and effective pulmonary ventilation. The objective of the study was to determine the interrater reliability of a tool for measuring body height in adult patients in an intensive care unit (ICU) in southwestern Colombia. MethodsThis cross-sectional observational study was conducted between January and May 2021, following the recommendations of the COSMIN protocol. Two physiotherapists in the roles of observer/evaluator measured the heights of 106 patients upon admission to the ICU with a previously designed. The sample size was calculated based on Pearson's correlation coefficient. For interrater reliability, the intraclass correlation coefficient (ICC) was used, and Bland–Altman analysis was used to assess concordance. The 95% confidence interval was established, and a P value <0.05 indicated statistical significance. ResultsA total of 106 individuals with a mean age of 59.3 years were included; the mean body height was 158.5 cm for women. The interrater reliability of the measurement of height was excellent (global ICC of 0.99, P = 0.000), and an almost perfect positive correlation was obtained between the raters for both women and men (R = 0.99). ConclusionsExcellent interrater/interobserver reliability was obtained for the measurement of body height in the ICU. This research highlights the importance of protocolizing the measurement of height in critical patients with valid and reliable instruments.

The relationship between thigh circumference and sarcopenia in Chinese community-dwelling elderly aged ≥60 years

BackgroundThere has been a growing body of research demonstrating that thigh circumference is closely associated with the development of various chronic disease. However, limited evidence has been obtained regarding the relationship between thigh circumference and sarcopenia. ObjectiveThe aim of this study was to investigate the relationship between thigh circumference and sarcopenia, and explore the potential role of thigh circumference for sarcopenia screening among community-dwelling older adults. MethodsThe investigation was carried out in six rural communities located in northwestern China with participants aged ≥60 years old. We collected variables related to sarcopenia, including function, muscle mass, and strength. The thigh circumference was categorized into four groups based on quartiles, with the first quartile (≤46.65cm); the second quartile (46.66-48.50cm); the third quartile (48.51-50.55cm); and the fourth quartile (>50.55cm). The associations and screening effect were estimated with multivariate logistics regression and ROC curves. ResultsOf the 1000 participants aged 70.72 ± 4.68 years. Compared with the first quartile (≤46.65cm), the odds ratios for the second, third, and fourth quartiles of thigh circumference were 0.465 (95%CI: 0.281–0.770, p=0.003), 0.199 (95%CI: 0.097–0.407, p<0.001), and 0.059 (95%CI: 0.016–0.220, p<0.001), respectively. The regression results were consistent across different sexes. The AUC and cutoff values of thigh circumference for sarcopenia were 0.873 (95% CI 0.836–0.909, p<0.001) and 48.83 cm for men and 0.861 (95% CI 0.822–0.900, p<0.001) and 46.78 cm for women. There was a positive correlation between thigh circumference and skeletal muscle mass (r=0.747, p<0.001), hand grip strength (r=0.337, p<0.001), and gait speed (r=0.142, p<0.001), while a negative correlation was observed with five-times-sit-to-stand test (r=-0.073, p=0.021). ConclusionThere was a negative correlation between thigh circumference and sarcopenia, suggesting that thigh circumference may serve as a potential useful indicator for sarcopenia screening in the elderly.

The Performance and Associated Risks of the Criteria for Sarcopenic Obesity Proposed by the European Association for the Study of Obesity in a Geriatric Population

Background: There is no gold standard definition of sarcopenic obesity (SO). Our objective is to evaluate the benefit of using the new definition proposed by the European Association for the Study of Obesity (EASO) in older people. Methods: Data from the Toledo Study of Healthy Aging, a study based on a cohort of community-dwelling older adults, were used. SO was defined according to the EASO and by a composite of the Foundation for the National Institute of Health (FNIH) for the diagnosis of sarcopenia and the WHO’s criteria for obesity (Body Mass Index, BMI ≥ 30 kg/m2; waist circumference, &gt;88 cm for women and &gt;102 cm for men). Frailty [Frailty Phenotype (FFP) and Frailty Trait Scale-5 (FTS5)] and disability (Katz Index) statuses were assessed at baseline and at the follow-up (median 2.99 years). Mortality at a 5-year follow-up was also assessed. The Logistic and Cox regression models were used to assess the associations. Results: Of the 1559 subjects (age 74.79 ± 5.76 years; 45.54% men), 30.15% (EASO/ESPEN) vs. 16.36% (FNIH) met the SO criteria (Kappa = 0.42). SO was associated with the prevalence of frailty by both the EASO’s [OR(95%CI): FFP: 1.70 (1.33–2.16); FTS-5 binary: 2.29 (1.60–3.27); β(95%CI): FTS-5 continuous 3.63 (3.00–4.27)] and FNIH+WHO’s criteria [OR (95%CI): 2.20 (1.61, 3.00)]. The FNIH + WHO’s criteria were cross-sectionally associated with disability [OR: 1.52 (1.07, 2.16); p-value 0.018], while the EASO’s criteria were not. The EASO’s criteria did not show any association at the follow-up, while the FNIH + WHO’s criteria were associated with incident frailty. Conclusions: The EASO’s new criteria for sarcopenic obesity demonstrate moderate agreement with the traditional definition and are cross-sectionally associated with adverse events, but they do not effectively predict the outcomes generally associated with sarcopenic obesity in older adults. Therefore, the performance of the EASO’s criteria in older people raises the need for refinement before recommending it for generalized use in this population.