Background: Advances in digital technology have transformed contemporary implant prosthodontics, offering new approaches to the design and fabrication of implant overdentures (IODs). Computer-aided design and manufacturing (CAD/CAM), additive manufacturing, and computer-assisted implant surgery have improved clinical accuracy, efficiency, and patient satisfaction. Understanding current digital workflows, manufacturing methods, and clinical implications as well as their limitations is essential to optimize treatment outcomes in IODs. Objectives: To provide a concise but comprehensive overview of the state of the art of digital implant overdentures focusing on the workflow, manufacturing, clinical outcomes, and associated complications. Conclusion: Digital technologies have improved precision and efficiency in removable implant prosthodontics. While CAD/CAM and additive manufacturing enhance fit and workflow, fully digital protocols still remain a challenge, especially in complex cases. Hybrid approaches combining conventional and digital methods currently provide the most predictable results, with future advances expected to expand clinical applicability.

Delayed deformation of the Neuroform Atlas Stent during follow-up: Observational findings and clinical implications.

Materials and device architectures for cortisol detection: Mechanisms, measurement technologies, and clinical implications.

Propolis, a natural wax-like resinous substance present in bee hives, has been extensively used in dietary supplements and as folk medicine for the treatment of several diseases, including neurological disorders. Propolis has been used as a traditional medicine for the treatment of depression and other neurological disorders. This review aims to investigate the clinical studies and various therapeutic potentials associated with propolis, direct the future scope of research, and discuss possible clinical implications. A total of 143 papers were selected using a database comprising Google Scholar, Scopus, PubMed, and Web of Science. Diverse keywords, such as propolis, bee, phytochemistry, pharmacology, and clinical study, were used to search the content. This review highlights the diverse biological activities of propolis, as evidenced by preclinical and clinical studies. In experimental models, propolis extract exhibited antidepressant-like and vasculoprotective effects, primarily through its anti-inflammatory and antioxidant potential. These benefits were associated with the suppression of pro-inflammatory cytokines, chemokines, and angiogenic factors. Propolis extract was found to delay the progression of atherosclerosis by improving lipid metabolism and modulating apoptosis. Furthermore, both in vitro and in vivo investigations suggest that propolis may protect vascular endothelial function due to its antiproliferative activity. Notably, anticancer potential was observed against the ovarian cancer cell line M12.C3.F6. Clinical studies also provided encouraging findings. In patients with type 2 diabetes mellitus, propolis extract has been shown to improve wound healing parameters in diabetic foot ulcers. Another trial reported promising outcomes with propolis extract formulated as niosomal oromucosal-adhesive films for recurrent aphthous ulcers. Overall, these results underline the multifaceted therapeutic promise of propolis across neurological, vascular, oncological, and wound-healing domains. This review summarizes clinical and experimental evidence on the therapeutic potential of propolis. It highlights its immunomodulatory, antioxidant, antimicrobial, antifungal, anticancer (skin, oral, lung, breast, cervical), antidepressant, anxiolytic, cardiovascular, chemopreventive, and anti-angiogenic properties. Several studies, including clinical trials, suggest its potential role in combating COVID-19 and other health conditions. Overall, findings indicate that propolis possesses significant medicinal promise and may serve as a lead candidate for developing novel therapeutic agents.

Unraveling the significance of carotid siphon calcifications: Mechanisms and clinical implications in vascular aging - A narrative review.

To advance patient-centered care for high-need homeless-experienced patients, we identified the rates of various personal health goals, the broader domains that underlie these goals, and associations between these domains and the health-related needs of this population. The sample consisted of 176 veterans from 3 VA Medical Centers who were enrolled in primary care, on VA's Homeless Registry, and high utilizers of acute care. An interview was conducted with each participant to collect information on their personal health goals and health-related needs. Exploratory factor analysis was used to identify broad domains underlying endorsement of personal health goals. Associations between these broad goal domains and health-related needs (substance use, mental and physical health, treatment engagement, and psychosocial) were examined using an exploratory structural equation modeling-within-confirmatory factor analysis approach. Three broad domains were found to underlie the personal health goals of the sample: social functioning, health promotion, and substance use. Social functioning and health promotion were highly correlated, whereas substance use was weakly correlated with both social functioning and health promotion. All substance use-related needs were positively associated with substance use goals. Mental and physical health needs were primarily associated with health promotion goals. Treatment engagement and psychosocial needs demonstrated associations across all 3 goal domains. Findings highlight the high value that many high-need homeless-experienced patients place on their social well-being and the potential benefits to measuring both deficiency and growth needs in this population. Clinical implications and future directions for research are discussed.

Chronic liver disease is a frequently encountered disorder and a major concern worldwide with a complex pathophysiology, which often affects the hemostatic system. Such alterations, which affect both primary and secondary hemostasis, are heterogenous, including prohemorrhagic (i.e., decreased coagulation factors, increased fibrinolysis, thrombocytopenia, and platelet dysfunction) and prothrombotic (i.e., decreased natural anticoagulants) changes. As a consequence of this unstable balance, patients with liver cirrhosis may experience both hemorrhagic complications and venous thromboembolic events, which are often unpredictable and whose management is particularly challenging for clinicians. This narrative review will address the most recent advances in the pathophysiology of key derangements of hemostasis in patients with chronic liver disease, focusing on their clinical implications and management.

Antibodies in Creutzfeldt-Jakob disease: A systematic review of patient characteristics, diagnostics, and clinical implications.

Cardiovascular diseases (CVDs) remain the leading cause of morbidity and mortality worldwide, and excess adiposity is a major contributor to cardiovascular (CV) risk. However, obesity is a heterogeneous condition, and body mass index (BMI) alone fails to capture important differences in fat distribution and lean mass that substantially influence CV outcomes. Growing clinical and epidemiological evidence indicates that body composition, rather than body weight per se, provides a more accurate and biologically meaningful framework for CV risk assessment. This narrative review summarizes clinical evidence linking key components of body composition, including total and regional adiposity, skeletal muscle mass, and ectopic fat depots, to CV risk and prognosis. Central and visceral adiposity are consistently shown to be more strongly associated with cardiometabolic dysfunction, atherosclerosis, and CV events than generalized obesity. In parallel, reduced lean mass and sarcopenia emerge as independent predictors of adverse CV outcomes, particularly in older adults and patients with established CVD. Ectopic fat depots, such as epicardial and hepatic fat, further contribute to CV pathology through local and systemic mechanisms. Collectively, these findings highlight the limitations of BMI-centered approaches and support the integration of body composition measures into CV risk stratification. Emphasizing body recomposition, with reduction of harmful fat depots and preservation of skeletal muscle, may enable more precise, individualized strategies for CV prevention and management.

SCF-FBXO31 E3 ubiquitin ligase in cancer: Molecular insights and clinical implications.

Dermatomyositis is a rare autoimmune disease characterized by muscle weakness and distinctive skin rashes. Patients typically present with symmetric proximal muscle weakness alongside extramuscular manifestations, including interstitial lung disease and skin infections. While the exact cause remains unknown, researchers believe genetics, infections, and underlying autoimmune processes contribute to its development. The disease likely involves inappropriate complement protein activation targeting the perimysium, which triggers blood vessel inflammation and destruction around muscle fascicles. This process leads to ischemia and infarction of muscle tissue, ultimately causing muscle inflammation and atrophy. This paper analyzes existing data to determine whether early diagnosis and treatment of dermatomyositis reduce musculoskeletal complications. Several factors contribute to diagnostic delays: dermatomyositis occurs less frequently than other myopathies, early symptoms remain non-specific, and accurate diagnosis requires combining clinical, serologic, and muscle biopsy findings. Current evidence demonstrates that early detection and treatment of autoimmune diseases like dermatomyositis result in higher remission rates and reduced disease activity.

Men comprise up to 16% of aesthetic patients; however, the unique motivations and experiences of male patients remain understudied. We aimed to synthesize evidence on social, emotional, and psychopathological drivers of male interest in aesthetic procedures and outline clinical implications for aesthetic practitioners.Changing expressions of masculinity, media, and technology, as well as social, romantic, and professional influences, were explored. Research regarding psychopathology and body dysmorphic disorder (BDD) in male aesthetic patients was reviewed.Modern, fluid notions of masculinity have normalized aesthetic interventions among male patients. However, men experience ongoing stigma as a barrier to accessing treatment. Men display similar motivations to women, but report professional drivers more frequently. Mental health concerns and BDD prevalence rates are inconsistently reported among male aesthetic patients, but are likely to predispose males to more challenging treatment experiences. Clinical implications and recommendations for working with male patients are discussed.As men continue to undertake cosmetic procedures more frequently, practitioners should take care to adapt their approaches to the unique preferences of male patients. This includes shifts in language, advertising, consultation, and treatment planning to overcome stigma and barriers to access, while prioritizing safe, ethical care.

Nutrition and endometriosis: Evidence, limits and clinical perspectives.

Mechanobiology in orthodontic tooth movement: update on knowledge and clinical implications

Alterations in neurovascular coupling are present in adolescent patients with major depressive disorder: An integrated resting-state fMRI and arterial spin labeling study.

From first responders to outcome modulators: The evolving paradigm of neutrophils in ischemic stroke and thrombolysis.

Gut–brain axis in Parkinson's and Alzheimer's disease: Emerging clinical and therapeutic implications

Circulating integrins as biomarkers for bone metastasis in prostate cancer.

Desert vipers (Eristicophis and Pseudocerastes) employ diverse procoagulant strategies despite their close phylogenetic relationships, yet the biochemical mechanisms underlying the variations in their coagulotoxic activities remain poorly understood. We conducted comprehensive coagulation factor activation studies across all four species in the clade: Eristicophis macmahoni (Ema), Pseudocerastes fieldi (Pfi), P. persicus (Ppe), and P. urarachnoides (Pur). Plasma clotting assays revealed extreme variation in coagulation speed (17.3-376.1 s), with E. macmahoni and P. urarachnoides emerging as rapid coagulators. Fluorometric zymogen activation studies demonstrated that all species require Factor Va as a cofactor for optimal activity, with species-specific preferences for either the endogenous form of Factor Va produced by circulating thrombin or the FVa produced by the venom directly cleaving Factor V. This suggests that the venoms cleave FV at sites distinct from the cleavage site utilised by endogenous thrombin. The species had dramatically distinct patterns of factor activation: Factor XII was most strongly activated factor, and had a venom rank order of Pur ≫ Ema > Pfi = Ppe; Factor X was the next most potently activated factor, with a venom rank order of Ema = Pfi > Pur > Ppe; followed by Factor VII Pfi > Ppe > Ema = Pur; and prothrombin (Factor II) Ema > Pur, with activation by Pfi or Ppe not detectable. None of the venoms activated Factor XI. Notably, despite being suggested as a bird-specialist, P. urarachnoides exhibiting the highest Factor XII activation capacity is significant as avians have secondarily lost FXII as a component in their coagulation cascade. As such, the potent activation of FXII suggest non-avian prey species such as lizards or small rodents make up a significant proportion of this species diet. Antivenom efficacy studies revealed species-specific patterns, with the VINS Jorven antivenom showing superior neutralization against P. urarachnoides and Eristicophis macmahoni relative to the Inosan Inoserp-MENA antivenom and National Antivenom and Vaccine Production Centre of Saudi Arabia antivenom. These toxicology findings reveal that despite morphological similarity and shared ecological niches, desert vipers have evolved fundamentally distinct coagulotoxicity approaches to prey immobilization. These species-specific pathophysiological profiles have important clinical implications for antivenom development and bite treatment protocols in endemic regions.

Impact of reverse total shoulder arthroplasty on scapulohumeral rhythm: a systematic review and meta-analysis.