Clinical Features Of Uveitis Research Articles

Uveitis in psoriatic arthritis: study of 406 patients in a single university center and literature review

Background/purposeThe manifestations of uveitis are well established in axial spondyloarthritis (ax-SpA), but not in psoriatic arthritis (PsA). We aimed to assess, in a large unselected series of PsA: (A) the...

LV Prasad Eye Institute EyeSmart electronic medical record-based analytics of big data: LEAD-Uveitis Report 1: Demographics and clinical features of uveitis in a multi-tier hospital based network in Southern India.

Purpose:To describe the demographics and epidemiology of uveitis presenting to a multi-tier ophthalmology hospital network in Southern India.Methods:Cross-sectional hospital-based study of 19,352 patients with uveitis presenting between March 2012 and August 2018.Results:In total, 1,734,272 new patients were seen across the secondary and tertiary centers of our multi-tier ophthalmology hospital network during the study period. Among them, 25,353 eyes of 19,352 patients were diagnosed with uveitis and were included in the study. Uveitis constituted 1.11% of all cases. The majority of patients were male (60.33%) and had unilateral (68.09%) affliction. The most common age group was 21–50 years with 12,204 (63.06%) patients. The most common type of uveitis was anterior uveitis, which was seen in 7380 (38.14%) patients, followed by posterior uveitis in 5397 (23.89%) patients. Among the infectious causes, tuberculosis was the most common etiology (2551 patients, 13%) followed by toxoplasmosis (1147 patients, 6%)Conclusion:Uveitis constituted 1.11% of all cases presenting to our clinics. It was more common in the age group of 21–50 and was predominantly unilateral. Anterior uveitis was the most common subtype seen in 38%.

Commentary: EyeSmart EMR based analytics of big data: LEAD-Uveitis Report 1: Demographics and clinical features of uveitis in a multi-tier hospital based network in Southern India.

Commentary: EyeSmart EMR based analytics of big data: LEAD-Uveitis Report 1: Demographics and clinical features of uveitis in a multi-tier hospital based network in Southern India.

The Association between QuantiFERON-TB Gold Test and Clinical Manifestations of Uveitis in the United States

To report the prevalence of QuantiFERON-TB Gold (QFT-G) positivity among uveitis patients compared to general population and to evaluate the differences in clinical features of uveitis. Retrospective cohort study. SETTING: Institutional. 418 consecutive new uveitis patients, regardless of clinical suspicion, were tested for QFT-G. Demographics, TB risk factors, clinical characteristics of uveitis were collected. The frequency of QFT-G positivity among uveitis patients and characteristic clinical features among QFT-G positive patients. QFT-G positivity was found in 60/418 patients with uveitis (14.4%, 95% CI: 11.18 - 18.14) higher than the general US population (5%, 95% CI: 4.2 - 5.8, p<.001). Age, gender and residence were similar between QFT-G positive and negative groups. Uveitis patients with positive QFT-G were more likely to be foreign born or have a recent travel history (OR:5.84; 95% CI: 2.83 - 12.05; p<.001). QFT-G positive patients were more likely to present with granulomatous uveitis (OR 2.90; 95%CI 1.36 - 6.21; p=.006). No significant association was found with specific clinical features such as choroiditis, retinal vasculitis, occlusive vasculitis, and serpiginoid choroiditis (p>.05 for each). Prevalence of TB-uveitis based on treatment response was 1.19%. Our study demonstrates significantly higher prevalence of QFT-G positivity among uveitis patients compared to average US population. Characteristic signs of TB uveitis reported in endemic countries were not seen in this cohort. Implications of higher prevalence of QFT-G positivity among uveitis patients require further investigation.

Epidemiologic and Clinical Features of Uveitis from a Tertiary Referral Hospital in Bulgaria from 2016

Epidemiologic and Clinical Features of Uveitis from a Tertiary Referral Hospital in Bulgaria from 2016

Epidemiology and Clinical Features of Uveitis from Urban Populations in South India

ABSTRACTPurpose: To report the epidemiology of uveitis in two urban centers in South India.Methods: Case records seen between January 2014 and December 2014 at two tertiary eye centers in South India were retrospectively reviewed.Results: A total of 1123 patients in the study population had uveitis. Anterior uveitis was seen in 48.9%, posterior in 20.5%, intermediate in 17.3%, and panuveitis in 13.3%. Of these cases, 68.4% were acute uveitis. Pediatric uveitis constituted 6.9% patients. Tuberculosis was the commonest infectious etiology.Conclusions: Idiopathic uveitis was highest in non-infectious and tuberculosis in infectious etiology. Toxoplasmosis was seen in the pediatric age group.

Serial Frequencies and Clinical Features of Uveitis in Hokkaido, Japan

ABSTRACTPurpose: Environmental and lifestyle changes influence the clinical features of uveitis. This study reviewed the epidemiologic trends of uveitis in the Japanese population.Methods: A retrospective review of the past 80 years of reports from Hokkaido University Hospital.Results: In the 1930s, tuberculosis accounted for 46% and syphilitic uveitis for 31% of cases. The frequency of these diseases decreased to 12% in the 1950s; 8% in 1969; 0.6% in the 1990s; and 0.8% in the 2000s, while the rate of non-infectious uveitis increased. The three most common specific diagnoses were: sarcoidosis, Vogt–Koyanagi–Harada disease, and Behçet disease. Although Behçet disease was the most frequent non-infectious uveitis until the 1980s, sarcoidosis is now the most frequent cause of newly diagnosed non-infectious uveitis.Conclusions: The etiology of uveitis has changed with the times. Tubercular and syphilitic cases have greatly decreased, and sarcoidosis is the most frequent type of uveitis today.

Clinical features of uveitis in children and adolescents at a tertiary referral centre in Tokyo

ObjectivesTo analyse clinical features, systemic associations, treatment and visual outcomes of uveitis in children and adolescents at a tertiary centre in Tokyo.MethodsClinical records of 64 patients under the age of...

THE ROLES OF GENETIC FACTORS IN UVEITIS AND THEIR CLINICAL SIGNIFICANCE

Uveitis is a diverse group of intraocular inflammatory disease and is a significant cause of visual loss worldwide. Recent studies have identified various endogenous immune mechanisms and genetic factors that are involved in the pathogenesis of uveitis. This review provides an overview on the role of genetics in the development and clinical course of uveitis. PUBMED was used for literature search, and articles published from 1970 to 2012 that evaluated the genetic associations and mechanisms involved in the development and clinical features of uveitis were included. Studies have demonstrated associations between various genetic factors and the development and clinical course of intraocular inflammatory conditions. Genes involved included genes expressing interleukins, chemokines, chemokine receptors, and tumor necrosis factor and genes involved in complement system, oxidation, and other intracellular molecular pathways. Multiple genetic factors play important roles in the pathogenesis of uveitis and may influence the clinical course of uveitis. Further studies to investigate the genetic mechanisms of uveitis might identify additional genetic associations and might have the potential for identifying novel therapeutic targets in the treatment of intraocular inflammation.

Uveitis in developing countries

Uveitis, also referred to as intraocular inflammation, is a complex inflammatory process, involving primarily the uveal tract, with or without the involvement of adjacent intraocular structures. The underlying cause of the intraocular inflammation may reside in the uveal tract, retina, lens, or other ocular tissues. Uveitis is a leading cause of blindness in both developed and developing countries, including India. Although the inflammation can be due to a variety of causes - infections, systemic diseases, organ-specific autoimmune processes (primarily to T-cell-mediated Th2 and or Th17 processes), trauma, and primary or secondary ocular neoplasm presenting with clinical features of uveitis - the resulting uveal inflammation usually presents with similar symptoms that affect the patient's vision. Most patients with uveitis are diagnosed accurately and the disease is subclassified as granulomatous or nongranulomatous anterior, intermediate, posterior or pan uveitis; but determining the proper underlying etiology can be a challenge. The current issue, containing several articles from leaders in the field of uveitis, provides a clinically valid and prudent approach to determining the underlying causes of uveitis and lays out the current medical and surgical interventions that can be used to preserve vision and prevent blindness.

Minor salivary gland biopsy in diagnosing ocular sarcoidosis

BackgroundTo ascertain the sensitivity, specificity, and positive and negative predictive value of minor salivary gland biopsy in subsets of patients with uveitis consistent with ocular sarcoidosis.MethodMinor salivary gland biopsies performed...

Uveitis in Rheumatic Diseases

Uveitis is a common extra-articular manifestation of many rheumatic diseases and can be associated with considerable morbidity, both in terms of vision loss and the need for systemic immunosuppression. Anterior uveitis is symptomatic in adults, presenting as a red, painful eye with photophobia, and is most commonly associated with HLAB27 disease. In contrast, chronic anterior uveitis can be silent in children with juvenile idiopathic arthritis, necessitating regular screening to detect its presence. Posterior segment inflammation carries a worse prognosis for vision, and usually manifests as floaters and visual impairment. This article reviews the pathophysiology and clinical features of uveitis occurring in association with systemic inflammatory disease, as well as discussing the current and emerging therapies available for treating its various manifestations.

Clinical patterns of uveitis in two ophthalmology centres in Bogota, Colombia

To describe the distribution pattern and the clinical features of uveitis in two ophthalmology referral centres in Colombia. This was a retrospective study in which clinical records of patients attending the centres between 1996 and 2006 were systematically reviewed. Data were analysed and compared with previous reports. Uveitis was found in 693 patients: 335 men (48.3%) and 358 women (51.7%). The mean age for the first presentation was 31.7 +/- 18.3 years. Unilateral (73.4%), acute (68.3%), posterior (35.9%) and non-granulomatous (90.6%) were the most common types of uveitis found in the sample. Toxoplasmosis was the most frequent cause in this study followed in order by idiopathic and toxocariasis. Vogt-Koyanagi-Harada, Behçet's disease, sarcoidosis and white dot syndromes were less common. Some causes such as systemic lupus erythematosus and tuberculosis were extremely rare. Presumed ocular histoplasmosis, onchocerciasis and Lyme disease were absent. The results of this study provide the first report of clinical patterns for uveitis in Colombia. This study will enhance awareness of uveitis, and data should assist in the development of public health policies in our population for the improvement of patient outcomes.

Demographic and Clinical Features of Uveitis in Tertiary Centers in Turkey

Purpose: To analyze the referral patterns and clinical features of uveitis in tertiary eye care centers in Turkey. Methods: Uveitis services of eight university clinics collected data on uveitis patients who presented during 2004. Data were collected on a form including a questionnaire on socio-demographic and clinical features which were documented at presentation. Results: A total of 761 patients (1187 eyes) with a mean age of 35.5 years were included in the study. Male to female ratio was 1.04:1. The majority of patients (89.6%) were from an urban population, 53% were referrals and 43% had had uveitis for more than one year. The most common type of uveitis was anterior uveitis (52.5%) followed by panuveitis (28.1%), posterior uveitis (12.7%) and intermediate uveitis (6.7%). In 56.8% of patients an etiological classification was established. The most common etiology was Behçet's disease (32.1%), followed by Fuchs' heterochromic iridocyclitis (5.1%) and ocular toxoplasmosis (4.7%). Among 48 pediatric patients uveitis associated with juvenile idiopathic arthritis and ocular toxoplasmosis both having equal frequencies (12.5%) were the most common diagnosis. These were followed by Behçet's disease with juvenile-onset (10.4%). At the time of presentation, 6.25% of the patients were legally blind (having visual acuity less than 0.1 in the better seeing eye). Conclusion: Compared to the uveitis series reported from other countries, Behçet uveitis was the leading cause of uveitis in this series. Uveitis associated with juvenile idiopathic arthritis and ocular toxoplasmosis were the most common cause of uveitis in childhood. On the other hand, entities like acquired immunodeficiency syndrome-related uveitis, presumed ocular histoplasmosis and Birdshot retinochoroidopathy were rare.

Anterior Uveitis: A Manifestation of Graft-versus-Host Disease

To describe the occurrence of anterior uveitis along with systemic manifestations of chronic graft-versus-host disease (GVHD) after nonmyeloablative allogeneic hematopoietic stem cell transplantation (HSCT) in 3 patients with hematologic malignancies. Retrospective small case series. Three patients who underwent HSCT and 4 age- and gender-matched controls for cytokine analysis in ocular fluid. Interventional study of patients who underwent HSCT. Screening for evidence of infectious causes and immunological analysis of ocular fluid samples. Clinical features of uveitis and results of aqueous analysis. Anterior uveitis developed during an exacerbation of chronic GVHD in 3 patients after allogeneic HSCT for hematologic malignancies. Patients exhibited no abnormalities on extensive uveitis screening, and in addition, serologic and wide-ranging aqueous analysis showed no evidence of recent infections. We observed signs of inflammation in the ocular fluid in 2 of 3 patients by the determination of different cytokines. No other explanation for uveitis was found except the exacerbation of GVHD. Treatment, both systemic and topical, directed to chronic GVHD induced remission of uveitis in all patients along with amelioration of other signs of GVHD. Anterior uveitis occurred in the wake of the acute exacerbation of chronic GVHD after HSCT and may represent an ocular manifestation of chronic GVHD.

The Decreasing Prevalence of Uveitis Associated with Juvenile Rheumatoid Arthritis

We studied the prevalence and characteristics of chronic uveitis in a population of children diagnosed with juvenile rheumatoid arthritis (JRA). Uveitis is one of the most important, potentially debilitating extra-articular manifestations of JRA and has been observed in as many as 20% of cases. The medical records of 230 patients diagnosed with JRA and treated at a tertiary care hospital ophthalmology clinic between 1992 and 2000 were retrospectively reviewed. Seventeen patients (7.4%) were found to have clinical features of uveitis. There was a preponderance of female patients (16/17) and pauciarticular disease (13/17). Only 12 of 17 were ANA positive. Six had uveitis at diagnosis. Patients who were receiving naproxen had less incidence of uveitis compared with those receiving other nonsteroidal antiinflammatory drugs. Despite a relatively low prevalence of uveitis, complications occurred in about 24% (4/17) of the patients, even with adequate treatment and close monitoring. The prevalence of uveitis in JRA seems to be decreasing and may be secondary to the increased use of naproxen. However, routine ophthalmologic screening should be continued in patients with JRA to avoid potential complications of chronic uveitis.

Prevalence of HTLV-1-associated uveitis in the Kanto Plain, Japan

Seroprevalence of antibody to human T-lymphotropic virus type I (HTLV-I) is high in the island of Kyushu, Japan. Reports on the etiological analysis of HTLV-I in patients with uveitis primarily document cases in this island. We studied the seroprevalence of HTLV-I at the Department of Ophthalmology in Yokohama City University Hospital and in Odawara Municipal Hospital, which are in the Kanto Plain on the island of Honshu, Japan. The subjects were 741 patients who visited the two hospitals. The presence of serum antibodies against HTLV-I was assessed using the method of particle agglutination. Of 454 patients with nonuveitic ocular diseases, 9 (1.98%) were seropositive. Of 143 patients with definite diagnosis of uveitis, 1 (0.70%) was seropositive. Of 144 patients with non-specific uveitis (etiology undefined), 8 (5.56%) were seropositive. Thus, the prevalence of serum antibodies to HTLV-I was higher in patients with non-specific uveitis than in patients with specific uveitis or nonuveitic ocular diseases. Common ocular symptoms of 8 HTLV-I-infected patients with non-specific uveitis were compatible with the clinical features of uveitis described as HTLV-I-associated uveitis (HAU). It is important to suspect HAU in patients with uveitis of unknown etiology, even outside known areas of prevalence.