The clinical syndrome in persons with syringomyelia often includes severe chronic pain. Few studies have addressed the nature of this pain, and as such, its specific clinical characteristics are not defined. This study was aimed to define the pain characteristics in people with syringomyelia to increase our understanding of this condition and possibly provide new treatment methods and modalities. Subjects were patients diagnosed with syringomyelia of multiple etiologies, i.e., posttraumatic, neoplastic, congenital and idiopathic. All underwent complete neurological examinations and routine MRI as part of their clinical evaluation. Only patients (n=30) with recent (within six months) clinical evaluations and chronic pain were selected from a larger sample (n=68) and asked to complete the Pain History Form (PHF). Fifty-two (78.8%) subjects of the larger sample experienced chronic pain. The subset of 30 subjects (63.3% women and 36.7% men) was included in the present study ranged in ages from 21 to 72 years (mean 45.8 ± 13.1). Sixty percent had syrinxes of non-traumatic etiology, 33.3% were caused by trauma and 6.7% were caused by minor trauma without neurological sequela. Fifteen patients (50.0%) presented with motor deficits and 25 (83.3%) with sensory deficits. Pain was most commonly reported in: neck and shoulders (NS, 70.0%), back (BA, 73.3%), arms and hands (AH, 56.7%) and legs and feet (LF, 50.0%). The most common descriptor for NS (33.3%), AH (29.4%) and LF (46.7%) was “burning,” while “aching” was most common for BA (45.5%). Overall, the most frequently selected pain descriptors were sharp (60.0%), burning (56.7%), aching (56.7) and stabbing (53.3%). Pain is a frequent symptom in patients with syringomyelia as is noted by its high prevalence in our sample. Based on the clinical characteristics of pain, i.e., descriptor choice and pain location, our population appears to experience primarily neuropathic-type pain.