Clinical Cardiopulmonary Bypass Research Articles

Doppler Ultrasound Estimation of Bubble Removal by Various Arterial Line Filters During Extracorporeal Circulation

The bubble extraction capacity of various arterial line filters was tested in vitro and in vivo. The depth adsorption filtration principle was superior in removing bubbles compared with screen filters, both in vitro and under clinical cardiopulmonary bypass situations.

The comparative effects of pulsatile and nonpulsatile myocardial perfusion during cardiopulmonary bypass

The salutary effects of pulsatile perfusion (P) during clinical cardiopulmonary bypass (CPB) remain controversial. The notion exists that coronary blood flow may be enhanced by P, especially when a significant coronary stenosis occurs. In this study pressure-flow characteristics were assessed during CPB with and without P in 13 fibrillating dog hearts (37°C). Radionuclide microspheres measured transmural blood flow in normal myocardium (NR) and in regions supplied by collateral coronary arteries (CR) which restrict blood inflow at mean pump pressures of 80 and 50 mm Hg during either P or nonpulsatile perfusion (NP). Retrograde circumflex pressure (RC P) also served as an index of CR perfusion. At both pressures, mean myocardial blood flow to both NR and CR was not augmented by P despite aortic pulse pressures of approximately 50 mm Hg. Moreover, endocardial/epicardial flow ratios were unchanged from control in both regions after beginning pulsatile flow. At the same time, the mean RCP in CR was not affected by P even though a pulsatile pattern was transmitted across the collateral bed. Thus, the most significant factors affecting transmural blood flow during pulsatile CPB appear to be the coronary perfusion pressure and degree of inflow limitation, not the perfusion wave form. Therefore, any benefits which might be associated with clinical pulsatile perfusion during CPB appear to result from factors other than coronary blood flow augmentation.

A Scanning Electron Microscopy Study of the Attachment of a Thromboresistive Surface Coating to a Membrane Blood Oxygenator

The need for systemic heparin anticoagulation during extended cardiopulmonary bypass (CPB) remains a serious impediment to clinical CPB support of circulatory and respiratory failures, especially in the newborn. Recent development of thromboresistive substrates which can be used to treat extracorporeal surfaces in contact with blood offers the potential for elimination of systemic blood heparinization. The present paper describes a scanning electron microscopy study of the attachment of one such substrate, tridodecyl- methylammonium chloride (TDMAC), to a novel micro-membrane oxygenator.Figure 1 shows a cross-sectional image of the alternating pattern of microchannel conduits for blood flow through the oxygenator. The micro-channels were fabricated on thin metal sheets with an approximate semi-circular shape (150 + 25 microns in radius). The gas exchange to the blood flow in the channels was accomplished through a micro-porous membrane which was placed across the diametric plane of the channels (1).

A Simple Method of Producing Pulsatile Flow During Clinical Cardiopulmonary Bypass

A method using the intraaortic balloon to produce pulsatile flow during cardiopulmonary bypass is described. The technique has been employed in 26 patients, and there have been no complications.

Portal venous hemodynamics during and after clinical cardiopulmonary bypass

Portal venous hemodynamics during and after clinical cardiopulmonary bypass

Influence of hyperosmolality on left ventricular stiffness.

ARTICLESInfluence of hyperosmolality on left ventricular stiffnessGH Templeton, JH Mitchell, and K WildenthalGH Templeton, JH Mitchell, and K WildenthalPublished Online:01 Jun 1972https://doi.org/10.1152/ajplegacy.1972.222.6.1406MoreSectionsPDF (1 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation Cited BySystems analysis of the mechanisms of cardiac diastolic function changes after microgravity exposureActa Astronautica, Vol. 63, No. 7-10Effects of hypertonic dextran in hypovolaemic shock: a prospective clinical trialInjury, Vol. 35, No. 5Na/H exchange inhibition improves long-term myocardial preservationThe Annals of Thoracic Surgery, Vol. 66, No. 2Fluid and Electrolyte Disorders in Neurosurgical Intensive CareNeurosurgery Clinics of North America, Vol. 5, No. 4Hypovolemic ShockCritical Care Clinics, Vol. 9, No. 2Use of Hypertonic-Hyperoncotic Fluids for Resuscitation of Trauma Patients1 July 1992 | Journal of Intensive Care Medicine, Vol. 7, No. 4Viscoelastic properties of the contracting detrusor. I. Theoretical basisJ. G. Venegas1 August 1991 | American Journal of Physiology-Cell Physiology, Vol. 261, No. 2Cardiovascular FunctionPitfalls in interpretation of pulmonary artery catheter dataJournal of Cardiothoracic Anesthesia, Vol. 3, No. 5Plasma expandersThe American Journal of Surgery, Vol. 155, No. 37.5% NaCl/Dextran 70 Solution in the Prehospital Care of the Trauma PatientLeft ventricular internal resistance and unloaded ejection flow assessed from pressure-flow relations: a flow-clamp study on isolated rabbit hearts.Circulation Research, Vol. 60, No. 5Misled by the Wedge?Chest, Vol. 89, No. 3In vivo effects of acute changes in osmolality and sodium concentration on myocardial contractilityAmerican Heart Journal, Vol. 109, No. 2Effects of Simulated Clinical Cardiopulmonary Bypass and Cardioplegia on Mass of the Canine Left VentricleThe Annals of Thoracic Surgery, Vol. 39, No. 2Constitutive stress-strain relations for the myocardium in diastoleJournal of Biomechanics, Vol. 18, No. 3Deviation of observed from passive states in diastoleJournal of Biomechanics, Vol. 15, No. 5On the mechanics of left ventricular diastoleJournal of Biomechanics, Vol. 13, No. 3Effect of hyperglycaemia-induced hyperosmolality on heart function in the dogEuropean Journal of Clinical Investigation, Vol. 9, No. 2Effects of open heart surgery on end-diastolic pressure-diameter relations of the human left ventricle.Circulation, Vol. 59, No. 4Influence of aging on left ventricular hemodynamics and stiffness in beagles.Circulation Research, Vol. 44, No. 2The influence of hyperosmolality on heart functionExperientia, Vol. 34, No. 12Left ventricular compliance: Mechanisms and clinical implicationsThe American Journal of Cardiology, Vol. 38, No. 5Contractility in mammalian heart muscle; calcium and osmolality.Circulation Research, Vol. 36, No. 1Influence of Temperature on the Mechanical Properties of Cardiac MuscleCirculation Research, Vol. 34, No. 5Effects of osmolality on hypoxic myocardium27 September 2008 | Archives Internationales de Physiologie et de Biochimie, Vol. 82, No. 5Effect of mannitol on the performance of the isolated canine heart after fibrillatory arrestThe Journal of Thoracic and Cardiovascular Surgery, Vol. 66, No. 2 More from this issue > Volume 222Issue 6June 1972Pages 1406-1411 Copyright & PermissionsCopyright © 1972 by American Physiological Societyhttps://doi.org/10.1152/ajplegacy.1972.222.6.1406PubMed5030197History Published online 1 June 1972 Published in print 1 June 1972 Metrics

Clinical Cardiopulmonary Bypass Utilizing Normothermia, Normotension and “Highflow”

Clinical Cardiopulmonary Bypass Utilizing Normothermia, Normotension and “Highflow”

Homologous fresh-frozen plasma as a priming fluid for clinical cardiopulmonary bypass.

Homologous fresh-frozen plasma as a priming fluid for clinical cardiopulmonary bypass.

Renal performance during clinical cardiopulmonary bypass with and without hemodilution

Summary Renal performances during clinical cardiopulmonary bypass, with and without hemodilution, were compared. The major difference consisted of a significantly larger rate of urine flow and a lower osmolality of urine during and immediately after cardiopulmonary bypass when hemodilution was utilized. Explanations for these phenomena were discussed. Glomerular filtration rate, effective renal plasma flow, and postoperative urine electrolyte excretion and osmolality patterns were generally similar in both groups of patients. It was concluded that the increased production of urine associated with hemodilution perfusion might well protect renal-tubular integrity during stressful situations, such as intracardiac surgery.

Observations on the electroencephalograph during experimental and clinical cardio-pulmonary by-pass.

Observations on the electroencephalograph during experimental and clinical cardio-pulmonary by-pass.