Limitations of classical left ventricular hypertrophy electrocardiographic criteria in hypertrophic cardiomyopathy: Transferring cardiac electrical activity onto a 3D heart model in a patient with recurrent ventricular fibrillations.

From 2D to 3D: Evolution of evaluation methods for femoral neck fracture reduction quality.

Monogenic diabetes in Japan and India: A call for broader screening.

Purpose: This study aimed to improve the language development of children aged 4–5 years, specifically their ability to understand and execute two simultaneous instructions, through chronological picture-based storytelling activities in Group A of TK Pertiwi VII Saruran. Methodology: A Classroom Action Research (CAR) design was employed, consisting of two cycles, each incorporating four phases: planning, implementation, observation, and reflection. The study involved 10 children (aged 4–5 years) in Group A. Data were collected through structured observation checklists using a four-point developmental scale: Not Yet Developed (BB), Beginning to Develop (MB), Developing as Expected (BSH), and Developing Very Well (BSB). Classical mastery was set at 80%. Results : In Cycle I, 50% of children (5 out of 10) achieved the mastery threshold. Following instructional refinements in Cycle II (simplification of instruction syntax, integration of commands into story dialogue, and progressive scaffolding), the mastery rate increased to 80% (8 out of 10), meeting the classical mastery criterion. Conclusions: Chronological picture-based storytelling is an effective instructional strategy for enhancing the receptive language development of early childhood students. The integration of sequential visual cues with narrative commands provides a structured, engaging, and contextually meaningful scaffold for dual-instruction comprehension. These findings contribute to early childhood language pedagogy and support the use of culturally relevant, visual storytelling as a differentiated instructional tool.

The potential and prospects for using the Dmethod for detecting hidden periodicities in data streams describing the unevenness of one-dimensional fibre flows across spinning mill transitions are examined. Computer statistical simulation, using classical mathematical statistics criteria, was used to study and analyse the results. Areas of potential application for the Dmethod, where it may offer advantages over harmonic spectral analysis, are reliably identified.

Uncovering subclinical retinal toxicity: The role of macular thickness mapping inhydroxychloroquine screening.

Resistant hypertension is conventionally defined as failure to achieve blood pressure control despite treatment with optimal or maximally tolerated doses of three antihypertensive drugs, typically including a renin-angiotensin system blocker, a calcium channel blocker, and a diuretic. In real-world practice, however, many patients receive four or more antihypertensive agents without necessarily fulfilling classical resistant hypertension criteria, and data describing such prescribing patterns among cardiologists are limited. We conducted a prospective, multicentre, cross-sectional observational study across 10 cardiology outpatient centres enrolling consecutive adult patients (≥ 18 years) receiving more than three antihypertensive drugs. Patients with renal denervation, renal transplantation, known renal artery stenosis, or incomplete data were excluded. Demographic characteristics, blood pressure, comorbidities, and antihypertensive prescriptions were recorded, with a predefined analysis of mineralocorticoid receptor antagonist (MRA) use in the overall cohort and in patients meeting guideline criteria for resistant hypertension. A total of 420 patients were included (mean age 65.2 years; male-to-female ratio 1:0.8). Renin-angiotensin system inhibitors, calcium channel blockers, and diuretics were prescribed in 89, 85, and 82% of patients, respectively, while beta-blocker use was high at 85%. Overall MRA use was low at 39%. Among patients fulfilling criteria for resistant hypertension (n = 273), MRA use was 27%, increasing to only 38% when serum potassium was ≤4.5 mEq/L. Serum potassium ≤4.5 mEq/L was the only independent predictor of MRA prescription. These findings highlight substantial underutilization of MRAs in real-world practice and an important opportunity to improve guideline-directed management of resistant hypertension.

Stability analysis of fractional-order impulsive Cohen-Grossberg neural networks with interdisciplinary applications in neurobiology and chemical kinetics.

Low mortality and favourable outcome in lung volume reduction surgery for different emphysema morphologies.

Opportunistic identification of Li-Fraumeni syndrome through germline TP53 variant detection from routine tumour next-generation sequencing: An analysis of 1394 cases.

The strength behavior of natural loess is governed by its inherent structure and is sensitive to humidity and stress paths, posing challenges for stability assessment in loess engineering. To address this, a three-dimensional strength criterion for structural loess is developed by introducing a shape change coefficient and a structural state parameter, effectively extending classical failure criteria to account for true triaxial stress effects. This criterion is integrated into the Mohr-Coulomb model and implemented in FLAC3D via a custom subroutine for numerical simulation. The model is validated against a series of true triaxial tests under various consolidation pressures (50-300kPa) and intermediate principal stress ratios (b = 0–1). Results show that the proposed criterion accurately captures the stress-strain response and strength evolution of loess, with simulation errors within 5% and strong correlation to experimental data. The study provides a practical theoretical tool for analyzing progressive failure in loess under hydraulic and mechanical actions, with direct relevance to slope, tunnel, and foundation engineering in loess regions.

Case C-211/24, opposing LEGO and the Hungarian company Pozitív Energiaforrás Kft., raises key issues concerning the protection of industrial designs applied to compatible modular systems. The dispute has enabled the Court of Justice of the European Union to clarify the scope of Article 8(3) of the Designs Regulation (the so-called “LEGO exception”), within the framework of the reform introduced by Regulation (EU) 2024/2822, which amends Regulation (EC) No 6/2002. In its judgment of 4 September 2025, the Court confirms that LEGO bricks do not benefit from a privileged regime: the classic criteria for assessing design protection relating to the “informed user”, the “overall impression”, and the “designer’s degree of freedom” remain fully applicable to modular products. The Court also delineates the scope of the “special reasons” under Article 89(1) CDR, emphasising their exceptional nature and strict interpretation in the context of remedies for design infringement. The decision constitutes a milestone in the European harmonisation of design law, strengthening legal certainty both for holders of modular system designs and for operators marketing compatible components, by clarifying the limits of protection and market conduct.

Non-ordinary state-based peridynamics (NOSB-PD) has been widely applied to rock fracture modeling due to its compatibility with continuum mechanics. However, the classical formulation frequently produces zero-energy modes and nonphysical displacement oscillations as a result of insufficient local deformation compatibility. Moreover, the direct use of classical shear failure criteria often leads to inconsistencies between simulated and experimentally observed shear crack paths. To address these issues, this study employs a bond-level deformation gradient constructed from the averaged deformation gradient at the bond scale, which restores local compatibility and effectively suppresses zero-energy modes. In addition, a triple shear energy criterion is incorporated to distinguish different shear-related mechanical states, thereby improving the physical consistency of shear crack identification and the accuracy of crack path prediction. The improved model is examined through three benchmark numerical examples and simulations of fractured rock. The results demonstrate that it can accurately reproduce crack initiation, propagation, and coalescence under complex loading conditions, while maintaining numerical stability and requiring minimal parameter calibration. Compared with existing NOSB-PD implementations, the approach offers a clearer mathematical structure and enhanced predictive capability, providing a reliable and applicable numerical tool for crack evolution analysis in rock materials.

Brain aging involves progressive disruption of tissue homeostasis and susceptibility to neurodegenerative disorders. Within this context, astrocytes are key determinants of region-specific physiology, given their roles in metabolic support, synapse regulation, proteostasis, neuroinflammation, and blood-brain barrier maintenance. Aging is accompanied by broad transcriptional and functional remodeling in astrocytes, leading to the emergence of distinct cellular states that cannot be defined by classical morphological criteria alone. This review discusses how aging modifies astrocyte identities toward reactive and senescence-like states. We summarize core features of astrocyte senescence, including altered secretory signaling, impaired neuronal support, and changes in mitochondrial and proteostatic pathways, while integrating recent single-cell and regionally transcriptomic studies that delineate multiple reactive states associated with aging and pathological contexts. We further address evidence that reactivity and senescence are not mutually exclusive endpoints, but may coexist, arise sequentially, or partially overlap depending on timing, brain region, biological sex, and pathological insults. Finally, we define key open questions and experimental priorities required to establish the temporal and causal relationships among astrocyte states. We argue that resolving these issues is essential for advancing therapeutic strategies that specifically target defined astrocyte phenotypes, rather than nonspecifically suppressing astrocyte activity, in aging and neurodegenerative diseases.

ОБОСНОВАНИЕОБОСНОВАНИЕ. В различных регионах Российской Федерации колебания медико-биологических характеристик носят неоднозначный, а зачастую и разнонаправленный характер, при этом одним из путей к пониманию значимости действия данных компонентов является изучение их влияния на метаболическое состояние человека, в частности на углеводный обмен в идентичных по образу жизни группах, но проживающих в различных климатогеографических условиях.ЦЕЛЬЦЕЛЬ. Оценка основных показателей углеводного обмена у молодых жителей различных климатогеографических зон проживания (северо-восток, северо-запад, средняя полоса России).МАТЕРИАЛЫ И МЕТОДЫМАТЕРИАЛЫ И МЕТОДЫ. Проведена оценка ключевых характеристик метаболизма углеводов у 243 лиц мужского пола, проживающих в различных регионах Российской Федерации: северо-восток России (г. Магадан) — 119 юношей, северо-запад России (г. Мурманск) — 72 юноши и средняя полоса России (г. Ульяновск) — 52 юноши. В работе использовали иммунохемилюминесцентный ферментативный метод и иммунохроматографический анализ.РЕЗУЛЬТАТЫРЕЗУЛЬТАТЫ. Установлено, что при сопоставимых рационах питания средние величины показателей метаболизма углеводов у обследуемых жителей различных регионов обследования соответствовали оптимальным физиологическим диапазонам с формированием региональных особенностей метаболического профиля. Выявлено смещение уровня гликемии и гликированного гемоглобина в сторону больших значений при низких концентрациях инсулина лишь в группе юношей северо-востока России на фоне повышенных значений сывороточного кортизола, наблюдаемых только в группах юношей-северян. Уроженцам северо-запада и средней полосы России была свойственна активация инсулярного аппарата поджелудочной железы, сопровождающаяся повышением уровня инсулина, высокой долей встречаемости признаков инсулинорезистентности (до 40% в выборке) при выраженной компенсаторной секрецией β-клеток поджелудочной железы.Полученные данные свидетельствуют о том, что метаболические паттерны, наблюдаемые у северян, отличаются от классических критериев «полярного метаболического типа», которые обычно ассоциируются с гипогликемией, гипоинсулинемией на фоне повышенных значений сывороточного кортизола. При этом наличие признаков инсулинорезистентности в выборке юношей северо-запада России может быть обусловлено дисбалансом в сторону большего доминирования симпатического отдела вегетативной нервной системы.ЗАКЛЮЧЕНИЕЗАКЛЮЧЕНИЕ. Полученные результаты свидетельствуют о том, что изменения в углеводном обмене имеют ярко выраженные «северные» особенности, но по-разному проявляющиеся у жителей северо-западных и северо-восточных регионов России. Установлено, что проживание в различных климатогеографических регионах Российской Федерации с их уникальными климатическими, географическими и широтными условиями приводит к формированию разнообразных вегетативных, эндокринных и метаболических профилей.

123P Health-related quality of life in newly diagnosed sarcoma patients: Longitudinal findings from the international QUEST study

124P Efficacy of nirogacestat in improving emotional impact outcomes in adults with desmoid tumors: Post hoc analysis from the DeFi Trial

Stability analysis of a time-delayed SIQR epidemic model with nonlinear transmission and control parameters.

A Comprehensive Experimental Database and Novel Onset Criterion for Heat Transfer Deterioration in Vertical Upward Supercritical CO₂

This study introduces Sharīʿah analytics, a novel methodological framework leveraging machine learning and big data analytics, to systematically analyze classical Islamic jurisprudential texts (furūʿ al-fiqh kitābs), and further assesses cryptocurrencies against the Islamic monetary principles. Sharīʿah analytics is done via computationally processing 55 texts across four Sunni and one Shia legal tradition, examining Arabic currency-related terms and their fundamentals to explain whether cryptocurrencies align with pre-modern juristic definitions rooted in physicality, standardization, and regional acceptance. Findings reveal that cryptocurrencies inherently diverge from classical criteria, e.g., weight-based valuation, intrinsic material purity, and communal consensus, interpreting them non-compliant with traditional Islamic currency frameworks. This approach advances Islamic monetary scholarship, offering a data-driven lens to reconcile ethical monetary principles with emerging digital economies. The study fills a gap in existing literature by systematically contextualizing cryptocurrency debates within primary juristic sources rather than relying on speculative analogies or fragmented scholarly opinions. ACKNOWLEDGMENT This research received funding from the Deanship of Scientific Research, Vice Presidency for Graduate Studies and Scientific Research, King Faisal University, Saudi Arabia [KFU252890]. In addition, this research also received funding from Majelis Pendidikan Tinggi Penelitian dan Pengembangan (Diktilitbang) Muhammadiyah Risetmu Penelitian Reguler Batch IX [0259.1043/I.3/D/2025].