Hybrid Class Research Articles

Superconducting Qubit Based on Twisted Cuprate Van der Waals Heterostructures.

Van-der-Waals assembly enables the fabrication of novel Josephson junctions featuring an atomically sharp interface between two exfoliated and relatively twisted Bi_{2}Sr_{2}CaCu_{2}O_{8+x} (Bi2212) flakes. In a range of twist angles around 45°, the junction provides a regime where the interlayer two-Cooper pair tunneling dominates the current-phase relation. Here we propose employing this novel junction to realize a capacitively shunted qubit that we call flowermon. The d-wave nature of the order parameter endows the flowermon with inherent protection against charge-noise-induced relaxation and quasiparticle-induced dissipation. This inherently protected qubit paves the way to a new class of high-coherence hybrid superconducting quantum devices based on unconventional superconductors.

Easy one-pot synthesis of multifunctionalized indole-pyrrole hybrids as a new class of antileishmanial agents.

A chemoselective one-pot synthesis of pharmaceutically prospective indole-pyrrole hybrids by the formal [3 + 2] cycloaddition of 3-cyanoacetyl indoles (CAIs) with 1,2-diaza-1,3-dienes (DDs) has been developed. The new indole-pyrrole hybrids were phenotypically screened for efficacy against Leishmania infantum promastigotes. The most active compounds 3c, 3d, and 3j showed IC50 < 20 μM and moderate cytotoxicity, lower than miltefosine. Compound 3d was the most active with IC50 = 9.6 μM and a selectivity index of 5. Consequently, 3d could be a new lead compound for the generation of a new class of antileishmanial hybrids.

New results on finite-time projective synchronization for memristor-based hybrid delayed BAM neural networks with applications to DNA image encryption

&lt;abstract&gt; &lt;p&gt;With the popularization of digital image technology, image information has inevitably developed to involved the disclosure of personal privacy; in this study, a color image encryption algorithm was designed to encrypt and decrypt images by using chaotic sequences of a class of memristor-based hybrid delayed bidirectional associative memory neural networks (MHDBAMNNs) to protect images from illegal acquisition and use. Additionally, the discontinuity problem of the right-hand side of the Filippov system due to the hopping property of the memristor has been treated by using differential inclusion and set-valued mapping theories, and a sufficient criterion for guaranteeing the synchronization of finite-time projections derived based on the drive-response concept, Lyppunov stability theorem, and inequality technique. To improve the security performance, a color image encryption algorithm based on a combination of Chen's hyperchaotic system and a DNA codec operation was adopted, also, the robustness and validity of our proposed approach was demonstrated through image performance analysis. Furthermore, the potential application of the model in secure transmission has been explored.&lt;/p&gt; &lt;/abstract&gt;

Thiazole orange-carboplatin triplex-forming oligonucleotide (TFO) combination probes enhance targeted DNA crosslinking.

We report a new class of carboplatin-TFO hybrid that incorporates a bifunctional alkyne-amine nucleobase monomer called AP-C3-dT that enables dual 'click' platinum(ii) drug conjugation and thiazole orange fluorophore coupling. Thiazole orange enhances the binding of Pt(ii)-TFO hybrids and provides an intrinsic method for monitoring triplex formation. These hybrid constructs possess increased stabilisation and crosslinking properties in comparison to earlier Pt(ii)-TFOs, and demonstrate sequence-specific binding at neutral pH.

Customer Personality Analysis for Churn Prediction Using Hybrid Ensemble Models and Class Balancing Techniques

Customer Personality Analysis for Churn Prediction Using Hybrid Ensemble Models and Class Balancing Techniques

TRANSFORMATIONAL PROCESSES IN ADULT EDUCATION IN THE REPUBLIC OF POLAND

The article discusses the transformational processes in adult education in the Republic of Poland. The normative legal documents that influenced the education of adults are analyzed; documents in the field of adult education, resolutions introduced for the period of temporary restriction of the functioning of units of the education system, in particular higher education institutions and other educational institutions, as well as employers, in connection with the prevention, counteraction and fight against COVID-19. It is concluded that, depending on the epidemic situation, online classes, hybrid or stationary classes were limited or cancelled, which affected both the organization of the educational process of adult learning, and its participants. Classes using distance learning methods and techniques have become a priority. The transformational processes in adult education in the Republic of Poland allow us to conclude that there is a clear relationship between adult education and change. Polish andragogues in their reflections and studies draw attention to this relationship. Attention is drawn to the fact that there is a double impact of transformations on adult education: the goal of transformation is not only to reduce the tension that led to the transformation, but also to create new conflicts that should stimulate the individual to creative activity in this new situation It is also necessary to pay attention to the dual impact of the transformation of the system on adult education: it is always stated that its purpose is not only to reduce tension, which led to transformation, but also to the creation of new conflicts that should stimulate the individual to creative activity in this new political formation. The forms and content of adult education today are determined by three vectors: the needs of the labor market, the resources and capabilities of the modern information society, and the individual aspirations of adults for education. The synergistic effect of the interaction of these vectors may be a change in the way of perception and organization of educational processes for adults, which will lead to a decrease in their institutionalization.

하이브리드 수업을 경험한 대학생의 수업 인식 및 교육만족도 분석

Objectives The purpose of this study is to analyze the class perception and education satisfaction of college students who have experienced hybrid classes, find effective ways to improve hybrid classes, and improve college students' perception and education satisfaction.&#x0D; Methods To this end, a survey was conducted on 354 college students who experienced hybrid classes at six universities in Chungcheong Province to measure their perception of hybrid classes and educational satisfaction. Descriptive statistics, independent sample t-test, one-way variance, and post hoc analysis were conducted to determine the difference between hybrid class awareness and education satisfaction through the collected data. In addition, the impact of hybrid class perception on educational satisfaction was verified through correlation and multiple regression analysis.&#x0D; Results As a result of analysis of 354 college students who experienced hybrid classes, first, by grade, fourth-year students showed a higher average perception of hybrid classes than second-year students, and in terms of class participation, students who participated in face-to-face classes showed higher awareness than students who participated in remote classes. Second, among the gender-specific subfactors of educational satisfaction, female students showed a higher average in all items than male students, and in terms of the type of university establishment, national university students showed a slightly higher average than private university students. In addition, students who participated in face-to-face classes showed higher educational satisfaction than students who participated in remote classes, and by grade, 4th grade students showed statistically higher averages in all factors than students of other grades. Lastly, as a result of analyzing the correlation between hybrid class perception and education satisfaction, it was found that among the sub-factors of hybrid class perception, the higher the perception of understanding, interaction, and intention to continue learning, the higher the education satisfaction.&#x0D; Conclusions These results provide basic data for the design and improvement of hybrid classes operated at each university, and are meaningful in suggesting limitations and improvement plans for hybrid classes.&#x0D;

Mind Map As A Tool For Enforcing Learning During Flipped Class: Application to Petroleum Engineering

Flipped learning has been proven to be an efficient learning strategy that can enforce learning and improve many desirable skills and attributes for learners. To properly implement a flipped class, the educator must use appropriate tools to facilitate learning during the pre-class (i.e., self-study) and in-class (i.e., with the educator) stages. The preclass stage of a complete flipped class process requires students to self-learn with the minimum educator guidance. However, educators should ensure they create a resourceful learning environment for students to learn properly. This environment should consider directing the students and supporting them with efficient learning tools and scaffolding instruments to minimise their endeavours and make them more learning-focused. Mind maps are examples of tools that students may use to summarise lecturing notes, digest the learning contents easily, discuss the concepts with peers and groups, share the contents with lecturers and class, and finally get constructive feedback from lecturers and peers. In this work, the mind map was used to enforce students’ learning during a flipped class of two petroleum engineering core subjects at a Malaysian university. Two batches of students simultaneously taking two core subjects in the January 2022 semester were guided to use mind maps for learning during the pre-class step of implemented flipped classes. Students were directed to reading material and asked to use mind maps during pre-class to summarise and digest the contents before presenting in hybrid (physical-online) classes, during which the lecturer gives instantaneous feedback. After the flipped class, data was collected to assess the impact of the implemented mind map-inclusive flipped class framework on learning performance. Two data sources were used, students’ responses to an online survey and student marks of two coursework components related to the intended course learning outcome (Quiz 2 and Test 2). The responses to the survey revealed that using mind maps has substantially improved all four indicators. The student marks in the two coursework components indicated satisfactory learning performance.Keywords: cognitive domain, engagement, flipped class, mind maps, soft skills.

Analysis of the Learning Models Needs in Hybrid Class Microteaching to Improve the Teaching Competencies

The purpose of this study is to analyze the need for learning models in microteaching courses for hybrid learning environments. Quantitative descriptive techniques are the research methods used; these techniques are intended to use quantitative data to describe and analyze specific phenomena or variables in the population. This approach aims to give an accurate picture of the situation or phenomenon under study rather than to test a hypothesis or bring about change. At this point, 80 enrolled in the Economics Study Program at Sriwijaya University will participate in a survey that takes the form of a questionnaire administered by researchers to fifth-semester students. The study's findings demonstrate the continued need for high-quality instruction in hybrid classes for microteaching courses. This study includes the development of an efficient learning model for hybrid classes as well as the utilization of current technology to foster a positive microteaching environment in newly created hybrid class.

Liriogerphines E–U, further unique sesquiterpene-alkaloid hybrids from the rare Chinese tulip tree

Seventeen undescribed sesquiterpene-alkaloid hybrids (liriogerphines E–U, 1–17) were isolated and identified during a further phytochemical investigation on the branches and leaves of Chinese tulip tree (Liriodendron chinense), a rare medicinal and ornamental plant endemic to China. These unique heterodimers are conjugates of germacranolide-type sesquiterpenoids with structurally diverse alkaloids [i.e., aporphine- (1–15), proaporphine- (16), and benzyltetrahydroisoquinoline-type (17)] via the formation of a C–N bond. The previously undescribed structures were elucidated by comprehensive spectroscopic data analyses and electronic circular dichroism calculations. Such a class of sesquiterpene-alkaloid hybrids presumably biosynthesized via an aza-Michael addition is quite rare from terrestrial plants. In particular, the sesquiterpene-benzyltetrahydroisoquinoline hybrid skeleton has never been reported until the present study. All the isolates were evaluated for their cytotoxic effects against a small panel of leukemia cell lines (Raji, Jeko-1, Daudi, Jurkat, MV-4-11 and HL-60), and some of them exhibited considerable activities.

The Analysis of Students’ Perceptions in Hybrid Classroom using Learning Management System (LMS)

This qualitative descriptive case study delves into the perceptions of students regarding the utilization of a Learning Management System (LMS) in a hybrid classroom setting and elucidates the challenges encountered by students while using the LMS. The research involved five junior high school students selected based on specific criteria and characteristics. Employing observation and interviews as the primary instruments, the study unfolded in distinct stages. The findings revealed varying perceptions among the students, with three displaying a positive outlook toward the use of LMS in hybrid classes, while the remaining two exhibited a negative perception. Challenges identified encompassed a lack of enthusiasm in engaging with both online and offline learning through the LMS, intermittent connectivity issues, tight deadlines, and difficulties in comprehending the instructional content delivered via the LMS.

Synthesis and Characterization of a New Class of Chromene-Azo Sulfonamide Hybrids as Promising Anticancer Candidates with the Exploration of Their EGFR, hCAII, and MMP-2 Inhibitors Based on Molecular Docking Assays

In this study, novel selective antitumor compounds were synthesized based on their fundamental pharmacophoric prerequisites associated with EGFR inhibitors. A molecular hybridization approach was employed to design and prepare a range of 4H-chromene-3-carboxylates 7a–g, 8, and 11a–e derivatives, each incorporating a sulfonamide moiety. The structures of these hybrid molecules were verified using comprehensive analytical and spectroscopic techniques. During the assessment of the newly synthesized compounds for their anticancer properties against three tumor cell lines (HepG-2, MCF-7, and HCT-116), compounds 7f and 7g displayed remarkable antitumor activity against all tested cell lines, outperforming the reference drug Cisplatin in terms of efficacy. Consequently, these promising candidates were selected for further investigation of their anti-EGFR, hCAII, and MMP-2 potential, which exhibited remarkable effectiveness against EGFR and MMP2 when compared to Sorafenib. Additionally, docking investigations regarding the EGFR binding site were implemented for the targeted derivatives in order to attain better comprehension with respect to the pattern in which binding mechanics occur between the investigated molecules and the active site, which illustrated a higher binding efficacy in comparison with Sorafenib.

Lead Halide Hybrids Templated by Two Coordinating Ligands for Enhanced and Stable Self-Trapped Emission.

Lead halide hybrids templated by coordinating ligands are a class of ultrastable broadband self-trapped emitters that overcome the stability problems of conventional ionically bound halide hybrids. However, enhancing their photoluminescence (PL) performances by crystal engineering remains a huge challenge. Herein, for the first time, we have successfully employed the synthetic strategy of two coordinating ligands to synthesize a series of layered lead halide coordination polymers, [Pb6X10]2+(chdc2-)(2,2'-bpy)2 (X = Cl/Br, chdc = trans-1,4-cyclohexanedicarboxylate), which involves chdc as a pillaring strut and 2,2'-bpy as a chelating ligand. The introduction of a chelating ligand (2,2'-bpy) enables stronger lattice distortion of lead halide layers and enhances UV-light absorption and ligand-to-metal charge transfer (LMCT) process, thereby achieving a substantial improvement of photoluminescence quantum yields (PLQYs) over the control layered materials templated by a single chdc ligand. This class of lead halide hybrids templated by two coordinating ligands exhibit chemical "inertness" after being subjected to various chemical conditions for 48 h, maintaining stable and efficient broadband emission. Density functional theory calculations and femtosecond transient absorption spectra (fs-TA) demonstrate that the broadband emission originates from self-trapped excitons, which are more populated with the LMCT contribution from 2,2'-bpy. This study shows a rational strategy at the molecular level to modulate the photophysical properties of chemically robust lead halide coordination polymers.

Mental health of South Korean adolescents in the COVID-19 Era: Web-based survey focused on suicide-related factors

BackgroundThe coronavirus disease 2019 (COVID-19) pandemic has negatively impacted many aspects of life. Measures for preventing the spread of COVID-19 (e.g., school lockdowns, remote and hybrid classes, group and outdoor activity restrictions, and social distancing in the classroom and meal time) could have led to adolescents to experience anxiety and depressive symptoms. Such mental health impacts could increase the risk of suicidal ideation in this population. Moreover, according to a report by the Organization for Economic Co-operation and Development, although the total number of suicide deaths in South Korea decreased in 2021, the suicide rate of those aged 10–29 years increased. One factor affecting the result is adolescent mental health by COVID-19. This study examines the mental health status of South Korean adolescents amid the prolonged COVID-19 pandemic, and identifies and analyzes predictors of suicidal ideation, suicide planning, and suicide attempts.MethodsThe study used data from 54,948 adolescents who participated in the 2020 Korea Youth Risk Behavior Web-based Survey. Based on their responses to suicide-related questions, the sample was divided into a healthy group, suicide-ideation group, suicide-planning group, and suicide-attempt group. The descriptive statistics of these groups were then analyzed. An analysis of covariance, post-hoc tests, and multiple logistic regression analysis were performed on the four groups.ResultsOverall, 6.9% of the participants reported suicidal ideation, 2.2% reported planning suicide, and 1.9% reported attempting suicide in the previous 12 months.ConclusionsDuring the prolonged COVID-19 pandemic, there is a strong need for various individualized programs that identify and intervene to support adolescents at risk of suicide by accurately assessing their mental health risk factors, such as stress, sadness and despair, loneliness, and generalized anxiety disorder. Accordingly, it is necessary to develop and distribute a mental health and well-being curriculum, strengthen suicide prevention programs and support services, expand mental health diagnostic tests, and school-based mental health programs.

“I felt like I was on campus” creating a situated learning environment through Instagram

The transition to online learning due to COVID-19 brought opportunities for applying Situated Learning Theory through mobile social media to enhance individual cognitive growth and community sense of belonging in online learning environments. In this study, we invited students from an Environmental Psychology course to participate in a semester-long project, during which they were required to post Instagram photos of their surrounding environments every week. We intend to understand the mechanism of integrating social media (Instagram) into a hybrid class amid the global pandemic, and how the project affects students’ learning experience. Through in-depth interviews with 22 study participants, we found that integrating Instagram into the course helped students effectively connect with both real contexts and their peers. The project enhanced participants’ situation awareness and a sense of belonging through posting, interacting with peers, and browsing profiles and posts. We then proposed a framework of creating a situated learning environment through social media using conjecture mapping to inform design implications and future studies in social and mobile learning communities.

Immunological analysis of hybrid neoantigen peptide encompassing class I/II neoepitope-pulsed dendritic cell vaccine.

Neoantigens/ are tumor-specific antigens that evade central immune tolerance mechanisms in the thymus. Long-term tumor-specific cytotoxic T lymphocyte activity maintenance requires class II antigen-reactive CD4+ T cells. We had previously shown that intranodal vaccination with class I neoantigen peptide-pulsed dendritic cells (DCs) induced a robust immune response in a subset of patients with metastatic cancer. The present study aimed to perform a detailed ex vivo analysis of immune responses in four patients receiving an intranodal hybrid human leukocyte antigen class II neoantigen peptide encompassing a class I neoantigen epitope (hybrid neoantigen)-pulsed DC vaccine. After vaccination, strong T-cell reactions against the hybrid class II peptide and the class I-binding neoantigen peptide were observed in all four patients. We found that hybrid class II neoantigen peptide-pulsed DCs stimulated CD4+ T cells via direct antigen presentation and CD8+ T cells via cross-presentation. Further, we demonstrated that hybrid class II peptides encompassing multiple class I neoantigen epitope-pulsed DCs could present multiple class I peptides to CD8+ T cells via cross-presentation. Our findings provide insight into the mechanisms underlying hybrid neoantigen-pulsed DC vaccine therapy and suggest future neoantigen vaccine design.

A comparative framework for the hybrid class nanomaterials (polyethylene glycol + water$$/$$zirconium dioxide + magnesium oxide) with radiative flux towards a moving surface

A comparative framework for the hybrid class nanomaterials (polyethylene glycol + water$$/$$zirconium dioxide + magnesium oxide) with radiative flux towards a moving surface

Student Preferences for Reference Services at a Remote Biological Station Library

abstract: During the 2020 and 2021 summer semesters, the University of Michigan Biological Station (UMBS) transitioned to hybrid classes that were primarily distance learning with two-week inperson sections. The library offered both synchronous and asynchronous reference assistance over the summer term. An analysis showed that students favored using the UMBS LibGuide over synchronous virtual reference help via Zoom. Students further preferred face-to-face interactions over virtual formats, and their preference for LibGuide assistance may carry into the post- COVID-19 classroom. This finding suggests that students prioritize convenience and immediacy over personalized assistance in the Zoom platform. Thus, in providing reference assistance to student populations in the field sciences, balancing face-to-face interactions with convenience and immediacy should be a priority. Recommendations based on the success of the 2020 and 2021 field seasons were suggested for reference interactions in future field courses.

Lived Experiences of Social Studies Teachers Conducting Hybrid Classes amidst COVID-19 Pandemic

This phenomenological qualitative research study aimed to investigate the lived experiences of social studies teachers in a hybrid learning class amidst COVID–19 pandemic. There were five participants who were purposive and selected. Interviews were recorded, transcribed, and thematically analysed. Based on the findings, sixteen subthemes and four major themes emerged, and these are: Challenges in Hybrid Learning, Stability of Internet Connection, Necessary Support from Administration, and Coping Mechanisms of the Teachers. It was revealed that the teachers faced challenges in the delivery of hybrid learning classes, such as quality of equipment class, equipment, internet connectivity, preparation of instructional materials, and motivation techniques to be used in everyday classes. However, the school took action by providing basic computer equipment like speakers and headsets, internet providers and some materials they needed for teaching. In this new normal, flexibility, adaptability, adjustments, and considerations are needed based on how one understands, responds, and manages an ever-changing environment. It is recommended that the school administration intensify their assistance and provide high-quality equipment, complete materials and various trainings for their hybrid learning teachers. In online classes of hybrid learning, the teachers need to think of varied motivational techniques that will make the students active participants. Teachers may also need to attend webinars and training on the new strategies for conducting hybrid classes to enhance their skills in teaching online and face-to-face classes at the same time. Future researchers may conduct further studies using other research designs.

Evolution of storytelling pedagogy in global health course at a U.S. Native American-Serving Nontribal Institution from Fall 2019 to Spring 2023.

Responding to COVID-19-induced disruptions to traditional teaching methodologies, and considering the relevance of narratives among indigenous populations, "storytelling as pedagogy" was developed and implemented in the undergraduate Global Health course in a Native American-Serving Nontribal Institution (NASNTI) in Colorado. We describe the evolving pedagogic adjustments and storytelling strategies incorporated into the global health course from Fall 2019 to Spring 2023. This entailed before the COVID-19 in-person format, online digital storytelling during the pandemic emergency, the HyFlex and hybrid classes with the emergence of "new normals," and finally the gradual move to in-person classes. The story arc in the course included the following: (1) Course learning outcomes revisited and the course syllabus language framed based on the native philosophies of empowerment education and experiential learning, (2) students' inputs sought to incorporate socioculturally responsive topics in the course syllabus (e.g., dental health disparities among indigenous populations), (3) strategic and non-threatening shifts such as "no textbooks" and "no finals" introduced, (4) global health thought partners invited by the course instructor and coached to use story-based teaching methods, (5) use of first-person trauma-informed storytelling methods to teach specific global health topics, and (6) students undertook gratitude journaling, a scaffolding exercise of writing letters on global health topics to global health thought partners. Storytelling as pedagogy was most effective in the in-person format, while digital storytelling during the COVID-19-induced online classes was extremely challenging considering the stark digital divide in the Navajo Nation. First-person, trauma-informed storytelling is a helpful approach to discuss insider-outsider perspectives and can potentially establish sustainable trustworthy relationships among the students, instructor, and global health thought leaders. Gratitude journaling and photovoice can be tweaked as powerful storytelling methods to build students' interaction-based critical thinking, intercultural humility, and professional networking. Mapping storytelling pedagogies' best practices can be useful in developing a granulated understanding of this strategy and utilizing them across diverse disciplines in higher education. Faculty capacity building is recommended to enable the former to conceptualize culturally responsive storytelling pedagogies and create assessment plans to assess students' learning outcomes through the utilization of this method.