Over fifty years have passed since Boeck first described a condition of the skin which he designated as sarcoid. Since that time many observers and investigators have contributed freely to the literature concerning the various manifestations of this disease The findings of greatest interest to us in sarcoid are hypercalcemia and soft-tissue calcifications, particularly nephrocalcinosis and nephrolithiasis. Very little is to be found in the literature referable to these changes, although hypercalcemia is given more attention than soft-tissue calcifications. During the past several years, at the Johns Hopkins Hospital, the Hospital of the University of Pennsylvania, and the University of Maryland Hospital, we have had the opportunity of studying and reviewing 7 cases of sarcoidosis with hypercalcemia and renal calcifications. Although roentgenograms for only 5 of these cases are now available, the histories of all 7, including postmortem studies in 3, will be presented. Case Reports Case I: N. S., a 44-year-old white male, was admitted to the Hospital of the University of Pennsylvania in September 1950, complaining of weakness, urinary frequency, nocturia, hematuria, and passage of white granular particles in the urine. Chronology of Symptoms: The onset of symptoms was in September 1949. At that time the patient was hospitalized elsewhere and, on the basis of clinical, roentgenologic, and laboratory studies, an impression of hyperparathyroidism was obtained. The parathyroid glands were explored surgically but no tumor or hyperplasia was found. Thereafter the physical status remained essentially unchanged until hospitalization at the University of Pennsylvania in September 1950. Significant Physical Findings: Calcium deposits were found in the sclera, conjunctiva, and cornea of each eye. Enlarged lymph nodes were present in the left axilla, and the spleen was enlarged to two fingers below the costal margin. Roentgen Findings: Roentgen examination showed miliary pulmonary infiltration bilaterally (Fig. 1A), bilateral nephrocalcinosis and a prominence of the gastric rugae (Fig. 1B), and numerous periarticular soft-tissue calcifications about the shoulder and hip joints, but with no bony demineralization (Figs. 1B and 1C). Laboratory Findings: Calcium, 15.5 and 14.4 mg. per cent; phosphorus, from 2.9 to 5.2 mg. per cent; phosphatase, 6.3 Bodansky units; serum proteins, 8.10 and 7.70 gm. with an A/G ratio of 5.50/2.60 and 3.00/4.70. Positive Sulkowitch test. Course in Hospital: A biopsy of an axillary lymph node revealed sarcoid, and the patient was referred for urethane therapy. Case II: R. N., a 38-year-old white male, was first admitted to the Johns Hopkins Hospital in 1948 because of calcium deposits in each kidney found during a routine insurance examination. Significant Symptoms and Signs: After admission, the patient was found also to have severe peripheral arteriosclerosis and calcifications in the cornea and conjunctiva.