Chronic Psychotic Symptoms Research Articles

Psychiatric Implications of Surgical Treatment of Epilepsy

Clinicians must consider the psychiatric issues relevant to patients undergoing neurosurgical procedures for epilepsy. Obtaining the patient's psychiatric history can facilitate stabilizing the patient's condition before operative intervention. Preoperatively, depressive and anxiety disorders are the most common psychiatric conditions diagnosed in candidates for surgical treatment of epilepsy. Although psychotic disorders occur infrequently, they demand attention because symptoms may interfere with patient compliance with follow-up care. Patients with chronic psychotic symptoms who have ongoing seizures postoperatively and bilateral seizure foci are at higher risk for a poor outcome and postoperative psychosis. When psychiatric disorders are present, surgical management is not contraindicated, but preoperative psychiatric intervention may be warranted. Most patients have a favorable outcome with the elimination of seizures, which simplifies the subsequent treatment of a psychiatric disorder.

Postictal and chronic psychoses in patients with temporal lobe epilepsy

This study sought to elucidate the relation of clinical, neuropsychological, and seizure variables to chronic and postictal psychoses in patients with temporal lobe epilepsy. Forty-four patients with treatment-refractory temporal lobe epilepsy were given formal psychiatric evaluations; 29 patients had no psychiatric disorder or a nonpsychotic disorder, eight patients had postictal psychoses, and seven patients had chronic psychoses. Comparisons of clinical, neuropsychological, magnetic resonance imaging, and seizure variables were made between the nonpsychotic and the psychotic patients and, secondarily, between the patients with transient postictal psychoses and those with chronic psychoses. Bitemporal seizure foci, clustering of seizures, and absence of febrile convulsions were associated with both postictal psychoses and chronic psychoses. Younger age at onset of epilepsy and lower verbal and full-scale IQs differentiated the patients with chronic psychoses from those with postictal psychoses. Patients with temporal lobe epilepsy with chronic and postictal psychoses show similar profiles of clinical and seizure variables, suggesting shared etiologic factors. These factors may increase the propensity to develop psychotic symptoms, while other factors, such as time of onset of epilepsy and underlying neuropathology, may determine whether transient or chronic psychotic symptoms develop. Even among patients with treatment-refractory temporal lobe epilepsy, a specific subgroup of patients, characterized by bitemporal seizure foci, an absence of febrile convulsions, and a history of clustering of seizures, appears to be particularly prone to develop psychotic disorders. A process similar to secondary epileptogenesis may be involved in the development of the psychoses.

Severe Paternal Sexual Abuse in Early Childhood and Systematic Aggression against the Family and the Institution

This report examines incest and its sequela in individuals suffering from severe chronic mental illness. Descriptive data drawn from 11 cases paints a clinical picture characterized by severe chronic psychotic symptoms and aggressive behaviour that are often precipitated by the family's rejection. In all patients, the incest for occurred over a long period of time, was violent, and was perpetrated by the male parental figure. Health care professionals need to increase their knowledge of and skills in the identification and treatment of sexual abuse.

Introducing the living with illness group: A specialized treatment for patients with chronic schizophrenic conditions

This paper introduces a specialized psychotherapy/psychoeducational group treatment for patients with chronic psychotic symptoms who receive only partial benefit from psychotropic medications, psychotherapy, and milieu/activities therapy. The goal of the group is to assist patients to accurately identify the feelings, thoughts, and behaviors that are dysfunctional symptoms of their disability and then use the functional aspects of their brain as well as learned coping strategies to compensate for their disability. The group format, philosophy, procedures, and typical topics of discussion are detailed.

Ten-year follow-up of drug abusers with acute or chronic psychosis.

To assess whether long-term outcome of former drug abuse patients who had psychotic symptoms was related to duration of psychosis before hospitalization, the authors rated the psychiatric, occupational, and residential outcome of 101 former drug abuse patients based on interviews conducted ten years after their admission to a psychiatric hospital. At admission, 45 had had psychotic symptoms for six months or more; 26 had had psychotic symptoms for less than six months; and 30 had not been psychotic. Seventy-one former psychiatric patients who had had a psychotic illness but had not abused drugs were also interviewed and rated. Drug abusers with chronic psychosis had significantly worse psychiatric outcome than the other drug abusers and significantly worse occupational outcome than acutely psychotic drug abusers. The authors conclude that drug abusers with chronic psychotic symptoms are a distinct subgroup of drug abusers who suffer from major psychotic illness.

Low serum neuroleptic levels predict relapse in schizophrenic patients.

Relapse occurs in a substantial proportion of schizophrenic patients treated with neuroleptics. The determinants of relapse have been elusive. In our study, low serum neuroleptic levels identified patients who had a relapse during a six-month period. Neuroleptic levels were measured by radioreceptor assay in 61 schizophrenic men and their clinical status was assessed in the subsequent six months. Ten patients had relapses, four showing a worsening of chronic psychotic symptoms and six showing eruption of psychotic symptoms after a period of remission. These ten patients had significantly lower normalized neuroleptic levels than those whose conditions remained stable. The lowest neuroleptic levels occurred in patients who had relapses after a period of remission. Serum neuroleptic levels in drug-responsive patients appear to be a critical determinant of remission. If these observations are replicated, a rational basis may be provided for prescribing and monitoring neuroleptic treatment and perhaps for preventing relapse.

γ-Type Endorphins and Schizophrenia-Reply

—We certainly welcome the additional data provided here supporting the antipsychotic efficacy of DTγE. The authors report that their experience of late, contrary to the initial suspicions, suggests that this endorphin fragment is most efficacious in persons in early schizophrenia who have had short neuroleptic histories. Indeed, the patients we described who were given DTγE were schizophrenics with chronic but active (in no way residual) psychotic symptoms. All of these DTγE-treated patients had previously responded to standard-dose neuroleptic treatment, although they were untreated at the time of DTγE administration. The schizophrenic population defined by Verhoeven et al as responders to DTγE treatment, schizophrenics with psychotic symptoms and drug treatment of short duration, may fall into the new<i>DSMIII</i>category of schizophreniform psychosis. Confirmation of these findings with DTγE, along with the new peptide fragment DEγE, from our and other research centers around the world would be ideal. We remain