Integrated metabolomics and proteomics analysis elucidated the therapeutic effect of Huangkui Capsule on tacrolimus-induced chronic nephrotoxicity in rats.

Elucidating the biological characteristics of overweight populations based on urine Raman spectroscopy and bioinformatics analysis.

Dyslipidemia is a major metabolic disorder and a key risk factor for atherosclerotic cardiovascular disease (ASCVD), particularly in the geriatric population. Elderly patients frequently present with multiple comorbidities, such as hypertension and hyperuricemia, which complicate clinical management and substantially increase cardiovascular risk. Moreover, acute conditions, including trauma-related injuries, may further disrupt metabolic control, functional capacity, and adherence to long-term therapy. This case report describes a 70-year-old male patient (RE) who presented to a primary healthcare center with swelling and intermittent pain in the right lower extremity following a fall. The patient had a known history of dyslipidemia, hypertension, and hyperuricemia. Laboratory investigations revealed elevated total cholesterol (242 mg/dL), borderline fasting plasma glucose (102 mg/dL), and uric acid level of 6.6 mg/dL. Physical examination was unremarkable except for edema and localized tenderness in the affected limb, consistent with a soft tissue injury. A holistic management approach was implemented, integrating pharmacological and non-pharmacological interventions. Statin therapy was initiated to address dyslipidemia, antihypertensive treatment was optimized, and analgesic therapy combined with limb elevation was provided to manage acute pain and edema. Non-pharmacological strategies included comprehensive lifestyle modification, encompassing dietary counseling (low saturated fat, low salt, and low purine diet), gradual resumption of physical activity following injury recovery, and structured patient–family education to improve adherence and prevent recurrent falls. Follow-up evaluation demonstrated clinical improvement, including resolution of edema, improved functional mobility, and better metabolic control. The novelty of this case lies in demonstrating how acute trauma in geriatric patients can act as a critical entry point for integrated chronic disease management within primary care settings. This case emphasizes that holistic, biopsychosocial–spiritual management not only improves lipid and blood pressure control but also enhances functional outcomes and quality of life in elderly patients with complex comorbidities.

Reproducing real-world clinical prediction models using the DIVE platform: A comparative validation study across three chronic diseases.

Decreasing Prevalence of Chronic Kidney Disease Among U.S. Adults With Diabetes, 1999-2018.

Construction of a risk prediction model for oral frailty in hospitalized elderly patients with chronic diseases.

Many regulated health insurance markets use prospective risk adjustment (RA) to mitigate risk selection incentives for insurers. However, prospective RA might underpay insurers for people diagnosed with a new chronic disease. By tracking spending and RA payments over the period t-2 to t+2 for individuals diagnosed with a new chronic disease in year t, we find a substantial payment gap in year t and, to a lesser extent, in prior and/or subsequent years. The extent to which these gaps stimulate selection incentives for insurers depends on the possibilities for insurers to distort consumers' choice of insurance products. Possibilities which-in turn-depend on whether and when consumers respond to the onset of the chronic disease when choosing an insurance product. By analyzing "insurer switching" in the period t-2 to t+2 we find that-on average-people first diagnosed with a chronic disease are more likely to switch insurer than others.

Individuals affected by chronic pain often have greater pain sensitivity compared to pain-free subjects, but there is a lack of population-based evidence in this regard. The factors playing a role in this relationship are rarely examined. The aims were to evaluate 1) whether pressure pain sensitivity is associated with a) the presence of musculoskeletal (MSK) pain and b) worse pain and 2) whether sex and the presence of chronic diseases moderate these associations. This population-based Northern Finland Birth Cohort 1966 study obtained data on pain frequency (daily, nondaily, and absent), number of pain sites (range 1-8), bothersomeness of pain (Numerical Rating Scale [NRS]-11), and intensity (NRS-11) from 5178 participants (43% males) aged 46 born in 1966. Measured pressure pain threshold (PPT) and pressure pain tolerance (PPTol) were dichotomized as the lowest quartile vs. the other quartiles (the reference). Logistic and linear regressions with adjustments were utilized. Lower PPT and PPTol were associated with daily MSK pain only among females (adjusted odds ratio 1.26, 95% confidence interval 1.00-1.58 for PPT; 1.29, 1.02-1.61 for PPTol). A positive relationship with bothersomeness of pain among individuals with daily or nondaily MSK pain was observed only among females. After stratification by chronic diseases, the associations between PPT/PPTol and daily MSK pain remained significant only among females with chronic diseases. The associations between pressure pain sensitivity and MSK pain varied according to sex and presence of chronic diseases. However, clinical relevance of our findings can be questioned.

Predictive modeling of anxiety and depression DALYs in Indonesia before and after the COVID-19 pandemic: Insights from the Global Burden of Disease 2021 study.

Dietary inflammatory potential and depression in middle-aged and older adults: A population-based study of associations and comorbid disease network.

Non-invasive tests to guide hepatocellular carcinoma surveillance.

Research on rhubarb's natural components and their potential for treating chronic kidney disease.

Association between behavioral-environmental risk patterns and multimorbidity of chronic non-communicable diseases among Chinese adolescents at schools.

Chronic liver disease is a frequently encountered disorder and a major concern worldwide with a complex pathophysiology, which often affects the hemostatic system. Such alterations, which affect both primary and secondary hemostasis, are heterogenous, including prohemorrhagic (i.e., decreased coagulation factors, increased fibrinolysis, thrombocytopenia, and platelet dysfunction) and prothrombotic (i.e., decreased natural anticoagulants) changes. As a consequence of this unstable balance, patients with liver cirrhosis may experience both hemorrhagic complications and venous thromboembolic events, which are often unpredictable and whose management is particularly challenging for clinicians. This narrative review will address the most recent advances in the pathophysiology of key derangements of hemostasis in patients with chronic liver disease, focusing on their clinical implications and management.

Sputum proteomics and phosphoproteomics for improving chronic obstructive pulmonary disease knowledge.

Introduction: Chronic Obstructive Pulmonary Disease (COPD) is a major cause of morbidity and mortality worldwide. Immunoglobulin free Light Chains (IgLCs) have been implicated in various inflammatory diseases; however, their role in COPD risk stratification remains unclear. Aim: To assess the correlation between IgLC levels and COPD severity and to evaluate their potential role in disease monitoring. Materials and Methods: This cross-sectional observational study was conducted at Rajiv Gandhi Government General Hospital, Chennai, Tamil Nadu, India, between March and December 2018. A total of 120 stable COPD patients aged over 40 years (post-bronchodilator FEV1 /FVC <70%) with no exacerbations in the preceding three months were included. COPD severity was staged according to the GOLD (Global Initiative for Chronic Obstructive Pulmonary Disease) criteria using spirometry. Venous blood samples were analysed for serum κ and λ free light chains using immunoturbidimetry, along with standard biochemical parameters. Demographic and exposure-related data, including age, sex, Body Mass Index (BMI), smoking status, biomass exposure, and history of tuberculosis, were recorded. Associations between IgLC levels, COPD severity, lung function (FEV1 %), and biochemical parameters were analysed using Pearson’s correlation, Analysis of Variance (ANOVA), and Chi-square tests. A p-value <0.05 was considered statistically significant. Results: The study included 120 COPD patients, comprising 45 (37.5%) males and 75 (62.5%) females, with a mean age of 59.2±10.6 years. The distribution across COPD stages was as follows: 20 (16.7%) in Stage I, 32 (26.7%) in Stage II, 40 (33.3%) in Stage III, and 28 (23.3%) in Stage IV. No significant differences were observed across disease stages with respect to sex, smoking status, biomass exposure, or history of tuberculosis (p-value >0.05). Pulmonary function (FEV1 %) declined significantly with increasing COPD severity, from 82.10±1.21% in Stage I to 26.21±2.45% in Stage IV (F=308.166, p-value <0.0001). Serum κ and λ free light chain levels increased progressively with disease severity (κ: 2.94±0.57 g/L to 5.50±0.81 g/L, F=87.318, p-value <0.0001; λ: 1.50±0.26 g/L to 2.80±0.53 g/L, F=43.616, p-value <0.0001), whereas the κ:λ ratio remained stable across all stages (p-value=1.000). Conclusion: Elevated IgLC levels showed a strong correlation with worsening COPD severity, declining lung function, and reduced BMI. Despite increases in individual κ and λ light chain concentrations, the κ:λ ratio remained stable across disease stages.

Transitions of care are the movement of a patient from one care setting or provider to another. Interprofessional collaboration is critical in ensuring patient safety and satisfactory health outcomes. Each time an interprofessional team transfers a patient, the team performs three important roles: representing the patient, providing patient information for other team members, and coordinating the transition. Poor transitions of care may contribute to negative health outcomes, especially for patients with chronic health conditions, complex medication regimens, and high-risk treatments. We present a case study of a patient with complicated chronic obstructive pulmonary disease that depicts the importance of successful interprofessional collaboration during the transition of care from hospital to home illustrating the unique contributions of the various disciplines involved in the patient's care.

Tubular STING drives renal fibrosis via extracellular vesicle-mediated activation of the SMO/GLI-1 pathway.

Multi-omics reveal the key role of gut microbiota metabolism in adenine-induced chronic kidney disease.

Apolipoprotein J-mediated hepato-renal crosstalk drives renal injury in chronic kidney disease.