Chief Organ Research Articles

From biomaterials to biotherapy: cuttlefish ink with protoporphyrin IX nanoconjugates for synergistic sonodynamic-photothermal therapy.

Biologically produced nanomaterials capable of therapeutic purposes have received increasing interest in tumor therapy because of their intrinsic biocompatibility. In this study, we made cuttlefish ink (extracted from cuttlefish) and protoporphyrin IX (PpIX) nanoconjugates (CIPs) where PpIX was an endogenous organic compound. In the case of CIPs, PpIX could be triggered by ultrasound (US) for sonodynamic therapy (SDT), and the cuttlefish ink could be excited by a near-infrared laser for photothermal therapy (PTT). Thereafter, tumor growth was greatly inhibited through synergistic SDT-PTT in comparison to single SDT or PTT. In addition, in vivo administration of CIPs showed no noticeable side effects for mouse blood and chief organs, providing an effective strategy for developing biologically produced biomaterials and using them for biotherapy.

Rozwój administracji stosunków gospodarczych w PRL. Zagadnienia prawne

Rozwój administracji stosunków gospodarczych w PRL. Zagadnienia prawne

Evaluation of bacteriological contamination of palms of pupils in the University of Benin Teaching Hospital Staff School, Benin City, Nigeria

Hands are the chief organs for physical manipulation of the environment. As a paired organ, the hand is controlled by the opposing brain hemisphere and enables one to all manner of conscious and unconscious activities. The hand serves as a medium for the propagation of microorganism from place to place and from one person to another. A well-structured questionnaire bothering on age, sex and parental social status of the pupils was administered to three hundred and sixty (360) respondents recruited for the purpose of this study in University of Benin Teaching Hospital Staff School (UBTHSS). The mean heterotrophic Bacterial Count ranged from 2.10±0.19 x 106 to 3.77±0.26 x 106 cfu/cm2. Total coliform count ranged from 0.88±0.08 x 106 to 2.08±0.18 x 106. November recorded the highest heterotrophic and coliform counts ranging from 2.70±0.24 x 106 to 3.77±0.26 x 106 cfu/cm2 and 1.14±0.11 x 106 to 2.08±0.18 x 106cfu/cm2. The male pupils had the highest Heterotrophic and coliform counts of 4.132 x106cfu/cm2 and 2.273x106cfu/cm2 against the female of 1.433x106cfu/cm2 and 0.667x106cfu/cm2. The mean heterotrophic bacterial counts of parental status ranged from 2.78±0.10 x 106 to 2.83±0.08 cfu/cm2 and total coliform counts of 1.24±0.05 x 106 to1.35±0.15 x 106. The mean Heterotrophic barial and coliform counts of age ranged from 2.51±0.74 x 106 to 3.38±0.15 x 106 cfu/cm2 and 0.59 -3.43 x 106 to 0.35 - 2.62 x 106cfu/cm2. A total of ten (10) Gram positive and negative bacterial were isolated in this study. The bacterial isolates with the highest frequency of occurrence were staphylococcus aureus and E.coli (12.00%), E.coli and the least frequency was salmonella enterica (7.3%). The antimicrobial sensitivity pattern showed that the bacteria isolates exhibits varying degree of resistance to the antibiotics before and after curing. The isolates were found to harbor plasmid of different sizes but below 1000bp.There was no plasmid after curing.

Application of the Concept of Islamic Welfare State is the Panacea to Remove the Evils of the Political System of Pakistan

Muslims were promised to establish a separate homeland with the enforcement of the Islamic political system in case of the establishment of a new state. But with the passage of time, politicians of Pakistan became negligent of the principles of the political system of Islam. Reports of international forums demonstrate that the performance of the chief organs of the Pakistani political system is not satisfactory. The research study sets the hypothesis that the application of the concept of the Islamic welfare state is the panacea for removing the evils of the political system of Pakistan. In this connection, a comparative study will be conducted to evaluate both Pakistan's and the Islamic political systems. The nature of the research study is qualitative along with a thematic analysis approach by conducting interviews with ten scholars having MPhil and PhD education. Finally, the findings will be derived on how far application of the concept of an Islamic welfare state is fruitful in removing the evils of the Pakistani political system.

Mushroom ( Amanita phalloides) Poisoning: Mechanisms, Pathogenesis, Prognosis and Strategies of Treatment

Poisoning due to mushroom consumption is uncommon, but it causes death by causing acute liver failure (ALF). The ingestion of Amanita phalloides, is one of the ultimate frequent causes of mushroom poisoning globally. This type has three main categories of toxins: amatoxins, phallotoxins, and virotoxins. From these toxins amatoxins and its metabolite α-amanitin, is the main cause of toxicity in population which cause deterioration in synthesis of protein and consequent cell necrosis and inhibition of RNA polymerase II ,so finally cause cell death. Liver is the chief organ involved in toxicity, kidneys and central nervous system also involved. Latent period has been proceeds the poisoning symptoms, which includes gastrointestinal symptoms followed by liver failure symptoms, coma and ultimately death. Management including supportive cares, gastrointestinal decontamination, special medications (Benzyl penicillin, N-acetyl cyctien, cimetidine, silibinin and others) and, finally liver transplantation if clinical condition deteriorated.

Peer review declaration

All papers published in this volume of Journal of Physics: Conference Series have been peer reviewed through processes administered by the Editors. Reviews were conducted by expert referees to the professional and scientific standards expected of a proceedings journal published by IOP Publishing.Type of peer review: Single-blind peer review• Conference submission management system: submissions were received and handled via e-mail• Number of submissions received: 46• Number of submissions sent for review: 38• Number of submissions accepted: 17• Acceptance Rate (Number of Submissions Accepted / Number of Submissions Received X 100): 37%• Average number of reviews per paper: 3• Total number of reviewers involved: 19○ Any additional info on review process: three independent referees one of which invited from outside the conference committee reviewed all the papers. All the accepted papers were checked and edited by volume editor and/or chief organizer.• Contact person for queries: Denis Yeltyshev, chief organizer, Cand. of Eng., associate professor at Department of Microprocessors in Automation, Perm National Research Polytechnic University, Perm, Russia, eltyshevdk@gmail.com

Peer review declaration

All papers published in this volume of IOP Conference Series: Earth and Environmental Science have been peer reviewed through processes administered by the Editors. Reviews were conducted by expert referees to the professional and scientific standards expected of a proceedings journal published by IOP Publishing.• Type of peer review: Single-blind peer review by two independent referees (committee members or external referee)• Conference submission management system: submissions were received and handled via e-mail (esgap@ortum-publish.ru)• Number of submissions received: 293• Number of submissions sent for review: 190• Number of submissions accepted: 145• Acceptance Rate (Number of Submissions Accepted / Number of Submissions Received X 100): 50%• Average number of reviews per paper: 2• Total number of reviewers involved: 36• Any additional info on review process: all the papers were reviewedo by the scientific committee member (normally by the one who moderated the corresponding session or their associates),o by the one of the core editors (or assigned external referee if necessary).• Contact person for queries: o Vyacheslav Kozlov, Dr. of Eng., supervising editor, professor, department of transportation machinery and exploitation technological equipment, Voronezh State Agricultural University n.a. Emperor Peter the First, vyakozlov@yandex.ru o Igor Yudaev, Dr. of Eng., councillor of the board, professor, department of power supply of enterprises and electrical engineering, St. Petersburg State Agrarian University, etsh1965@mail.ru o Valentina Miroshnikova, Cand. of Eng., chief organizer, head of the R&D department, Azov-Black Sea Engineering Institute, mvalentina04@gmail.com

Cеминариум имени Н. П. Кондакова – европейский крымоведческий центр (20-е годы XX столетия)

An art historian and an expert in architectural objects restoration N. P. Kondakov emigrated to Czechoslovakia where a circle of emigrant historians shaped around him. This scholarly society developing from the Byzantologist N. P. Kondakov’s home circle in Prague was titled in Byzantine way, Seminarium Kondakovianum. After his death in February 1925, this small-in-number academic community with support from the Czechoslovak government developed into a foreign school of Byzantologists and Russian historians. Thus, there appeared a Russian institution with international statute in Prague. The study of intertwined western and eastern influences in Russian history became a typical motif of Russian scholarly thought in emigration. In this connection, the Crimea became an interesting object for the researches and historical generalizations by the Seminaium members. The paper introduces into the scholarship the materials from the archive of the Seminarium Kondakovianum (Kondakov Institute) now residing in the Archives of the Czech Academy of Sciences. The analysis attracts the documents from N. P. Kondakov’s personal collection at the Literary Archives of Written National Monuments of the Slavonic Library in Prague. There are interesting unpublished manuscripts by the Seminarium members discovered by the author. There were three circles of Crimean researchers determined at the Seminarium’s works: historians living in Prague who studied the mediaeval history of the Crimea and the history of research (N. M. Beliaev, G. V. Vernadsky, A. P. Kalitinskii, D. А. Rasovskii, N. P. Toll’); a group of historians from the USSR attracted by G. V. Vernadsky to send their papers for discussion (D. V. Ainalov, S. А. Zhebelev, N. V. Izmailova, A. I. Markevich, and others); Russian emigrant historians living in other countries (M. I. Rostovtsev, alter on G. V. Vernadsky). G. V. Vernadsky was the chief organizer and the academic curator of the Seminarium. G. V. Vernadsky’s skillful practice on attraction to the Seminarium of leading Soviet experts in the Crimean studies allowed the annual to publish their works thus enlarging the sphere of the historians’ scholarly communications. The contacts (correspondence) with the Taurida Society for History, Archaeology, and Ethnography (Simferopol) and the State Museum of Chersonese (Sevastopol) were established. Hysteria made by the Soviet secret service and Communist party leaders around the “case of S. A. Zhebelev,” directly connected with the cooperation of Soviet and emigrant historians, resulted in the cease of the said contacts and book exchange. In 1931, the Seminarium was reshaped into N. P. Kondakov Institute with the change of the participants and the disappearance of the Crimea aspect from the agenda for sessions.

Pathological and Microbiological Study of Multiple Hepatic Abscesses in Barbari Goat

A carcass of an eleven months old Barbari female goat was presented for post-mortem examination in the post-mortem house of Division of Animal Health, ICAR-Central Institute for Research on Goats, Makhdoom, Mathura, Uttar Pradesh. The external appearance of the carcass was weak and emaciated. Necropsy revealed enlarged liver with multiple greyish white, round to oval spherical nodules (1-2 cm in diameter) over the diaphragmatic, right and left lobes yielding thick creamy yellow pus upon incision. Study portrayed isolation and confirmation of causative agent by microbiological, histopathological and by polymerase chain reaction (PCR). On histopathology of the affected tissue, severe hepatic destruction and hepatocytes as icebergs in the sea of inflammatory cells and bile duct hyperplasia were recorded. Microbiological examination revealed E. coli showing metallic sheen on EMB and hemolytic colony on blood agar, while in microscopy, gram negative coccobacilli were observed. As the liver is the chief organ of the body and is exposed to so many toxic and non-toxic insults which cause potential damage to its functions. Hematogenous transmission of E. coli affecting the vital organs is common in neonates causing colisepticaemia, but in the current study adult goat showed multiple abscess in liver and the causative agent has been confirmed as E. coli using species specific PCR and pathotyping multiplex PCR for identification of virulence genes. The present study emphasized the need for identification of causative micro-organisms for rational therapy to prevent the economic loss and life of animals and at the same time to document various pathological affections caused by E. coli on goats.

Chemotherapeutic doses of arsenic trioxide delays hepatic regeneration by oxidative stress and hepatocyte apoptosis in partial hepatectomy rat

The extensive regeneration potential of the liver makes use of hepatic re-sectioning and split liver transplantation for treating advanced liver diseases. Heavy metals such as cisplatin, carboplatin, and arsenic trioxide (ATO) are being practiced as chemotherapeutic agents for different cancers. Further, research is progressed on using different heavy metal nano-particles as a drug, drug carrier and diseases detective agent. Since liver is the chief organ metabolize ingested materials, the current study focuses on the involvement of ATO on acute liver injury regeneration using a partially hepatectomised (PHx) rat model. Scrutiny of serum liver markers such as albumin, AST, ALT & ALP and hepatic antioxidants like reduced glutathione, glutathione peroxidase, glutathione S-transferase, catalase & superoxide dismutase reveled ATO mediated hepatocyte injury and oxidative stress. Further, oxidative stress is confirmed with elevated TBARS and 8-OHdG in the hepatocyte nucleus in ATO supplemented healthy and regenerating liver and are co-relating with the H&E histological observations. It is noticed that ATO supplementation reduced liver regeneration potential as evidenced by reduced proliferative markers (Ki-67 and PCNA) and meanwhile increases apoptotic protein PARP-1. ICP-MS analysis displayed several-fold hiked serum and liver arsenic in ATO administrated normal and liver regenerating animals. This study concludes that ATO at a chemotherapeutic concentration augments oxidative stress and hepatocytes apoptosis, thereby delays liver regeneration potential and could affect the outcome of liver transplantation.

Dysregulation of Nrf2 in Hepatocellular Carcinoma: Role in Cancer Progression and Chemoresistance.

The liver executes versatile functions and is the chief organ for metabolism of toxicants/xenobiotics. Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and the third foremost cause of cancer death worldwide. Oxidative stress is a key factor related with the development and progression of HCC. Nuclear factor erythroid 2 [NF-E2]-related factor 2 (Nrf2) is a cytosolic transcription factor, which regulates redox homeostasis by activating the expression of an array of antioxidant response element-dependent genes. Nrf2 displays conflicting roles in normal, healthy liver and HCC; in the former, Nrf2 offers beneficial effects, whereas in the latter it causes detrimental effects favouring the proliferation and survival of HCC. Sustained Nrf2 activation has been observed in HCC and facilitates its progression and aggressiveness. This review summarizes the role and mechanism(s) of action of Nrf2 dysregulation in HCC and therapeutic options that can be employed to modulate this transcription factor.

Depression from the perspective of modern and Persian medicine

BackgroundDepression is one of the five most-common diseases globally, and is expected to be the second leading cause of disability by 2020 and its economic and social burden is a major problem worldwideObjectiveThe aim of this research was to elucidate the causes and symptoms of depression according to Persian Medicine (PM) and classic medicine.MethodsIn this study, works that were investigated were the Canon of Medicine, Al-Hawi Fi Teb, Kamel Al-Sina’a, Zakhireh Kharazmshahi and Exir A’azam. Classic medicine sources investigated were Kaplan and Sadock’s Synopsis of Psychiatry and related articles in the Web of Science, Medline, Scopus, SID and Magiran. Research was done from January through April 2017, using keywords.ResultsTo explain the biologic causes, various factors including humoral dystemperaments, cold and hot dystemperaments of chief organs especially heart and brain and some qualitative and quantitative changes in medical spirit should be considered. According to manuscripts some mental-emotional events in life can cause these changes. They independently may cause depression. Semiologically some symptoms and signs happen consequently to in the above-mentioned causes which are in common with depression signs and symptoms including grief, crying, low libido, weight loss, appetite and sleep disorders, exhaustion, slow cognitive processing, indecisiveness and willingness to die.ConclusionThe major biological causes of depression is a group of dystemperamental syndromes (hot, cold, dry, and wet) on different bodily structures (humors, organs, and spirits). So preventive and therapeutic strategies for depression couldn’t be the same for all patients and the treatment should be designed according to the exact diagnosis.

Fitzi, True-Believer: The Legacy of M. Eleanor Fitzgerald

Abstract M. Eleanor Fitzgerald (known to friends and colleagues as “Fitzi”) was the long-time business manager of the Provincetown Players and the subsequent incarnations of the group that continued until 1929. This article traces her legacy from her humble childhood in northern Wisconsin, experiences with the Seventh Day Adventist Church and Dr. Kellogg's Battle Creek Sanitarium, to her work and relationships with anarchists Emma Goldman and Alexander Berkman and their publication Mother Earth. Beginning with the Players in 1918, she ultimately served as their business manager, as well as becoming their chief organizer, protector, guiding spirit, and conscience. Her work continued with the Group Theatre, Federal Theatre Project and, finally, the Dramatic Workshop at the New School for Social Research, run by German playwright and director Erwin Piscator. Because of her passion and devotion to her work and those she worked with, she developed close and influential friendships with O'Neill, Berkman, Goldman, Piscator, and the many playwrights and actors she shepherded over the years. Malcolm Cowley wrote, “The story of the new American theater cannot truly be told without mentioning Fitzi's part in it” and this article attempts to do just that.

2014年研究大会「記録管理と地域連携への新たな潮流～創造的展開に向けて～」を終えて(記録管理学会2014年研究大会)

2014年研究大会「記録管理と地域連携への新たな潮流～創造的展開に向けて～」を終えて(記録管理学会2014年研究大会)

Aberrations in Renal Function Parameters Following Oral Administration of <i>Phyllanthus amarus</i> in Cadmium-Induced Kidney Damage in Adult Wistar Rats

Renal disease has been found to be the ninth leading cause of death. Environmental pollution is a serious cause for concern nowadays and the exposure of humans to heavy metals released into the environment by several sources produces deleterious and lethal effects. Cadmium (Cd) which is a non-essential heavy metal known to possess toxic effects on living things can be found almost anywhere and its toxicity is of concern to industrial workers and all humans due to its use in some industrial products and also in agriculture. The chief organ of toxic impact in the human is the kidney, where the proximal tubule is a major target of Cd deposition. The present study investigated if ethanolic extract of Chanca Piedra (CP) (<i>Phyllantus amarus</i>) has any prophylactic or ameliorative effects against nephrotoxicity induced by cadmium sulphate in adult male Wistar rats. A total of forty-two (42) adult male Wistar rats were used for this study and were divided into seven (7) groups (n=6) as follows: Group A (control), Group B (40mg/kg BW), Group C (100mg/kg BW of CP and 40mg/kg BW of Cd), Group D (200mg/kg BW of CP and 40mg/kg BW), Group E (40mg/kg BW and 100mg/kg BW of CP), Group F (40mg/kg BW and 200mg/kg BW of CP), Group G (200mg/kg BW of CP). Both cadmium and Chanca Piedra were administered orally through oro-gastric cannula. Results showed that exposure to Cd lowered the activities of the kidney by increasing the plasma creatinine and urea levels. Exposure to CP also lowered the activities of the kidney by increasing the plasma creatinine and urea levels. The findings suggest that the administration of CP extract has no prophylactic or ameliorative effects on cadmium induced kidney damage and continue use of this extracts in the treatment of some diseases may be deleterious to the kidney.

Salomon Greiwer i Warsztaty Miejskie w Bochni

The municipal authorities in Bochnia created in 1941 workshops in the town, in order to employ Jews and produce the goods on request of the German authorities. The manager and chief organizer was Solomon Greiwer. The article is focused on the functioning of workshops, and on their impact on the fate of Jews from the Bochnia ghetto.

Subcellular nutrient element localization and enrichment in ecto- and arbuscular mycorrhizas of field-grown beech and ash trees indicate functional differences.

Mycorrhizas are the chief organ for plant mineral nutrient acquisition. In temperate, mixed forests, ash roots (Fraxinus excelsior) are colonized by arbuscular mycorrhizal fungi (AM) and beech roots (Fagus sylvatica) by ectomycorrhizal fungi (EcM). Knowledge on the functions of different mycorrhizal species that coexist in the same environment is scarce. The concentrations of nutrient elements in plant and fungal cells can inform on nutrient accessibility and interspecific differences of mycorrhizal life forms. Here, we hypothesized that mycorrhizal fungal species exhibit interspecific differences in mineral nutrient concentrations and that the differences correlate with the mineral nutrient concentrations of their associated root cells. Abundant mycorrhizal fungal species of mature beech and ash trees in a long-term undisturbed forest ecosystem were the EcM Lactarius subdulcis, Clavulina cristata and Cenococcum geophilum and the AM Glomus sp. Mineral nutrient subcellular localization and quantities of the mycorrhizas were analysed after non-aqueous sample preparation by electron dispersive X-ray transmission electron microscopy. Cenococcum geophilum contained the highest sulphur, Clavulina cristata the highest calcium levels, and Glomus, in which cations and P were generally high, exhibited the highest potassium levels. Lactarius subdulcis-associated root cells contained the highest phosphorus levels. The root cell concentrations of K, Mg and P were unrelated to those of the associated fungal structures, whereas S and Ca showed significant correlations between fungal and plant concentrations of those elements. Our results support profound interspecific differences for mineral nutrient acquisition among mycorrhizas formed by different fungal taxa. The lack of correlation between some plant and fungal nutrient element concentrations may reflect different retention of mineral nutrients in the fungal part of the symbiosis. High mineral concentrations, especially of potassium, in Glomus sp. suggest that the well-known influence of tree species on chemical soil properties may be related to their mycorrhizal associates.

Friend and Father to the Fatherless: Monsignor Nelson Baker’s Ministry to Youth

Venerable Monsignor Nelson Baker (1842–1936) built an iconic reputation through his supervision of St. Joseph Orphan Asylum and St. John’s Protectory, and his establishment of an infant home for unwed mothers in Lackawanna, New York, just south of Buffalo. For more than fifty years, Baker, who always preferred the more familiar title of Father Baker, served thousands of male youth, young mothers, and their children through a ministry of outreach and compassion. His institutions, locally known as the “Second Holy City,” educated, trained in trades, and gave proper religious formation to orphans and wayward boys who had no other place to go. Well known in his day, both locally through his work, and nationally through his two chief organs, the Annals and the Victorian , his work and holiness have been noted through his elevation to the ranks of “venerable” by Pope Benedict XVI in January 2011. His legacy remains today through Our Lady of Victory Homes of Charity and Baker Victory Services, as well as the Basilica of Our Lady of Victory.

From the Editor

From the Editor Steven Franks, Editor-in-Chief It is hard to believe that JSL is in its 22nd year and that the Slavic Linguistics Society is already planning its ninth (and even tenth) meeting. The eighth meeting, which took place at the end of October in Szczecin, went off without a hitch, for which we need to thank its chief organizer, Sylwester Jaworski. SLS9 will be in Seattle—at last a stateside meeting that I won’t be driving to—and SLS10 is planned for 2015 in Heidelberg. Seattle dates are already set for 19–21 September 2014, and I for one am very excited about being a part of it. Invited speakers for the University of Washington meeting include Greville Corbett, Roumyana Pancheva, and Olga Yokoyama. Other news is that the newly elected SLS board members are Bojan Belić and Anton Zimmerling. Welcome to both of you! Rotating off are Catherine Rudin, who is replaced by Marc Greenberg as chair, and Andrea Sims. Catherine and Andrea have done a superb job during their tenure in developing the organizational structure of the SLS. So dedicated are they that they have agreed to remain in their current respective positions as treasurer and webmaster. If you have not already done so, check out the SLS web site at: http://www.slaviclinguistics.org/. Additional accomplishments include the fact that we now have by-laws and are incorporated with official 501(c)(3) non-profit status. More to the point, financially SLS is solidly in the black, thanks not only to careful management but also to your donations and to the generosity of 11 (at last count) life members. So if you want to help SLS grow, or if you have ideas for new projects, please contact Marc, Catherine, Andrea, or any member of the board. Closer to home, there has been yet another change in JSL staffing. Tyler Madsen, who only recently took over as Managing Editor, has decided to move on. Fortunately, we have been able to recruit Rosie Connolly, who served previously as Managing Editor for about five years. While she will have to work remotely, from Texas, in this technological age even I should be able to manage. Reinstating Rosie will draw on her great experience and will add long sought-after continuity to the Journal. [End Page 1] The number of submissions to JSL continues to grow. I remind you that authors are expected to be members before the Associate Editors send their work out for review. We also continue to serve the larger community by publishing memorial tributes (two of which appear in this issue), reviews of books of interest to our readers, and shorter pieces such as “Remarks” and “Replies” as well as editorials under the “Reflections” rubric. Indeed, it has been some time since we printed one of the latter, so if you have any thoughts on the state of the field which you wish to share, I encourage you to contact me with a proposal. Book reviews, as always, are ably handled by Associate Editor Wayles Browne. I wish you a healthy, happy, and productive 2014. [End Page 2] Copyright © 2014 Steven Franks

Father Nelson Baker and the Blessed Virgin Mary: A Lifetime of Devotion

Monsignor Nelson Baker (1842–1936), an iconic figure in Western New York through his administration of two institutions that served orphaned boys and an infant home for unwed mothers and their children, found his inspiration for ministry through his devotion to the Blessed Virgin Mary. A casual and unscheduled visit to the Church of Our Lady of Victory in Paris, while a member of a pilgrimage to Rome, inaugurated for Baker a lifetime of devotion to Mary under this title. For fifty-four years as superintendent of “The Second Holy City,” in Lackawanna, just south of Buffalo, Baker found his inspiration through Our Lady of Victory. Through his two chief organs, The Annals of Our Lady of Victory and The Victorian , Baker’s ministry in Mary’s name attracted national attention. His crowning achievement, however, was his construction of the Basilica of Our Lady of Victory, chronologically the third church so designated in the United States and today a national shrine. By any standard, Nelson Baker’s (known to history as Father Baker) efforts to minister to those on the margins were significant, but they would not have been possible without the inspiration he received from Mary, Our Lady of Victory.