The management and optimization of radiation dose in computed tomography (CT) examinations is of paramount importance, especially when the safety of patients is concerned. This study evaluated the effect of implementing national diagnostic reference levels (NDRLs) for radiation dose optimization in 1991 adult chest CT scans at a major Saudi hospital. Data was analyzed before and after NDRL implementation, with 21.5% of scans using contrast and 78.5% without. Before implementation, 11.1% used contrast and 36.7% did not; after implementation, 10.4% used contrast and 41.7% did not. The majority (83.5%) of scans passed NDRL criteria [CTDIvol and DLP are set at 12 (mGy) and 430 (mGy · cm)], with higher pass rates for contrast (91.8%) versus non-contrast (81.5%) scans. Effective dose (ED) was compared before and after NDRL implementation. For non-contrast scans, ED declined 2.43% from 12.37 ± 5.25 mSv to 12.07 ± 4.99 mSv after implementation (non-significant, p > 0.05). For contrast scans, ED declined more substantially, 6.77% from 9.6 ± 4.61 mSv to 8.95 ± 4.44 mSv (non-significant, p > 0.05). The findings highlight higher NDRL compliance in procedures with contrast and show areas for dose optimization improvement in procedures without contrast. Results suggest NDRLs provide guidance for optimizing radiation dose, but other factors like patient characteristics, protocol settings, and quality assurance programs should also be considered to ensure doses are as low as reasonably achievable (ALARA) without compromising diagnostic quality. Regular monitoring and review of CT protocols is recommended to avoid unintended consequences of dose reduction. Continued optimization is encouraged to reduce dose while ensuring quality.