Characterization Of Benign Lesions Research Articles

FHER2, PR, ER, Ki-67 and Cytokeratin 5/6 Expression in Benign Feline Mammary Lesions.

Simple SummaryFeline mammary neoplasias are highly prevalent in domestic cats and present many similarities to their human counterparts. Since information about benign feline mammary lesions is still scarce and often controversial, studies using a wider panel of oncological biomarkers are necessary to understand their potential contribution to malignant lesions. This study analyzed 47 benign lesions from 27 queens, regarding the expression of estrogen and progesterone receptors (ER and PR, respectively), fHER2 protein and two malignancy indicators (Ki-67 and CK 5/6). Our results showed that most of the lesions were ER positive (91.5%), PR negative (63.8%), fHER2 negative (64.4%), Ck 5/6 negative (76.6%) and with a low Ki-67 index (78.7%). Additionally, significant correlations were found between younger ages and ER positivity and between larger lesions and negative PR status. Our results highlight the importance of estrogen receptors in the development of benign feline mammary lesions, further contributing to the development of preventive and monitoring strategies in feline mammary oncology.Biomarkers are essential in the characterization of neoplastic lesions and aid not only in the classification of the nature of the lesions, but also in the understanding of their ontogeny, development and prognosis. In cats, while mammary carcinomas are increasingly being characterized, information on their benign lesions is still scarce. Indeed, a better characterization of benign lesions could have an important role in unravelling mammary oncogenesis, similar to that in human breast cancer. Thus, in this study, the expression of five markers was analyzed in 47 benign mammary lesions (hyperplasia, dysplasia and benign tumors) collected from 27 queens. Dysplastic and hyperplastic lesions were the most common (41/47, 81.7%). Most of the lesions were classified as ER positive (43/47, 91.5%), PR negative (30/47, 63.8%), fHER2 negative (29/47, 64.4%), CK 5/6 negative (36/47, 76.6%) and with a low Ki-67 index (37/47, 78.7%). Statistical analysis revealed a correlation between younger ages and ER positivity (p = 0.013) and between larger lesions and negative PR status (p = 0.038). These results reinforce the importance of evaluating the expression of the ER status, prevalent in benign lesions, as a putative precursor in cancer progression.

Simulated Dose Reduction for Abdominal CT With Filtered Back Projection Technique: Effect on Liver Lesion Detection and Characterization.

Previous studies have shown the possibility to reduce radiation dose in abdominal CT by 25-50% without negatively affecting detection of liver lesions. How radiation dose reduction affects characterization of liver metastases is not as well known. The objective of this study was to investigate how different levels of simulated dose reduction affect the detection and characterization of liver lesions, primarily hypovascular metastases. A secondary objective was to analyze the relationship between the lesion size and contrast-to-noise ratio (CNR) and the detection rate. Thirty-nine patients (19 with metastases and 20 without) were retrospectively selected. The following radiation dose levels (DLs) were simulated: 100% (reference level), 75%, 50%, and 25%. Five readers were asked to mark liver lesions and rate the probability of malignancy on a 5-grade Likert scale. Noninferiority analysis using the jackknife free-response ROC (JAFROC) method was performed as well as direct comparison of detection rates and grades. JAFROC analysis showed noninferior detection and characterization of metastases at DL75 as compared with DL100. However, the number of benign lesions and false-positive localizations rated as "suspected malignancy" was significantly higher at DL75. Radiation dose can be reduced by 25% without negatively affecting diagnosis of hypovascular liver metastases. Characterization of benign lesions, however, is impaired at DL75, which may lead to unnecessary follow-up examinations. Finally, increased image noise seems to affect the detection of small lesions to a degree that cannot be explained solely by the reduction in CNR.

Frequency and characterization of benign lesions in patients undergoing surgery for the suspicion of solid pancreatic neoplasm.

A diagnosis of benign lesions (BLs) is reported in 5% to 21% of pancreatoduodenectomies performed for neoplasms; no data for body-tail resections are available. The aims were to investigate the frequency and characterize the BLs mimicking cancer in the head and the body-tail of the pancreas. This study is a retrospective review of pancreatic specimenscollected from 2005 to 2011 in the pathology database of Mainz (Germany). Patients with final diagnosis excluding malignancy were analyzed by histology, imaging, and clinical aspects. Among 373 patients, 33 patients (8.8%) were diagnosed with a benign disease: 25 (8.4%) of 298 in the pancreatic head and 8 (10.7%) of 75 in the body-tail resections. Paraduodenal pancreatitis was diagnosed in 13 (3.5%) of 373 patients; autoimmune pancreatitis (AIP), in 11 (2.9%); "ordinary" chronic pancreatitis, in 6 (1.6%); and accessory spleen, in 3 (0.8%). In pancreatic head resections, the most frequent diagnoses were paraduodenal pancreatitis (13/298, 4.4%) and AIP (9/298, 3%), whereas in the body-tail, the most frequent diagnoses were accessory spleen (3/75, 4%), chronic pancreatitis (3/75, 4%), and AIP (2/75, 2.7%). Benign lesions are observed with the same frequency inspecimens of the head or the body-tail of the pancreas.

Frequency and characterization of benign lesions in patients undergoing surgery for the suspicion of solid pancreatic neoplasm

Frequency and characterization of benign lesions in patients undergoing surgery for the suspicion of solid pancreatic neoplasm

Systematic review of the literature on the use of sealants in pancreatic surgery

Systematic review of the literature on the use of sealants in pancreatic surgery

Frequency and characterization of benign lesions in pancreatic specimens of patients operated for the suspicion of pancreatic cancer

Context A final diagnosis of benign lesions is reported in up to 21% of patients who underwent duodenocephalopancreatectomy for neoplasia, whereas no data have yet been published for resection of the body-tail. Objective To investigate the frequency and to characterize the benign lesions mimicking a neoplasia in the head and in the body-tail of the pancreas. Methods We retrospectively reviewed all the pancreatic specimens collected from 2005 to 2011 in the database of the Institute of Pathology of Mainz. Patients with a final diagnosis excluding malignancy were analyzed by histological, clinical and imaging findings. Results Three-hundreds and 73 patients were identified. A final diagnosis of benign disease was observed in 33 patients (8.8%), in 25 out of 298 (8.4%) in the resections of the pancreatic head and in 8 out of 75 (10.7%) of the body-tail. Among them we found paraduodenal pancreatitis (PP) in 13 cases (39.4%), autoimmune pancreatitis (AIP) in 11 (33.3%), chronic pancreatitis (CP) in 6 (18.2%) and accessory spleen in 3 (9.1%). In the head of the pancreas the most frequent diagnosis is PP and AIP, whereas in the body-tail accessory spleen and CP. Patients with benign lesions were more likely to be males, younger, smokers and drinkers, with longer lasting pain. Lower serum levels of CA 19-9 and lower frequency of jaundice were more frequently observed in this group. Pancreatic calcifications were more frequently associated with benign lesions whereas a larger dilation of common bile duct in the malignant lesions. AIP and PP have different clinical and radiological profiles. Conclusion Benign lesions are observed with the same frequency in specimens of the head or body-tail of the pancreas, while the type of final diagnosis is different.

Frequency and Characterization of Benign Lesions in Pancreatic Specimens of Patients Operated for the Suspicion of Pancreatic Cancer

Context A final diagnosis of benign lesions is reported in up to 21% of patients who underwent duodenocephalopancreatectomy for neoplasia, whereas no data have yet been published for resection of the body-tail. Objective To investigate the frequency and to characterize the benign lesions mimicking a neoplasia in the head and in the body-tail of the pancreas. Methods We retrospectively reviewed all the pancreatic specimens collected from 2005 to 2011 in the database of the Institute of Pathology of Mainz. Patients with a final diagnosis excluding malignancy were analyzed by histological, clinical and imaging findings. Results Three-hundreds and 73 patients were identified. A final diagnosis of benign disease was observed in 33 patients (8.8%), in 25 out of 298 (8.4%) in the resections of the pancreatic head and in 8 out of 75 (10.7%) of the body-tail. Among them we found paraduodenal pancreatitis (PP) in 13 cases (39.4%), autoimmune pancreatitis (AIP) in 11 (33.3%), chronic pancreatitis (CP) in 6 (18.2%) and accessory spleen in 3 (9.1%). In the head of the pancreas the most frequent diagnosis is PP and AIP, whereas in the body-tail accessory spleen and CP. Patients with benign lesions were more likely to be males, younger, smokers and drinkers, with longer lasting pain. Lower serum levels of CA 19-9 and lower frequency of jaundice were more frequently observed in this group. Pancreatic calcifications were more frequently associated with benign lesions whereas a larger dilation of common bile duct in the malignant lesions. AIP and PP have different clinical and radiological profiles. Conclusion Benign lesions are observed with the same frequency in specimens of the head or body-tail of the pancreas, while the type of final diagnosis is different.