Pandemics recur every 30 to 40 years. Every pandemic that has ever occurred brings changes in architectural design. This study conducts a literature study of the effect of pandemics on adaptation of the design of the artificial environment. Particularly the influence of the Covid-19 pandemic on changes in human behavior and its adaptation to residential architectural designs. In this paper, a qualitative approach with descriptive analysis methods is used to get a deep and a very basic understanding based on the problem being observed. The uncertain conditions of the Covid-19 pandemic have resulted in humans realizing that they cannot avoid the spread of this virus, so that a new environment and lifestyle are formed to live with this virus in a better way. During Covid-19, a house must adapt so it can effectively protect its residents from infectious diseases and facilitate all activities that were previously carried out outside the house. Some of the adaptations needed for residential design during this pandemic are in: housing characteristics; housing layout; interior, building material and furniture; natural lighting and indoor air quality; exterior, outdoor, and landscape; and value.