Changes In Mood States Research Articles

Exercise Intensity as a Predictor of Mood States During a Group Cycling Class

Increases in positive mood states after exercise has been well documented. Group cycling classes are a popular mode of exercise in the fitness industry. There is limited research on the effect of group fitness classes on mood states and whether intensity level will have an impact on the mood enhancing benefits. PURPOSE: The purpose of this study was to determine if exercise intensity predicts changes in mood states during a group cycling class. METHODS: A total of 99 subjects, ages 18 to 25 years old, volunteered for the study. No previous experience with group cycling classes was required. The subjects participated in one group cycling class instructed by a certified cycling instructor. Prior to the cycling session the subjects filled out an informed consent, medical history, and Subjective Exercise Experience Scale (SEES). Subjects were then given a heart rate monitor, instructed on proper bike set up and how to operate the bike during class. The cycling class consisted of a 5 min warm up, a 30 min conditioning phase with a mix of sprints, hills and jumps typically performed in a cycling class. The class ended with a 5 minute cool down and 5 minute stretch off the bike. Heart rate and percent heart rate reserve (%HRR) was continuously tracked during class. After the class, subjects filled out a second (post) SEES. A hierarchical regression analysis was used to examine whether intensity measured by %HRR predicted changes in each of the 3 mood state categories on the SEES (positive well-being, psychological distress, fatigue). Three related sample t-tests were run examining changes in mood following the cycling class. RESULTS: % HRR was negatively related to positive well-being (β = -.178, p = .046) and positively related to fatigue (β = .30, p = .003). There were no significant differences in fatigue after the cycling class (p > .05), however positive well-being increased (p = .001) and psychological distress decreased (p = .021) after the class. CONCLUSION: The intensity level of an acute exercise session may affect the mood enhancing benefits of exercise. The group cycling class did increase positive well-being and decrease psychological distress. However, individuals who exercised at higher intensity levels had increased levels of perceived fatigue and decreased feelings of positive well-being.

The Effects of Viewing Natural Scenery Indoors on Middle School Students’ Changes in Mood States and Concentration

The purpose of this study was to investigate the mood states and concentration of students when they see the natural scenery indoors throughout the...

Serum Endocannabinoid and Mood Changes after Exercise in Major Depressive Disorder.

We aimed to describe acute changes in serum eCB across a prescribed moderate (MOD) and a self-selected/preferred (PREF) intensity exercise session in women with major depressive disorder (MDD) and determine relationships between changes in eCB and mood states. Women with MDD (n = 17) exercised in separate sessions for 20 min on a cycle ergometer at both MOD or PREF in a within-subjects design. Blood was drawn before and within 10 min after exercise. Serum concentrations of eCB (anandamide [AEA], 2-arachidonoylglycerol) and related lipids (palmitoylethanolamine, oleoylethanolamine, 2-oleoylglycerol) were quantified using stable isotope-dilution, liquid chromatography/mass spectrometry/mass spectrometry. The profile of mood states and state-trait anxiety inventory (state only) were completed before, 10 min and 30 min postexercise. Significant elevations in AEA (P = 0.013) and oleoylethanolamine (P = 0.024) occurred for MOD (moderate effect sizes: Cohen's d = 0.58 and 0.41, respectively). Significant (P < 0.05) moderate negative associations existed between changes in AEA and mood states for MOD at 10 min (depression, confusion, fatigue, total mood disturbance [TMD] and state anxiety) and 30 min postexercise (confusion, TMD and state anxiety). Significant (P < 0.05) moderate negative associations existed between 2-arachidonoylglycerol and mood states at 10 min (depression and confusion) and 30 min postexercise (confusion and TMD). Changes in eCB or related lipids or eCB-mood relationships were not found for PREF. Given the broad, moderate-strength relationships between improvements in mood states and eCB increases after MOD, it is plausible that the eCB system contributes to the mood-enhancing effects of prescribed acute exercise in MDD. Alternative mechanisms are likely involved in the positive mood state effects of preferred exercise.

EXTREME CONDITIONING TRAINING: ACUTE EFFECTS ON MOOD STATE

ABSTRACT Introduction: The search for strategies aimed at reducing daily stress is increasing in the current literature. As a result, several types of fitness training are constantly being investigated for their influence on mood states. However, we know little about strategies that use higher intensities. Objective: To investigate the acute effects of an extreme conditioning training (ECT) session on the mood states of individuals with or without prior experience in this type of training. Methods: Volunteers were divided into TRAINED (n = 10) and CONDITIONED (n = 10) groups, undergoing a single 9-minute ECT session. Mood states (BRUMS scale) were analyzed at baseline, immediately afterwards, and after 30 minutes. Results: Anger, confusion and tension were significantly reduced in both groups immediately afterwards and post 30 minutes. The TRAINED group showed a significant reduction in fatigue 30 minutes after the end of the session. Effect size for all variables was considered small to moderate. The TRAINED group had significantly increased vigor immediately after the end of the session compared to baseline. However, the CONDITIONED group had significantly reduced vigor 30 minutes afterwards, in comparison to baseline. The increase in vigor in the TRAINED group was considered moderate (ES = 0.68), while the decrease in vigor in the CONDITIONED group was considered major (ES = −0.88). Conclusion: An ECT session is powerful enough to induce significant, albeit small and moderate, changes in mood states in both trained and untrained individuals in this particular type of exercise. Level of evidence II, Therapeutic studies-investigation of treatment results.

Heart Rate Variability as a Marker of Changes in Mood State in Daily Life by Photoplethysmography Technique

Introduction: The different mood states in our daily life can affect our mental and emotional health. The aim of our study was to explore photoplethysmography to record heart rate variability as a marker of changes in mood states in our daily life.Materials and Methods: Two groups of affective pictures categorized into positive and negative sets were shown to thirty subjects on two different consecutive days with simultaneously recording of heart rate variability for 5 minutes by photoplethysmography technique. Immediately after recording on each day, 0-9 self-assessment scale was used to assess the mood state of the subject after viewing the set of pictures.Results: Sympathetic domains of heart rate variability like low frequency (200.3 ±4.1 vs. 166.7 ±2.8, p&lt;0.05), low- and high frequency ratio (1.45 ± 0.21 vs. 0.55 ± 0.07, p&lt;0.05) and low frequency (55.8 ± 2.9 vs. 38.6 ± 2.8, p&lt;0.05) significantly increased in negative mood state condition as compared to positive mood state condition. High frequency (157.9 ± 3.9 vs. 264.3 ± 5.3, p&lt;0.05) and high frequency (44 ± 2.9 vs. 61.2 ±4.2, p&lt; 0.05) significantly increased in positive mood state condition as compared to negative mood state condition. There was significant increase in heart rate (78 ± 2.99 vs. 73 ± 3.11, p&lt;0.05) in negative mood state as compared to positive mood state.Conclusions: Increase in sympathetic activity during negative mood state and increase in parasympathetic activity during positive mood state measured by photoplethysmography technique validates this easy and noninvasive mental assessment tool to determine different mood states.

Direct Electrical Stimulation of Lateral Orbitofrontal Cortex Acutely Improves Mood in Individuals with Symptoms of Depression

Mood disorders cause significant morbidity and mortality, and existing therapies fail 20%-30% of patients. Deep brain stimulation (DBS) is an emerging treatment for refractory mood disorders, but its success depends critically on target selection. DBS focused on known targets within mood-related frontostriatal and limbic circuits has been variably efficacious. Here, we examine the effects of stimulation in orbitofrontal cortex (OFC), a key hub for mood-related circuitry that has not been well characterized as a stimulation target. We studied 25 subjects with epilepsy who were implanted with intracranial electrodes for seizure localization. Baseline depression traits ranged from mild to severe. We serially assayed mood state over several days using a validated questionnaire. Continuous electrocorticography enabled investigation of neurophysiological correlates of mood-state changes. We used implanted electrodes to stimulate OFC and other brain regions while collecting verbal mood reports and questionnaire scores. We found that unilateral stimulation of the lateral OFC produced acute, dose-dependent mood-state improvement in subjects with moderate-to-severe baseline depression. Stimulation suppressed low-frequency power in OFC, mirroring neurophysiological features that were associated with positive mood states during natural mood fluctuation. Stimulation potentiated single-pulse-evoked responses in OFC and modulated activity within distributed structures implicated in mood regulation. Behavioral responses to stimulation did not include hypomania and indicated an acute restoration to non-depressed mood state. Together, these findings indicate that lateral OFC stimulation broadly modulates mood-related circuitry to improve mood state in depressed patients, revealing lateral OFC as a promising new target for therapeutic brain stimulation in mood disorders.

Real-world unexpected outcomes predict city-level mood states and risk-taking behavior.

Fluctuations in mood states are driven by unpredictable outcomes in daily life but also appear to drive consequential behaviors such as risk-taking. However, our understanding of the relationships between unexpected outcomes, mood, and risk-taking behavior has relied primarily upon constrained and artificial laboratory settings. Here we examine, using naturalistic datasets, how real-world unexpected outcomes predict mood state changes observable at the level of a city, in turn predicting changes in gambling behavior. By analyzing day-to-day mood language extracted from 5.2 million location-specific and public Twitter posts or ‘tweets’, we examine how real-world ‘prediction errors’—local outcomes that deviate positively from expectations—predict day-to-day mood states observable at the level of a city. These mood states in turn predicted increased per-person lottery gambling rates, revealing how interplay between prediction errors, moods, and risky decision-making unfolds in the real world. Our results underscore how social media and naturalistic datasets can uniquely allow us to understand consequential psychological phenomena.

Nitrate-Rich Fruit and Vegetable Supplement Reduces Blood Pressure in Normotensive Healthy Young Males without Significantly Altering Flow-Mediated Vasodilation: A Randomized, Double-Blinded, Controlled Trial.

Nitric oxide (NO) is a primary vasodilatory factor released from endothelial cells of the peripheral vasculature. NO production is stimulated through enzymatic-dependent mechanisms via NO synthase and from dietary intake of nitrate-containing foods or supplements. We evaluated the efficacy of a nitrate-rich fruit and vegetable liquid supplement (FVS, AMPED NOx, Isagenix International LLC) versus a juice low in nitrates (prune juice, PRU) on circulating nitrates/nitrites as well as cardiovascular parameters in 45 healthy normotensive men (18–40 y). Blood pressure, flow-mediated dilation (FMD), and plasma nitrates and nitrites were measured at baseline and after two weeks of supplementation (2 oz/d). Subjects also completed questionnaires on sleep quality and mood since these measures have been associated with endothelial function. In contrast to PRU, FVS significantly increased plasma nitrates and nitrites (+67%, p < 0.001) and decreased diastolic blood pressure (−9%, p=0.029) after two weeks. The change in FMD for FVS supplementation versus PRU supplementation was not significant (+2% vs. −9%, respectively, p=0.145). Changes in sleep quality or total mood state did not differ between groups after the 2-week study. Thus, the nitrate-rich FVS supplement increased plasma NO and reduced diastolic blood pressure in young normotensive men, but increased plasma NO was not associated with improvements in FMD, mood, or sleep. This trial is registered with ClinicalTrials.gov NCT03486145.

The accuracy of passive phone sensors in predicting daily mood.

Smartphones provide a low-cost and efficient means to collect population level data. Several small studies have shown promise in predicting mood variability from smartphone-based sensor and usage data, but have not been generalized to nationally recruited samples. This study used passive smartphone data, demographic characteristics, and baseline depressive symptoms to predict prospective daily mood. Daily phone usage data were collected passively from 271 Android phone users participating in a fully remote randomized controlled trial of depression treatment (BRIGHTEN). Participants completed daily Patient Health Questionnaire-2. A machine learning approach was used to predict daily mood for the entire sample and individual participants. Sample-wide estimates showed a marginally significant association between physical mobility and self-reported daily mood (B=-0.04, P<0.05), but the predictive models performed poorly for the sample as a whole (median R2 ∼ 0). Focusing on individuals, 13.9% of participants showed significant association (FDR<0.10) between a passive feature and daily mood. Personalized models combining features provided better prediction performance (median area under the curve [AUC]>0.50) for 80.6% of participants and very strong prediction in a subset (median AUC>0.80) for 11.8% of participants. Passive smartphone data with current features may not be suited for predicting daily mood at a population level because of the high degree of intra- and interindividual variation in phone usage patterns and daily mood ratings. Personalized models show encouraging early signs for predicting an individual's mood state changes, with GPS-derived mobility being the top most important feature in the present sample.

Mood State Changes Accompanying the Crossfit Open™ Competition in Healthy Adults.

Background: Specific mood states were examined during the CrossFit Open, a consecutive 5-week fitness competition involving five separate CrossFit® workouts, to determine whether the unique design or strenuous workouts of the competition resulted in acute and/or chronic mood state alterations. Methods: Participants (n = 8) completed the Profile of Mood States (POMS) questionnaire one-week prior to the competition (baseline), prior to (PRE), immediately post (IP), 30-min post- (30P) and 60-min post-workout (60P) each week. Tension, depression, anger, confusion, fatigue and vigor were derived from the POMS, as was Total Mood Disturbance (TMD) and an Energy Index (EI). Results: Workout intensity exceeded 93% HRmax each week. No differences were observed between baseline and PRE-workout mood states across weeks, indicating little effect of the unique competition design. Significant (week x time) interactions were observed for TMD (p = 0.037), EI (p = 0.038) and fatigue (p = 0.005). Acute mood state fluctuations were consistent across each week, where mood states improved to and beyond PRE values 60-min post-workout. Conclusions: In competitors, the differences in workout design between each week did not influence mood states. This may be related to adaptation to this style of training, while the acute mood state alterations are likely due to the workout intensity.

Combining frontal gamma asymmetry neurofeedback with virtual reality: A proof of concept case study

The current proof of concept case study was designed to determine if a consumer-grade neurofeedback system (Muse) could be used in conjunction with specially designed VR environments (Positivity by Healium) to impact gamma frontal asymmetry as well as create positive changes in mood states. Four firefighters served as subjects and completed pre-post mood rating scales as well as 19-channel EEG recordings. An examination of sLORETA frontal lobe ROI’s demonstrated a post-intervention gamma asymmetry shift to the left in 3 of the 4 subjects. In addition, subjects generally reported changes in mood consistent with the frontal asymmetry changes. Overall, these results provide initial support for the idea that a consumer grade BCI/VR intervention can potentially have therapeutic utility and deserve further study.

'Singing with your baby': an evaluation of group singing sessions for women admitted to a specialist mother-baby unit.

This paper reports on the acceptability, experience of participation and the immediate impact on maternal mood state of group singing sessions, introduced as a routine component of a mother-baby unit (MBU) treatment programme. Data was collected from 27 women who participated in the pilot programme. Results showed that implementation of a singing intervention in this setting is positively appraised by women and is associated with positive changes in self-reported mood state from pre- to post-session. Key facilitators and barriers to the success of the programme and directions for future research are discussed.

Change in drawing placement: A measure of change in mood state reflective of hemispheric lateralization of emotion

The Valence Hypothesis of cerebral lateralization of emotion suggests greater right hemisphere activation during negative mood and greater left hemisphere activation during positive mood. This can manifest as visual field attentional bias. Here, study participants completed an assessment of current mood state (PANAS) and made a drawing (Drawing 1). To induce positive or negative mood, participants played a game; then, the winner read a script depicting a positive interpersonal interaction and the loser read a script depicting a negative interpersonal interaction. Participants then drew a second picture (Drawing 2) and completed the PANAS. We hypothesized that the game outcome would change current mood state and hemispheric activation, which would be reflected in drawing placement. The placement of Drawing 2 moved right for winners and left for losers. Winners experienced a greater increase in positive affect from Time 1 to Time 2 than losers and had decreased negative affect from Time 1. Losers had decreased positive affect from Time 1 and had a greater increase in negative affect from Time 1 to Time 2 than winners. Our results suggest that change in current mood state may be objectively observed by evaluating hemispatial bias reflective of brain hemispheric activation with drawings.

Effect of Coordinated Probiotic/Prebiotic/Phytobiotic Supplementation on Microbiome Balance and Psychological Mood State in Healthy Stressed Adults

BackgroundInterest in and knowledge of the gut microbiome has increased exponentially in the past decade. This once overlooked component of the gastrointestinal tract is now implicated in multiple aspects of human health, including mental wellness (e.g. depression, anxiety, stress), metabolic (e.g. diabetes, obesity), neurologic (e.g. Alzheimer's, Parkinson's, Autism Spectrum Disorder), gastrointestinal (e.g. irritable bowel syndrome, Crohn's), and immunologic (e.g. inflammation, cancer), among others.Purpose/ObjectivesPrevious research has demonstrated the “strain specificity” of probiotic therapy – elucidating that targeted health benefits are related to the specific strain of bacteria (e.g. Lactobacillus helveticus R0052 for serotonin/depression; Bifidobacterium longum R0175 for GABA/anxiety; Lactobacillus rhamnosus R0011 for cortisol/stress). Similarly, probiotic bacteria demonstrate different growth trajectories based on availability of preferred fiber substrates (e.g. prebiotics) and phytonutrients such as flavonoids/polyphenols (e.g. phytobiotics). Thus, our objective was two‐fold: to determine the change in microbiome ecology/balance; and to assess the change in psychological mood state (e.g. depression/anxiety/vigor) following a coordinated pro‐/pre‐/phyto‐biotic supplementation regimen.MethodsThirty‐two healthy subjects screened for “moderate” levels of psychological stress were randomly assigned to 30‐days of Supplement (Amare Fundamentals containing specific strains of probiotic bacteria, prebiotic fibers, and phytobiotic plant extracts, N=21) or look‐alike Placebo (N=11). Microbiome balance was assessed in fecal samples using a PCR‐based analysis (BiomeTracker) that has previously compared favorably to 16S sequencing (ACN 2017) for abundance quantification for major phyla/families of bacteria. Psychological mood state parameters were assessed using the validated Profile of Mood States survey (POMS) to generate scores for Global Mood State, and six sub‐scales (Depression, Tension, Fatigue, Anger, Confusion, and Vigor).ResultsFollowing 30‐days of supplementation, there was a significant increase in populations of “good” bacteria in the Supplement group (+28% Lactobacillus; +30% Bifidobacterium) and overall composite score (+17%) versus Placebo (p&lt;0.05). Psychological indices were significantly improved in the Supplement group for both positive (+25% Global Mood; +25% Vigor) and negative (−60% Depression; −54% Tension; −52% Fatigue; −42% Confusion; −39% Anger) parameters versus Placebo (p&lt;0.05).ConclusionsThe World Health Organization has identified mental wellness issues as the leading contributor to global health burden – highlighting the urgency to develop lifestyle interventions to effectively manage depression, anxiety, and stress. These results demonstrate the close relationship between microbiome balance and psychological parameters – and the utility of targeted supplementation to positively influence the gut‐brain‐axis for improved mental wellness.Support or Funding InformationThis trial was funded by Amare Global and conducted jointly by EQQIL and Wasatch ScientificThis abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.

Effect of Coordinated Probiotic/Prebiotic/Phytobiotic Supplementation on Microbiome Balance and Psychological Mood State in Healthy Stressed Adults

BackgroundInterest in and knowledge of the gut microbiome has increased exponentially in the past decade. This once overlooked component of the gastrointestinal tract is now implicated in multiple aspects of human health, including mental wellness (e.g. depression, anxiety, stress), metabolic (e.g. diabetes, obesity), neurologic (e.g. Alzheimer's, Parkinson's, Autism Spectrum Disorder), gastrointestinal (e.g. irritable bowel syndrome, Crohn's), and immunologic (e.g. inflammation, cancer), among others.Purpose/ObjectivesPrevious research has demonstrated the “strain specificity” of probiotic therapy – elucidating that targeted health benefits are related to the specific strain of bacteria (e.g. Lactobacillus helveticus R0052 for serotonin/depression; Bifidobacterium longum R0175 for GABA/anxiety; Lactobacillus rhamnosus R0011 for cortisol/stress). Similarly, probiotic bacteria demonstrate different growth trajectories based on availability of preferred fiber substrates (e.g. prebiotics) and phytonutrients such as flavonoids/polyphenols (e.g. phytobiotics). Thus, our objective was two‐fold: to determine the change in microbiome ecology/balance; and to assess the change in psychological mood state (e.g. depression/anxiety/vigor) following a coordinated pro‐/pre‐/phyto‐biotic supplementation regimen.MethodsThirty‐two healthy subjects screened for “moderate” levels of psychological stress were randomly assigned to 30‐days of Supplement (Amare Fundamentals containing specific strains of probiotic bacteria, prebiotic fibers, and phytobiotic plant extracts, N=21) or look‐alike Placebo (N=11). Microbiome balance was assessed in fecal samples using a PCR‐based analysis (BiomeTracker) that has previously compared favorably to 16S sequencing (ACN 2017) for abundance quantification for major phyla/families of bacteria. Psychological mood state parameters were assessed using the validated Profile of Mood States survey (POMS) to generate scores for Global Mood State, and six sub‐scales (Depression, Tension, Fatigue, Anger, Confusion, and Vigor).ResultsFollowing 30‐days of supplementation, there was a significant increase in populations of “good” bacteria in the Supplement group (+28% Lactobacillus; +30% Bifidobacterium) and overall composite score (+17%) versus Placebo (p&lt;0.05). Psychological indices were significantly improved in the Supplement group for both positive (+25% Global Mood; +25% Vigor) and negative (−60% Depression; −54% Tension; −52% Fatigue; −42% Confusion; −39% Anger) parameters versus Placebo (p&lt;0.05).ConclusionsThe World Health Organization has identified mental wellness issues as the leading contributor to global health burden – highlighting the urgency to develop lifestyle interventions to effectively manage depression, anxiety, and stress. These results demonstrate the close relationship between microbiome balance and psychological parameters – and the utility of targeted supplementation to positively influence the gut‐brain‐axis for improved mental wellness.Support or Funding InformationThis trial was funded by Amare Global and conducted jointly by EQQIL and Wasatch ScientificThis abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.

Dynamic Measures of Anxiety-Related Threat Bias: Links to Stress Reactivity.

Exaggerated attention to threatening information, or the threat bias, has been implicated in the development and maintenance of anxiety disorders. Recent research has highlighted methodological limitations in threat bias measures, such as temporal insensitivity, leading to the development of novel metrics that capture change and variability in threat bias over time. These metrics, however, have rarely been examined in non-clinical samples. The present study aimed to explore the utility of these trial-level metrics in predicting anxiety-related stress reactivity (stress-induced negative mood state) in trait anxious adults (N = 52). Following a stressor, participants completed the dot probe task to generate threat bias scores. Stress reactivity was measured via stress-induced changes in subjective mood state. More variability in trial-level bias scores and greater bias away from threat (both mean and peak negative trial-level bias scores) predicted increased stress reactivity. The temporal characteristics of threat bias and implications for clinically-relevant measurement are discussed.

Poster Number: EI 25 - Examining Relationships among Subjective Cognitive Concerns and Positive and Negative Afffect in Cognitvely Normal Older Adults Using a Weekly, Internet-Based Method: A Pilot Study

Introduction: Subjective cognitive concerns (SCC) may serve as an early indicator of subtle cognitive change in preclinical Alzheimer's Disease (AD). Despite the clinical relevance of SCC, the stability of SCC over time is not well understood, nor is the influence of changes in mood states on SCC. Better understanding these relationships has important implications for future design of secondary prevention clinical trials in AD, which often rely on SCC as outcome measures.

Lithium + Colchicine: A Potential Strategy to Reduce Pro-inflammatory Effects of Lithium Treatment.

Rosenblat and McIntyre (Acta Psychiatr Scand. 2015;132: 180-191) propose that immune disorders are important mediators between bipolar disorders and medical comorbidities. Rosenblat et al (Bipolar Disord. 2016;18:89-101) present a meta-analysis showing that adjunctive anti-inflammatory agents could evoke moderate antidepressant responses in bipolar disorders. We propose using the anti-inflammatory drug colchicine to improve the long-term safety and efficacy of lithium treatment for bipolar disorders. This report is based on searches of the PubMed and Web of Science databases. Bipolar disorders are associated with significant medical comorbidities such as hypertension, overweight/obesity, diabetes mellitus, metabolic syndrome, and arteriosclerosis, accompanied by enhanced release of pro-inflammatory markers during changes in mood state. During lithium therapy, granulocyte-colony stimulating factor, CD34+ hematopoietic stem/progenitor cells, and neutrophil elastase enter the circulation with activated neutrophils to promote the extravascular migration of activated neutrophils and enhance tissue inflammation. Concurrent treatment with lithium and low-dose colchicine could facilitate the responsiveness of bipolar patients to lithium by reducing leukocyte tissue emigration, the release of neutrophil elastase, and the release of leukocyte pro-inflammatory cytokines such as IL-1β that are regulated by the NLRP3 inflammasome assembly complex. Concurrent therapy with lithium and low-dose colchicine could reduce complications involving leukocyte-mediated inflammatory states in bipolar patients and promote patient acceptance and responsiveness to lithium therapy.

Actividade Física e Estados Afectivos: Humor e Emoções

The present paper aims to present a synthesis of the knowledge already accumulated on the relation between physical exercise and states of humor. Very few studies on physical activity and physical exercise have examined mood or emotion in the perspective of a contemporary theory of emotions. It has yet to be unequivocally demonstrated that acute exercise of the type commonly practiced for leisure or fitness alters emotional responses. The reasons why many people decide to adopt exercise include weight loss and health benefits, including changes in mood states. Adoption of a life healthy style based on physical exercise involves time and a considerable effort in the short term, and visible results do not occur immediately, but rather after a long period of time (months). Advanced motives for exercising have included humor as a factor and, in fact, humor continues to play a significant, conceptually meaningful role as a reason for people to exercise.

Combined and Isolated Effects of Alcohol Intake and One Night of Sleep Deprivation on Mood States, Hormonal and Inflammatory Responses in Healthy Male Adults: a Crossover Randomized Controlled Trial.

Alcohol (ALC) intake and sleep deprivation (SDP) are conditions that cause changes in the physiological status. However, the relationship between biological markers and mood states is not entirely clear yet. The purpose of the study was to compare isolated and combined effects of ALC intake and SDP on hormonal and inflammatory responses and in changes in the state of mood. Also, we intended to explain possible changes in mood states through biochemical variations using multiple stepwise regression analysis. Ten healthy male were randomized in four situations: (1) placebo intake + normal sleep (PLA + SLE); (2) ALC intake + SLE; (3) PLA intake + SDP; (4) ALC intake + SDP. While subjects ingested ALC (1 g/kg of beer), PLA intake was a non-alcoholic beer. The subjects had one night of SLE or were subjected to SDP in the lab for 8 h. After each experimental condition, morning blood samples were taken for assessments of serum levels of glucose, cortisol, testosterone, epinephrine, interleukin-6 (IL-6), interleukin-10 (IL-10) and C-reactive protein (CRP). The subjects were also asked to fill in a Profile of Mood State questionnaire. The results showed that the glucose level was significant lower in ALC + SDP compared to the PLA + SLE condition. Total Mood Disturbance was lower in ALC + SDP and PLA + SDP compared to the PLA + SLE condition. Fatigue was higher under SDP conditions compared to PLA + SLE. Vigor was lower under the ALC + SDP condition compared to the PLA + SLE condition. Regression analysis showed that Total Mood Disturbance and fatigue under ALC + SDP were associated with changes in the cortisol levels. Our results showed that combined and isolated ALC intake and one night of SDP did not change the hormonal and inflammatory responses tested, and the combined effects caused a reduction in the glucose levels. Vigor, fatigue and Total Mood Disturbance were affected by each condition. Furthermore, Total Mood Disturbance and fatigue were possibly explained by changes in the cortisol levels in the combined condition.