Nanoparticle-based strategies have emerged as transformative tools for addressing critical challenges in sustainable agriculture, offering precise modulation of plant–environment interactions through enhanced biocompatibility and stimuli-responsive delivery mechanisms. Among these innovations, selenium nanoparticles (SeNPs) present unique advantages due to their dual functionality as both essential micronutrient carriers and redox homeostasis modulators. Compared to conventional selenium treatments, SeNPs offer a more efficient and environmentally friendly solution for improving plant resilience while minimizing toxicity, even at low doses. This review provides a comprehensive analysis of methods for synthesizing SeNPs, including chemical reduction, green synthesis using plant extracts, and biological techniques with microbial agents. Additionally, the review discusses the effects of SeNPs on biotic and abiotic stress responses in plants, focusing on how these nanoparticles activate stress-response pathways and enhance plant immune function. The primary objective of this study is to offer theoretical insights into the application of SeNPs for addressing critical challenges in modern agriculture, such as improving crop yield and quality under stress conditions. Moreover, the research highlights the role of SeNPs in advancing sustainable agricultural practices by reducing reliance on chemical fertilizers and pesticides. The findings underscore the transformative potential of SeNPs in crop management, contributing to a more sustainable and eco-friendly agricultural future.
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