A0614 Prior TURP does not affect perioperative outcomes at radical prostatectomy: A pairmatched analysis of a single center series

V066 Single-port off-clamp robotic partial nephrectomy: Surgical technique, perioperative, pathologic and early functional outcomes of a single center series

We give a description of the Linnell division ring of a countable residually (poly- Z \mathbb {Z} virtually nilpotent) (RPVN) group in terms of a generalised Novikov ring, and show that vanishing top-degree cohomology of a finite type group G G with coefficients in this Novikov ring implies the existence of a normal subgroup N ⩽ G N \leqslant G such that c d Q ( N ) > c d Q ( G ) cd_\mathbb {Q}(N) > cd_\mathbb {Q}(G) and G / N G/N is poly- Z \mathbb {Z} virtually nilpotent. As a consequence, we show that if G G is an RPVN group of finite type, then its top-degree ℓ 2 \ell ^2 -Betti number vanishes if and only if there is a poly- Z \mathbb {Z} virtually nilpotent quotient G / N G/N such that c d Q ( N ) > c d Q ( G ) cd_\mathbb {Q}(N) > cd_\mathbb {Q}(G) . In particular, finitely generated RPVN groups of cohomological dimension 2 2 are virtually free-by-nilpotent if and only if their second ℓ 2 \ell ^2 -Betti number vanishes, and therefore 2 2 -dimensional RPVN groups with vanishing second ℓ 2 \ell ^2 -Betti number are coherent. As another application, we show that if G G is a finitely generated parafree group with c d ( G ) = 2 cd(G) = 2 , then G G satisfies the Parafree Conjecture if and only if the terms of its lower central series are eventually free. Note that the class of RPVN groups contains all finitely generated RFRS groups and all finitely generated residually torsion-free nilpotent groups.

Abstract The weak commutativity group χ ⁢ ( G ) \chi(G) is generated by two isomorphic groups 𝐺 and G φ G^{\varphi} subject to the relations [ g , g φ ] = 1 [g,g^{\varphi}]=1 for all g ∈ G g\in G . We obtain new expressions for the terms of the derived series and the lower central series of χ ⁢ ( G ) \chi(G) . We also present new bounds for the exponent of some sections of χ ⁢ ( G ) \chi(G) .

Consider the random Cayley graph of a finite group G with respect to k generators chosen uniformly at random, with 1 \ll \log k \ll{\log}|G| ; denote it by G_{k} . A conjecture of Aldous and Diaconis (1985) asserts, for k \gg{\log}|G| , that the random walk on this graph exhibits cutoff. Further, the cutoff time should be a function only of k and |G| , to sub-leading order. This was verified for all Abelian groups in the ’90s. We extend the conjecture to 1 \ll k \lesssim{\log}|G| . We establish cutoff for all Abelian groups under the condition k - d(G) \gg 1 , where d(G) is the minimal size of a generating subset of G , which is almost optimal. The cutoff time is described (abstractly) in terms of the entropy of random walk on \mathbb{Z}^{k} . This abstract definition allows us to deduce that the cutoff time can be written as a function only of k and |G| when d(G) \ll{\log}|G| and k - d(G) \asymp k \gg 1 ; this is not the case when d(G) \asymp{\log}|G| \asymp k . For certain regimes of k , we find the limit profile of the convergence to equilibrium. Wilson (1997) conjectured that \mathbb{Z}_{2}^{d} gives rise to the slowest mixing time for G_{k} amongst all groups of size at most 2^{d} . We give a partial answer, verifying the conjecture for nilpotent groups. This is obtained via a comparison result of independent interest between the mixing times of nilpotent G and a corresponding Abelian group \overline G , namely the direct sum of the Abelian quotients in the lower central series of G . We use this to refine a celebrated result of Alon and Roichman 1994: we show for nilpotent G that G_{k} is an expander provided k - d(\overline G) \gtrsim{\log}|G| . As another consequence, we establish cutoff for nilpotent groups with relatively small commutator subgroup, including high-dimensional special groups, such as Heisenberg groups. The aforementioned results all hold with high probability over the random Cayley graph G_{k} .

Real-world impact of pembrolizumab-based chemoimmunotherapy in recurrent or metastatic cervical cancer: a large retrospective single center series

A new machine learning model to predict novel trifecta achievement and validation of its prognostic significance in a large single centre series of minimally invasive partial nephrectomy.

This study aimed to describe the causes of aseptic failure leading to conversion from unicompartmental knee arthroplasty (UKA) to total knee arthroplasty (TKA) and to report implant selection and mid-term outcomes in a high-volume orthopaedic centre. In this retrospective single-centre case series, 27 patients (13 women, 14 men; mean age 68.9 years, range 55-81) undergoing conversion from UKA to TKA between January 2013 and December 2020 were included. Causes of UKA failure, type of revision implant (posterior-stabilised [PS], constrained posterior-stabilised [CPS] or legacy constrained condylar knee [LCCK]), and use of tibial stem extensions were recorded. Implant survival after conversion was estimated using Kaplan-Meier analysis, and re-revision rates were documented. Absolute numbers with percentages were reported. The most common causes of UKA failure were periprosthetic tibial fracture (10/27; 37%), tibial component loosening (8/27; 30%) and progression of osteoarthritis (7/27; 26%). PS implants were used in 17 patients (63%; 6 with cemented tibial stem), CPS in 9 (33%; all with stems) and LCCK in 1 (4%; with stem). Overall, tibial stem extensions were used in 16 cases (59%). At a mean follow-up of 23 months (range 0-89), 2 patients (7%) underwent re-revision: one for tibial loosening and one for instability. Kaplan-Meier analysis estimated a median implant survival of 74 months (SD 17.1; 95% CI: 40.6-107.4 months). In this specialised high-volume centre, conversion of UKA to TKA was most performed for mechanical failure or disease progression. Most cases could be managed with PS implants, with selective use of stems or higher constraint when indicated. Re-revisions were rare, but findings should be interpreted cautiously given the small sample size, variable follow-up and potential selection bias. Level IV.

Abstract Introduction Oesophagectomy remains a highly morbid operation, in spite of advances in neoadjuvant approaches, perioperative care, and minimally invasive surgery. Textbook outcome (TBO) is a composite metric assessing surgical quality and perioperative outcomes. Our group has previously demonstrated a survival advantage with a TBO. Additionally, operating by a minimally invasive approach combined with TBO further improves survival. Robotic assisted minimally invasive oesophagectomy (RAMIO) is oncologically safe and may improve perioperative outcomes. This study aims to determine rates of TBO in RAMIO, and compare this with a pre-existing cohort. Method Patients undergoing oesophagectomy from 2011-2024 were included. Only patients undergoing RAMIO were included post-February 2020. Standard clinicopathologic variables were recorded. TBOs were calculated as previously described1. Statistical analyses were performed with jamovi 2.3.28. Results 362 patients underwent oesophagectomy. 93 had a RAMIO, 139 underwent open oesophagectomy (OO) and 130 underwent laparoscopic oesophagectomy (LO). 53% of RAMIO patients achieved a TBO, compared with 19% of OO and 45% LO (p=0.001, 0.34). For the RAMIO group the most common reason for not achieving a TBO was a post-operative complication (39%), followed by a prolonged length of stay (19%), similar to the non-RAMIO group (32% and 28% respectively). In the RAMIO group there were no associations between age, ASA status, patient sex and neoadjuvant regimen and the likelihood of achieving a TBO. Conclusions The introduction of RAMIO incrementally improve TBO rates, particularly compared with OO. As the use of RAMIO expands, there may be a corresponding incremental impact on long-term oncologic outcomes.

Simplified dual-time-point 99mTc-pyrophosphate scintigraphy in patients with suspected transthyretin amyloid cardiomyopathy: A single center series

Chemotherapy free ponatinib + asciminib achieves optimal disease controlpreallohsct in advanced – CML

Defining the factors for positive surgical margins in radical robotic assisted laparoscopic prostatectomy - A case series of a single center

Background The role of platelet function testing in patients with intracranial aneurysms undergoing flow diversion remains controversial with limited evidence of its influence on thrombotic outcomes. We report an observational cohort analysis evaluating whether P2Y12 assay testing is associated with lower thrombotic events in patients undergoing flow diversion. Methods We performed a retrospective review of a single center prospectively maintained procedural database to identify patients who underwent flow diversion between March 2015 and July 2025. One physician within our practice never performs P2Y12 assay testing. The remaining physicians utilize P2Y12 assay testing as part of routine practice. These two different patient cohorts were compared. Acute thrombotic events were our primary outcome. Secondary outcomes included delayed intracerebral hemorrhage, intimal hyperplasia without clinical sequalae, and transient neurologic deficits. Results We identified 397 unruptured aneurysm patients who underwent flow diversion at our institution between March 2015 and July 2025. Median age was 58 years old (Interquartile range (IQR) 49‐67), with 328 females (83%) and 69 males (17%). Out of 397 patients, 283 (71%) patients were treated by physicians who performed routine pre and postoperative testing of aspirin and Plavix assays, with subsequent adjustment of antithrombotic dosing accordingly, while 114 patients (29%) were treated with aspirin and clopidogrel pre‐and post‐operatively without testing.Eighteen out of 397 patients (4.5%) had an acute thrombotic event requiring intraarterial anti‐thrombotic infusion or urgent thrombectomy, or both. Of these, 16 were from the 283‐patient testing cohort (5.6%), and two in the 114 patients non‐testing cohort (1.8%) (p=0.09). Patients experiencing a thrombotic event had similar demographics, vascular risk factors, maximal aneurysmal diameter, and stent diameter. In a multivariable analysis adjusting for hypertension, stent diameter, aneurysmal diameter and age, P2Y12 sensitivity assay testing was not significantly associated with acute thrombotic events in aneurysm patients undergoing flow diversion (Odds ratio (OR)=1.5, 95% Confidence Interval (CI)= 0.15‐3.4), p=0.057). Secondary outcomes were comparable between both groups; transient neurologic deficits were noted in 36/283 in the testing group (13%), and 18/114 in the non‐testing group (16%) (p=0.4),endothelial hyperplasia was noted in 40/283 in the testing group (14%), and 12/114 in the non‐testing group (11%) (p=0.3), and intracranial hemorrhage occurred in 1 patient in the testing group (p>0.9). Conclusion Platelet function testing was not correlated with thrombotic events or patient outcomes in this single center series. While platelet function testing is widely used in patients undergoing flow diversion of intracranial aneurysms there remains insufficient to suggest such testing is necessary. Larger prospective studies are required.

Moreau’s Tanganyika-Nyasa Montane Chain is a series of mountain ranges running from south-eastern Kenya, south and west through Tanzania, and thence southwards through Malawi and extreme north-western Zambia to Mulanje Mountain in southern Malawi. These mountain ranges are the links in Moreau’s Tanganyika-Nyasa Montane Chain (the Chain). This is examined in terms of a series of butterfly Centres of Endemism. Butterflies endemic to the Chain are listed and distributions within it are examined. Neighbouring butterfly Centres of Endemism are used as counterfactuals to test the validity of the Chain, and butterflies endemic to these centres are also listed. The southernmost mountains of the Chain are found to belong to the South East Africa Montane Archipelago ecoregion, while the more northerly part of the Chain, from the Taita Hills in Kenya to the Nyika Plateau west of Lake Malawi, is found to be divide naturally into two overlapping Centres of Endemism, separated by altitude: the Eastern Arc Mountains of southern Kenya and Tanzania, and the ‘Tanzania – Malawi Highlands’; the former is already known but the latter we now identify as a new butterfly Centre of Endemism. Connecting the links in the Chain is shared butterfly endemism between the individual mountain blocks, enabling the identification and delineation of Centres of Endemism. The important endemic butterfly fauna of the adjoining Zanzibar – Inhambane Coastal Forest Mosaic, the Eastern Africa Coastal Zone, is separated from that of the montane highlands inland, and is discussed. This study shows that few otherwise locally endemic species have distributions which transgress from neighbouring Centres of Endemism into the Chain or vice versa. Conservation issues are considered.

Abstract We consider the associated graded $\bigoplus_{k\geq 1} \Gamma_k \mathcal{I} /\Gamma_{k+1} \mathcal{I} $ of the lower central series $\mathcal{I}\,=\,\Gamma_1 \mathcal{I}\supset \Gamma_2 \mathcal{I}\supset \Gamma_3 \mathcal{I} \supset \cdots$ of the Torelli group $\mathcal{I}$ of a compact oriented surface. Its degree-one part is well understood by D. Johnson’s seminal works on the abelianization of the Torelli group. The knowledge of the degree-two part $(\Gamma_2 \mathcal{I} / \Gamma_3 \mathcal{I})\otimes \mathbb{Q}$ with rational coefficients arises from works of S. Morita on the Casson invariant and R. Hain on the Malcev completion of $\mathcal{I}$ . Here, we prove that the abelian group $\Gamma_2 \mathcal{I} / \Gamma_3 \mathcal{I}$ is torsion-free, and we describe it as a lattice in a rational vector space. As an application, the group $\mathcal{I}/\Gamma_3 \mathcal{I}$ is computed, and it is shown to embed in the group of homology cylinders modulo the surgery relation of $Y_3$ -equivalence.

Microsurgical treatment of recurrent and residual previously clipped/or coiled intracranial aneurysms: a single center series of 22 patients

Minimal presentation, finite quotients and lower central series of cactus groups

BackgroundPancreaticoduodenectomy(PD) is the only effective treatment for the peri-ampullar carcinoma. However, postoperative pancreatic fistula(POPF) is the most intractable complication causing relevant mortality. Moreover, pancreatic juice may exude from the wound that would lead to more serious complications. Tapering pressure of wall vacuum-assisted closure (VAC) therapy is considered one of the best treatment to wound exudation. Here, we report on a single center series of 5 POPF cases accompanying wound exudation following open or Laparoscopic-assisted pancreatoduodenectomy, successfully managed by VAC.MethodsWe enrolled all patients who experienced POPF ensuing wound exudation following open or Laparoscopic-assisted pancreatoduodenectomy (OPD or LAPD) and received tapering pressure of vacuum-assisted closure (VAC) therapy between July 2017 and August 2024. For VAC, we utilized wall suction device devised by our center applying the technique of negative pressure wound therapy(NPWT). And we adjusted the tapering pressure of the abdominal wound wall vacuum which fixed to a 8Fr or 12Fr suction catheter and connected to the pressure regulator between −50 and −100 mmHg according to the wound exudation amount. When the amount of the wound exudation were less than 100 ml, the wall vacuum suction catheter could be connected to the negative pressure balloon so that the patients could be able to get out of bed. The wall vacuum of VAC was removed when the pancreatic fistula had sufficiently healed which resulting in complete wound healing.ResultsA total of 60 patients underwent OPD or LAPD. Among them, 9 had occured clinically related pancreatic fistulaI(CR-POPF)according to International Study Group on Pancreatic Fistula grade (POPF; 30%). one of the 3 grade C patients underwent Re-laparotomy due to the completely separated pancreaticojejunostomy and postoperative hemorrhage. 5 of the 6 grade B patients was performed tapering pressure of wall vacuum-assisted closure therapy for pancreatic juice exudation from the wound, and all of these patients had good outcomes by this VAC therapy.ConclusionTapering pressure of wall VAC therapy could be a safe and effective treatment in the management of POPF ensuing wound exudation following open or Laparoscopic-assisted pancreatoduodenectomy. And this therapy may potentially reduce POPF-associated mortality.

Abstract Clasper surgery induces the ‐filtration over the monoid of homology cylinders, which serves as a 3‐dimensional analogue of the lower central series of the Torelli group of a surface. In this paper, we investigate the torsion submodules of the associated graded modules of these filtrations. To detect torsion elements, we introduce a homomorphism on induced by the degree part of the LMO functor. Additionally, we provide a formula that computes this homomorphism under clasper surgery, and use it to demonstrate that every nontrivial torsion element in has order 3.

860 MRguided prostate SBRT for prostate cancer. A single centre series of 440 consecutive patients.