Article1 June 1948MASSIVE DOSAGE OF PENICILLIN ADMINISTERED BY CONTINUOUS INTRAMUSCULAR INFUSIONRALPH LEE FISHER, A.B., M.D., F.A.C.P., MORRIS ZUKERMAN, A.B., M.D.RALPH LEE FISHER, A.B., M.D., F.A.C.P.Search for more papers by this author, MORRIS ZUKERMAN, A.B., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-28-6-1143 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWe wish to present a review of our experience with 24 patients treated with a massive dosage of penicillin by continuous intramuscular infusion.The dose varied from 500,000 to 2,000,000 units of penicillin administered daily for a period of three to 19 days. The first nine patients were given crude penicillin and the last 15 penicillin G.Technic of Administration:The penicillin was dissolved in 500 c.c. of 5 per cent glucose in water. A No. 20 gauge spinal needle was inserted in the lateral aspect of the thigh after infiltration with 1 per cent procaine hydrochloride. Ten c.c. of...Bibliography1. HIRSCHDOWLING HLHF: Observations on the continuous intramuscular method of administering penicillin, Am. Jr. Med. Sci., 1945, ccx, 435. CrossrefGoogle Scholar2. MCADAM : Quoted by Hirsch and Dowling.1 Google Scholar3. SMITHHARFORD ROCG: The administration of penicillin by continuous intramuscular drip, Jr. Lab. and Clin. Med., 1945, xxx, 502-509. Google Scholar4. JONESWILLIAMS ANGE: Aseptic necrosis at sites of continuous intramuscular penicillin infusions, Lancet, 1945, ii, 817. CrossrefGoogle Scholar5. MORGANCHRISTIEROXBURGH HVRVIA: Experience in the systemic administration of penicillin, Brit. Med. Jr., 1944, i, 515. CrossrefGoogle Scholar6. KEEFER cited by Gordon.8 Google Scholar7. MOORE cited by Gordon.8 Google Scholar8. GORDON EJ: Delayed serum sickness reaction to penicillin, Jr. Am. Med. Assoc., 1946, cxxxi, 727. CrossrefGoogle Scholar9. BAKERLYONS cited by Gordon.8 Google Scholar10. TUCKERROBINSON HARC: Neurosyphilitic patients treated with penicillin: probable Herxheimer reactions, Jr. Am. Med. Assoc., 1946, cxxxii, 281. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Detroit, Michigan*Received for publication September 10, 1947.From the Department of Medicine, Riverside Clinic, Detroit, Michigan. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1948Volume 28, Issue 6Page: 1143-1149KeywordsGlucosePenicillin ePublished: 1 December 2008 Issue Published: 1 June 1948 PDF downloadLoading ...