Case Of Schwannoma Research Articles

A Case of Esophageal Schwannoma with Lymphadenopathy Diagnosed Preoperatively Using EUS-FNA and Treated with Enucleation

A Case of Esophageal Schwannoma with Lymphadenopathy Diagnosed Preoperatively Using EUS-FNA and Treated with Enucleation

A Case of Nasal Schwannoma in a Pediatric Patient

A Case of Nasal Schwannoma in a Pediatric Patient

Multiple Intestinal cystic schwannoma mimicking an ovarian tumor with carcinomatosis: case report

Schwannomas are benign tumors composed of schwann cells, these tumors theoretically can present anywhere in the body where nerves reside rarely on gastroIntestinal tract. The definitive diagnosis of this rare form is made on complete excision of the mass but it can be identified through the combination of imaging and biopsy. We report a case of an intestinal cystic schwannoma simulating an ovarian tumor.

Schwannoma of the clitoris: a case report

Schwannoma (neurilemoma or neurinoma) is a tumor that develops from the Schwann cells in the myelin sheath of the peripheral nerves. It is most commonly observed on the head, neck, upper and lower extremities, posterior mediastinum and retroperitoneum. Schwannomas are rarely found in the external female genitalia. To the best of our knowledge, only 6 cases of clitoral schwannoma have been reported in medical literature. We currently report the case of a 46-year-old woman who was presenting with a 3 × 2 cm, painless mass in her clitoris for the past two years. She has no history of neurofibromatosis. Surgical excision of the mass was undertaken. Histopathology and immunohistochemistry revealed schwannoma of the clitoris. No evidence of local recurrence was noted after 6 months of follow-up. We are reporting the current patient because of the rare location of schwannoma. In the present case report, clinical features, treatment guidelines, diagnostic features and the immunohistochemical characteristics of this tumor are reviewed.

Comparative analysis within diagnostics and treatment of retroperitoneal schwannoma

Introduction: Retroperitoneal schwannoma is a rare tumor that originates from the Schwann cells of the peripheral nerve sheath. It is mostly located in the brain and spinal cord, but can affect other untypical places such as the scrotum and penis. Aim: The aim of this study was to present two different cases of retroperitoneal schwannoma. Case study: The authors present two cases of patients with benign and malignant retroperitoneal schwannomas (malignant peripheral nerve sheath tumor – MPNST). Results and discussion: It has been reported that only 0.7% of schwannomas occur in the retroperitoneum. It is difficult to diagnose this tumor preoperatively because of the clinical variety and a lack of the characteristic symptoms. These tumors can mimic different conditions, such as pancreatic tail tumors, a hepatic tumor in the caudate lobe, or lymph node metastases. They can arise at any age, but generally occur between 30 and 50 years of age and develop in any race. Based on the literature published in the last 20 years regarding schwannomas arising in retroperitoneum 20 cases were reported. Conclusions: Careful monitoring is highly recommended after retroperitoneal schwannoma removal.

A case of facial schwannoma discovered in the wake of repeated facial paralysis

A case of facial schwannoma discovered in the wake of repeated facial paralysis

Intraosseous schwannoma of tibia: Report of a rare case with review of literature

Intraosseous schwannomas are rare and represent 0.2% of all bone tumors. Their occurrence in tibia is extremely rare and only five cases have been reported till date. We report an additional case of intraosseous schwannoma in right tibia of a 46-year-old female whose plain radiograph of right knee joint revealed an osteolytic expansile lesion with trabeculations in the proximal tibia. Magnetic resonance imaging study showed a well defined, lobulated mass in the anteromedial aspect of upper tibia. Histopathological examination of the excised specimen revealed schwannoma which was confirmed by positivity for S-100 on immunohistochemistry.

A Case of Cervical Schwannoma that Was Initially Suspected as a Cystic Lymph Node Metastasis Secondary to Papillary Thyroid Carcinoma

A Case of Cervical Schwannoma that Was Initially Suspected as a Cystic Lymph Node Metastasis Secondary to Papillary Thyroid Carcinoma

Intraspinal schwannoma: a case report

Intraspinal schwannomas are the most common benign tumors in the spinal canal, accounting for about half of the benign tumors in the spinal canal. They originate from the sheath of nerve roots, and most of them are located in the extramedullary subdural space. Most of them originate from the posterior root of the spinal nerve, and the affected nerve is fusiform and usually solitary. Clinically, once diagnosed, surgery should be performed. The posterior approach laminectomy is the most common surgical method. In this paper, a case of spinal schwannoma underwent surgical treatment. It was found that the preoperative MRI examination was inconsistent with the actual location of the tumor during the operation. The report is as follows.

Two Cases of Schwannoma Diagnosed by Bronchoscopy

Two Cases of Schwannoma Diagnosed by Bronchoscopy

Schwannoma of Dorsal spine: A case report of a 25 year old female with Schwannoma at D10-11 level

Background: Spinal Schwannomas are benign nerve sheath tumors within the spinal canal, typically arising from the spinal nerve roots and it is the most common nerve sheath tumor of spine. Case presentation: This report describes a case of Schwannoma at D10-11 level in a 25 year old Indian female. The clinical, radiological, neurological evaluation and management are presented in this report. Conclusion: nerve sheath tumor has high propensity to involve at dorsal spine and early diagnosis and gross total excision usually give very good clinical and neurological outcome.

A Case of Schwannoma of the Lesser Omentum Diagnosed Laparoscopically and Resected

A Case of Schwannoma of the Lesser Omentum Diagnosed Laparoscopically and Resected

Schwannoma on Cervical Cervices (C2 & C3): A Case Report

Background: Schwannoma is classified as a benign, encapsulated tumor, derived from the perineural cells which are classified as neural cell membranes. About 10% of Schwannomas has occurred in the head and neck and the incidence of Schwannoma arising from the Cervical C2 nerve roots is extremely rare. Aims of study: This case report aims to provide a rare case report on Schwannoma located in cervical cervices (C2& C3). Case presentation: A 37-year-old female patient with a lump in the left neck for 4 years ago, the first lump appeared as a larger (increasingly large 1×1 cm) marbles with no pain in the lump but over the past 4 months the patient felt his legs and arms are weak. Patients have a history of surgical removal of tumors in the back of the neckline by the end of 2016. At first, we estimated the lump that appeared on the left neck of the patient stands alone in the sense that it was not related to the history of the first lump surgery, but when further examination, the tumor was apparently related to the lump that appeared previously who had surgery. Conclusion: The extracranial Schwannoma in the head and neck areas is a rare neoplasm. The extracranial Schwannoma case is a case that is difficult to diagnose, in addition to good clinical examination, imaging examination, such as CT scan and MRI are an indispensable way of ensuring the diagnosis of an extracranial Schwannoma.

Phrenic nerve schwannoma: an unusual cause of painless neck lump

Schwannoma (neurilemmoma) arising from the cervical phrenic nerve is a relatively rare tumour type. We describe a case of phrenic nerve schwannoma in the head and neck region in a patient who presented with a painless neck swelling. Analysis of aspiration was suggestive of benign nerve sheath tumour. A computed tomography scan was done to confirm the location and entity of the tumour. The patient was treated with complete excision of the tumour including the maternal nerve fibres. He developed right hemidiaphragm palsy postoperatively, which was treated conservatively. Postoperative immunohistochemistry examination established the diagnosis of cellular schwannoma. The case highlights the challenges associated with the diagnosis and management of cervical schwannoma.

Immunoexpression of BDNF, TrkB, and p75NTR receptors in peripheral neural lesions of the head and neck.

Brain-derived neurotrophic factor (BDNF) and neurotrophin receptors have been recognized as fundamental regulators of normal brain development, homeostasis, and plasticity. They have also been studied in the behavior of central nervous system tumors. Here, we studied the pattern of BDNF, TrkB and p75NTR immunoexpression in peripheral benign and malignant neural lesions in head and neck. This cross-sectional analytical study included 79 cases of head and neck neural lesions. Nineteen cases of traumatic neuromas (TN), 20 cases of granular cell tumors (GCT), 16 cases of neurofibromas (NF), 20 cases of schwannomas (SC), and 4 malignant peripheral nerve sheath tumor (MPNST) were submitted to immunohistochemistry with BDNF, TrkB, and p75NTR antibodies. A semi-quantitative analysis was performed. The analysis of BDNF demonstrated a high percentage of positive cells in TN, GCT and SC with a decrease in cases of NF and MPNST. TrkB presented a lower significant immunoexpression in GCT in relation to the TN, NF, SC, and MPNST (P<.0001); and TN showed less percentage of positive cell compared to SC (P=.0017). Regarding p75NTR, the percentage of positive cell was significantly reduced in MPNST compared GCT (P=.009), NF (P=.0138) and SC (P=.0069). Also, a decrease in TN compared to GCT (P=.007) was observed. Our results showed the immunoreactivity of BDNF, TrkB, and p75NTR in head and neck peripheral neural lesions. Reduction of BDNF and p75NTR in MPNST might suggest down-regulation during the acquisition of malignant phenotype.

Hemorrhage in long segment cervical schwannoma; case report and literature review.

Background: Although hemorrhages associated with cervical and thoracic intraspinal schwannomas are typically localized to the subarachnoid hemorrhages (SAH) or subdural hemorrhages (SDH) compartments, rare intratumoral bleeds may also occur.Methods: In the literature, we found and analyzed multiple factors for 13 cases (e.g., epidemiological, clinical, and pathological) of cervical schwannomas with intratumoral hemorrhages (ITH). We added the 14th case of a 35-year-old female with along segment cervical schwannoma with ITH who presented with acute quadriplegia and respiratory decompensation.Results: These 14 patients averaged 51.77 years of age, 60% were male, and the tumor involved 2.83 segments. The incidence of SAH and ITH was noted in five cases each, while SDH’s were very rare. The pathological characteristics were consistent with the diagnosis of cellular schwannomas with S-100 positivity. The clinical outcomes were good (100%) in all the cases, including the one presented (modified McCormick score III).Conclusion: Cervical schwannomas with ITH are rare, and the surgical outcomes in such patients are good-excellent (>90%). The histopathology is always of prime importance and decisive in establishing and confirming the etiology of such ITH.

Management of giant presacral schwannoma. Clinical series and literature review

PurposePresacral schwannomas are rare tumors. Due to their benign nature and slow growth, these tumors are often giant and become difficult to treat. Their removal is a surgical challenge with different strategies reported in the literature. This study presents the consecutives cases of presacral schwannomas operated on in our institution, our surgical strategy and literature review. MethodsThis retrospective study includes all consecutive patients operated on for a pre-sacral schwannoma in our department between 2006 and 2019, i.e. 6 patients. We report clinical features, pre and post-operative imaging, surgical data and post-operative outcomes. ResultsAll patients had symptoms before surgery (constipation, dysuria, radicular or lower back pain) with an average duration of 7.4 months. All patients underwent an MRI and a CT scan before the surgery. Five patients had type III schwannoma according to Klimo classification and one patient had a type II. The average size was 504,9 cm3 (range 53,1-1495,4). All the patients were operated on by an anterior approach in a double team with an mean duration of 246 min. Intraoperative bleeding was less than 500 ml for 4 patients, 2 patients had significant bleeding (2700 and 2900 mL). Excision was total or subtotal in all cases. One patient had an intraoperative complication (air embolism). Follow up at 3 months was excellent with a disappearance of symptoms for all patients except one patient who retained constipation. One patient had a late complication (bowel obstruction due to tissue adhesions). At last follow-up after phone interview, no patient had clinical symptoms that could suggest a recurrence. ConclusionThe anterior approach with a double surgical team is a great option for the treatment of presacral schwannoma. Combined with adequate preoperative imaging and intraoperative stimulation, it reduces the risk of intra and postoperative complications.

구강 설부에 발생한 신경초종 1례

Schwannomas are benign, encapsulated and solitary masses originating from Schwann cells in the peripheral nerve sheath. Tumors grow slowly and develop about 25 to 40% of schwannomas in the head and neck area. Oral schwannoma occurs mostly on the tongue and can also occur in palate, buccal, mouth floor, gingiva and other oral mucosa. Schwannomas are usually treated by complete excision. A 21-year-old female patient with asymptomatic swelling on the tip of the tongue visited our hospital. Here, we report a case of schwannoma of the oral tongue with the review of literature. (J Clinical Otolaryngol 2020;31:281-285)

Partial laryngectomy and reconstruction with rotation of the epiglottis in the treatment of a rare laryngeal schwannoma: a case report

BackgroundNeurogenic tumors of the larynx are rare, with few cases having been reported in the literature. Schwannomas are responsible for 0.1% of all benign tumors of the larynx. They arise in the sheaths of the peripheral, autonomic, and cranial nerves. The objective of this report is to describe a case of a bulky laryngeal schwannoma, the surgical procedure for its removal, and the long-term patient follow-up.Case presentationA 19-year-old Brazilian woman presented to our institution with a complaint of progressive dyspnea over the preceding year, as well as dysphonia, dysphagia for solids, and globus pharyngeus. Direct rigid laryngoscopy showed a supraglottic tumor obstructing approximately 90% of the larynx. With the symptoms progressing to severe dyspnea, an emergency tracheostomy was performed. After infusion of intravenous contrast, magnetic resonance imaging revealed a mass lesion with intense, heterogeneous contrast enhancement along the posterior wall of the hypopharynx, blocking all of the lumen and measuring 2.8 cm and 2.2 cm at its largest diameters. The image suggested a neoplastic lesion. The patient underwent open surgery for tumor resection. Her postsurgical recovery was uncomplicated. Histopathology and immunohistochemistry revealed the tumor to be a laryngeal schwannoma.ConclusionThe definitive diagnosis of laryngeal lesions can be difficult, and histopathology plays a pivotal role. Laryngeal schwannomas are rare; however, tumors can become large and may ultimately lead to airway obstruction.

Isolated schwannoma of maxillary sinus: a rare occurrence

&lt;p&gt;Schwannomas are benign tumors originating from the neural crests (schwann cells), which are cells that form the nerve sheath of peripheral nerve fibers. Around 25-45% cases of schwannomas occur in the head and neck, of which less than 4% occurs in the nasal cavity and the paranasal sinuses. Isolated schwannomas of the maxillary sinus appear to be extremely rare. We report a case of an isolated maxillary schwannoma in a 45 years old lady who presented with swelling in the right cheek for 1 year and right sided nasal obstruction for 4 months. The swelling was not associated with epistaxis, fever, headache or visual disturbances. We report this case keeping in mind the rarity in occurrence of isolated maxillary schwannomas&lt;/p&gt;