Cases Of Salivary Gland Tumors Research Articles

Immunohistochemical expression of monoclonal antibody against epithelial membrane antigen in salivary gland tumors.

A total of 154 cases of salivary gland tumors were studied by an indirect method with the use of monoclonal antibody to epithelial membrane antigen (EMA) from human milk fat globule membrane. Normal salivary glands displayed positive reaction of EMA staining in the luminal and lateral borders of serous acinar cells, and in the luminal border of ducts. Immunohistochemical expression of EMA in salivary gland tumors was chiefly classified into two types: one is the luminal surface-positive type and the other is the whole cellpositive type. Pleomorphic adenoma was usually positive for EMA staining in luminal borders of tubular, duct-like and cystic structures, and occasionally positive in the cytoplasm of the cells comprising these structures. Warthin's tumor was positive for EMA staining on the luminal surface of eosinophilic tumor epithelial cells, or EMA-positive reaction was evident in various areas scattered throughout the epithelial structures. Acinic cell tumor, carcinoma in pleomorphic adenoma (carcinoma cell), and mucoepidermoid tumor showed positive reaction of EMA staining throughout their cytoplasm depending on histological malignancy. No positive reaction to EMA staining was given by either normal myoepithelial cells, and transformed or neoplastic myoepithelial cells.

唾液腺腫よう９２例の臨床統計

Ninety two cases of salivary gland tumors surgically treated since January, 1979 to December, 1984 in our clinic are reported. They were composed of 66 cases of benign tumors and 26 cases of malignant tumors. Salivary gland malignancies constituted about 3 % of all head and neck malignancies. Salivary gland tumors were composed of 57 parotid gland tumors, 19 submandibular gland tumors and 16 minor salivary gland tumors and incidence malignant tumors in each region were 19%, 42% and 44%. Later two regions were found significantly different from parotid gland. Pleomorphic adenomas were the common of all tumors, which comprised 81% of benign salivary gland tumors. Adenoid cystic carcinomas and adenocarcinomas were most frequently encountered malignancies; the former in submandibular gland and minor salivary gland, and the latter in parotid gland. Malignant tumors were significantly more common in men than women. It was characteristic of patients with malignant tumor, as compared with patients with benign tumor, that average age at first examination was about 60 year-old, that interval from onset was short, and that facial palsy, pain and adhesion were observed.

ヒト唾液腺腫ようの免疫組織化学的研究

Histogenesis of the salivary gland tumor is controversial due to the variety of histopathologic features.Recently, localization of various antigens and cytoskeletal filamentous proteins have been morphologically identified, as the immunohistochemistry developed.In the present study, 70 cases of salivary gland tumors removed surgically in our hospital were stained immunohistochemically.Antibodies used for immunostaining were S-100 a, lactoferrin (LF), secretory component (SC), CEA, keratin, prekeratin, myosin as the polyclonal antibody, and S-100 b, PKK-1, vimentin as the monoclonal antibody.Positive immunostaining for S-100 a was only observed in pleomorphic adenoma. All of chondroid cells and some of spindle cells, epithelial tumor cells showed intense immunoreactivity for S-100 a.LF was predominantly positive in pleomorphic adenomas and was stained in a few cases of adenolynphoma, adenoid cystic carcinoma and adenocarcinoma.SC reacted positively not only in LF positive tumors but also in 50% of mucoepider moid tumors.The positive rate for CEA was 22% in benign tumors and 50% in malignant tumors.Keratin and prekeratin thought to be the epithelial tumor markers were frequently stained in almost all tumors.Myosin-positive cells were localized in some of spindle cells, chondroid cells in pleomorphic adenoma, and also some of undifferentiated polygonal cells in adenoid cystic carcinoma.According to the immunohistochemical staining pattern, the following results were concluded.1) S-100 a stained pleomorphic adenoma specifically.2) Duct-like structure in pleomorphic adenoma retains the function of production of LF and SC in accordance with functional differentiation.3) Regezi's bicellular theory presents a reasonable explanation of the origin of the salivary gland tumor.

最近の 5 か年間における口腔腫瘍の臨床的観察 : 唾液腺腫瘍について

Tumors of major and minor salivary glands are relatively uncommon, representing between 2 and 10% of all oral neoplasms. A total of 25 cases reported as salivary gland tumors of oral cavity in the Second Department of Oral Surgery, Kyushu Dental College Hospital, during the period from 1978 to 1982, were clinically analysed. The following results were obtained. 1. A series of 25 cases of salivary gland tumors has been reported. Its incidence was seen in 0.34% of outpatients and in 12.2% of the patients with oral neoplasm. In this series of 25 cases, there were 17 cases (68.0%) of benign tumor and 8 cases (32.0%) of malignant tumor. 2. A total of 25 cases was a tumor originating from minor salivary glands. The salivary gland tumor in the majority of 25 cases was located on the hard palate. 3. Of the benign salivary gland tumor (17 cases), 13 cases (76.5%) were between 30 and 50 years of age (the average 49.8 years). Of the malignant salivary gland tumor (8 cases), 6 cases (75%) were over 30 years of age (the average 47.5 years). 4. As to the incidence by sex, the incidence of benign tumor was slightly higher in males. Also in the malignant tumor, the incidence was slightly higher in females. However, males and females were equally affected by the salivary gland tumors. 5. The complaint most commonly reported was a painless mass. The recorded known duration of benign tumors showed a range of 1 month to 12 years. That of malignant tumors showed a range of 5 days to 6 years. 6. The majority of the salivary gland tumors were thumb-tip size. In only 3 cases was there a history of pain. Ulceration was apparent in only 4 cases. 7. This series was found histopathologically to be ; in benign tumor (17 cases), plemorphic adenoma was 16 cases and warthin's tumor was 1 case. In malignant tumor (8 cases), mucoepidermoid carcinoma was 4 cases, adenoid cystic carcinoma was 3 cases and adenocarcinoma was 1 case. 8. Treatment was performed mostly by surgical excision of the lesion.

Salivary gland tumors: review of 643 cases

643 cases of salivary gland tumors constitute two series of histological sections that were studied from hospitals and dental schools in Southeast Scotland and Southern Ontario. The Scottish series represented epithelial tumors of the parotid and intra-oral salivary glands, but the Canadian series also included tumors of the submandibular and sublingual glands. Classification was based on that recommended by the World Health Organisation (Thackray 1972). While direct statiscal comparisons between the two series are not appropriate, the differences between them suggest that malignant tumors are more common in Canada. The Scottish series contains the largest proportion of benign salivary tumors so far reported. In the Scottish series, 88.7% of parotid tumors were benign compared with 51.9% of Canadian series. In the Canadian series from the submandibular glands, 21.2% only were benign. Of the intra-oral salivary tumors, 62.2% from the Scottish series were benign compared with only 34.7% from the Canadian series.

Histopathological study of salivary gland tumors

Ninety-three cases of salivary gland tumors were examined histologically and his-tochemically. The materials consisted of pleomorphic adenoma 49, adenolymphoma 4, mucoepi-dermoid tumor 22, adenoid cystic carcinoma 15 and adenocarcinoma 3. The stainings were done by PAS, mucicarmine and toluidin blue (pH 4.1). The specimens with positive γ-metachromasia were examined by enzymatic digestion te chniques (chondroitinase ABC, testicular hyaluronidase, streptomyces hyaluronidase and sialida se).Histochemical study showed two diff erent types of mucosubstance produced by neoplastic cells: epithelial and mesenchymal mucosubst ance. The former contained sialic acid and the latter hyaluronic acid and chondroitin A and/or C sulfate. Considering both histological and hist ochemi-cal findings, it seems reasonable that the epithelial mucosubstance is secreted by glandular epithe -lium and mesenchymal one by myoepithelial cells. In pleomorphic adenoma and adenoid cystic carcinoma, myoepithelial cells are likely to take an important role in their pathogenesis. In adenolymphoma, mucoepidermoid tumor and adenocarcinoma, glandular epithelium is a source of their genesis.

Facial nerve paralysis secondary to benign parotid tumor

THE PRESENCE of facial nerve paralysis associated with an ipsilateral parotid mass is almost pathognomonic of parotid malignancy. This constant association has prompted such authorities as Anderson and Byars1to consider facial paralysis in this setting as the only certain diagnostic sign of malignancy. Indeed, a review of the recent literature has revealed only one case of partial facial nerve dysfunction caused by a mixed tumor of the gland. In that case, mentioned by Ward and Hendrick,2a partial paralysis of those muscles supplied by the lower branches of the facial nerve resulted from trauma to a grapefruit-size benign mixed tumor, caused by a hemorrhage into the neoplasm. Frazell,3in a review of 877 cases of salivary gland tumors at the Memorial Hospital, found facial palsy to be a not uncommon presenting symptom in those patients with parotid malignancy, but, in no instance could it be linked

Facial nerve paralysis secondary to benign parotid tumor.

THE PRESENCE of facial nerve paralysis associated with an ipsilateral parotid mass is almost pathognomonic of parotid malignancy. This constant association has prompted such authorities as Anderson and Byars1to consider facial paralysis in this setting as the only certain diagnostic sign of malignancy. Indeed, a review of the recent literature has revealed only one case of partial facial nerve dysfunction caused by a mixed tumor of the gland. In that case, mentioned by Ward and Hendrick,2a partial paralysis of those muscles supplied by the lower branches of the facial nerve resulted from trauma to a grapefruit-size benign mixed tumor, caused by a hemorrhage into the neoplasm. Frazell,3in a review of 877 cases of salivary gland tumors at the Memorial Hospital, found facial palsy to be a not uncommon presenting symptom in those patients with parotid malignancy, but, in no instance could it be linked

Tumors of the salivary glands

1. 1. A series of 403 cases of salivary gland tumors seen over twenty-seven years at the Tata Memorial Hospital in Bombay are reviewed. 2. 2. Malignant tumors were relatively more frequent (204 malignant to 199 benign tumors). 3. 3. Mixed salivary gland tumors were the most common type (46 per cent) of salivary gland tumors. Adenoid cystic carcinomas were next in frequency (21 per cent) and were found more commonly in the submaxillary gland and in minor salivary glands. 4. 4. Although the parotid gland was the most common site (53.3 per cent), salivary gland tumors occurred frequently in minor salivary glands (35.7 per cent). Investigators in other tropical countries have had similar experiences. 5. 5. Surgery had been the treatment of choice in management of benign and malignant salivary gland tumors. Adoption of aggressive treatment in recent years has resulted in dramatic reduction of recurrence rate of benign mixed tumors. 6. 6. Results of treatment of malignant salivary gland tumors are far from satisfactory and have shown no progress in three decades. Hope lies in early diagnosis and initial radical surgery.

Salivary Gland Tumors

Abstract One hundred twenty-three cases of salivary gland tumors treated at Grace-New Haven Community Hospital from 1922 to 1952 have been reviewed, and the findings are as follows. 1. 1. The parotid gland was the most frequent tumor site. 2. 2. Malignant and recurrent tumors were found most often in the parotid gland. 3. 3. All biopsied tumors recurred, with three exceptions. 4. 4. The tumor-free survival period of surgically treated recurrent tumors was low. 5. 5. Treatment was generally by surgery. X-ray therapy sometimes was used after surgery, but it was seldom used alone. 6. 6. A small group of patients with histologic benign tumors presented a problem from the point of therapy because of repeated recurrence. 7. 7. Standardization of histologic criteria would simplify and contribute much in comparative studies of these tumors.

Congenital capillary hemangioma of the parotid salivary gland.

THIS IS a report of a case of a congenital hemangioma of the right parotid salivary gland. A recent extensive review of the tumors of the major salivary glands (Foote and Frazell) briefly mentioned this rare but significant tumor. Foote and Frazell found no instances in 877 cases of salivary gland tumors collected over a period of 20 years. McFarland reviewed 33 cases and added one new case of this tumor in 1930. In more recent years, a few case reports have been presented, among others, by Fein, Glaser and co-workers, and Caldwell. It is the purpose of this case report to emphasize the clinical, anatomic, and biologic features of this tumor. <h3>REPORT OF CASE</h3> <i>History</i>.—A 16-month-old white girl had a soft, compressible, nontender, warm swelling in the right preauricular region for 10 months. The mass measured 2 by 2 cm. and was not associated with cervical lymph node

Salivary gland tumors

One hundred twenty-three cases of salivary gland tumors treated at Grace-New Haven Community Hospital from 1922 to 1952 have been reviewed, and the findings are as follows. 1. 1. The parotid gland was the most frequent tumor site. 2. 2. Malignant and recurrent tumors were found most often in the parotid gland. 3. 3. All biopsied tumors recurred, with three exceptions. 4. 4. The tumor-free survival period of surgically treated recurrent tumors was low. 5. 5. Treatment was generally by surgery. X-ray therapy sometimes was used after surgery, but it was seldom used alone. 6. 6. A small group of patients with histologic benign tumors presented a problem from the point of therapy because of repeated recurrence. 7. 7. Standardization of histologic criteria would simplify and contribute much in comparative studies of these tumors.

Pseudo-Adenomatous Basal-Cell Carcinoma of the Tongue (Salivary Gland Tumor)

The so-called “mixed tumors” of the salivary gland type, although occurring predominantly in the large salivary glands, are not infrequently encountered in other locations. In 1851 a lip tumor with characteristics identical with the usual parotid neoplasm was described by James Paget. Since then, examples of such tumors located in the lacrimal gland (orbit), nasal cavity, accessory sinuses, pharynx, tonsil, larynx, trachea, lip, buccal mucosa, palate, and tongue have been reported (1). Mixed salivary gland tumors of the tongue are not common. In 1930 Brunschwig (2) collected 10 cases from the literature and added one of his own. Schreiner and Mattick (3), reporting 66 cases of salivary gland tumors, mention one tongue case. Pack and LeFevre (4), discussing the incidence of various neoplasms seen at the Memorial Hospital from 1917 to 1929, tabulate 17 tumors of the palate and the tongue; the number of tongue cases is not given. Eigler (5), Patey (6), Curtis and Razemon (7), Lemaitre, Ardoin, and Lemaitre (...