Objective To determine the immunoexpression of CD138, CK19 CD34, vascular endothelial growth factor (VEGF), BCL-2, p53, KI-67, mast cell tryptase, calretinina, and orosomucoid 1 in odontogenic myxomas (OMs). Study Design Analytical and retrospective study was conducted. Immunohistochemistry was performed for 30 cases of OM. Results Four CK19 and CD138 samples were positive, confirming the presence of odontogenic epithelium; also, CD138 was found in the extracellular matrix (moderated immunoexpression), and tumoral cells (high immunoexpression). Microvascular density (MVD) was measured with CD34 and VEGF expression, being 7.51 and 5.35 blood vessels, respectively. Orosomucoid 1 and mast cell tryptase showed a high immunoexpression in tumoral cells. Calretinin was negative in all the samples. KI67, BCL2 and p53 showed a low expression. Conclusions The high immunopositivity found in orosomucoide 1, VEGF, and mast cell tryptase suggests a proangiogenic modulator among these proteins. The presence of CD138 in tumor cells and extracellular matrix suggests a relationship between this protein and extracellular components of OM, even though its role on this neoplastic process should be clarified. To determine the immunoexpression of CD138, CK19 CD34, vascular endothelial growth factor (VEGF), BCL-2, p53, KI-67, mast cell tryptase, calretinina, and orosomucoid 1 in odontogenic myxomas (OMs). Analytical and retrospective study was conducted. Immunohistochemistry was performed for 30 cases of OM. Four CK19 and CD138 samples were positive, confirming the presence of odontogenic epithelium; also, CD138 was found in the extracellular matrix (moderated immunoexpression), and tumoral cells (high immunoexpression). Microvascular density (MVD) was measured with CD34 and VEGF expression, being 7.51 and 5.35 blood vessels, respectively. Orosomucoid 1 and mast cell tryptase showed a high immunoexpression in tumoral cells. Calretinin was negative in all the samples. KI67, BCL2 and p53 showed a low expression. The high immunopositivity found in orosomucoide 1, VEGF, and mast cell tryptase suggests a proangiogenic modulator among these proteins. The presence of CD138 in tumor cells and extracellular matrix suggests a relationship between this protein and extracellular components of OM, even though its role on this neoplastic process should be clarified.