Abstract Full-matrix synthetic aperture imaging (FMSA) is a well-established and widely used modality for ultrasound imaging Nevertheless, the accompanying relatively large amount of data acquisition, storage, and process results in heavy costs of computation and memory, which further hinders FMSA from real-time implementation. Moreover, the most existing FMSAs employed the hypothesis uniform sound velocity to reconstruct the soft tissues, which is not suitable for hard tissue imaging, irrespective of the high acoustic impedance contrast (i.e., the difference of sound velocity) between the bone and soft tissues. To overcome these limitations, a half-matrix ultrasound bone tomography method combining the reciprocity principle and sound velocity estimation was proposed for cortical cross-section imaging. The travel-time inversion was firstly utilized for sound velocity prediction, and then half-matrix synthetic aperture (HMSA) with ray-tracing was conducted to image the cortical cross-section. An ex-vivo bovine femur was used to validate the effectiveness of the method. Compared to the full-matrix capture method, the proposed method was demonstrated to be an accurate and cost-effective modality for cortical bone tomography.
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