Cases Of Canine Cancer Research Articles

Detection of Autoantibodies against Survivin in Sera from Cancer Dogs

Survivin overexpression has been reported in relation to tumor malignancy, suggesting that it is an unfavorable prognostic marker, and antibody responses to this protein have been confirmed in human cancer patients. In this study, we investigated antibody responses to survivin in canine cancer cases, and examined the prevalence of such responses by enzyme-linked immunosorbent assay (ELISA) using recombinant canine survivin protein as the antigen. The cut-off value for positivity in the anti-survivin ELISA was 0.35, as determined using the mean absorbance +2 S.D. of samples from healthy dogs. Sera from 16 of 59 (27.1%) cancer and 3 of 25 (12%) non-cancer disease dogs were positive on ELISA. The highest positivity rates (>50%) among the cancer cases were seen in dogs with mammary tumor, squamous cell carcinoma and melanoma.

Spatial and temporal comparison of selected cancers in dogs and humans, Michigan, USA, 1964–1994

Our aim was to investigate the geographic and time distributions of some biologically similar neoplasms in dogs and humans living in Michigan, USA, between 1964 and 1994. Our objective was to describe and compare the patterns of cancer in the two species while assessing the strength and dependence of those patterns. In this retrospective, registry-based study, histologically confirmed incident human and canine cancer cases were mapped, and second-order ( K function) spatial analysis and one-dimensional nearest neighbor temporal analysis were performed on residence addresses and dates of hospital discharge/diagnosis. Included in the study were all 528 incident cases of canine lymphosarcoma, mammary adenocarcinoma, melanoma and spindle-cell sarcomas diagnosed at a veterinary teaching hospital between 1964 and 1994 having residence addresses in Ingham, Oakland, and Wayne Counties; and a stratified random sample of 913 incident human cases of comparable cancers diagnosed during the same time period from the same counties. Results suggest that processes determining spatial aggregation of cases in dogs and humans were not independent of each other, did not act uniformly over different geographic areas, operated at spatial scales <2000 m regardless of species, and tend to act upon dogs more strongly at shorter distances than on humans. Little evidence of interspecies concurrence of temporal clustering was found.

Six Cases of Canine Cancer

Six cases of malignant disease in dogs are described. In each, the lesion was a recurrence following the excision of an apparently simple skin tumour, one of several present on the abdomen or inner aspect of the limbs. One such primary tumour, examined histologically, closely resembled the neuro-fibroma of man. The malignant tumours presented a diverse histological picture. In two cases the appearances were those of sarcomatous change in a neuro-fibroma. The remaining tumours were a malignant melanoma, a leiomyosarcoma, a fibro-sarcoma, and an undifferentiated spindle-cell sarcoma respectively. All the dogs were over eight years of age.