The function of tissue-associated macrophages is tightly linked to their energy metabolism. Yet, the diversity of macrophage metabolic profiles coexisting in tissues at homeostasis or during immune challenges is incompletely understood. Here, we introduce Met-Vision, an imaging-based pipeline for single-cell functional profiling and classification of energy metabolism. Across multiple tissue contexts, we identified that macrophages do not adopt a uniform metabolic profile but typically coexist in four discrete metabolic states with distinct dependence on OXPHOS and metabolic plasticity. Inflammation reconfigured the distribution of macrophage metabolic profiles that remained heterogeneous. Notably, inflammation-derived nitric oxide finely tuned the distribution of macrophage energetic states. These findings challenge the view of homogeneous metabolic activation and reveal a layer of metabolic diversity in tissue at steady state and during inflammation. The ability to stratify macrophage energy metabolic profiles with Met-Vision should help guide the development of metabolism-targeted therapies for inflammatory diseases, cancer, and metabolic disorders.

Formulation and characterization of polyethylenimine-coated magnetopolymeric nanoparticles with potential application in thermal cancer therapies.

Mechanistic insights and regulatory strategies of ZBP1 in tumorigenesis, progression, and cancer therapy.

Natural dyes and pigments are attracting renewed scientific interest as sustainable alternatives to synthetic colorants due to growing environmental and health concerns associated with conventional dyes. Unlike many synthetic counterparts, natural pigments are generally biodegradable, biocompatible, and derived from renewable bio-resources, making them attractive for emerging technological applications beyond traditional textile and food industries. This review provides a comprehensive overview of the sources, chemical classification, extraction techniques, and functional properties of natural dyes and pigments, with emphasis on their roles in renewable energy, biomedical, and sensing technologies. Advanced extraction strategies, including supercritical fluid extraction, microwave-assisted extraction, and solid-phase extraction, are discussed in relation to pigment stability, purity, and structure–property relationships that govern functional performance. Particular focus is placed on the application of natural pigments as photosensitizers in dye-sensitized solar cells, where molecular structure, anchoring groups, and interfacial interactions with semiconductor photoanodes critically influence charge transfer and device efficiency. The biomedical potential of natural dyes as photosensitizers and fluorescent probes for cancer imaging and photodynamic therapy is also examined, highlighting their intrinsic photochemical activity and reduced cytotoxicity compared to synthetic agents. In addition, recent advances in colorimetric and fluorescence-based sensing and biosensing platforms utilizing natural pigments are reviewed, demonstrating their responsiveness to environmental and biological stimuli. Finally, current limitations related to stability, scalability, and resource sustainability, are critically assessed, and future research directions are proposed to enable the translation of natural pigment-based systems from laboratory studies to practical, environmentally responsible technologies. • Natural dyes and pigments offer sustainable alternatives to synthetic colorants for advanced technologies. • Green extraction methods strongly influence pigment stability, purity, and functional performance. • Molecular structure and anchoring groups govern electron injection efficiency in DSSC photoanodes. • Natural pigments exhibit strong potential as photosensitizers and fluorescent probes in cancer therapy. • Colorimetric and fluorescent responses enable effective sensing and biosensing applications. • Stability, scalability, and resource sustainability remain key challenges for industrial translation.

Recent advances of metal-based sonosensitizers in cancer therapy.

Exploiting CD36 as a self-facilitated endocytic receptor for PROTAC-mediated protein degradation: A new paradigm in cancer therapy.

"Metal-based compounds in antiviral and Antiparasitic research: Mechanistic insights from HIV NCp7 and leishmaniasis case studies".

Unravelling the multi-faceted roles of microRNAs in non-apoptotic regulated cell death (RCD) to improve cancer therapy.

Nanozymes for ferroptosis-based cancer theranostics.

Plant-derived exosomes: Structure, isolation, biological functions, and therapeutic potentials.

Dual-functional selenium-doped carbon dots for photothermal ablation and immune activation in cancer therapy

Combined treatment of TROP‑2 targeted CAR-T and vascular disruptor CBP enhances anti‑tumor activity in triple‑negative breast cancer.

Biomimic colloidal self-assembly of epirubicin/ferric ion multi-enzyme delivery for synergistic photothermal therapy of metastatic triple-negative breast cancer.

DA-5: A novel azaindole-based GPX4 inhibitor inducing ferroptosis for targeted therapy of triple-negative breast cancer.

Elective neck dissection and adjuvant therapy in N0 major salivary gland cancer: An analysis of the SEER cancer database.

Nuances of Perioperative Therapy in Gingivobuccal Cancers.

Tucatinib (Irbinitinib, ARRY-380), a potent oral, selective HER2 kinase inhibitor that the FDA, has approved for the treatment of HER2-positive metastatic breast cancer and colorectal cancer. Tucatinib provides a powerful, targeted therapy for HER2-positive cancers, showing substantial benefits in survival and disease control, especially for patients with difficult-to-treat brain metastases, extending options beyond standard chemotherapy. This research aimed to create and validate a new rapid, sensitive, and specific LC-MS/MS technique for measuring tucatinib in dried blood spots (DBS) from mice, with afatinib serving as an internal standard (IS) following regulatory guidelines in the linearity range from 0.178 to 1009 ng/mL (r > 0.990). The chromatographic separation of tucatinib and IS was achieved using the Acquity BEH C18 column with an isocratic mobile phase at a flow rate of 0.6 mL/min within 1.15 min total run time and 2 μL injection volume. Detection and quantification of tucatinib and the IS was done by using a triple quadrupole mass spectrometer in multiple reaction monitoring (MRM) mode. Tucatinib remained stable under various storage conditions. Comparison of DBS versus plasma samples concentrations showed a strong correlation, suggesting that DBS can serve as a valid alternative to plasma for pharmacokinetic evaluation.

"Dual-lock" activated nanosystem for colorectal cancer: Defect engineering-driven NIR-II PTT-enhanced ferroptosis to trigger antitumor immunity.

Iron-based multifunctional self-assembled nanoplatform for synergistic chemodynamic-ferroptosis-photodynamic therapy of prostate cancer

Effects of quantum dots on integrin expression and cellular responses in DU145 prostate cancer cells.