Cancer Sufferers Research Articles

The Relationship Between Family Support and Anxiety of Breast Cancer Patients undergoing Chemotherapy at Dr. H. Abdul Moeloek Hospital, Lampung Province, 2019

Background : According to WHO, breast cancer sufferers will increase by 20% every year and 84 million people will die worldwide. One of the treatments for breast cancer is chemotherapy. However, chemotherapy has physical and psychological side effects that will cause anxiety in patients, which will actually complicate the healing process, so family support is needed so that patients will not think that the chemotherapy they are undergoing is something threatening. Research objective: to determine the relationship between family support and anxiety in breast cancer patients undergoing chemotherapy at Abdul Moeloek Hospital, Bandar Lampung. Type of research : analytical survey, with a cross-sectional design . The population is all breast cancer patients undergoing chemotherapy at RSUD. Abdul Moeloek Bandar Lampung in 2018, totaling 120 people, and the sample uses accidental-sampling . This study uses univariate and bivariate analysis with statistical tests, namely chi square . Results: found from 120 breast cancer patients, the majority had good family support of 84.2%, and patients who were not anxious were 58.3%. The results of statistical tests with Chi Square on Pearson Chi Square p value (0.000) <0.05. Conclusion : There is a relationship between family support and anxiety in breast cancer patients undergoing chemotherapy at Abdul Moeloek Hospital, Bandar Lampung in 2018.

Chronic pain is a risk factor for all-cause and cancer-specific mortality in cancer survivors: a population-based cohort study

BackgroundEvidence is lacking on whether chronic pain is related to the risk of cancer mortality. This study seeks to unveil the association between chronic pain and all-cause, cancer, as well as non-cancer death in cancer patients based on the National Health and Nutrition Examination Survey (NHANES) database.MethodsCancer survivors aged at least 20 (n = 1369) from 3 NHANES (1999–2004) cycles were encompassed. Chronic pain and cancer were determined through self-report. We employed records from the National Death Index for the determination of death status and reason. All-cause, cancer, and non-cancer deaths were primary outcomes. We used time-dependent ROC curve assessment to evaluate the predictive value of chronic pain for death in cancer patients.ResultsOver a median 141-month follow-up (interquartile range: 61–201 months), 884 (64.57%) of 1,369 cancer sufferers died, of which 259 (18.91%) died from cancer, and 625 (45.65%) from other causes. Compared with non-chronic pain survivors, chronic pain correlated with elevated all-cause mortality (Hazard Ratio (HR), 1.40; 95% CI, 1.14–1.72, p = 0.001) and cancer death (HR, 1.75; 95% CI, 1.16–2.64, p = 0.008), primarily in patients with pain lasting 3 months or more. Chronic pain was related to higher non-cancer mortality (HR, 1.38; 95% CI, 1.04–1.82, p = 0.025), and no significant results were found in pain duration. Time-dependent ROC curves showed the area under the curve (AUC) for all-cause mortality at 1, 3, 5, 10, and 20-year survival for chronic pain of 0.71, 0.78, 0.84, 0.89, and 0.96, respectively. The AUCs for cancer mortality at 1, 3, 5, 10, and 20-year for chronic pain were 0.83, 0.87, 0.91, 0.94, and 0.95, respectively, and those for non-cancer mortality at 1, 3, 5, 10, and 20-year for chronic pain were 0.82, 0.86, 0.90, 0.91, and 0.97, respectively.ConclusionChronic pain is associated with heightened all-cause and cancer mortality in the cancer population. Clinical staff should focus on chronic pain in this patient population.

''Mitigating cancer pain: What else matters?"-A qualitative study into the needs and concerns of cancer patients in Sri Lanka.

In Sri Lanka, cancer is a significant contributor to both morbidity and mortality rates. In 2022, 33,243 new cancer cases were reported, resulting in an age- standardized incidence rate of 106.9 per 100,000 individuals. The overall experience of cancer pain reflects patients' needs and concerns. Therefore, a thorough understanding of the patient's needs and concerns is crucial to implementing satisfactory pain outcomes. This study aims to explore the needs and concerns of patients with cancer pain in Sri Lanka. This study employed a descriptive qualitative approach among purposively selected patients with cancer and registered at the pain management unit. Participants recruited were 18 years or older with cancer-related pain. Noncancerous pain and those with psychological disorders, and brain metastases were excluded. Twenty-one semi-structured interviews were conducted until data saturation using a semi-structured interview guide, each lasting 30-60 minutes. Data were analyzed by Graneheim and Lundman's content analysis method. The study primarily involved participants aged 51-60 Sinhalese Buddhists. It highlighted two main themes: 'Changes in normal lifestyle' and 'Needs and expectations'. The 'Changes in normal lifestyle' theme included subthemes like 'Functional limitations', 'Emotional reactions', 'altered interpersonal relationships', and 'Socio-financial problems'. The 'Needs and expectations' theme covered desires for a 'Pain-free life', a return to a 'Normal lifestyle', and the 'Need for a caregiver'. The findings emphasize that the most significant issue for cancer patients is the disruption to their normal lifestyle due to various challenges, while their primary need is to live without pain. 'Life without pain' is a cancer sufferer's greatest need while 'changes in normal lifestyle' owing to bio-psycho-social-spiritual problems is their primary concern.

Correlation between knowledge healthcare workers in doing Pap Smear and HPV Vaccination in Sampit City, Central Kalimantan

Background: GLOBOCAN data states that cervical cancer is the fourth leading cause of cancer death in women after breast, colorectal and lung cancer. The high number of cervical cancer cases in Indonesia has led WHO to place Indonesia as the country with the 2nd highest number of cervical cancer sufferers in the world. In Indonesia, there is still little research that discusses the relationship between knowledge of female health workers to perform Pap Smears and HPV vaccinations. The purpose of this study was to analyze the relationship between knowledge of health workers in performing Pap Smears and HPV vaccinations. Method: quantitative analytical observational study using a cross-sectional study approach. The sample of this study was 104 female health workers working in Sampit City, Central Kalimantan with a purposive sampling technique. The independent variables are the knowledge of female health workers, the dependent variable is the behavior of implementing Pap Smears and HPV vaccines. The research instrument used was a questionnaire with Google Form and data analysis using the chi-square test with a significance of 5%. Results: Most female health workers have good knowledge as many as 55 people (52.9%) and a small number of them have carried out Pap Smear examinations and HPV vaccination as many as 43 people (41.3%). The results of the statistical test of the relationship between knowledge and behavior p = 0.304 (p>0,05). Conclusion: knowledge is not related to the behavior of Pap Smear examinations and HPV vaccination.

Highly efficient electrochemical biosensing platform in breast cancer detection based on MOF-COF@Au core-shell like nanostructure

Nowadays, rapid and facile diagnosis of cancer using user friendly processes has attracted much attention. In this regard, an electrochemical (EC) biosensor with high sensitivity was fabricated by merging MIL156 MOF@COF nanocomposite with Au nanoparticles for the detection of CA15-3. Herein, metal clusters of MIL-156 as a Metal organic frameworks (MOF) were coated by a crystalline covalent organic frameworks (COF) through covalent bonding and created core-shell-like structures. The active part of the working electrode was modified in two consecutive steps. First, MIL-156 MOF@COF and then Au nanoparticles were electrodeposited on the glassy carbon electrode (GCE). The porosity of nanocomposite has significantly increased the surface area and improved the conductivity. Au nanoparticles also form an acceptable substrate for bonding antibodies due to their high affinity with amino groups. In addition, Au nanoparticles amplify the EC signal of the biosensor with their undeniable conductivity. Nanocomposite was characterized with XRD, SEM, and EDAX techniques. To investigate the proposed biosensor, differential pulse voltammetry (DPV) was used as an analytical technique. The CA15-3 calibration provided a linear range between concentrations of 30 and 100 nU/mL, thus expressing the powerful diagnostic potential of the designed biosensor. Furthermore, the suggested biosensor has been used in serum samples and discriminate breast cancer sufferers from healthy individuals with high confidence levels.

RNA-based Therapeutics: Past, Present and Future Prospects, Challenges in Cancer Treatment.

It is becoming more and harder in today's climate to disregard the impact of cancer on social health. Even though a significant amount of money is spent annually on cancer research, it still ranks as the second leading cause of death worldwide. Additionally, only about half of the patients suffering from complex forms of cancer survive a year after receiving traditional cancer therapies. A method for silencing genes is called RNA interference (RNAi). Such a method is very effective in focusing on genes linked to cancer. Most gene products implicated in cancer have recently been used as RNA interference (RNAi) therapeutic targets. According to the findings from this research, RNAi application is necessary for today's cancer treatment to target functioning carcinogenic molecules and tumor resistance to chemotherapy and radiation. Proapoptotic and antiproliferative activity has been reported from previous research studies on cell culture systems, animal models, and clinical trials through the knockdown of gene products from RNAi technology. Numerous novel RNAi-based medications are now in the clinical trial stages thanks to the discovery of the RNAi mechanism and advancements in the area. In the future, genomic-based personalized medicines can be developed through this RNAi therapy. Hopefully, cancer sufferers will find this sort of therapy to be one of the most effective ones. Various kinds of RNA-based treatments, such as aptamers, small interfering RNAs, microRNAs, antisense oligonucleotides, and messenger RNA, are covered in broad terms in this study. We also present an overview of the RNA-based therapies that have received regulatory approval in the past or are now undergoing clinical studies.

Self-Acceptance in Breast Cancer Patients: A Concept Analysis

Breast cancer is still one of the fears for most women in the world and ranks first regarding the number of cancers in Indonesia and is one of the first contributors to cancer deaths. Breast cancer patients with low self-acceptance will cause stress, lack of confidence, lack of enthusiasm for recovery and will affect poor health management. Self-acceptance is directly proportional to the patient's quality of life. The greater the patient's self-acceptance of their disease, the better the quality of life of breast cancer patients. The purpose of this analysis is to explain self-acceptance in breast cancer patients. An analysis of the concept of self-acceptance was conducted on articles published between 2019 and 2024. The databases used include Google Scholar, Proquest, Pubmed, and Science Direct. The results of the analysis show that the concept of self-acceptance has four attributes, namely, acceptance of physical changes, acceptance of physical and emotional limitations, accepting social and role limitations, accepting the healing process and uncertainty. Based on these attributes, nurses assess self-acceptance in breast cancer sufferers comprehensively. The results of the assessment will be the basis for nurses in determining appropriate diagnoses and nursing interventions to improve self-acceptance in breast cancer patients, by reducing psychological burden to improve quality of life.

Progressive Muscle Relaxation As An Effort To Reduce Pain Intensity In Cervical Cancer Sufferers

Progressive Muscle Relaxation As An Effort To Reduce Pain Intensity In Cervical Cancer Sufferers

In medicine today – Cancer and the prorogation of clinical reality in favour of probabilistic outcomes

Abstract How essential is the randomised trial in cancer therapeutics? Is it conceivable that prospective randomised clinical trials in cancer medicine could, one day, safely be abandoned in favour of Phase II studies supplemented with real-world data from cancer centres, without detriment to the progress of cancer therapeutics or the welfare of cancer sufferers? If feasible, such practice could reduce the cost of new drug development, while freeing clinical investigators from the ethical burden of random allocation of treatment or indeed providing no therapy with the administration of a placebo to cancer sufferers.

Histopathological Features and Diagnosis of Breast Cancer

In Indonesia, the high number of breast cancer cases is not always followed by complete clinical and histopathological determination, even though clinical and histopathological staging is needed to determine the diagnosis and further management. Breast cancer is a malignant mass originates from the uncontrolled division of cells in breast tissue Breast cancer or mammary carcinoma is a lump that grows and develops abnormally in the cells and tissues located in the breast, such as the fat tissue and connective tissue in the breast, ducts and lobules. The histopathological examination procedure is that the patient must undergo a biopsy. Biopsy results can be used to diagnose breast cancer and also monitor the success of therapy. Mammary carcinoma can spread to surrounding tissue or to other organs through blood vessels. Breast cancer is the most common cancer in Indonesia. The prognosis of breast cancer is determined by the 5 years survival rate. The survival rate for cancer sufferers in Indonesia is low compared to other developing countries, namely 51.07%. This research is in the form of a literature review with 14 papers as references. The results obtained were that invasive ductal carcinoma was the most common mammary carcinoma and grade II-III was found to be the dominant grade.

Suicide in Gynecological and Breast Cancer: A Systematic Review.

Depression and suicide rates are high among cancer sufferers. Women with breast and gynecological cancer show high levels of distress, depressive symptoms, cognitive impairment, and anxiety. Understanding suicide rates and risk factors in this population would represent a viable tool in planning tailored, prevention strategies. The objective of this study was to estimate suicide rate and identify the determinants of suicide risk in women with breast and other gynecologic cancer. A systematic research was performed in PubMed and PsycINFO from anytime to September 26, 2023. The following search strategy was used: (Gynaecol* OR Gynecolog*) AND (cancer OR tumor OR tumor OR neoplas* OR malignan*) AND suicid*. In this review, we adhered to PRISMA statement. Nine papers met inclusion criteria. Women with breast or gynecological cancers showed higher suicide rates compared to the general population. Ovarian cancer was associated with higher suicide risk and suicidal ideation compared to other gynecological cancers. The extent of surgical demolition was positively associated with both. Psychological factors, such as self-perceived burden and alexithymia, might also influence suicidal thinking. Women with breast and gynecological cancer are at high risk of suicide. Intervention aimed to reduce burden related to psychological factors might help reducing such risk.

The Effect of Mindfulness Based Cognitive Therapy (MBCT) for Optimizing Efficacy Self-Care in Cancer Patients Undergoing Treatment

Cancer is a disease that can threaten a person's life which can occur in every cancer sufferer, apart from that cancer can also cause psychological problems such as low efficacy of patient self-care which will have an impact on treatment compliance in cancer patients.Objective: The aim of this study was to determine the effect of the MBCT intervention on whether it could increase self-care efficacy in cancer patients undergoing cancer treatment. Method: The method used in this research is an experiment with a pretest-posttest design with control group design. The research subjects were 20 people who were divided into experimental and control groups with inclusive. Data analysis used the Wilcoxon and Mann-Whitney tests. Results: The results showed an increase in self-care efficacy after administering the mindfulness-based cognitive therapy (MBCT) intervention with a self-care efficacy value of Z = -2.660 and p = 0.008. Conclusions: The research results show that mindfulness based cognitive behavior therapy (MBCT) can increase patient confidence in carrying out treatment regularly. Cancer patients who Applying MBCT in everyday life they can also feel the effects such as tense muscles becoming more comfortable, better conscious breathing begins to feel the impact on the subject's calmness, and increased ability to detect the body. Mindfulness-based cognitive therapy (MBCT) changes the behavior of each participant to be able to accept themselves in any situation, more easily adapt to changes that occur in their physical and life and establish social relationships with other people.

THE EFFECTIVENESS OF HEALTH EDUCATION ON KNOWLEDGE ABOUT BREAST SELF EXAMINATION AS AN EARLY DETECTION OF BREAST CANCER IN WOMEN IN BENGKULU CITY

Breast cancer is one of the causes of death in women. To reduce the death rate in breast cancer sufferers, early detection is necessary, which can be done through Breast Self Examination. Where BSE is the easiest way to do it, but there are still many women who don't know how to do BSE properly. The purpose of this study is to find out how health education affects women's knowledge of BSE as a means of early breast cancer screening in Bengkulu City. This research method uses pre-experimental with one group pre-post test design. The population in this study were women aged 26-35 years with a total sample of 86 people using purposive sampling technique. The results of the T Test statistical test p value = 0.000, this shows that there is an influence of Health Education on women's level of knowledge about BSE. Health education can increase knowledge, so nurses need to carry out health education about BSE in early detection of breast cancer.

Factors Related To Breast Self-Examination (Sadari) In Women Of Fertile Age In Ujong Patihah Village, Kuala District, Nagan Raya Regency

The Aceh Health Service recorded that the number of cancer sufferers reached 1,318 people throughout 2022. This number is based on Community Health Center-based Non-Communicable Disease (NCD) Surveillance. The most cancer cases in Indonesia are breast cancer. The number of breast cancer survivors reached 1,117 people. While the second position is cervical cancer. The high incidence of breast cancer is caused by one of the reasons being the lack of awareness in women to do early detection of breasts if they experience abnormalities such as lumps. The research method is cross -sectional. The sampling technique is random probability sampling of 223 people. The results of the study showed that the p value of the 5 independent variables studied were knowledge (0.000), attitude (0.578), education (0.000), exposure to information (0.000) and support from health workers (0.000) so that it can be concluded that 4 variables have a relationship with BSE behavior, namely knowledge, education, exposure to information and support from health workers. Then the most dominant variable influencing is the variable of exposure to information. The conclusion is that there is a relationship between knowledge, education, exposure to information and support from health workers with SADARI examination in Ujong Patihah Village, Kuala District, Bireuen Regency in 2024.

Effect of Progressive Muscle Relaxation on Reducing Anxiety in Cancer Patients: Literature Review

One of the symptoms of cancer is the emergence of pain and anxiety related to each other, especially in patients who suffer from cancer. This can be caused by pain from cancer, examinations carried out and treatment that sufferers undergo. Anxiety can be caused by uncertainty about the prognosis of the disease, the effectiveness of treatment for recovery of the condition which is often found in cancer patients, especially at an advanced stage. Anxiety management is provided through the main nursing interventions, namely progressive muscle relaxation techniques. The purpose of this study was to identify progressive muscle relaxation to reduce anxiety in cancer patients. The database used by the author in the literature search comes from studies that have been conducted and published online with the latest research. To find search results that include the author's journal, authors use Garuda Ristekbrin, PubMed, Google Scholar and Science Direct searches. After filtering, the author examines the contents of the article in accordance with the subject matter in accordance with the author's title. There were 10 journals selected for review by the authors, 6 of which used a quasy experiment, 3 used a systematic review, and 1 used a randomized controlled trial. The results of statistical tests for the 10 journals selected, all journals showed a significant influence on the nursing intervention carried out, namely Progressive Muscle Relaxation therapy in reducing anxiety in cancer sufferers. It is hoped that this literature review will become a reference and reference for nursing interventions in reducing anxiety in cancer patients, one of which is progressive muscle relaxation therapy

WNT5A is a putative epi-driver of prostate cancer metastasis to the bone.

Current diagnostic tools are unable to distinguish low-grade indolent prostate cancer (PrCa) from that with a propensity to become metastatic and/or lethal. Recent evidence suggests that reprogramming of the transcriptome may drive the metastatic phenotype, and that this reprogramming is controlled, at least in part, by epigenetic changes to the DNA of cancer cells, including methylation. These changes, referred to as 'epigenetic drivers,' have previously been associated with cancer cell survival. Here, using Illumina Methylation EPIC array data of paired primary PrCa and metastatic bone samples, we identified WNT5A as a putative epi-driver of PrCa metastasis to the bone, which was further validated invitro. Significantly higher WNT5A methylation was observed in primary PrCa samples and 22Rv1 cells compared to metastatic bone samples and PC-3 cells. This higher methylation was associated with significantly lower WNT5A gene expression. Given the limited effective therapies available for metastatic cancer sufferers, particularly those whose disease has metastasised to the bone, WNT5A presents as a potential putative target for therapy.

In vitro assessment of a gallium-doped glass polyalkenoate cement: chemotherapeutic potential, cytotoxicity and osteogenic effects

Metastatic bone lesions are often osteolytic, which causes advanced-stage cancer sufferers to experience severe pain and an increased risk of developing a pathological fracture. Gallium (Ga) ion possesses antineoplastic and anti-bone resorption properties, suggesting the potential for its local administration to impede the growth of metastatic bone lesions. This study investigated the chemotherapeutic potential, cytotoxicity, and osteogenic effects of a Ga-doped glass polyalkenoate cement (GPC) (C-TA2) compared to its non-gallium (C-TA0) counterpart. Ion release profiles revealed a biphasic pattern characterized by an initial burst followed by a gradually declining release of ions. C-TA2 continued to release Ga steadily throughout the experimentation period (7 d) and exhibited prolonged zinc (Zn) release compared to C-TA0. Interestingly, the Zn release from both GPCs appeared to cause a chemotherapeutic effect against H1092 lung cancer cells in vitro, with the prolonged Zn release from C-TA2 extending this effect. Unfortunately, both GPCs enhanced the viability of HCC2218 breast cancer cells, suggesting that the chemotherapeutic effects of Zn could be tied to cellular differences in preferred Zn concentrations. The utilization of SAOS-2 and MC3T3 cell lines as bone cell models yielded conflicting results, with the substantial decline in MC3T3 viability closely associated with silicon (Si) release, indicating cellular variations in Si toxicity. Despite this ambiguity, both GPCs exhibited harmful effects on the osteogenesis of primary rat osteoblasts, raising concerns about excessive burst Zn release. While Ga/Zn-doped GPCs hold promise for treating metastatic bone lesions caused by lung cancers, further optimization is required to mitigate cytotoxicity on healthy bone.

Revolutionizing Healthcare with AI: Innovative Strategies in Cancer Medicine

By improving early detection, diagnosis, treatment planning, and patient management, artificial intelligence (AI) is transforming the way that cancer is treated. An overview of AI's function in cancer is given in this article, with special attention to how it advances precision medicine and improves patient outcomes. Numerous AI applications are discussed, such as predictive analytics, pathology interpretation, genetic profiling, and medical imaging analysis. Case studies highlight effective AI applications in cancer care, showcasing the technology's effectiveness in enhancing the precision of diagnoses, directing individualized treatment choices, and tracking treatment response. The paper delves into the possible advancements in early identification, therapy optimization, and patient engagement through an exploration of future directions and innovations in AI-driven oncology research. The conclusion emphasizes how AI has the ability to completely change the way cancer is treated and enhance the lives of cancer sufferers all over the world.

The Correlation Between Protein Intake And Muscle Mass in Breast Cancer Patients at Dr. H. Abdul Moeloek Regional Hospital

Breast cancer is the second-leading cause of death among women. Since protein serves as a building ingredient for cells, muscles, and tissues, eating enough of it is thought to be essential for gaining muscle mass. The cornerstone for cancer patients to maintain and/or gain muscle mass will be an adequate protein intake. In this study, breast cancer patients' muscle mass was measured and a 24-hour recall of their weekdays and weekends was conducted. The average amount of protein consumed by participants was 31.22 grams, and the average percentage of muscle mass was 24.02%. The purpose of this study is to ascertain how breast cancer patients' protein consumption and muscle mass relate to one another. This study uses quota sampling as the sample method and a cross-sectional design. There were fifty-six responders in the sample. This research uses the Spearman rank. The normality test results show that the significance value for muscle mass is p value = 0.016 (p < 0.05), it can be concluded that the data is distributed abnormally. Meanwhile, the normality test results for protein intake p-value = 0.200 (p > 0.05) can be concluded that the data is normally distributed, so it is continued with the Spearman rank correlation test. Based on the results of the Spearman rank correlation test, a correlation coefficient value of 0.488 was obtained with a significance p-value of 0.0001. So there is a positive significant correlation between protein intake and muscle mass in breast cancer sufferers at Dr. H. Abdul Moeloek Regional Hospital of Lampung Province p value = 0.0001 (p<0.05).

Factors Associated with Extravasation Incident of Cancer Patients with Chemotherapy at RSUP Dr. Mohammad Hoesin Palembang

Cancer is currently the second leading cause of death in the world after heart disease. Global number of deaths from cancer in 2020 reached 10 million people. In Indonesia, the number of cancer sufferers has reached more than 369 thousand cases. Cancer treatment consists of various types such as intravenous chemotherapy. However, intravenous chemotherapy can cause complications at the injection spot known as extravasation. The incidence of extravasation at RSUP Dr Mohammad Hoesin Palembang is quite high. In 2019 there were 11 extravasation incidents, in 2020 there were 4 incidents, in 2021 there were 17 incidents and in the period January to October 2022 there were 32 extravasation incidents. This study aimed to determine what factors are associated with the incidence of extravasation in cancer patients with chemotherapy at RSUP Dr. Mohammad Hoesin Palembang. The research design used was a cross sectional purposive sampling technique with a total sample of 78 outpatient chemotherapy (One Day Care). Data analysis was carried out using the Chi Square test (X2). Statistical test results showed that gender, age and type of medicine was not related to the incidence of extravasation, while the vein's spot where the IV catheter inserted was significantly associated with the incidence of extravasation with a p value 0.043. It can be concluded that the incidence of extravasation is related to the vein spot where the intravenous catheter is inserted.