Over 40% of Jordan's population falls within the adolescent and young adult (AYA) age group (15-39 years). Cancer diagnosed in this population has unique biological, clinical, and psychosocial characteristics. This study describes national incidence trends and treatment outcomes among AYA patients in Jordan. This retrospective observational study utilized data from Jordan Cancer Registry (JCR) reports (2000-2022), King Hussein Cancer Center (KHCC) registry outcomes, and the latest GLOBOCAN report. Descriptive statistics, Kaplan-Meier survival analysis, and log-rank testing were used to evaluate cancer incidence and overall survival. The median age at cancer diagnosis in Jordan is 57 years, significantly younger than in Western countries. Over the past 23 years, the total number of cancer cases among AYA increased from 654 in 2000 to 1,167 in 2022, representing 13.3% of all cancer diagnoses in that year. Most cases (36.8%) occurred in the older AYA subgroup (35-39 years). Age-standardized incidence rates (ASIRs) were consistently higher in females than males across all AYA age groups, largely driven by breast and thyroid cancers. ASIR increased from 17.3 per 100,000 in the youngest group (15-19 years) to 84.4 per 100,000 in the oldest group (35-39 years). The 5-year overall survival (OS) among AYA patients was 73.0% (95% confidence interval (CI), 71.8-74.1), significantly better than older adults at 57.1% (95% CI, 56.4-57.8). Jordan's population is predominantly young, with over 40% classified as AYA. Although cancer incidence is lower in this age group compared with older adults, outcomes are generally more favorable. A comprehensive AYA oncology strategy incorporating specialized psychosocial, fertility, and survivorship services should be prioritized, particularly in resource-restricted settings.

Background: Colorectal cancer (CRC) represents a rapidly escalating public health challenge in the Kingdom of Saudi Arabia (KSA), where it is the second most common cancer overall and the leading cancer among men.(1,2) Methods: A Systematic review of current evidence for colorectal cancer in Saudi Arabia, its financial impact, and the human resources required to support care of such burden. A comprehensive literature search was conducted across PubMed/MEDLINE, Embase, Scopus, Web of Science, and Google Scholar, as well as gray literature sources, including Saudi National Cancer Registry reports and documents from the Saudi Ministry of Health. The search identified 27 records from database searching and 21 records from the registry and other sources. After the removal of 8 duplicates, 40 records were screened at the title and abstract level. Full texts of CRC articles were assessed for eligibility, of which 10 were excluded (non-Saudi populations, insufficient CRC-specific data, or non-original research), leaving 30 studies included in the final qualitative synthesis. A PRISMA-style flow was used to summarize the study selection process. Results: In 2020, the incidence and mortality rate of CRC in Saudi Arabia were 14.6% and 1.48% among all cancers, respectively [1]. National guidelines in Saudi Arabia recommend CRC screening for all individuals above 45 years using colonoscopy, flexible sigmoidoscopy, or fecal occult blood test. The incidence of cancer increased (1990-2016) approximately 10-fold for colon Cancer [2], A dangerous combination of genetic vulnerability and modern lifestyle pressures fuels this epidemic. Approximately 11.6% of young Saudi CRC patients have confirmed Lynch Syndrome(3). And 83% of all Saudi CRC patients carry the GSTM1 null genotype, this genetic trait leaves them highly sensitive to environmental carcinogens [4]. These genetic risks collide with modifiable factors, including sedentary habits and poor knowledge of high-fiber diets [5,2,4], leading to metabolic weaknesses like widespread Vitamin D deficiency [6]. The high overall one-, three-, and five-year survival rates were 83, 65, and 52.0% [7]. is fundamentally driven by failures in early detection. Screening rates are extremely low [8,9] primarily because physicians fail to recommend testing [8,10] and the public wrongly believes screening is unnecessary unless they feel sick [9,10,11]. Conclusion: To control Colorectal cancer demands immediate risk-stratification, genetic testing for all early-onset cases, and aggressive, physician-led efforts to increase public engagement with non-invasive screening options. The increasing incidence of CRC in Saudi Arabia, along with rising treatment costs, underscores the necessity for early detection and efficient healthcare resource allocation. Managing the projected increase in CRC cases over the next five years requires a strategic assessment of workforce needs, including ensuring sufficient numbers of oncologists, nurses, and allied health professionals, alongside effective training and recruitment strategies.

Objective.This study aimed to evaluate the prevalence and distribution of oral cancer and potentially malignant disorders among older adults in each region of Thailand, based on screening data between 2020 and 2024.Methods.Oral cancer screening data of patients aged 60 years between October 2020 and July 2024 were obtained from (1) the Health Data Center (community screening) and ( 2) Cancer Registry reports and Thai Cancer Base (hospital screening).Descriptive statistics were provided, and spatial analysis was performed.Results.Of 1 614 549 older adults screened, 540 (0.03%) had signs suggestive of oral cancer or potentially malignant disorders.The highest prevalence was observed among individuals aged 60 to 65 years.The incidence of oral cancer reached 8 per 100 000 among men and 4 per 100 000 among women.Tongue cancer was the most prevalent, followed by cancer of the floor of the mouth and lip cancer.The highest incidences of oral cancer were reported in the central and southern regions. Conclusions.Although the prevalence of oral cancer and potentially malignant disorders was low, the screening programme facilitates early intervention.Dental health education, regular oral evaluation, and effective referral may reduce late-stage diagnoses, while region-specific surveillance and data-informed planning support efficient resource allocation.

Objective: To develop a tool package that meets the routine statistical analysis requirements of population-based cancer registries in China based on R language, with the aim of improving data quality and efficiency, and promoting the nationwide scientific utilization of cancer registry data. Methods: The functional demands for statistical analysis of population-based cancer registry staff were collected through questionnaires or face-to-face interviews. Based on the concept of generic functions in R software's S3 object system, functions were developed by defining specific S3 classes for different data types, allowing the same function to perform diverse tasks depending on the class of input data. A stepwise development strategy was adopted to ensure logical coherence among functional modules, and all functions were systematically tested and validated in accordance with standard R package development guidelines. Results: Six categories of functions, including data reading, data manipulation, data processing, statistical calculation, visualization, and statistical reporting, were developed to support routine statistical analysis of population-based cancer registry data. Data reading functions support reading data formats required by the National Cancer Registry. Data manipulation functions empower conditional filtering of registry data and support regrouping, merging, or transforming the data based on registry attributes (such as urban/rural location) to accommodate different analytical needs. Data processing functions includes age grouping, International Classification of Diseases 10th Revision (ICD-10) classification, childhood cancer classification, and population estimation. Statistical calculation functions permit the calculation of age-standardized rates, truncated rates, cumulative rates, cumulative risks, life tables, and expansion from abridged to complete life tables. Visualization functions can generate commonly used statistical charts, including population pyramids, bar charts, and line graphs. Statistical reporting functions can integrate key indicators, charts, and narrative descriptions into comprehensive cancer registry reports. Conclusion: An R package named Canregtools was developed based on the concept of S3 generic functions. This package is free of charge, open-source, and highly efficient. It can meet the diversified needs in cancer registry data analysis, visualization, and reporting through standardized data processing workflows, thereby enhancing the quality and efficiency of routine statistical analysis in population-based cancer registries in China.

Background: Uterine cancer, largely endometrial carcinoma, is among the most common gynecological malignancies worldwide, with incidence and mortality exhibiting marked geographical disparities. Recent trends highlight a rising incidence in both high-income countries (HICs) and low- and middle-income countries (LMICs), with obesity, elevated body mass index (BMI), and sociodemographic shifts identified as key risk factors. Histopathologically, endometrioid adenocarcinomas remain strongly associated with metabolic risk profiles, while aggressive non-endometrioid subtypes (such as uterine serous carcinoma, clear cell carcinoma, and carcinosarcoma) disproportionately drive mortality. Although human papillomavirus (HPV) vaccination primarily targets cervical carcinogenesis, emerging evidence suggests broader oncological and histopathological benefits in modifying gynecological cancer risk. Methods: A systematic review was conducted according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, identifying 11 eligible studies from global databases and reference lists. Eligible studies included global burden analyses, regional cancer registry reports, risk factor evaluations, and narrative reviews addressing preventive strategies, including HPV vaccination. Results: Global evidence demonstrates a steadily increasing incidence of uterine cancer, particularly in HICs, while LMICs experience rising mortality due to delayed diagnosis and limited oncological treatment infrastructure. Obesity and high BMI were consistently identified as dominant modifiable risk factors across datasets. Age–period–cohort analyses revealed increasing incidence among younger cohorts. Two reviews emphasized HPV vaccination as an indirect but valuable preventive strategy in gynecologic oncology. Conclusion: The global burden of uterine cancer is rising, driven primarily by obesity and sociodemographic transitions, while health system inequities sustain high mortality in LMICs. Prevention strategies, including weight management, lifestyle modification, metabolic risk reduction, and HPV vaccination, should be integrated into comprehensive cancer control programs to mitigate future burden

519 Background: Debt delinquency is common and precedes bankruptcy. However, unlike bankruptcy, the impact of debt delinquency on cancer treatment is not well understood. We hypothesized that patients with debt delinquency at diagnosis may struggle to afford and adhere to treatment, especially those with CML or MM, for whom OAMs are indicated at diagnosis. We examined the association between debt delinquency and OAM adherence among patients with CML or MM in Washington (WA) State. Methods: We conducted a retrospective analysis of patients with CML or MM diagnosed from 2012-2021 who initiated OAMs within 180 days. OAMs included Bcr-Abl tyrosine-kinase inhibitors (CML) and immunomodulators (MM). We used a unique database that links data from WA cancer registry, insurance claims (commercial plans, Medicare, Medicaid), and longitudinal TransUnion credit reports. We identified patients as having debt delinquency if they had past-due accounts within 50 days of diagnosis. Concordant with prior studies, we defined adherence as a medication possession ratio (MPR; drug supplied days divided by total days) of > 0.8 over 180 days. We performed nonparametric bivariate analyses and multivariable logistic regression (adjusting for age, sex, race, ethnicity, and insurance type) to test the association between debt delinquency and OAM adherence. Results: We identified 407 patients (109 CML, 298 MM) who were eligible, with a mean age of 65.8 years (SD 13.4); 56%, 87%, and 97% were male, white, and non-Hispanic, respectively. Most patients had either Medicare (45%) or commercial (31%) insurance. Approximately 12% of patients had debt delinquency at diagnosis. Across all patients, debt delinquency was significantly associated with mean age (56 vs. 67 years, P < 0.001), gender (16% female, 9% male, P = 0.04), insurance type (39% Medicaid, 11% multiple, 9% commercial, 7% Medicare, P < 0.001), and disease type (21% CML, 9% MM, P < 0.001). OAM adherence differed significantly by disease type; patients with CML and MM were 72% and 37% adherent, respectively. Among patients with CML, debt delinquency was not associated with OAM adherence (19% in adherent vs. 26% in non-adherent, P = 0.45 by bivariate analysis; OR 0.76, 95% CI: 0.24-2.39, P = 0.64 by multivariable analysis). In contrast, among patients with MM, debt delinquency was significantly associated with OAM adherence (4% in adherent vs. 12% in non-adherent, P = 0.02 by bivariate analysis; OR 0.27, 95% CI: 0.09-0.86, P = 0.03 by multivariable analysis). Conclusions: The differences in OAM adherence rates between patients with CML and MM and the impact of debt delinquency on adherence might be explained by OAM cost and access (i.e., generic drug available for CML versus proprietary only for MM). Therefore, interventions addressing personal debt delinquency may improve adherence among patients taking expensive OAMs.

Liver cancer is a leading cause of cancer mortality and morbidity worldwide. Existing data on the liver cancer burden in Saudi Arabia are limited. Therefore, this study aimed to analyze liver cancer incidence and mortality trends in Saudi Arabia over two decades (2001–2020) and to compare them with the regional and worldwide data. Liver cancer incidence data in Saudi Arabia were collected from the national cancer registry reports for the study period (2001 to 2020). Additionally, global and regional data on liver cancer burden were obtained from the World Health Organization (WHO); the International Agency for Research on Cancer (IARC); and the Global Cancer Observatory website. Saudi Arabia revealed a relatively lower burden of liver cancer compared to global rates. Males showed a decreasing trend in age-standardized incidence rates during the study period, while females displayed steady rates. In 2020, liver cancer incidence in males was nearly doubled compared to females with a male-to-female ratio of 1.8:1. Additionally, significant regional variations in the incidence of liver cancer were observed across the administrative regions in Saudi Arabia. Liver cancer ranked first as a cause of cancer death in Saudi Arabia for the year 2020. This trend extends to the broader Gulf Cooperation Council region that includes Saudi Arabia, Qatar, Kuwait, Oman, Bahrain and United Arab Emirates; with Saudi Arabia experiencing the highest liver cancer mortality rate (5.1 per 100,000 people). In conclusion, this study highlights the importance of gender- and region-specific analysis of liver cancer in Saudi Arabia. While the decline of liver cancer incidence in males is promising, further investigations are needed to understand the underlying causes and maintain observance. The high national mortality rate from liver cancer underscores the need for improved prevention, early detection, and management strategies.

Introduction: Over the past three decades, the global incidence of thyroid cancer has markedly increased. However, to date, no comprehensive nationwide study has been conducted in Iraq to evaluate trends at a national level. This study aims to provide the first Iraqi national assessment of thyroid cancer incidence, using data from the Iraqi National Cancer Registry and GLOBOCAN. Methods: Thyroid cancer data spanning from 1995 to 2023 were extracted from the Iraqi Ministry of Health’s annual cancer registry reports, supplemented with data from GLOBOCAN. Population estimates by age and gender were sourced from the United Nations Population Division Central Agency For Public Mobilization And Statistics/ ministry of planning/ Iraq. Crude and age-specific incidence rates were calculated by gender and governorate. Trends were analyzed using Joinpoint regression to determine annual percentage changes (APC) and evaluate significant shifts in incidence rates over time. Results: A steadily increasing trend in thyroid cancer incidence was observed throughout the study period, with an overall APC of +7.51%. When compared globally, Iraq demonstrated a moderate age-standardized incidence rate. Notably, from 2007 to 2023, the APC increased sharply for females (+14.27%) and males (+10.97%). The female-to-male incidence ratio rose significantly from 1.7 in 2000 to 4.14 in 2023. An upward trend was also observed across all age groups. Conclusions: This study reveals a marked rise in thyroid cancer incidence in Iraq from 1995 to 2023. Further investigations are necessary to identify contributing risk factors such as radiation exposure, obesity, smoking, and iodine deficiency, which are essential for guiding prevention and control strategies.

To collect and analyse cancer data of all malignancies from the Hyderabad Cancer Registry (HCR) for the estimation of cancer incidence (2020-2023) in various age groups and genders to identify common malignancies and any risk factors to facilitate cancer control initiative and prioritisation by the government and private sector. Observational study. Place and Duration of the Study: Hyderabad Cancer Registry (HCR) Secretariat, Liaquat University of Health Sciences (LUMHS), Jamshoro, in collaboration with Karachi Cancer Registry, Health Research Institute, NICH, JPMC, Karachi, Pakistan, from January 2020 to December 2023. Cancer data of HCR collected from across Sindh province were analysed using SPSS. Parameters included age, gender, first contact date, primary site, and ICD coding. Data were cleaned, merged, and analysed. As per the standard guidelines, patients aged 0-14 years were classified as children, 15-19 years as adolescents, and aged 20 years and above as adults. Age-standardised incidence rates (ASIR) were also determined. During these four years, i.e., from January 2020 to December 2023, a total of 7,169 malignant cases were received. This included 3,310 (46.2%) males and 3,859 (53.8%) females, respectively. Out of a total of 7,169 cases, 6,967 (97.18%) tumours were seen in adults (≥20 years), 104 (1.45%) in adolescents, and 98 (1.37%) in children. In male adults, the oral, prostate, and urinary bladder, while in females, the breast, oral, and ovary constituted the three most common sites. The overall ASIR in males was 188.96 for adults, 2.25 for adolescents, and 2.41 for children. The overall ASIR in females was 236.68 for adults, 2.17 for adolescents, and 1.62 for children. Both genders combined, breast cancer was the most common malignancy in Sindh. Oral cancer (OC) topped the list in males as the most common cancer, while it was 2nd most common in females after breast. OC, though largely a preventable cancer, has shown an upward trend mostly due to highly prevalent chewing habits, while breast cancer, largely a non- preventable one, not only shows an upward trend but more and more cases are occurring in young and pre-menopausal women. In adolescents and children, the orbital, oral, brain, colorectal, and bone malignancies were predominant. Hyderabad, Sindh, Cancer registry, Oral cancer, Breast cancer.

According to the 2019 Malaysia National Cancer Registry Report (MNCR), 3,981 cases of cervix uteri cancer were diagnosed between 2012 and 2016, compared to 4,352 cases in the 2007-2011 report. The third most common cancer in women was cervix uteri cancer, ranked ninth in Malaysia, up from seventh in the previous survey. Over the last five years, the incidence rate has dropped from 7.6 to 6.2 per 100,000 people. Cervical cancer is the most prevalent disease among women. The Pap smear is the main technique for identifying potentially cancerous cells. The purpose of this research paper is to investigate women's knowledge and understanding of cervical cancer in Malaysia, attitudes toward cervical cancer (CC) among Malaysian women, and the challenges faced by medical professionals. The primary articles came from the two established databases, which are SCOPUS and Web of Science (WoS). The advanced searching focuses on two keywords: cervical cancer and Malaysia. Based on previous research, the study involves an overview of women's awareness and knowledge, a cross-sectional study, a self-sampling device, and perceived barriers to having a pap smear test in Malaysia. Furthermore, it was discovered that ethnicity promotes HPV vaccines, and MSPs may be given for medical students' programs aimed at preventing the spread of cervical cancer, as well as vaccination subsidies. Providers and academia should co-operate to raise immunization coverage. The majority of women surveyed in Malaysia are women between the ages of 21 and 60. In contrast to other research, there is still a shortage of understanding about cervical cancer, which has resulted in implicit cluelessness and negative perceptions toward it. Regarding the risk aspects, there are two well-known among Malaysian women: unprotected sexual partners and sexually transmitted infections. Participants are aware that a normal Papanicolaou (Pap) smear would detect cervical cancer and that an operation may be an option. Besides that, people in Malaysia have a modest understanding of Pap smears as a preventative measure to diagnose and prevent Cervical Cancer at a preliminary phase. In summary, most women in Malaysia understand the importance of the Pap test screening technique for early detection and operation as a cure. More initiative will be needed with the potential to increase understanding of women's perceptions to-wards cervical cancer.

Changes in the use of chemoradiotherapy for non-small cell lung cancer after guideline implementation in Finland between 2016 and 2020.

Background:Cancer patterns in China are becoming similar to those in the United States (US). Comparing the recent cancer profiles, trends, and determinants in China and the US can provide useful reference data.Methods:This study used open-source data. We used GLOBOCAN 2022 cancer estimates and United Nations population estimates to calculate cancer cases and deaths in both countries during 2024. Data on cancer incidence and mortality trends were obtained from the Surveillance, Epidemiology, and End Results (SEER) program and National Centre for Health Statistics in the US and cancer registry reports of the National Cancer Center (NCC) of China. Data from the Global Burden of Disease study (GBD) and a decomposition approach were used to estimate the contributions of four determinants to the change in cancer deaths.Results:In 2024, there are an estimated 3,246,625 and 2,510,597 new cancer cases and 1,699,066 and 640,038 cancer deaths in China and the US, respectively. The highest estimated cancer cases are lung cancer in China and breast cancer in the US. The age-standardized incidence rates of lung and colorectal cancer in the US, and stomach, liver, and esophageal cancer in China have decreased, but the incidence rates of liver cancer in the US and colorectal cancer, prostate cancer in men, and cervical cancer in women in China have increased. Increases in the adult population size and population aging are main reasons for the increase in cancer deaths; case fatality rates are a main reason for the decrease in cancer deaths in both countries.Conclusions:China has made progress in cancer control but lags the US. Considering the transformation in China’s pattern of cancers epidemiology, it is imperative to develop stronger policies by adopting the cancer prevention and control strategies used in the US to address population aging and curb growing cancer trends.

The reports have stated that the timeliness of lung cancer care varies significantly across different regions. According to the Victorian Lung Cancer Registry report, the timeliness of lung cancer care in Victoria has changed over time. Therefore, we aimed to quantify the extent of these spatial inequalities over time and to identify area-level determinants contributing to these changes. The study analyzed lung cancer cases reported to the Victorian Lung Cancer Registry between 2011 and 2022. Bayesian spatiotemporal conditional autoregressive models were fitted, incorporating spatial random effects, temporal random effects, and spatiotemporal interactions. The best performing model was selected using the deviance information criterion. For the final best fit model, the adjusted RRs and their 95% credible intervals were reported. More than half (51.24%) of patients with lung cancer experienced treatment delays, whereas approximately one third (30.98%) encountered diagnostic delays. Moderate spatiotemporal variations were observed in both delayed diagnosis and treatment. In the final best fit model for treatment delay, an increase in the percentage of smokers was significantly associated with a higher risk of treatment delay (RR = 2.13; 95% credible interval, 1.13-4.20). Identifying high-risk areas provides useful information for policymakers, helping in the reduction of delays in lung cancer diagnosis and treatment. This study has revealed spatiotemporal inequalities in diagnostic and treatment delays, providing valuable insights for identifying areas that should be prioritized to ensure timely care for lung cancer.

This study assesses the health symptoms and longer-term health outcomes of firefighters who attended the Grenfell Tower fire. All available data sources were analyzed, including databases published by the Public Inquiry, the Firefighter Cancer and Disease Registry, incident logs, and sickness reports up to 3 years postfire. More than three times as many firefighters who reported exposure to smoke during the fire also reported digestive and respiratory diseases following the fire, compared with those not reporting exposure to smoke. Other more complex relationships are reported among smoke exposure, immediate health symptoms, and longer-term health outcomes. The incident's urgency led professional firefighters to operate without respiratory protection equipment, resulting in debilitating health effects.

Methylation of the MGMT promoter is a molecular marker of predictive relevance in brain tumors. Methylation of the MGMT promoter is related to an improved prognosis and may influence therapy decisions. According to the most recent Malaysian National Cancer Registry Report (MNCRR) for 2012–2016, there were 2097 cases of brain tumors in Malaysia overall, with 1117 cases involving men and 908 cases involving women. This research aims to create prediction models for detecting MGMT promoter methylation in brain tumors. So, a dataset from the BraTS (Brain Tumor Segmentation) challenge, which included MRI scans and clinical data for patients with brain tumors, was utilized and explored using Exploratory Data Analysis (EDA) and data visualization techniques. The dataset has 306 methylation cases identified as “1” and 276 unmethylated cases identified as “0”. The average number of scans of train data for modality per patient is between 127 and 171, which provides a wealth of information for pattern learning while the average number of scans of test data for modality per patient is between 124 and 165. In both sets, FLAIR has the least number of files while T2w has the highest number of files among them. Two models of deep learning approaches, ResNet50 and EfficientNetV2, were used to construct and form the prediction models. Various criteria were employed to evaluate the performance of the models. The T2w modality consistently achieved the highest validation accuracy, precision, recall, and F1-score for both the ResNet50 and EfficientNetV2 models. Specifically, the T2w modality achieved a validation accuracy of 0.9453 and a validation loss of 0.2417 for ResNet50. Furthermore, the brain tumor diagnosis interface utilized DICOM images from MRI scans to identify MGMTp methylation status, aiding in therapy effectiveness prediction. Pre-trained ResNet50 model on T2w images was used for classification. The interface displayed the original MRI image, predicted state, and treatment effectiveness indication, while promptly notifying users of invalid or inadequate data for accurate analysis.

Background. Breast cancer (BC) is the commonest tumor in women. It is the leading malignancy in world, and representing an emerging oncologic issue in all countries. In Iraq, BC cases reached 7246 in 2021by Iraqi Cancer Registry reports. Objectives. The study conducted for assessment the clinical and pathological responses to neoadjuvant chemotherapy in BC among molecular subtypes and for description the clinico-pathologic features, and patterns of BC according to molecular subtypes. Methods. A prospective study of 60 females with breast cancer histologically confirmed were enrolled. All women received neoadjuvant chemotherapy. Then all patients underwent definitive surgery including MRM+AC or BCS+AC. The patients’ demographic, the pathologic and molecular subtypes date of the primary tumor were recorded. Results. The mostly distributed age group was belong to group 46-55 yrs in 22, 36.7%. The mean age was 49.7±10.8 yrs. The IDC represented the most common histopathological types of BC. The most of cases seen in upper-outer quadrant (UOQ). The results post-chemotherapy as followed: ypTx stage reported in 32 (53.3%), ypT1 in 15 (25.0%), ypT2 in 10 (16.7%) and ypT3 in 3 (5.0%). ypN0 stage in 40 patients (66.7%), ypN1 in 11 (18.3%), ypN2 in 6 (10.0%), and ypN3 in 3 (5.0%). There was a high statistical difference between cT and ypT in pre and post-chemotherapy (P<0.0001), between cN and ypN in pre and post-chemotherapy (P=0.001) and between M and ypM in pre and post-chemotherapy (P=0.002). The mass location (P=0.005) and tumor size (P = 0.011) had significantly impacted on BC responses post NACT. 18(30.0%) had clinical complete response (cCR), 32 women (53.3%) had partial response (cPR), six cases (10.0%) had stable disease, and four cases (6.7%) had progressive disease. The cCR was better seen in T1 (77.8%) than T2 (22.2%), with statistical significant difference (P=0.002). The cCR was better seen in N0 (61.1%) than N1 (38.9%), with a high statistical significant difference (P<0.0001). Conclusions. The commonest age breast cancer is four to five decade. The IDC and mass situated at UOQ are the most common features of BC. Approximately, 30.0% of women have clinical complete response (cCR), 53.3% have partial response (cPR), 10.0% have stable disease, and 6.7% have progressive disease post NACT. The ER positive, PR positive, and HER2neu negative are the mostly frequent subtype recorded in this study. The cCR is better seen in T1 and N0 stages. ER+ and PR+ are more reported after NACT whereas HER2neu- is more post NACT.

Abstract Background: Guam has significant ethnic disparities in breast cancer incidence, with rates varying from 46.7 per 100,000 among Asian women to 137.5 per 100,000 among Micronesian women. Incidence rates for Filipino, CHamoru (indigenous people), and White women are 59.8, 94.0, and 121.9 per 100,000, respectively (2013-2017). The Hawai‘i and Pacific Island Mammography Registry (HIPIMR), a collaborative effort between the University of Hawai‘i Cancer Center and the University of Guam Cancer Research Center, collects health and breast imaging data to enhance early cancer detection tailored to the unique ethnic profiles of women in Hawai‘i and Guam. This study aims to identify the distribution of breast cancer risk factors among different ethnic groups in women undergoing screening in Guam. Differences in the prevalence of risk factors may explain variations in incidence patterns. Methods: This study included 1,413 women undergoing mammography screening at FHP Health Center in Guam, from November 2023 to May 2024. The risk factors were classified as follows: BMI (≥25), age of menarche (≤13), age of first pregnancy (≥30), number of live births (≤1), age of menopause (≥55), and family history of first-degree relatives. The robust Poisson method was used to estimate prevalence ratios (PR) of risk factors among ethnic groups, adjusted for age and education. Asians were used as the reference group due to their lowest incidence rates. Furthermore, the total risk score was calculated by summing all the risk factors. ANOVA was used to test the differences in average risk scores among different ethnic groups. Results: All ethnic groups had significantly higher prevalence of being overweight or obese compared to Asian women. The prevalence ratios were highest for Micronesians (PR=1.73, 95% CI: 1.40, 2.13) and CHamoru (PR=1.55, 95% CI: 1.27, 1.90). CHamoru women had the highest rates of breast cancer family history (PR=1.74, 95% CI: 1.19, 2.54). However, CHamoru women had a lower prevalence of having a small number of live births (PR=0.39, 95% CI: 0.24, 0.65) and an older age at first birth (PR=0.83, 95% CI: 0.71, 0.96) when compared to Asian women. There was a significant difference in average score among ethnic groups (P<.001). CHamoru women had significantly higher score (2.35) than Filipino (2.08) and Asian (2.00) women. Conclusion: Our study reveals disparities in risk factors across ethnic groups, consistent with the Guam Cancer Registry's reports of high breast cancer rates among Micronesian and CHamoru women. This project is ongoing, with the aim of linking our data with the Guam Cancer Registry. This linkage will enable us to identify breast cancer cases among participants and compare risk factors across different ethnic groups for women with and without breast cancer. Acknowledgement: This research was funded by the National Cancer Institute: The University of Guam/University of Hawaii Cancer Center Partnership to Advance Cancer Health Equity, Grant U54CA143728 (University of Guam, YCP)/Grant U54CA143727 (University of Hawaii Cancer Center). Citation Format: Gian Paras, Su Bin Jin, Rose Grino, Cabrini Aguon, John Shepherd, Grazyna Badowski. Ethnic variations in breast cancer risk factors distribution in Guam, HIPIMR study [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr A027.

This review will determine the prevalence and incidence of oral cancer and pre-cancerous lesions in indigenous populations. There are approximately 476 million indigenous individuals worldwide. Oral cancer affected over 350,000 people globally in 2018, with approximately 80% of cases occurring in the indigenous population. Moreover, the incidence of pre-cancerous lesions is high in this population, accounting for 48.3%. Limited evidence exists regarding the burden of oral cancer among indigenous populations despite research on oral health disparities in this group. Studies on the burden of oral cancer and pre-cancerous lesions in indigenous groups, considering rates, ratios (prevalence or mortality), or survival proportions, will be considered for inclusion. There will be no limitations on study design, language, age, gender, or geography. We will exclude studies that only identify, diagnose, or screen oral cancer and pre-cancerous lesions without mentioning prevalence and incidence. This review will follow the JBI methodology for systematic reviews of prevalence and incidence. Databases to be searched will include MEDLINE (Ovid), Embase (Ovid), CINAHL (EBSCOhost), Cochrane Central Register of Controlled Trials, Scopus, and Dentistry and Oral Sciences Source (EBSCOhost). ProQuest Dissertations and Theses, OAIster, International Association for Dental Research conference abstracts, Google Scholar, government reports, and cancer registry reports will also be screened for unpublished studies. Two reviewers will independently screen articles, and data will be extracted using a customized form. Narrative data synthesis will be conducted and, where appropriate, meta-analysis will be performed. Methodological quality will be assessed using JBI's critical appraisal tool for prevalence studies. PROSPERO CRD42023402858.

Squamous cell carcinoma of the nasal vestibule (SCCNV) is a rare disease, distinctly different in presentation, treatment, and outcome from squamous cell carcinoma (SCC) of the nasal cavity and paranasal sinuses. However, these are often not analyzed separately. The Netherlands Cancer Registry (NCR) and pathology reports from the Dutch Nationwide Pathology Databank (PALGA) were used to identify all newly diagnosed SCCNV cases in the Netherlands between 2008 and 2021. A total of 763 patients were included. The yearly incidence rate displayed a significant downward trend with an annual percentage change (APC) of -3.9%. The 5-year overall survival (OS) and disease-free survival were 69.0% and 77.2%, respectively. The 5-year relative survival was 77.9% and improved slightly over the inclusion period. OS for patients who were staged cT3 appeared to be worse than those staged cT4a, calling the applicability of the TNM-classification into question. SCC of the nasal vestibule is rare, with declining incidence rates. Introducing a specific topography code for SCCNV is recommended to enhance registration accuracy. The TNM classification seems poorly applicable to SCCNV, suggesting the need to explore alternative staging methods.

Introduction. Colon cancer is considered one of the most significant health issues in the world where, according to the GLOBOCAN 2020 data, it is diagnosed in 1,931,590 patients annually and is the cause of death in 935,173 patients. Approximately 3,500 new cases of colon cancer are diagnosed each year in Croatia. Aim. To present and analyze the recent trends in the incidence of colon cancer in Croatia for the period from 2001 to 2018 and trends in mortality for the period from 2001 to 2019. Methods. The analysis of colon cancer incidence reports for the period from 2001 to 2018 gathered from the Croatian National Cancer Registry and mortality reports obtained from the database of the Croatian Bureau of Statistics and the Croatian Institute of Public Health. The trends in incidence and mortality were processed using the Joinpoint program. Results. An incidence rate of 626.8 per 100,000, 706.4 per 100,000 for males, and 552.4 per 100,000 for females was recorded. In the year 2018, 13,809 people died from cancer in Croatia, including 8,049 men and 5,760 women. The mortality rates were 337.8 per 100,000, 407.5 per 100,000 for males, and 272.6 per 100,000 for females. In women, colon cancer ranked second in terms of incidence, while in men it was in the third place. The total number of new cases was 2,121 for men and 1,508 for women, totaling 3,629 cases. The share of colon cancer in the number of neoplasms in 2018 was 14.1%. Conclusion. The trends in the incidence and mortality rates of colorectal cancer in Croatia still show an increasing tendency in standardized rates.