Canakinumab For Atherosclerotic Disease Research Articles

A bibliometric analysis of immunotherapy for atherosclerosis: trends and hotspots prediction.

An increasing number of studies have demonstrated that immunotherapy may play a significant role in treating Atherosclerosis and has emerged as a promising therapy in this field. The aim of this study is to provide a comprehensive perspective through bibliometric analysis and investigate the existing hotspots and frontiers. This study searched records from Web of Science, PubMed, and Scopus from January 1, 1999, to May 27, 2023. By using bibliometric software CiteSpace (6.3.R1) and VOSviewer (1.6.19), co-occurrence analysis was used to count the frequency of co-occurrence of certain elements (e.g., countries, regions, institutions, etc.), cluster analysis was used to classify keywords, and burst analysis was used to identify research trends and hotspots. The results showed that the number of annual publications has grown in a fluctuating manner; the USA, China, and the Netherlands have the highest numbers of publications, and the top three institutions are located in the Netherlands, Sweden, and the USA. In addition, Nilsson J published the highest number of papers; Ridker PM and his article "Anti-inflammatory Therapy with Canakinumab for Atherosclerotic Disease" have played prominent roles. The top four Journals with the highest numbers of publications are "Arteriosclerosis Thrombosis and Vascular Biology", "Frontiers in Cardiovascular Medicine", "Circulation" and "Vaccine". In addition, keyword analysis indicates that inflammation, nanoparticles, adverse events associated with immune checkpoint inhibitors, T cells and tumor necrosis factor will be future research hotspots. This study provides a comprehensive bibliometric analysis of immunotherapy in atherosclerosis, offering insights that advance scientific understanding. It not only assists researchers in grasping the current hotspots in this field but also reveals potential directions for future investigation. Moreover, future studies can optimize immunotherapy strategies based on hotspot predictions to decelerate the progression of atherosclerosis.

Association between Chronic Liver Disease and Atherosclerosis: An Inflammation as Common Pathway

Atherosclerosis status as an inflammatory disease has been suggested and anti-inflammatory therapy with canakinumab for atherosclerotic disease has been recently reported. The author previously described the relationship between APRI (aspartate aminotransferase to platelet ratio index) and endothelial function assessed by Flow-Mediated Vasodilation (FMD), thereby suggesting that APRI may reflect systemic atherosclerosis condition in elderly patients without hepatic-related causes. Some reports of the relationship between NAFLD/NASH and atherosclerosis status and between chronic Hepatitis C Virus (HCV) infection and atherosclerotic state have been described. As both chronic liver disease and atherosclerosis involve severe inflammatory processes, at least common pathway may be present for the development and treatment of these inflammatory diseases. The current knowledge of the relationship between chronic liver diseases (NAFLD/NASH and HCV infection) and atherosclerosis and a novel therapeutic strategy is reviewed. Based on the several evidences, the author suggests that an association between chronic liver disease and systemic atherosclerosis may be present due to the presence of the inflammation as a common pathway. It is plausible that direct acting antivirus therapy is a potential strategy for not only liver disease but also endothelial dysfunction and atherosclerosis in patient with HCV infection. It has been suggested that momelotinib as a novel treatment may play a potential therapeutic benefit to a high-risk patients with NAFLD/NASH.

Coronavirus 2019 Disease (COVID-19), Systemic Inflammation, and Cardiovascular Disease.

Acute respiratory failure associated with the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2), has rapidly spread worldwide and presents critical challenges for the public health and medical communities The World Health Organization (WHO) has declared SARS-CoV-2 a public health emergency of international concern, with a global estimate of over 7 million human infections and more than 400000 deaths worldwide as of June 12, 2020 A 2020 report by the China Medical Treatment Expert Group for Coronavirus disease 2010 (COVID-19) (2) showed that the clinical spectrum of the viral infection is dominated by fever (up to 88 7% of patients during hospitalization) and cough (67 8% of patients) followed by symptoms such as headache, fatigue, or shortness of breath

A New Perspective for Chinese Medicine Intervention for Coronary Artery Disease: Targeting Inflammation.

Inflammation, which plays a critical role in atherosclerosis and the occurrence of acute cardiovascular events, may be a new target for treatment of coronary artery disease (CAD) to reduce residual cardiovascular risk. Recently, Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease (CANTOS), the largest scale clinical trial that targeted inflammation but not lipids, has affirmed for the first time the inflammatory hypothesis of artherosclerosis and marked the advent of an exciting era of targeting inflammation for the prevention and treatment of cardiovascular diseases. Chinese medicine (CM) is a promising adjuvant therapy for CAD in light of its safety and pleiotropic effect of anti-inflammation, anti-platelet, lipid-regulating, endothelium-protection, microcirculation-improving, etc. In recent years, exploration of anti-inflammatory treatment of CAD with CM has been going on from theory to practice. Taking CANTOS as an example, the design strategy to combine CM and Western medicine to inhibit inflammation were discussed in this paper, which might provide a new perspective for CM intervention on CAD.