Activity limitations among transgender and non-binary individuals remain largely unexplored using population-based samples. This study examines the risk of activity limitations across different gender identities in Canada. Using data from the 2021 Canadian long-form Census, logistic regressions estimated the adjusted odds of reporting activity limitations (seeing, hearing, mobility/dexterity, mental, cognitive, and other) across gender identities. Non-binary individuals assigned female at birth (AFAB) had the highest predicted probability of reporting any activity limitations (76.13%), followed by non-binary individuals assigned male at birth (AMAB) at 61.56%, transgender men (44.71%), and transgender women (34.41%). Cisgender men (19.31%) and cisgender women (21.98%) had the lowest probabilities. Mental limitations showed the largest disparity, with 39.4% of non-binary AFAB individuals affected, compared to 4.9% of cisgender men. These findings highlight significant disparities in activity limitations across gender identities. Non-binary and transgender individuals are most at risk for activity limitations. These findings underscore the need for targeted policies to address challenges faced by gender-diverse populations. Future research should investigate the mechanisms behind these disparities. Healthcare policies must prioritize culturally competent, transgender-inclusive care to reduce disparities in activity limitations.
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