Calcium Research Articles

Exploring multivariate machine learning frameworks to parallelize PM2.5 simultaneous estimations across the continental United States.

Exploring multivariate machine learning frameworks to parallelize PM2.5 simultaneous estimations across the continental United States.

Optimized detection of calcium ion in serum using constant potential coulometry with metastable liquid-liquid contact doping enhanced PEDOT: PSS ink.

Optimized detection of calcium ion in serum using constant potential coulometry with metastable liquid-liquid contact doping enhanced PEDOT: PSS ink.

LIPUS activated piezoelectric pPLLA/SrSiO3 composite scaffold promotes osteochondral regeneration through P2RX1 mediated Ca2+ signaling pathway.

LIPUS activated piezoelectric pPLLA/SrSiO3 composite scaffold promotes osteochondral regeneration through P2RX1 mediated Ca2+ signaling pathway.

Piezo1 Promotes Odontogenic Differentiation of Dental Pulp Stem Cells Under Stress Conditions.

Piezo1 Promotes Odontogenic Differentiation of Dental Pulp Stem Cells Under Stress Conditions.

Inosine-5'-monophosphate interacts with the TAS1R3 subunit to enhance sweet taste detection.

Umami and sweet taste detection is mediated by the activation of the TAS1R1/TAS1R3 and TAS1R2/TAS1R3 receptors, respectively. TAS1R2-Venus flytrap domain (VFT) constitutes the primary ligand-binding site for most of the sweeteners whereas TAS1R1-VFT contains the orthosteric binding site for umami compounds. Inosine-5'-monophosphate (IMP), previously known to potentiate umami taste, binds to a site of TAS1R1-VFT adjacent to the L-glutamate site leading to umami synergy. However, the involvement of the TAS1R3 subunit in umami receptor-ligand interactions or in synergy with IMP has never been demonstrated. To elucidate the VFT contribution to umami and sweet detection, we expressed human TAS1R1- and TAS1R3-VFTs in bacteria. Ligand binding studies quantified by intrinsic tryptophan fluorescence revealed that both TAS1R1- and TAS1R3-VFTs are able to interact with umami compounds. Cellular assays revealed that IMP is able, like cyclamate, to modulate the response of TAS1R2/TAS1R3 and TAS1R3 alone stimulated by calcium ions. IMP also acted as an enhancer of TAS1R2/TAS1R3 when stimulated with sucralose, neotame and cyclamate. Taking together, our data demonstrated that IMP modulates sweet compound detection at the receptor level acting via the TAS1R3 subunit. This research suggests more complex receptor interactions between umami and sweet taste qualities and paves the way for development of new sweetness enhancers.

Seroprevalence of zoonotic pathogens and related haematological and biochemical profiles in Fonni's dogs in rural conditions.

Seroprevalence of zoonotic pathogens and related haematological and biochemical profiles in Fonni's dogs in rural conditions.

Trypsin-catalyzed asymmetric aldol reactions of isatins with cyclic ketones and the mechanistic insights on activity differences at theoretical level.

Trypsin-catalyzed asymmetric aldol reactions of isatins with cyclic ketones and the mechanistic insights on activity differences at theoretical level.

Pollution in marine bivalves: The immunosuppressive effects of microplastics on Anadara granosa.

Pollution in marine bivalves: The immunosuppressive effects of microplastics on Anadara granosa.

Label-free optical mapping for large-area biomechanical dynamics of multicellular systems.

Label-free optical mapping for large-area biomechanical dynamics of multicellular systems.

Adipose-targeted nanohybrid as a browning inducer for synergistic hyperthermia-pharmacotherapy of obesity.

Adipose-targeted nanohybrid as a browning inducer for synergistic hyperthermia-pharmacotherapy of obesity.

Mitochondrial calcium overload contributes to mechanical allodynia in neuropathic pain via inducing mitochondrial dynamic imbalance.

Mitochondrial calcium overload contributes to mechanical allodynia in neuropathic pain via inducing mitochondrial dynamic imbalance.

Biocompatibility and osteogenic potential of novel tricalcium silicate-based materials in human dental pulp stem cells: Advancing vital pulp therapies.

Biocompatibility and osteogenic potential of novel tricalcium silicate-based materials in human dental pulp stem cells: Advancing vital pulp therapies.

Advances in the study of NMDA receptors in depression pathogenesis and the antidepressant efficacy of their antagonists.

Advances in the study of NMDA receptors in depression pathogenesis and the antidepressant efficacy of their antagonists.

CUPID: A free drug discovery platform for the explainable multi-ion channel assessment of cardiotoxicity.

CUPID: A free drug discovery platform for the explainable multi-ion channel assessment of cardiotoxicity.

Investigating potential molecular mechanisms of antiepileptic drug-induced depression through network toxicology and molecular docking.

Investigating potential molecular mechanisms of antiepileptic drug-induced depression through network toxicology and molecular docking.

Toxic effects and transcriptome analysis of the early life stages of Larimichthys crocea exposed to the bloom-forming dinoflagellate Alexandrium tamarense.

Toxic effects and transcriptome analysis of the early life stages of Larimichthys crocea exposed to the bloom-forming dinoflagellate Alexandrium tamarense.

Ultrasound-actuated ion homeostasis perturbator for oxidative damage-augmented Ca2+ interference therapy and combined immunotherapy.

Ultrasound-actuated ion homeostasis perturbator for oxidative damage-augmented Ca2+ interference therapy and combined immunotherapy.

Changes in calcium ion concentration as the common driver for Na, K, S, and B incorporation during inorganic calcite precipitation in Mg-free artificial seawater

Changes in calcium ion concentration as the common driver for Na, K, S, and B incorporation during inorganic calcite precipitation in Mg-free artificial seawater

In vitro reversible photoinactivation in a novel variant of Mnemiopsin 2.

In vitro reversible photoinactivation in a novel variant of Mnemiopsin 2.

Transcriptomic analysis reveals potential biomarkers for early-onset pre-eclampsia using integrative bioinformatics and LASSO based approach.

Transcriptomic analysis reveals potential biomarkers for early-onset pre-eclampsia using integrative bioinformatics and LASSO based approach.