This article discusses the designing of multi-level information systems based on a subject domain model in the form of ontology. The principles of construction of multilevel systems are formulated; description structure and management levels of such systems are defined. Formal model of multilevel system is proposed. Proposed model is based on set-theoretic approach and takes into account aspects of multilevel system functioning: hierarchical, administrative, functional, and communicational. The peculiarities of creation and use of such systems are analyzed. Semantics of each level of the multilevel system based on ontological description is itemized. An approach to building of multilevel agents-based information systems using ontology of subject domains of their application is proposed. The universality of model description of agents within of the proposed approach is shown. The main roles of the agents as parts of multilevel systems and aspects of using and enriching by them of knowledge about the subject area of application are defined. The proposed approach to the designing of multilevel agent-based systems ensures the harmonization of semantics, functionality and architectural design implementations, and allows to realize pass-through process design with a combination of different notation for modeling systems. This model represents different levels of abstraction when considering information systems, while maintaining a meaningful relationship between these levels, ensuring correct transition from one level to another abstract representation, without losing the semantic unity at all levels.
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