Desulfurization building gypsum was used as the main gelled material and fly ash was used as filler to prepare the new type desulfurization gypsum block. the mechanical properties of the new type desulfurization gypsum block was improved by adding compound excitation agent into the desulphurization gypsum-fly ash cementing material to stimulate its activity. The water resistant performance of the new type desulfurization gypsum block was improved through adding wax-alcohol compound waterproofing agent into it. Experimental results show that when the filling amount of fly ash was 20%(the quality of desulfurization gypsum), the impact on the strength of gypsum was minimal; when the dosage of compound excitation agent was 1.75%, the excitation effect of desulphurization gypsum-fly ash cementing material was best; when the dosage of wax-alcohol compound waterproofing agent was 0.4%, the water resistance of new desulfurization gypsum block was optimal.