Case1.—In October, 1928, a student, aged 18, of Italian origin, consulted me at Georges polyclinic for seborrhea of the face and scalp. Careful examination disclosed that he was of great scientific interest, owing to the unusual coloration of his skin and gums. During childhood he had had measles and diphtheria. He had smoked a great deal since the age of 15. He suffered from constipation, which sometimes lasted five days. There was nothing of importance in the heredity except that his father's brother had strikingly dark skin. The patient was of middle height and normal constitution, and his general condition was satisfactory. The mental faculties were higher than the average. The internal organs were normal, except that systolic sounds were heard at the apex of the heart. Analysis of the urine gave normal results. There were no signs of syphilis or Addison's disease. The patient firmly refused to