To investigate the clinical and in vitro performance of single-component orthodontic adhesives under metal brackets. Bimaxillary orthodontic treatment was required for sixty patients and 60 premolar teeth were divided into three groups (n: 20). The single-component orthodontic adhesives Biofix and GC Ortho Connect (GC) that did not require primers were compared to the control group using Transbond XT, which was applied with a primer. For each patient, total bonding time was measured. The Adhesive Remnant Index (ARI(Bracket)) score was noted over 12months. In vitro tests were used to evaluate specimens, shear bond strength (SBS), ARI(Bracket), and Enamel Surface Index (ESI). After in vitro debonding, the enamel surface and bracket base were analyzed using scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDX). Clinical failure rate with primer was 9.0%, while it was 8.0 and 10.0 for GC and Biofix, respectively. The mean in vitro SBS values of the Biofix, GC, and Transbond XT groups were 8.21, 8.07, and 7.37MPa, respectively. There were no statistically differences in clinical failure (p = 0.160) and SBS values (p = 0.158). Mean differences in bond-up time per jaw were 9.65, 10.51, and 11.97min, which were statistically significant (p = 0.0001). Single-component adhesives had acceptable SBS values and enamel effects according to SEM-EDX analysis. Clinically, bonding failure was not shown statistically inferior to bonding with primer. There was also a significant difference in bond-up times. Considering an intensely working clinic with bonding processes for at least two jaws per day, this means a saving of the chair time of 1 patient per week. However, better saliva contamination and moisture control with lack of the primer stage and, thereby, an acceptable bracket failure rate will bring clinically significant results with less chair time for clinicians.
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