Blood Sugar Levels In Diabetics Research Articles

Total Phenolics, Flavonoids, and ɑ-Glucosidase Inhibitory Activity of Red Betel (Piper crocatum) Extract in Various Solvents

Alpha-glucosidase enzyme activity needs to be inhibited to avoid increasing blood sugar levels in diabetics. Red betel leaf extract is reported to have active compounds such as phenolics and flavonoids that have alpha-glucosidase enzyme inhibition activity. Previous research showed that 70% betel leaf extract has an ɑ-glucosidase enzyme inhibition activity of 69.84%, but it is not yet known how the effect of extracts with different levels of polarity on the inhibition activity of alpha-glucosidase enzyme. This study aimed to determine extracts that have optimal levels of phenolic and flavonoid content and the highest suppression of α-glucosidase activity. The multistage maceration method was used to extract red betel leaf simplicia using solvents with different levels of polarity (n-hexane, ethyl acetate, methanol). Tests were conducted on overall phenolic concentration, flavonoids, and ɑ-glucosidase inhibition ability. Data were analyzed using one-way ANOVA test with Tukey's further test (p<0.05). The results of the assessment of phenolic concentration, flavonoids, and α-glucosidase inhibitory activity as a whole showed statistically significant differences (p<0.05) in all extracts with the highest total phenolic and flavonoid content found in the n-hexane extract of 25.68 ± 0.29 mg GAE/g and 65.84 ± 0.96 mg QE/g respectively. Meanwhile, methanol extract of red betel leaf became the best extract in this study with the greatest inhibition among all extracts with a percent α-glucosidase inhibition value of 43.87 ± 1.83%.

Exploring the relationship between self-management and blood glucose level in patient with type 2 diabetes mellitus

Background: Diabetes mellitus (DM) is a condition characterized by high blood sugar levels resulting from unstable blood sugar levels in diabetics. DM can not only be treated with pharmacological therapy but also requires non-pharmacological therapy, one of which is self-management. Objective: to determine the relationship between the level of self-management and blood glucose in type 2 diabetes mellitus. Methods: This research employed a cross-sectional design with 35 respondents selected through an accidental sampling technique. Data collection involved using the Summary of Diabetes Self-Care Activities (SDSCA) questionnaire and a Glucometer. The data were then analyzed using the Spearman Rank Test. Results: The data analysis revealed that 62.9% of patients with Type 2 DM experienced self-management in the medium category, and 88.6% had blood sugar levels in the high category. Based on the analysis results, a p-value of 0.180 was obtained, indicating that there is no relationship between self-management and blood glucose levels in patients with type 2 diabetes mellitus. The correlation coefficient of -0.232 indicated a low correlation strength, and as the correlation coefficient is negative, the relationship between the two variables is not in the same direction. Conclusions: It is evident that need more investigation of self-management practices to achieve stable or normal blood sugar levels. Improving self-management is crucial as it can help prevent complications associated with diabetes mellitus.

Benefits of Huangqi Herbal Treatment for Patients with Diabetes Mellitus

Introduction: Diabetes mellitus (DM) is a metabolic disorder caused by abnormalities in insulin secretion and an imbalance between insulin supply and demand. In Traditional Chinese Medicine (TCM), diabetes mellitus is better known as Xiao Ke. In TCM, Xiao Ke disease is caused by internal heat exhaustion deficiency, and one of the traditional treatments for diabetes is the herbal Huang Qi (Radix astragali). Method: This research is a case study, where the researcher makes an in-depth observation of the use of Huang Qi herbs in diabetes mellitus patients. Result and Discussion: The results of diabetes treatment in the initial observation of the patient's blood sugar were 152 mg/dL, and in week 4, it decreased to 86 mg/dL. Isoflavonoids, saponins, and polysaccharides are the three main types of beneficial compounds that have pharmacological activity and therapeutic efficacy in many diseases, one of which is diabetes. In TCM, Huang Qi is beneficial for tonifying Qi and strengthening Yang in spleen Qi deficiency so that the spleen can increase its effectiveness in transformation and transportation. Conclusion: The results of the treatment of diabetes mellitus, or Xiao Ke, using Huang Qi herbs are proven to be able to reduce blood sugar levels in diabetics.

PENGARUH REBUSAN DAUN BINAHONG (ANREDERA CORDIFOLIA) TERHADAP KADAR GULA DARAH PENDERITA DIABETES MELITUS TIPE 2

Diabetes mellitus (DM) is a chronic disease that occurs when the body does not get proper use of insulin or the pancreas does not produce enough insulin. High blood sugar levels will be a thing that must be considered for people with DM if prevention and treatment are not carried out. One of the herbal plants that can be used as traditional medicine for the treatment of diabetes mellitus is Binahong. The purpose of this study was to determine the effect of binahong leaf decoction on blood sugar levels in patients with type 2 diabetes mellitus. This type of research was a quasi-experimental design with one group pretest posttest design. This research was conducted at the Rejosari Health Center. The research sample was 15 people using the purposive sampling technique who were given binahong leaf decoction for 4 consecutive days who were checked for blood sugar before consuming the stew (pretest) and 2 hours after consuming the stew (posttest). Analysis of the data used in this study is the dependent T test. The results showed that there was an effect of giving binahong leaf decoction on blood sugar levels with p-value (0,000) < alpha (0,05). There is an effect of steeping the stew of binahong leaves on the blood sugar levels of people with diabetes mellitus in the working area of ??the Pekanbaru Rejosari Health Center. Research on giving binahong leaf decoction to diabetics is very effective because binahong leaves contain compounds that can lower blood sugar levels such as saponins, flavonoids and alkaloids, so that blood sugar levels in diabetics can go down by consuming one of these herbal medicines.

An Observational Study on the Effect of Yoga and Sudarshan Kriya in Type 2 Diabetes Mellitus Patients.

IntroductionOne of the major health problems in many countries including India is type 2 diabetes. Yoga is being explored as an alternative therapy for the management of diabetes.MethodsAmong the total of 137 participants who successfully completed the ‘Living Well’ workshop by the Art of Living, 84 with type 2 diabetes were assessed for change in random blood sugar levels, systolic and diastolic blood pressure levels (SBP/DBP), and pulse rate over seven days. In the Living Well workshop, the participants performed a comprehensive Yogic Breathing Program that included yogic movements and postures (Asana), relaxation practice, three-stage Pranayama, Sudarshan Kriya Yoga (SKY), breathing techniques, and discussion of stress relieving principles over those seven days. The parameters were recorded at the time of enrollment and after the completion of seven days of the workshop.ResultsThere was a greater (p<0.05) percent reduction in the mean blood sugar level in diabetics as compared to non-diabetic individuals. However, the reduction in SBP and DBP were similar (p>0.05) in diabetics and non-diabetics. The percent reduction in the pulse rate however was greater (p<0.05) in diabetics than non-diabetics.ConclusionComprehensive yogic breathing practices comprising SKY may be beneficial in patients with type 2 diabetes mellitus.

Herbal Supplementation to Improve Management of Diabetes Mellitus Patient Care: Current Progress

Diabetes affects millions of patients round the world, with dancing complications, inclusion, cardiovascular diseases, neuropathie and rétinopathie. Howe ver, the progression of type 2 diabetes mellites might be slowed down and its health impact limited. Nevetheless, current anti-diabetic treatments have limitations and is not Enugu to significantly improve the cardiovascular prognosis of diabetic patients. This work focus on herbal supplement and nutrition as potentiel thérapies for type 2 diabètes mellitus. Actually, Herbal and nutritional supplémentation is required in the management of diabétiques patients, a binding shared unanimously by scientists. Récent diabetologists have come to the évidence that a therapeutic supplement consisting of nutrients and herbal is necessary to optimize the treatment of diabetes. The treatment of Type 2 diabetes mellitus, winch is very often Associate with overweight, is based on hygiene and dietetic measures and, where appropriate, on taking oral antidiabetics. This review describes the therapeutic arsenal of conventionnel oral antidiabetic drugs and emphasizes on innovative therapeutic option introduction herba medicine and nutrition to the management of diabetic patients. Recent studies showed interesting potential in the reduction of blood sugar for many herbal for example Cinnamon, also berberine has been linked to the reduction of blood glucose levels, insulin levels and showed to be as effective as metformin, the most commonly prescribed drug for diabetics, at controlling blood sugar levels in diabetics. Moreover, a medicinal plant or herbal mixture can provide multi-targeted therapeutic action due to its complex chemical composition with hundreds of active ingredients such as oligosaccharides, alkaloids, polyphenols, flavonoids, tannins and at the same time ensure safety for the patients. We conclude by the fact that herbal and nutritional supplementation can bring major and promising progress in order to improve the patient care, by slowing the progression of type 2 diabetes and limiting its complications.

A Brief Review on Botanical Description, Medicinal Uses and Pharmacological Actions of Lablab Purpureus

Lablab purpureus is a species of the beans, which is commonly known as a Dolichos bean belongs to the family Fabaceae. The crop is believed to be cultivated in south Asia and introduced into Africa. It is a multipurpose leguminous plant and holds a unique position as a vegetable among legumes because of its high level of nutritional value. The different varieties of the plant show the different composition. It is a rich source of proteins which possess a variety of health benefits, including reducing susceptibility to heart and kidney disease, and lowering blood sugar levels in diabetics. The field crop is an herbaceous, climbing, short-lived plant with a vigorous taproot and cultivated in a large extent in Karnataka and adjoining districts of Kerala, Tamil Nadu, Andhra Pradesh, Uttar Pradesh and Maharashtra. The phytochemical analysis of the plant shows the presence of various components such as sugar, alcohols, phenols, steroids, essential oils, alkaloids, tannins, flavonoids, saponins, coumarins, terpenoids, pigments, glycosides, and anthranoids. The pharmacological study of the plant showed that it possesses antioxidant, antimicrobial, cytotoxic, insecticidal, anti-obesity, immuno-modulatory, hypolipidemic, antiviral, anticancer, analgesic, anti-fungal, hepatoprotective, anticholesterolemic, antidote and carminative activity. The plant was also used as anti-inflammatory, aphrodisiac, antispasmodic, antidiabetic, febrifuge, flatulent and for phlegmatic disorders. Keywords: Botanical description, Dolichos bean, Lablab purpureus, Nutritional value, Protein, Pharmacological actions.

Deranged Blood Sugar Levels in Type 2 Diabetics induced impairment of nerve conduction

Background: One of the complications of diabetes is Peripheral neuropathy that becomes the source of frailty and indisposition. Metabolic malfunction is the root cause in diabetes that target nerve damage. Aim: To evaluate electrophysiological case research with respect to effect of diabetics on nerves and to link it along with blood sugar Methods: Assessment of nerves related to of upper limb was carried out for motor nerve by aid of computerized system and surface electrodes in 40 male individuals suffering from type 2 and 40 healthy males. The ulnar and median nerve was selected for case research. Parameters that were being discussed included conduction velocity and distal latency Results: Diabetics have increased distal delay and reduced conduction velocity. These variables were linked to blood sugar levels in diabetics. Conclusions: There is affect to nerves in case of diabetes as shown by poor motor nerve function and depicted via testing electro physiologically. Increase in sugar blood levels is associate with damage to nerves. Keywords: Electrophysiological tests, Conduction velocity, Peripheral neuropathy, Diabetes,

Diabetes mellitus quality care management: The promise of herbal supplementation

Overcoming diabetes is a major health challenge of the 21st century. WHO predicts that by 2030 it will be the seventh leading cause of death in the world and calls for global action to stop its rise and improve care. Actually, Herbal and nutritional supplementation is required in the management of diabetic patients, a finding shared unanimously by scientists. Recently diabetologists have come to the evidence that a therapeutic supplement consisting of nutrients and herbal is necessary to optimize the treatment of diabetes. The treatment of Type 2 diabetes mellitus, which is very often associated with overweight, is based on hygiene and dietetic measures and, where appropriate, on taking oral antidiabetics .This review describes the therapeutic arsenal of conventional oral antidiabetic drugs and emphasizes on innovative therapeutic option introducing herbal medicine and nutrition to the management of diabetic patients. Recent studies showed interesting potential in the reduction of blood sugar for many herbal for example Cinnamon, also berberine has been linked to the reduction of blood glucose levels, insulin levels and showed to be as effective as metformin, the most commonly prescribed drug for diabetics, at controlling blood sugar levels in diabetics. Moreover, a medicinal plant or herbal mixture can provide multi-targeted therapeutic action due to its complex chemical composition with hundreds of active ingredients such as oligosaccharides, alkaloids, polyphenols, flavonoids, tannins and at the same time ensure safety for the patients. We conclude by the fact that herbal and nutritional supplementation can bring major and promising progress in order to improve the patient care, by slowing the progression of type 2 diabetes and limiting its complications.

Evaluation of peripheral nerves of upper limb and its correlation with blood sugar levels: A electrophysiological study in type 2 diabetics

Introduction: Peripheral neuropathy is a complication of diabetes which causes considerable indisposition and frailty. Metabolic derangement in diabetes affects nerve. Aim: To carry out electrophysiological study of nerves in diabetics and to correlate it with blood sugar. Materials and Methods: Nerves of upper limb were assessed for motor nerve conduction with the help of surface electrodes and windows based (Neuro perfect software) computerized system in 50 type 2 diabetic male patients and 50 healthy males. The nerves chosen for study were median and ulnar. Parameters studied were distal latency and conduction velocity. Results: Observation revealed increased distal latency and decreased conduction velocity in diabetics with statistically significant difference. These parameters also showed association with blood sugar levels in diabetics. Conclusions: Diabetes affect nerves as indicated by declined motor nerve function through electrophysiological testing. Elevated blood sugar levels are related with nerve damage. Keywords: Peripheral neuropathy, Diabetes, Electrophysiological tests, Conduction velocity.

A Study on The Impact of The Cassia Auriculata Flower Powder on Blood Sugar Level in Diabetics

A Study on The Impact of The Cassia Auriculata Flower Powder on Blood Sugar Level in Diabetics

In Silico Study of Aglycon Curculigoside A and Its Derivatives as α-Amilase Inhibitors

α-amilase is an enzyme that catalyzes the hydrolysis of starch polysaccharides into oligosaccharides to then produce glucose. Inhibitions of the α-amylase enzyme is an effective strategy in modulating blood sugar levels in diabetics. The aglycon curculigoside A has similar structure to chalcon which is able to inhibit the α-amilase enzyme for the treatment of type 2 diabetes. The aim of this study was to determine the interaction of the curculigoside A aglycone compound and its derivatives with the α-amylase enzyme by using the docking simulation method. Docking simulations were carried out by using AutoDock 4.2 and α-amilase protein (PDB ID: 1B2Y) as macro molecule. The docking results showed that the aglycone curculigoside A and its derivatives able to interacted into the active site of the α-amylase enzyme. Three best ligands according to the simulation and prediction tests were compound 10, compound 23, and compound 41 has formed hydrogen bonding to Asp197, Glu233 and Asp300 residues with free bonding energy of -7.29, -7.22, dan -7.84 kcal/mol, respectively. In conclusion, Three best ligands has the same pattern of hydrogen bonds to the native ligand AC1 (6-methyl-5-(4,5,6-trihydroxy-3-hydroxymethyl-cyclohex-2-enylamino)-tetrahydro-pyran-2,3,4-triol) via amino acids redisues of α-amylase that play a role in the substrate by hydrolysis process. Keywords: aglycon curculigoside A, α-amylase, diabetes, docking

New electrical technique for painless, non-invasive blood glucose tests

A simple capacitive device consisting of a silicon sleeve inside a copper tube shows great promise for monitoring and measuring blood sugar levels in diabetics.

Pengaruh Puasa Ramadhan terhadap Kadar Gula Darah pada Pasien Diabetes Mellitus Tipe II

The purpose of this research is to know the influence of Ramadan Fasting towards blood sugar levels in diabetics in the health center in West Java of Purwakarta. The design of this research uses quasi experiment of pre and post test with the control group, the method uses Purposive sampling done by the sum of 36 samples of respondents. The results of this research are using Independent T-test fast differences in blood sugar levels after fasting Ramadaan in the control group and the intervention group obtained the value of p = 0.039 &lt; α = 0.05. Conclusion the results of this study showed the presence of the influence of fasting of Ramadan towards blood sugar levels in type II diabetes mellitus patients in Healty Center of Purwakarta. It can be concluded that fasting during Ramadan can be used as an alternative diet method that has positive benefits if it is run by type II diabetes mellitus patients which can reduce blood sugar to be more stable.&#x0D; Keywords: Ramadhan Fasting, Blood Glukose Level, Diabetic Mellitus Type II

LEVELS OF DIABETES BLOOD SUGAR WITH TYPE OF CATARACT

Diabetes mellitus was a disease with macro and micro risk of angiopathy, which includes the impact of causing cataracts. Diabetic patients with high sugar levels have a greater chance of developing cataracts at a younger age and certain tendencies towards cataract type. The aim of the study was to analyze the correlation between diabetes blood sugar levels and cataract type. The research design was correlation analysis with Cross-Sectional approach. Samples in the study were some cataract patients who had a history of diabetes mellitus in Surabaya Undaan Eye Hospital as many as 125 people, it was taken using consecutive sampling technique, and fulfilling the criteria of the study (age range 45 - 65 years, have complete medical records related to the continuity of sugar examination results in blood, the incidence of cataracts is not caused by congenital cataracts, juveniles, due to trauma, chemical exposure to UV radiation). Independent variable was the blood sugar level of Diabetes mellitus and the Dependent variable was cataract type. The instruments used were laboratory tests related to blood sugar levels, and medical diagnosis related to cataract type. Data were analyzed by Spearman rho, with a significant value &lt;0.05. The results showed a close association between diabetes and cataracts, where as many as 47.2% with high blood sugar levels, 40% with nuclear cataract type and from 59 respondents with high blood sugar levels 26 people experienced nuclear cataract type, with rho value = 0.001. The mechanism of glucose toxicity in Diabetes Mellitus which causes cataracts can go through three paths: increased activity of the aldose reductase enzyme which causes the formation of sugar alcohol, sorbitol and galactitol in crystalline lenses; through the non-enzymatic replication process; and at high blood glucose levels a glucose oxidation process will occur which causes oxidative stress conditions. Maintenance of managing blood sugar levels must be a concern for diabetics.&#x0D; &#x0D; Keywords: Blood Sugar Level, Diabetes Mellitus, Type of Cataract &#x0D;

LEVELS OF DIABETES BLOOD SUGAR WITH TYPE OF CATARACT

Diabetes mellitus was a disease with macro and micro risk of angiopathy, which includes the impact of causing cataracts. Diabetic patients with high sugar levels have a greater chance of developing cataracts at a younger age and certain tendencies towards cataract type. The aim of the study was to analyze the correlation between diabetes blood sugar levels and cataract type. The research design was correlation analysis with Cross-Sectional approach. Samples in the study were some cataract patients who had a history of diabetes mellitus in Surabaya Undaan Eye Hospital as many as 125 people, it was taken using consecutive sampling technique, and fulfilling the criteria of the study (age range 45 - 65 years, have complete medical records related to the continuity of sugar examination results in blood, the incidence of cataracts is not caused by congenital cataracts, juveniles, due to trauma, chemical exposure to UV radiation). Independent variable was the blood sugar level of Diabetes mellitus and the Dependent variable was cataract type. The instruments used were laboratory tests related to blood sugar levels, and medical diagnosis related to cataract type. Data were analyzed by Spearman rho, with a significant value &lt;0.05. The results showed a close association between diabetes and cataracts, where as many as 47.2% with high blood sugar levels, 40% with nuclear cataract type and from 59 respondents with high blood sugar levels 26 people experienced nuclear cataract type, with rho value = 0.001. The mechanism of glucose toxicity in Diabetes Mellitus which causes cataracts can go through three paths: increased activity of the aldose reductase enzyme which causes the formation of sugar alcohol, sorbitol and galactitol in crystalline lenses; through the non-enzymatic replication process; and at high blood glucose levels a glucose oxidation process will occur which causes oxidative stress conditions. Maintenance of managing blood sugar levels must be a concern for diabetics.&#x0D; &#x0D; Keywords: Blood Sugar Level, Diabetes Mellitus, Type of Cataract &#x0D;

Glycation of collagen matrices promotes breast tumor cell invasion.

Cancer metastasis is a physical process in which tumor cells break away from the primary tumor, enter, and then exit the blood or lymph vessels, and establish secondary tumors in distant organs. Current clinical studies report a higher risk of cancer metastasis for diabetics than non-diabetics. However, due to complex overlapping risk factors between diabetes and cancer, the mechanism underlying this correlation is largely unknown. Elevated lifetime blood sugar levels in diabetics are known to increase glycation of collagen, causing stiffening of the ECM and connective tissue. In this study, we explored the roles of glycation of 3D collagen matrices in tumor cell invasion and migration. Using time-lapse images, we quantitatively compared the motility behavior of malignant breast tumor cells (MDA-MB-231) and co-culture spheroids (1:1 ratio of MDA-MB-231 cells with normal epithelial MCF-10A cells) embedded in glycated and non-glycated collagen matrices of various concentrations. Experimental results demonstrated that glycation increased tumor invasion within collagen matrices. More specifically, the average speed of MDA-MB-231 cells was higher in glycated collagen gels than in non-glycated collagen gels for all three gel concentrations tested. Cell spreading characterized by its diffusion coefficient or the effective spheroid radii at various time points was significantly greater in glycated collagen than in non-glycated collagen at a concentration of 3.5 mg/mL. This enhancement was moderate and less evident at lower collagen concentrations of 1.0 and 2.0 mg/mL. These results suggest a possible biomechanical link that relates to the high blood sugar level in diabetic patients and the cancer metastatic outcome.

Aloe Vera: The Miracle Plant and its Therapeutic Uses

Aloe vera is a wonder plant with health benefits so myriad and astounding that hardly any part of human body remains uninfluenced by its healing touch. It acts as a natural fighter against all sorts of infection, an efficient anti oxidant, helps in treating all digestion related problems, heartburn, arthritis, stress, diabetes, rheumatism pain, asthma, cancer and AIDS. It also acts as a laxative, beauty enhancer and it has an effect on lowering blood sugar levels in diabetics. Aloe vera is the oldest medicinal plant ever known and the most applied medicinal plant worldwide. Extracts of Aloe vera is a proven skin healer. Aloe vera help to soothe skin injuries affected by burning, skin irritations, cuts and insect bites and its bactericidal properties relieve itching and skin swellings. Aloe is a powerful detoxifier, antiseptic and tonic for the nervous system. It also has immune-boosting and anti-viral properties. Aloe vera is a useful source of vitamins. Aloe vera gel contains a large range of vitamins - even vitamin B12, Vitamin A, contains B-Group vitamins, Vitamin C, Vitamin E and folic acid. Aloe vera gel contains important ingredients including 19 of the 20 amino acids needed by the human body and seven of the eight essential ones that just cannot be made. Commercially, aloe can be found in pills, sprays, ointments, lotions, liquids, drinks, jellies and creams, to name a few of the thousands of products available.

Applications of Nanotechnology in Diabetes

Nanotechnology offers sensing technologies that provide more accurate and timely medical information for diagnosing disease, and miniature devices that can administer treatment automatically if required. Some tests such as diabetes blood sugar levels require patients to administer the test themselves to avoid the risk of their blood glucose falling to dangerous levels. Certain users such as children and the elderly may not be able to perform the test properly, timely or without considerable pain. Nanotechnology can nowoffers new implantable and/or wearable sensing technologies that provide continuous and extremely accurate medical information.The purpose of this review is to throw more light on the recent advances and impact of nanotechnology on biomedical sciences to cure diabetes.

The Effects of Diet and Vanadyl Sulfate Supplementation on Blood Glucose levels of Diabetics: Review of Current Human Data and Recommendations for Further Study

Studies in the literature have shown that vanadium supplementation has an insulin mimetic effect on the blood glucose levels of both animals and humans [1-8]. In the current literature, several studies have examined the effects of vanadium supplementation on blood glucose levels of both type 1 and type 2 diabetics. However, dietary intake of vanadium has not been considered. It is highly probable that vanadium from food sources may be more effective than supplementation alone due to the synergistic effects of the various food components. This raises several questions: Could a diet high in food sources of vanadium be more effective in controlling blood sugar levels in diabetics compared with vanadium supplements alone? Could a diet high in food sources of vanadium increase the intestinal absorption of vanadium? Could a diet high in food sources of vanadium reduce the need for vanadium supplements while maintaining the effects of lowering blood glucose levels in diabetics? [5,8]. This review examines current human studies in the literature which report the lowering effects of vanadium on blood glucose levels of both type 1 and type 2 diabetics. The authors also recommend further study to determine whether a diet high in vanadium containing foods will improve blood glucose levels in type 1 and type 2 diabetics thereby providing an alternative and complementary means of managing both type 1 and type 2 diabetes.