Aims & Objectives: To assess feasibility (safety and efficacy) of CRRT in children weighing ≤ 10kg using standard adult-sized CRRT machines. Methods 8-year (2010 – 2017) retrospective analysis of data from all patients weighing ≤ 10 kg undergoing CRRT. Survival to PICU discharge, duration of mechanical ventilation,ICU stay, primary diagnosis, markers of illness,severity at admission, CRRT indication, machine, vascular access and CRRT characteristics collected. Descriptive analysis compared survivors and non-survivors. Serial progression in markers were collected(changes in creatinine, fluid overload and electrolytes, bleeding episodes, vascular complications and hypotension following CRRT initiation). Multivariate logistic analysis with step wise regression identified risk factors for non-survival. Subgroup analysis compared ≤5 kg and 5–10 kg children. Results 51 children (≤ 5kg n=29, 5-10kg n=22) received 11349 Hrs of CRRT, 60% had Liver failure. Median weight was 4.4 kg. 56.8% survived to hospital discharge. Survivors had lower PIM2 score at ICU admission (p=0.0019) lower FiO2 requirement at CRRT initiation (p=0.339). Analysis of acute changes showed reductions in fluid overload at 48 hours (p=0.0002) serum creatinine at 24 and 48 hours (p=0.0023, p=0.0110) serum potassium at 4 hours (p=0.0139). No complications related to blood priming, anticoagulation, bleeding or hypotension were observed. On subgroup analysis, filter life was longer in children ≤ 5kg (p<0.0001), maximum blood flow was higher (p=0.0194), and survival was not significantly different (p=0.1672) between less than and more than 5 kg. Conclusions Study demonstrates that CRRT can be safely and effectively delivered on children ≤ 10kg using adult-sized CRRT machines with no major complications and literature-matched survival