Long-term blood pressure (BP) monitoring is necessary for the early diagnosis and treatment of hypertension and other cardiovascular diseases. But they are invasive and intermittent, and they are a real pain in the ass for the patient. The most recent advancements in wearables have transformed the smartwatch into a physical embodiment of a service that, in theory, could enable all-day blood pressure monitoring. In this paper, It propose a deep learning model for CMT (Continuous Monitoring of Blood Pressure), which can be measured using a smartwatch's sensors. For this, it utilizes optical and HR sensors, as well as an accelerometer, on the smartwatch to measure the physiological information of the wearer, such as heart rate (HR) and motion data. The behavior indicators are then input into a deep CNN for feature learning and an LSTM for analyzing temporal characteristics. The features from CNN and LSTM are extracted individually and then integrated and input into the regression model to estimate blood pressure. In this experiment, It acquired physiological signals from 50 unique subjects, as well as the reference blood pressure values, which were used as the dataset for training and testing the framework. It developed out the automatic pipeline, presented in this blog post, on a split dataset of 3 (train, validation, test). Results: It demonstrates the effectiveness of the framework, outperforming most state-of-the-art methods with a Mean Absolute Error of 3.26 mmHg and 2.12 mmHg in SBP and DBP, respectively. The presented framework enables non-intrusive and continuous 24/7 monitoring of blood pressure using widely used personal smartwatches. It’s not implausible to envision wearing a device like this 24/7, keeping track of blood pressure all the time and alerting to possible problems long before they even begin. This one, focusing on hypertension and other cardiovascular diseases (CVDs), may potentially contribute to what is needed to achieve better control and, ultimately, better overall health. (2) Its approach is extensible and applicable to other wearable devices, making it suitable for a broader range of users. In this context, the issue is raised regarding a (smart) watch that purportedly measures blood pressure daily and its significance for medical care.

We planned to reveal the relationship between OPG (osteoprotegerin) level and right heart function in hypertensive patients with normal ejection fraction, using strain analysis, which is a sensitive method in demonstrating subclinical dysfunction. Between February and June 2018, 625 consecutive patients with a diagnosis of hypertension who applied to the cardiology out-patient clinic of our hospital were evaluated for our study and 175 eligible patients were included. The patients were divided into two groups according to their OPG level. Strain analysis was performed in the echocardiographic evaluation. The mean OPG value was 6.33 ± 1.87 pg/l. There were 93 patients (age 51.1 ± 8.5 years) in the low OPG group and 82 patients (age 54.6 ± 10.4 years) in the high OPG group. A significant difference was found between the two groups with regard to age (p = 0.016), statin use (p = 0.026), C-reactive protein level (p = 0.048), office systolic blood pressure (SBP) (p = 0.001) and office diastolic blood pressure (DBP) (p = 0.001). A significant difference was found between values of strain during reservoir phase (RASr) (p = 0.01), strain during conduit phase (RAScd) (p < 0.001) and peak strain rate during reservoir phase (pRASRcd) (p = 0.044). In multivariate regression analysis, age (OR: 1.162, 95% CI: 1.064-1.269, p = 0.001), office DBP (OR: 1.089, 95% CI: 1.020-1.161, p = 0.011) and RAScd (OR: 0.890, 95% CI: 0.815-0.972, p < 0.010) were found to be independent predictors of high OPG. In our study, we found high OPG level was inversely correlated with right atrial strain values and linearly associated with high blood pressure. In order to take advantage of the negative indicators of high OPG, positive results can be obtained in strain values of the right heart by indirectly reducing the afterload of the right heart. This can be done by reducing high systemic blood pressure and providing tight blood pressure control.

The identification of a predisposition in young people to the development of arterial hypertension (AH) is an urgent task of preventive medicine, since the formation of hypertension does not begin at 40—50 years old, as previously thought, but at an earlier age. The article presents the results of a study of systemic hemodynamics by volumetric compression oscillometry (VCO) in students of the Medical Faculty of the State University of Education. In the examination of 191 students aged 18—25, normal blood pressure was noted in 78.5% of cases, a downward trend in blood pressure was detected in 19.4% of the subjects and 2.1% of the subjects had elevated blood pressure. The determination of the main indicators of hemodynamics by the VCO method made it possible to correlate each respondent with a certain profile. Among the examined group, 16 hemodynamic profiles were identified. The hemodynamic profile 222, corresponding to the normal values of heart rate, systemic vascular resistance and stroke volume, was noted in this group only in 31.4% of respondents. The discrepancy in this group of subjects in the number of detected cases with normal blood pressure values to the number of detected cases with normal values of key hemodynamic constants proves the need for early prevention of hypertension, allows identifying a risk group for hypertension, prescribing personalized preventive measures and optimizing preventive medical examination.

Comprehensive ABC (HbA1c, blood pressure, LDL-C) control and cardiovascular disease risk in patients with type 2 diabetes mellitus and major depressive disorder in a South African managed healthcare organisation

Even with modern therapy, people living with HIV (PLWH) commonly experience fatigue and face increased risk of cardiovascular disease. Obstructive sleep apnea (OSA) is common in PLWH and might contribute to these symptoms, yet the impact of OSA treatment in this population is underinvestigated. Academic university-affiliated HIV and sleep medicine clinics. One hundred twenty PLWH underwent polysomnography and completed questionnaires measuring fatigue, daytime sleepiness, perception of cognitive functioning, and sleep quality. Those with OSA were offered positive airway pressure (PAP) therapy. All measurements were repeated after 12 weeks of treatment. Cardiovascular outcome markers included peripheral arterial tonometry (reactive hyperemia index), heart rate, and blood pressure. Seventy persons had OSA and 41 (59%) elected to use PAP. Participants demonstrated a mean (secure digital) age of 52.8 (8.8) years, 39 men, mean body mass index 28.2 (3.9) kg/m 2 , and apnea hypopnea index 4% 33.5 (26.1). PAP therapy was associated with statistically ( P < 0.05) and clinically significant improvements in fatigue [pre 39 (27 to 44) vs. post 42 (32 to 48)], reactive hyperemia index [1.6 (1.4 to 2.2) vs. 2.1 (1.7 to 2.7)], and heart rate [73 (64 to 80.50) vs. 68 (61 to 73) beats per minute]. Daytime sleepiness, sleep quality, and perception of cognitive functioning all showed improvement ( P < 0.05), although changes were clinically modest. Treatment of OSA in PLWH can improve fatigue and markers of cardiovascular health, consistent with PAP treatment of OSA in non-PLWH populations. Our findings support assessment and treatment of OSA in PLWH to address commonly experienced symptoms.

Association Between High-Density Lipoprotein Cholesterol and the Risk of Cardiovascular Disorders: A Cohort Study of Healthy Adults.

In Russia, mortality from major non-communicable diseases accounts for more than 2/3 of total mortality of population. The purpose of the study is to investigate prevalence of main risk factors of development of chronic non-communicable diseases (NCDs) among patients. The study was carried out in 2023-2024 at the basis of the Republican Health Center of Makhachkala of the Republic of Dagestan. The prevalence of risk factors for non-communicable diseases was analyzed using results of sociological survey of 465 respondents and outpatient card data. The low physical activity, high cholesterol, overweight, obesity and high blood pressure are more common among persons with higher education. The smoking, excessive salt intake and insufficient consumption of fruits and vegetables are more common among persons with secondary and secondary specialized education. The highest percentage of smokers was detected in groups of 41-50 age old (24.7%) and 31-40 years old (20.7%). The insufficient awareness about one's level of cholesterol was detected in 17.8% of males and 23.9% of females and about one's level of blood sugar in 34.6% of males and 38.1% of females. The prevalence of main risk factors for NCDs was established for high blood pressure - 30.1%, overweight - 29.2%, obesity - 14.9%, smoking - 18.1%, elevated cholesterol - 41.5%. This data is to be taken into account in developing regional educational preventive programs.

The article presents modern data on non-communicable diseases (NCDs) and their risk factors. The tendency of increasing mortality from NCDs due to increase in the number and aging of the population is noted. The data is presented testifying that, in addition to biological risk factors, influence of environmental factors is increasing, including atmospheric and household air pollution, the levels of which are high in a significant number of countries. It is emphasized that green spaces (e.g., trees, grass, forests and parks) and blue spaces (e.g., lakes, rivers, ponds, etc.) provide beneficial effect on human health, being in fact protective factors for NCDs. The NCD risk factors are found to interact closely with each other: air pollution, depression, tobacco smoking, high blood pressure and obesity have been linked to all NCDs. The evidence is provided that presence of behavioral risk factors for NCDs exacerbates severity of infectious pathology, particularly COVID-19 and other infectious diseases (influenza, HIV, tuberculosis, hepatitis, etc.). Given that NCD risk factors can occur in early childhood, promoting healthy lifestyles among expectant mothers and adolescents should be a priority to reduce NCD risks, especially in low- and middle-income countries.

A comprehensive story of pea peptides and pea polyphenols: Research status, existing problems, and development trends.

Arterial hypertension is a major risk factor for morbidity and mortality in Germany. No current data are available on trends in the incidence of hypertension. The incidence of diagnosed hypertension (ICD codes I10.- to I15.-) and the utilization of 24-hour ambulatory blood pressure measurement (ABPM) and antihypertensive drugs were determined in an analysis of anonymized routine data on 4.8 million persons covered by the statutory health insurance system in Germany. The data were linked to the German Index of Socioeconomic Deprivation on the basis of the subjects' place of residence and evaluated with stratification by age group, sex, and regional socioeconomic deprivation. In 2017, the age-standardized incidence of diagnosed hypertension was 20.6 per 1000 persons. It fell in the first year of the COVID-19 pandemic, rose again in 2021, and reached 20.7 per 1000 in 2023. In 2023, the incidence of diagnosed hypertension was markedly higher in regions with high socioeconomic deprivation than in low-deprivation regions (24.6 versus 17.9 per 1000). Among persons who received a diagnosis of hypertension in 2023, 82.3% received medication and 30.1% underwent ABPM within one year of their diagnosis. The high incidence of diagnosed hypertension underscores the need for a well-developed preventive strategy. The downward trend that was observed over the past decade is no longer evident. This matter should be investigated further with a nationwide investigative survey that also takes undiagnosed hypertension into account.

Lessons Learned From Treating 34 Million People With Hypertension: The Global HEARTS Initiative.

Vipassana meditation (VM), a mindfulness-based practice, has been known to promote good health all the way. Global chronic diseases such as cardiovascular diseases, diabetes, and hypertension often bring physical and mental pain together. Through developing emotional regulation and helping to reduce stress, VM can be used as an alternative medicine in combination with the conventional therapies now used for treating this condition. The aim of the study was to evaluate how VM alters key health measures, including body weight, blood pressure and sugar levels, pulse rate, body mass index (BMI), and emotional state. It also sought to identify changes in emotional spectrum of reactions, such as fear, expectations, and concern before/after the 10-day VM camp. A pre-experimental study was done at Khadavli Vipassana Center, from which time it admitted 156 first-time participants. After excluding four participants, the final sample size was 152. Health indices were assessed before and after the meditation using standard tools, while the emotional spectrum was ascertained with a unstructured questionnaire. Paired samples t-tests and analysis of the content of emotional responses were conducted on the data. There were significant improvements in physical health: the participants' mean weight decreased by 0.8 kg, BMI dropped 0.3 kg/m², and their systolic and diastolic readings were slightly reduced. This was accompanied with reduced random blood sugar (by 8.8 mg/dl). Oxygen saturation (SpO2) increased by 0.92%. Emotional responses demonstrated a marked reduction in fear and a corresponding increase in positive affect, including enhanced feelings of peace and well-being, observed upon completion of the 10-day intervention period. People said that they had found peace of mind and taken away stress. VM has a significant impact on the physical health system and psychological health, which suggests that it may be not only useful in relieving chronic illness but also could become an adjunct to standard medical treatment. Randomized controlled trials are needed to confirm these findings.

Heavy alcohol use (HAU) is a modifiable risk factor that may influence intracerebral hemorrhage (ICH) severity and cerebral small vessel disease (cSVD), but its role remains insufficiently understood. We aimed to investigate how HAU is associated with acute ICH characteristics and cSVD burden. In this cross-sectional study, we analyzed prospectively collected data from consecutive patients admitted with spontaneous, nontraumatic ICH to Massachusetts General Hospital between 2003 and 2019. HAU was defined as regular alcohol consumption of ≥3 drinks per day. Multivariable regression models assessed associations between HAU and acute ICH clinical and radiologic features and MRI markers of cSVD. Among 1,600 patients (851 male patients [53%]; median age 75 [interquartile range 64-82] years), 104 (7%) met criteria for HAU. Compared with the non-HAU cohort, patients with HAU were significantly younger at ICH onset (median 64 vs 75 years; p < 0.001) and had larger hematoma volume (1.7-fold increase, p = 0.005) and greater odds of deep hemorrhage location (adjusted odds ratio [aOR] 2.01; 95% CI 1.11-3.64; p = 0.021) and intraventricular extension (aOR 1.95; 95% CI 1.02-3.70; p = 0.045). Among 1,195 patients with MRI (75%), analysis of markers of cSVD showed that HAU was independently associated with severe white matter hyperintensities (aOR 3.04; 95% CI 1.43-6.49; p = 0.004) and a hypertensive cSVD pattern (aOR 1.82; 95% CI 1.04-3.20; p = 0.035). No other MRI markers of cSVD were associated with HAU. HAU was also associated with lower platelet counts (β = -17.73; 95% CI -32.75 to -2.72; p = 0.021) and higher admission blood pressure (β = 4.81; 95% CI 0.06-9.56; p = 0.047). HAU is associated with younger age at ICH onset, larger hematoma size, and imaging features consistent with more advanced hypertensive cSVD, including a greater burden of white matter hyperintensities. These findings suggest that HAU may exacerbate acute ICH severity and accelerate long-term cerebral small vessel pathology. Study limitations include the cross-sectional design, MRI availability restricted to a subset, and lack of detailed lifetime alcohol exposure. Future studies should clarify alcohol-related mechanisms underlying cSVD progression and ICH severity and inform prevention strategies.

This study aimed to investigate the effects of paeonol (pae) on blood pressure, tissue damage, and the fetuses and placentas in a preeclampsia (PE) rat model induced by L-NAME, and to explore the potential regulatory mechanism involving the NEDD4L-ACSL4 axis.By quantitatively analyzing urinary protein, blood pressure, and sFlt-1 levels, the role of pae in the PE rat model was evaluated. The effects of pae on HTR-8/SVneo and primary trophoblast cells were investigated using a cell model. The role of pae in the process of NEDD4L-mediated ACSL4 ubiquitination was determined through experiments such as Co-IP and ubiquitination assays.Pae reduced blood pressure, urinary protein, and sFlt-1 levels in a PE rat model, increased the fetal survival rate, and improved placental and renal damage. Mechanistically, pae mediated the ubiquitination level of ACSL4 by promoting the interaction between ACSL4 and NEDD4L, thereby reversing hypoxia-induced ferroptosis.In brief, pae further inhibited ferroptosis by facilitating NEDD4L-mediated ACSL4 ubiquitination, exerting a significant improving effect on blood pressure and tissue damage in PE. Thus, it provided a new strategy for the treatment of PE and laid a foundation for further research on the mechanism of action of pae and its related compounds.

Background: A higher protein diet (HPD) is recommended for older adults to support their muscle mass maintenance, but its cardiovascular protective effects in this population remain controversial, potentially due to differences in protein sources. Objective: To investigate the effects of HPDs with different sources within a healthy dietary pattern (HDP) on conventional cardiovascular disease (CVD) risk factors and vascular health-related outcomes in Singapore older adults. Methods: In this 16-week randomized controlled trial, 55 participants were assigned to one of the three groups: following a HDP alone (Control, n = 19), following a HDP supplemented with 20 g day-1 of either casein protein isolate powder (HPD-CP, n = 18) or soy protein isolate powder (HPD-SP, n = 18). Blood pressure, lipid-lipoprotein profiles and composite CVD risk indicators were evaluated at the baseline and post-intervention. Parameters of vascular function (flow-mediated dilation) and vascular regeneration (endothelial progenitor cell percentage and blood outgrowth cell functions) were also assessed. Results: The Control group exhibited significant increases in triglyceride levels (+0.33 ± 0.1 mmol L-1) and composite CVD risks (atherogenic index: +0.31 ± 0.11; Framingham predicted long-term CVD risk: +0.8 ± 0.43%). In contrast, both HPD groups showed maintenance of the lipid-lipoprotein profile and CVD risk predictors, with further significant reduction in the total cholesterol level in the HPD-SP group (-0.28 ± 0.12 mmol L-1). All groups showed significant increases in CD34+ cell expression, and particularly, the HPD-SP group demonstrated potential to enhance the angiogenic capacity of blood outgrowth endothelial cells. However, no changes were observed in other vascular functions and vascular regeneration parameters. Conclusions: Adherence to an HPD, particularly from soy protein, within an HDP supports the maintenance of the lipid-lipoprotein profile and CVD risk predictors among Singapore older adults. These findings highlight HPD as a potential dietary strategy to promote cardiovascular health when adhering to an HDP in older adults; however, the source of protein may influence its effectiveness. This study was registered at clinicatrials.gov as NCT05400005.

The legalization of recreational and medical cannabis has shifted consumption patterns, with vaping emerging as a common alternative to smoking. This review summarizes recent evidence comparing the respiratory and cardiovascular health effects of these two modes of administration. Vaping reduces exposure to combustion-related toxicants and allows modulation of Δ9-tetrahydrocannabinol (THC) bioavailability compared to smoking cannabis. However, both modes of consumption produce comparable physiological effects, including acute increases in heart rate and blood pressure, and altered immune responses in lung. There is clear association between THC vaping and e-cigarette or vaping associated lung injury. Vaping is also linked to increased risk of respiratory symptoms. Evidence regarding the long-term risks of vaping cannabis such as chronic obstructive pulmonary disease, lung cancer, myocardial infarction and stroke remains limited and inconclusive. While vaping cannabis may mitigate some combustion-related harms compared to smoking, it introduces distinct respiratory and cardiovascular concerns. Evidence on long-term comparative safety remains limited, highlighting the need for longitudinal and experimental studies examining health outcomes across different modes of consumption, devices, temperatures and formulations.

This study seeks to better understand the impact of schedule change on physiological and self-report measures of stress and quality of life among career firefighters. This study examined the impact of a schedule change from 24/48 to a 24-hour on/72-hour off, 48-hour on/72-hour off (i.e., 1/3/2/3) shift rotation on markers of stress among career firefighters over a seven-month period. Physiological measures such as salivary biomarkers (cortisol, testosterone, testosterone-to-cortisol ratio, interleukin-6) and blood pressure as well as self-reported survey instruments for occupational stress and job satisfaction were assessed throughout the study. By the end of the study, participants demonstrated significantly lower salivary cortisol concentrations, improved quality of life, and better sleep quality. These findings suggest that transitioning to a 1/3/2/3 schedule may reduce physiological stress and improve quality of life among career firefighters.

The community service partner is the elderly and families in Tambak Baru Ilir Village. Hypertension in the elderly is often accompanied by pain, either due to complications of hypertension or due to physical decline due to aging. Uncontrolled pain can lead to increased blood pressure, sleep disturbances, depression, and a reduced quality of life. In addition to pharmacological treatment, non-pharmacological approaches are needed to help reduce pain, one of which is Quranic recitation therapy. Recitation therapy has been shown to have a calming effect and can help reduce anxiety and stress levels, as well as improve sleep quality in the elderly, contributing to pain reduction and blood pressure stabilization. The result of this interventions, There was a decrease in pain levels in elderly people with hypertension after being given Murottal therapy in Tambak Baru Ilir Village. Murottal therapy activities can be given to elderly people with hypertension to reduce the level of pain they feel.

Heart failure in China: a macroeconomic modelling study of intervention strategies.

BACKGROUNDSuboptimal fetal growth (SFG), being born small for gestational age (SGA), and catch-up (CU) growth are, individually and together, linked to cardiometabolic risks. However, not all develop adverse outcomes. This study aimed to validate a transcriptomic signature to identify individuals at greatest cardiometabolic risk.METHODSUsing National Heart, Lung and Blood Institute (NHLBI) criteria to define cardiometabolic risk, healthy and prehypertensive 17-year-olds were identified in the Avon Longitudinal Study of Parents and Children (ALSPAC) (UK) childhood cohort. Epigenomic and transcriptomic differences were analyzed. A hypergraph identified functionally related genes, which were used in random forest classification to predict prehypertensive phenotypes. The BabyGRO (UK) cohort included 80 children aged 3-7 years, born at term following pregnancies with SFG risks. Anthropometric and cardiometabolic markers and transcriptomic profiles were collected, fetal and childhood weight trajectories and their relationship to cardiometabolic markers were assessed, and transcriptome was used for prediction.RESULTSIndividuals with CU-SGA in ALSPAC were 1.6 times more likely than all others to be prehypertensive at 17 years (P < 1 × 10-5). A 42-gene hypergraph cluster was highly predictive of prehypertension (AUC 0.984, error rate 5.4%). In BabyGRO, 20 of these genes accurately predicted higher systolic blood pressure (AUC 0.971, error rate 3.6%). This transcriptomic signature could help identify children with adverse pre- and postnatal growth who may develop prehypertension.CONCLUSIONA blood transcriptomic signature exists in childhood which distinguishes those at risk of adult cardiometabolic disease among children with adverse pre- and postnatal growth.TRIAL REGISTRATIONRegional ethics committee reference 17/NW/0153, IRAS project ID 187679.FUNDINGCentre grant to the Maternal and Fetal Health Research Centre by Tommy's The Pregnancy and Baby Charity, Child Growth Foundation, European Research Council funding as part of the Health and Environment-wide Associations based on Large Population Surveys (HEALS) study.