Landslides pose a significant threat to the safety and stability of settlements in karst regions worldwide. The long-standing tight balance state of settlement funding and infrastructure makes it difficult to allocate disaster prevention resources effectively against landslide impacts. There is an urgent need to fully leverage the landscape resources of karst settlements and develop landslide risk prevention strategies that balance economic viability with local landscape adaptability. However, limited research has explored the differential resilience characteristics and patterns of landslide disaster risk and settlement landscapes from a spatial coupling perspective. This study, based on landslide disaster and disaster-adaptive landscape data from a typical karst province in China, employs the frequency ratio-random forest model and weighted variance method to construct landslide disaster risk (LDR) and disaster-adaptive landscape (DAL) base maps. The spatial characteristics of urban, urban–rural transition zones, and rural settlements were analyzed, and the resilience differentiation and driving factors of the LDR–DAL coupling relationship were assessed using bivariate spatial autocorrelation and geographical detector models. The key findings are as follows: (1) Urban and peri-urban settlements exhibit a high degree of spatial congruence in the differentiation of LDR and DAL, whereas rural settlements exhibit distinct divergence; (2) the Moran’s I index for LDR and DAL is 0.0818, indicating that urban and peri-urban settlements predominantly cluster in H-L and L-L types, whereas rural settlements primarily exhibit H-H and L-H patterns; (3) slope, soil organic matter, and profile curvature are key determinants of LDR–DAL coupling, with respective influence strengths of 0.568, 0.555, and 0.384; (4) in karst settlement development, augmenting local vegetation in residual mountain areas and parks can help maintain forest ecosystem stability, effectively mitigating landslide risks and enhancing disaster-adaptive capacity by 6.77%. This study helps alleviate the contradiction between high LDR and weak disaster-adaptive resources in the karst region of Southwest China, providing strategic references for global karst settlements to enhance localized landscape adaptation to landslide disasters.
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