Trends in Poverty and Birth Outcomes in the US.

Associations of glyphosate and aminomethylphosphonic acid (AMPA) concentrations with birth outcomes in pregnant women from the Midwestern U.S.

Maternal exposure to PM2.5 and its association with adverse pregnancy and birth outcomes: A prospective cohort study.

Cost Comparison of 2 Different Targets for Glycemic Control in Women With Gestational Diabetes: Evaluation From the TARGET Stepped-Wedge Randomized Trial.

Prolonged exposure to nitrate in drinking water does not adversely impact prenatal or birth outcomes in a rat model.

Extreme ambient heat and outcomes of assisted reproduction in the continental United States, 1996 to 2018.

Cross-linking geotagged social media data with public health registries for spatial health research.

Untreated women with Gaucher disease (GD) are at an increased risk of GD-related complications during pregnancy. Enzyme replacement therapy with imiglucerase is effective at improving hematologic, visceral, and bone manifestations of GD, and the Food & Drug Administration prescribing information supports that imiglucerase is not associated with adverse maternal or fetal outcomes when used during pregnancy. This study population included women with GD enrolled in the International Collaborative Gaucher Group Gaucher Registry (NCT00358943) Pregnancy Sub-Registry who were treated with imiglucerase during at least one pregnancy as of October 2023. We describe frequency of pregnancy outcomes, birth outcomes, and maternal and neonatal complications. Imiglucerase exposure was reported in 110 pregnancies in 68 women with GD type 1; 68% of pregnancies were exposed during all three trimesters. Of 104 fetuses with reported data, 92 were live births (88.5%), eight were spontaneous abortions (7.7%), and four were elective/therapeutic terminations (3.8%); no stillbirths (> 20 weeks gestation) were reported. The majority of infants (80 of 85 [94.1%]) were born at term. Among 108 pregnancies with data, maternal pregnancy, labor and delivery, and post-partum complications were reported for 33 (30.6%), 26 (24.1%), and 24 (22.2%) pregnancies, respectively, with anemia, thrombocytopenia, and vaginal bleeding among the most prevalent complications. Among 74 infants with data, neonatal complications were reported for seven infants (9.5%). Most pregnancies to women with GD treated with imiglucerase resulted in live births and healthy infants, with risk of spontaneous abortions similar to that of the general population (12%-18%).

Ethno-cultural risk of ante-natal lead exposure among South Asian women in the UK.

Antenatal lifestyle interventions to reduce gestational weight gain: Where should we start and how much will it cost?

Residential green and blue space effects on newborn health: findings from a retrospective longitudinal study in Wales.

Perineal trauma remains a common outcome of spontaneous vaginal birth, often leading to immediate and long-term complications. Although numerous studies have examined clinical factors, the influence of individual clinician characteristics-such as professional role, experience, training, and attitudes-has received less attention. This scoping review synthesized existing evidence on the association between clinician characteristics and variations in perineal outcomes including obstetric anal sphincter injury, episiotomy, spontaneous tears and intact perineum. The review also examined methods of risk assessment and strategies to mitigate trauma related to clinician factors. The review was conducted following Joanna Briggs Institute methodology to map the breadth of evidence in this field. A systematic search was undertaken across multiple electronic databases using predefined keywords and inclusion criteria. Sixty-two studies, published between 1969 and 2024 from 25 countries, were included. Study designs encompassed cohort, cross-sectional, randomized controlled trials, qualitative and mixed methods. Episiotomy was the primary outcome in 57 studies, while 27 studies focused on obstetric anal sphincter injury and 10 on intact perineum. Clinician factors, particularly professional role, attitudes, experience and education, were consistently associated with variations in perineal outcomes. Midwifery-led care frequently corresponded with lower episiotomy rates, although it was sometimes linked with similar or slightly higher spontaneous tear rates. Reducing perineal trauma requires addressing both fixed and modifiable clinician factors. Standardized episiotomy training, adherence to evidence-based guidelines and collaborative, woman-centered care are recommended strategies to enhance the quality of maternity care for improved patient outcomes.

Birth interventions and outcomes among first time mothers: A population-based register study in four Nordic countries.

Morphokinetic assessment of the blastocyst's trophectoderm re-expansion post-warming: predictive markers for clinical pregnancy in ART.

Endometrial immune profile: A predictor of pregnancy success.

Polycyclic aromatic hydrocarbons-induced suppression of the PPARα/ACAA1 axis drives hepatic steatosis: Integrating epidemiology, network toxicology, and experimental validation.

The endometrium: is thickness all that counts?

Pregnancy is a critical physiological period characterized by increased nutritional demands to support maternal adaptations, placental function, and fetal growth. Fruits are an important component of prenatal nutrition, providing essential micronutrients such as vitamin C, folate, potassium, and antioxidants that contribute to immune function, hematopoiesis, neural development, and oxidative stress regulation. Adequate fruit consumption has been associated with improved pregnancy outcomes, including reduced risk of maternal anemia, enhanced fetal neurodevelopment, and favorable birth outcomes. However, concerns regarding the safety of certain fruits, particularly unripe papaya, pineapple, and grapes, have led to widespread misconceptions and unnecessary dietary restrictions. Current scientific evidence indicates that most fruits are safe when consumed in moderate amounts, and the concept of inherently teratogenic fruits is not supported by robust human data. Instead, potential risks are primarily associated with microbial contamination, pesticide exposure, or excessive intake of bioactive compounds in non-dietary forms. Avoidance of fruits without appropriate nutritional substitution may result in deficiencies of essential micronutrients, increasing the risk of adverse maternal and fetal outcomes. Clinical recommendations emphasize safe handling, proper washing, and balanced dietary intake rather than unnecessary restriction. This review highlights the importance of fruits in pregnancy, evaluates safety concerns, and provides evidence-based recommendations to optimize maternal and fetal health outcomes.

Platelet-rich plasma (PRP) is used as an adjunctive treatment in various medical fields, including orthopaedics, plastic surgery, dermatology, and wound healing. However, PRP application in reproductive medicine, particularly for fertility restoration, remains controversial, specifically for women with diminished ovarian reserve (DOR), premature ovarian insufficiency (POI), and pre-menopause. This systematic review aimed to comprehensively evaluate the existing literature on autologous PRP use for ovarian rejuvenation, with a focus on refining and standardising PRP protocols and identifying appropriate candidate populations. A comprehensive literature search was conducted on the autologous PRP use using Cochrane, Embase, PubMed, MEDLINE, NCBI, and Google Scholar databases. Studies on PRP application in reproductive medicine were identified and classified into two categories: DOR and POI. The PRP preparation protocol was assessed, and the results were compared. This narrative systematic review, carried out in compliance with PRISMA 2020 guidelines, combined results, although meta-analysis was not feasible due to significant variation in study design, PRP preparation, and outcome measures. Several studies reported restoration of menstruation following intraovarian PRP administration in women with POI. In women with DOR, studies reported changes in ovarian reserve markers, including increases in serum anti-Müllerian hormone (AMH) levels and reductions in follicle-stimulating hormone (FSH) levels; however, these changes were not consistently associated with higher antral follicle counts or oocyte yield. Instead, sseveral studies reported higher proportions of mature oocytes and pregnancy and live birth outcomes, particularly following repeated PRP treatment cycles in women with long-standing ovarian dysfunction. Intraovarian PRP may have a potential role in activating dormant follicles in a selected subset of women with poor ovarian response. However, the current evidence remains limited and heterogeneous, supporting its use only within structured clinical or research protocols until higher-quality, standardised studies are available.

Respiratory syncytial virus (RSV) remains a leading cause of infant morbidity and mortality, with the highest burden concentrated in low- and middle-income countries (LMICs). Existing preventive options, including long-acting monoclonal antibodies, can be constrained by cost, logistics, and access, leaving many high-risk infants unprotected. This article is a structured narrative review summarizing clinical efficacy, immunological mechanisms, safety and public health implications of maternal RSV immunization for preventing infant RSV lower respiratory tract infection (LRTI), with an explicit implementation focus for LMICs. Evidence was identified through targeted searches of major biomedical databases and prioritized by clinical relevance and policy importance, including phase III efficacy trials, regulatory and technical documents, post-authorization safety signals, and modelling studies evaluating potential impact in LMICs. Across the evidence base, maternal vaccination induces robust RSV-neutralizing IgG responses and efficient transplacental antibody transfer, providing passive protection during the first months of life when RSV risk is highest. In phase III data, maternal RSV vaccination demonstrated high efficacy against severe medically attended RSV LRTI in early infancy (e.g., up to 81.8% within the first 90 days for a licensed maternal RSV vaccine). Modelling studies project substantial global reductions in hospitalizations and deaths, although real-world effectiveness in LMICs will depend on antenatal care coverage, timing feasibility, seasonality, and equity of delivery. Safety findings were generally favorable; nonetheless, continued post-licensure monitoring,particularly for pregnancy and birth outcomes such as preterm birth,remains essential. Maternal RSV immunization is a scalable strategy that can leverage existing antenatal platforms and, if equitably implemented, could meaningfully reduce infant RSV morbidity and mortality, especially in LMIC settings.