Bilateral Fibroadenomas Research Articles

A Rare Case of Multiple Bilateral Fibroadenoma in a Young Woman: A Case Report and Literature Review

Background: Fibroadenoma is the most common type of breast tumor diagnosed in young women, in children and adolescents it is called juvenile fibroadenoma. These tumors often result in emergence, self-confidence, and anxiety in adolescents. Case Report: A 21-year-old female patient came to the surgical clinic with lumps in the right and left breasts since about 4 years ago. History and physical examination showed the right and left breast tumors were suspiciously benign. Ultrasound results showed multiple hypoechoic (solid) lesions, on the right breast the largest size was 4 cm, with BIRADS 2, the left breast the largest size was 3.5 cm, with BIRADS 2. The patient then underwent surgical excision of the tumor and performed histopathological examination. The results of histopathological examination provide an overview of fibroadenoma. Conclusion: The presentation of the case report from the authors hopes to expand the literature and provide insight into multiple fibroadenoma and the need for anamnesis, comprehensive physical examination, accompanied by ultrasonography to FNA in a young female patient who has a lump in the breast.

A Rare Case of Multiple Bilateral Fibroadenoma in a Young Woman: A Case Report and Literature Review

A Rare Case of Multiple Bilateral Fibroadenoma in a Young Woman: A Case Report and Literature Review

Benign breast diseases: Correlation of clinical findings with those of FNAC, ultrasound and histopathology

Fibroadenoma is the most common lesion of the breast; it occurs in 25% of asymptomatic women. They are benign, spherical, well-demarcated tumors of varying size. They arise from the epithelium and stroma of the terminal duct-lobular unit. It is usually a disease of early reproductive life; the peak incidence is between the ages of 15 and 35 years. All the patients were examined systematically including breast examination and systematic examination and assessment of nutritional status. All underwent routine investigations which included blood counts- Hb%, BT, CT, Blood sugar levels(RBS), Blood urea, Serum creatinine, Urine routine and ECG. Investigations like USG and Mammography were done in some number of required cases. 34 out of 50 of our patients underwent USG examination of the breast. 15 of these i.e. 30% had features of fibroadenoma, 6(12%) had features of Abscess, 7(14%) had features of benign breast disease and the remaining 5 had other features suggestive of galactocele, benign cyst, phylloides, lipoma of the breast. One patient had bilateral fibroadenoma of the breast.

Early onset, multiple, bilateral fibroadenomas of the breast: a case report

BackgroundWhile fibroadenomas are common in the general population, affecting 10–20% of women, they are rarely early-onset, multiple, and bilateral.Case presentationAn 18-year-old woman presented with a 6 year history of multiple, bilateral breast masses without family history of breast disease. Magnetic resonance imaging (MRI, Fig. 1) of the breasts showed innumerable, bilateral breast masses ranging in size from 0.5 to 4 cm. Two needle biopsies showed fibroadenoma. Although the patient’s family history did not meet National Comprehensive Cancer Network (NCCN) guidelines for genetic testing, it was performed due to the rarity of her presentation. Genetic testing identified a pathogenic mutation in the phosphatase and tensin homolog (PTEN) gene.ConclusionsA germline mutation in PTEN is associated with an increased risk of breast cancer and often occurs as part of Cowden Syndrome. This case highlights the importance of genetic testing in patients with unusual presentations of early-onset, bilateral, and multiple (greater than four) fibroadenomas.

Bilateral fibroadenoma and gynecomastia in a young male: sequential or concurrent diseases: case report

In this case report of bilateral fibroadenomas of the breast in a 17-year-old male, we add to the relatively small number of reported cases. Initially assumed to be HAART-associated gynecomastia, our patient with congenital HIV, had normal hormone levels and was otherwise of normal secondary sexual development, except for an uncomplicated undescended testis. The conjunction of clinical finding, imaging and histological finding confirmed a fibroadenoma with gynecomastia. Only a small number of bilateral fibroadenoma in male have been reported in the literature. The finding of co-occurring gynecomastia strengthens the argument for gynecomastia as a necessary prerequisite for the development of fibroadenoma in male due to the quasi inexistent glandular tissue in a normal male breast (the so called sequential theory). The finding suggest that despite the scarcity of fibroadenoma in male, this condition can still be found in the spectrum of male breast pathologies.

Bilateral giant fibroadenoma in a nulliparous lady: challenges in management

Bilateral giant fibroadenoma in a nulliparous lady: challenges in management

Bilateral Giant Fibroadenoma of The Breast: A Case Report

Background: fibroadenoma of the breast is one of the ANDI (Aberration of the Normal Development and Involution of the Breast) groups. Benign breast disorders are common in females younger than 30 years, but such masses are not common in juvenile or pre-menarche age groups. The exact pathological diagnosis can be investigated after surgery. For treatment, surgical procedures are needed to remove the lump. Case: a 30-year-old girl visited the outpatient clinic with psychological distress due to the presence of lumps in her both breasts. The lumps have been growing bigger and bigger in the last 3 years. On the physical examination both breasts are huge. FNAB showed the interpretation of atypical ductal hyperplasia and excisional biopsy examination confirmed the presence of bilateral giant fibroadenoma of breast. In this patient, the treatment was carried out in two-staged surgery due to her initial rejection to undergo total breast lumps and tissue removal. Several lumps still remained in the right breast which was indicated for the second surgery. The following surgery was done to remove all of the lumps and breast tissue with reduction breast surgery. Conclusion: conducting breast surgery on the young girl or un-married is not easy as many physical and psychology problems should be considered. Therefore, conducting breast surgery, in this case, should be performed wisely as the recurrence of the lumps was still possible.

Bilateral Invasive Lobular Carcinoma Arising within a Fibroadenoma: A Rare Case Entity

: Fibroadenoma is the most common benign tumor of the breast. It may be associated with proliferative epithelial changes, fibrocystic changes, and very rarely, insitu and invasive cancer. This report describes malignant transformation of a bilateral fibroadenoma. The histopathological characteristics and clinical course of a rare case of invasive bilateral lobular carcinoma arising within fibroadenoma in a young female are discussed.

Multiple bilateral fibroadenoma of the breast and axillary accessory breast: case report

Multiple bilateral fibroadenoma of the breast and axillary accessory breast: case report

Bilateral fibroadenoma of the ectopic breast tissue in axilla: A case report

Anomalies associated with breast development are common, presenting as supernumerary nipples (polythelia) and less often as supernumerary breast (polymastia) in 1–5% of population. These anomalies are more common in women and also most frequently located along the mammary line, extending from the axilla to pubic region. The axillary polymastia is the most common variant of ectopic breast tissue (EBT). EBTcan undergo the same physiological and pathological processes as the normal breast. The incidence of fibroadenoma developing in ectopic breast is a rare entity, most common being the carcinoma. We report here a case of fibroadenoma of EBT in both axillae of a 33-year-old Asian woman. This case has been reported for its rarity and to reemphasize the importance of screening of EBT for any pathology during routine screening of breast.

Audit on breast ultrasound in women under 25 years

Women younger than 30 years with a focal breast finding have a low incidence of malignancy. Targeted ultrasound is an accurate primary imaging test. All breast ultrasounds performed from July 1, 2011 to September 30, 2011 were reviewed. All ultrasounds in patients under 25 years were reviewed with regard to indication, imaging findings, and pathology results. Over a 3-month period, 855 breast ultrasounds were performed; 4.1 % breast ultrasounds were performed in a patient under 25 years. Twenty patients had imaging features consistent with a fibroadenoma. Pathology confirmed the diagnosis of fibroadenomas in 15 of the patients. Five patients did not have biopsies performed due to young age or presence of bilateral fibroadenoma. A breast nodule in a patient under the age of 25 years with benign clinical findings and imaging features consistent with a fibroadenoma does not require biopsy.

Cyclosporine-A therapy-induced multiple bilateral breast and accessory axillary breast fibroadenomas: a case report

IntroductionBreast adenoma is common. However, in the setting of post-transplantation immune suppression it may be expressed differently.Case presentationA 35-year-old Sudanese woman, with a history of renal transplantation two and half years prior to presentation, was on a single immune suppression therapy in the form of cyclosporine-A since the transplantation. During a regular follow-up visit, she was noticed to have gingival hypertrophy and bilateral breast and axillary swellings. She underwent successful surgical resection of the bilateral fibroadenomas.ConclusionsCyclosporine-A therapy post renal transplantation is associated with an increased incidence of benign breast changes as fibroadenoma. Regular follow-up and appropriate selection of immunosuppressant therapy are essential in the post transplantation management of these patients.

Interstitial Laser Therapy of Breast Fibroadenomas With 6 and 8 Year Follow-Up

Fibroadenomas are non-cancerous breast tumors commonly seen in teenagers but also found in women at the time of first mammogram. They have distinct physical findings and imaging features but the definitive diagnosis is made by ultrasound or stereotactic guided needle biopsy. Treatment options are observation or surgical removal. Recently, removal by ultrasound-guided technique has been reported. Alternatively, the tumor may be ablated within the breast by cold (cryotherapy) or by heat (laser, radiofrequency, focused ultrasound and microwave). In this paper the laser treatment in two patients, one with bilateral fibroadenomas, with 6 and 8 year follow-up is presented.

The utilization of an ultrasound-guided 8-gauge vacuum-assisted breast biopsy system as an innovative approach to accomplishing complete eradication of multiple bilateral breast fibroadenomas

BackgroundUltrasound-guided vacuum-assisted breast biopsy technology is extremely useful for diagnostic biopsy of suspicious breast lesions and for attempted complete excision of appropriately selected presumed benign breast lesions.Case presentationA female patient presented with 16 breast lesions (eight within each breast), documented on ultrasound and all presumed to be fibroadenomas. Over a ten and one-half month period of time, 14 of these 16 breast lesions were removed under ultrasound guidance during a total of 11 separate 8-gauge Mammotome® excision procedures performed during seven separate sessions. Additionally, two of these 16 breast lesions were removed by open surgical excision. A histopathologic diagnosis of fibroadenoma and/or fibroadenomatous changes was confirmed at all lesion excision sites. Interval follow-up ultrasound imaging revealed no evidence of a residual lesion at the site of any of the 16 original breast lesions.ConclusionThis report describes an innovative approach of utilizing ultrasound-guided 8-gauge vacuum-assisted breast biopsy technology for assisting in achieving complete eradication of multiple bilateral fibroadenomas in a patient who presented with 16 documented breast lesions. As such, this innovative approach is highly recommended in similar appropriately selected patients.

Bilateral Presentation of Fibroadenoma With Digital Fibroma–like Inclusions in the Male Breast

Fibroepithelial lesions are uncommon in the male breast. Most published reports describe phyllodes tumors. Fibroadenomas are very common in female breasts, but are exceedingly rare in the male breast. Gynecomastia and/or lobular differentiation have been known to coexist in both types of fibroepithelial lesions in men. We report an exceptional case of recurrent, bilateral fibroadenomas in a man under treatment for prostatic carcinoma. Intracytoplasmic inclusion bodies in stromal cells identical to those seen in infantile digital fibromatosis were identified in one fibroadenoma. To the best of our knowledge, this is the first reported case of bilaterally occurring fibroadenomas in the male breast, one of which also contained digital fibroma-like inclusions, a second unreported phenomenon.

Recurrent Bilateral Giant Fibroadenomas of the Breasts

Recurrent Bilateral Giant Fibroadenomas of the Breasts

Cyclosporin A and multiple fibroadenomas of the breast.

Multiple bilateral fibroadenomas are uncommon. This finding in four women who had received renal transplants prompted further inquiry. A prospective study was performed on 39 women under the age of 55 years who had received a renal transplant at least 1 year earlier. Clinical examination and breast ultrasonography were performed. Factors considered included immunosuppressive therapy, concurrent medication and renal function. Blood was taken for estimation of oestradiol, prolactin, follicle-stimulating hormone (FSH) and sex hormone binding globulin levels. Fibroadenomas were found in 13 of 29 women who had received cyclosporin A: multiple in ten and bilateral in five. No abnormal breast findings were seen in 10 patients immunosuppressed with steroids and azathioprine alone (chi 2 = 7.30, 1 d.f., P < 0.01). Serum oestradiol concentration was raised in women with fibroadenomas compared with that in those with normal breasts (P < 0.05) and the level of FSH was lower (P < 0.01). Cyclosporin A may act on breast fibroblasts by humoral mechanisms and direct action.

Breast fibroadenomas in renal transplant recipients

Breast fibroadenomas are the most common solid lesions found in young women. We report on four patients who underwent renal transplantation and developed bilateral fibroadenomas while on cyclosporine (CsA). One patient developed symptomatic giant fibroadenomas and underwent bilateral mammoplasty. A significant decrease in the size of the breasts was noticed after switching to tacrolimus in three patients. Awareness of the association between CsA and fibroadenomas should help to achieve the correct diagnosis in transplant patients without subjecting them to unnecessary procedures.

Fibroadenoma with Foci of Infiltrating Ductal Carcinoma

Fibroadenoma is a biphasic tumor of breast with stromal and epithelial components. It is a very common benign tumor among young female. Malignant transformation in a fibroadenoma is uncommon. We report a case of an elderly patient with bilateral fibroadenomas harboring foci of invasive ductal carcinoma. The intent of this presentation is to increase general awareness as to the existence of carcinomas arising in fibroadenomas and also to actively discourage the practice of rendering gross pathological diagnoses of fibroadenomas. DOI: http://dx.doi.org/10.3329/jom.v13i1.10088 JOM 2012; 13(1): 115-117

Widespread heterotopic ossification in a patient with anoxic brain injury: Case report and review of literature

Heterotopic ossification (HO) is the formation of bone in the soft tissue, which exhibits no properties of ossification. Widespread HO is an uncommon condition. We present the findings in an 18-year-old young female who presented with benign bilateral fibroadenoma of the breast. However, she suffered an anoxic brain injury following cardiac arrest and had mechanical ventilation for some weeks. Thereafter, she developed widespread HOs, which were subsequently managed conservatively but required surgery for the ossification around the right hip. The report highlighted the multiplicity of risk factors vis-a-vis the challenges of management. A plan for the future care of this patient in relation to some of the currently available literature has also been highlighted.