Bilateral Femoral Bone Mineral Density Research Articles

Clinical efficacy of gamma-oryzanol combined with Femoston for perimenopausal syndrome.

Perimenopausal syndrome (PMS) is a chronic disease associated with estrogen deficiency. Because of the unsatisfactory outcomes of current conventional treatments for this condition, its treatment must be continuously explored and optimized. To assess the clinical effectiveness of γ-oryzanol in combination with Femoston for PMS. A total of 119 patients with PMS were selected from June 2023 to December 2023, which included 59 and 60 patients in the control and observation group, respectively. The control and observation groups were treated with Femoston and γ-oryzanol + Femoston, respectively. Comparative analyses were performed in terms of clinical effectiveness, safety (dizziness and headache, nausea and vomiting, and breast tenderness), sex hormones [estradiol (E2), luteinizing hormone (LH), and follicle-stimulating hormone (FSH)], lumbar spine (L1-4) and bilateral femoral bone mineral density (BMD), and sleep quality (sleeping time and frequency of awakenings from sleep). Compared with the control group, the observation group had statistically higher total effective rates of treatment; lower overall incidence of adverse events; higher post-treatment E2 levels and L1-4 and bilateral femoral BMD; and lower LH and FSH levels, sleeping time, and frequency of awakenings from sleep after treatment. Therefore, for the treatment of PMS, γ-oryzanol combined with Femoston is significantly better than Femoston alone in terms of clinical effectiveness, exhibiting more pronounced clinical advantages in improving safety, sex hormone levels, BMD, and sleep quality.

Unilateral vs Bilateral Hip Bone Mineral Density Measurement for the Diagnosis of Osteoporosis

It has not been established whether unilateral or bilateral hip dual-energy X-ray absorptiometry (DXA) is preferable for the diagnosis of osteoporosis. We investigated the discordance in DXA measurements in bilateral hips to determine whether unilateral DXA is valid for osteoporosis diagnosis. The subjects were 2964 Japanese patients without a previous diagnosis of primary osteoporosis. We measured bilateral femoral bone mineral density (BMD) and calculated indices, related to the unilateral results, for predicting contralateral hip osteoporosis. A likelihood ratio (LR) of a negative test (LR [−]) of less than 0.2 was considered to exclude the diagnosis. In the normal spinal BMD group, the sensitivity of unilateral DXA for women was 27–73% and LR (−) was 0.28–0.73; the sensitivity for men was 0–50% and LR (−) was 0.51–1.00; the diagnosis of contralateral osteoporosis was not excluded. Sensitivity increased and LR (−) increased with worsening spinal BMD status; however, LR (−) did not meet the cutoff for exclusion. We could exclude unilateral hip osteoporosis, in women only, by performing contralateral femoral DXA; this necessitated lowering the T-score cutoff from −2.5 to −2.0. Unilateral femoral DXA is not useful for excluding the diagnosis of contralateral hip osteoporosis.

What happens to femoral neck bone mineral density after hip resurfacing surgery?

The major advantage of hip resurfacing is the decreased amount of bone resection compared with a standard total hip replacement. Fracture of the femoral neck is the most common early complication and poor bone quality is a major risk factor. We undertook a prospective consecutive case control study examining the effect of bone mineral density changes in patients undergoing hip resurfacing surgery. A total of 423 patients were recruited with a mean age of 54 years (24 to 87). Recruitment for this study was dependent on pre-operative bilateral femoral bone mineral density results not being osteoporotic. The operated and non-operated hips were assessed. Bone mineral density studies were repeated over a two-year period. The results showed no significant deterioration in the bone mineral density in the superolateral region in the femoral neck, during that period. These findings were in the presence of a markedly increased level of physical activity, as measured by the short-form 36 health survey physical function score.

Bilateral Femoral Bone Mineral Density Measurements in Chinese Women and Men

The aim of this study was to assess the contralateral femoral bone mineral density (BMD) difference as measured by dual-energy X-ray absorptiometry (DXA) in mainland Chinese women and men. We measured bilateral proximal femora (i.e., total hip, femoral neck, upper femoral neck, and trochanter) using DXA in 1101 subjects (284 males, 817 females), among whom 504 were postmenopausal. Data were analyzed by descriptive statistics, Student's t-tests, and Pearson's correlation coefficients ( r). With bilateral femur measurements and the acquisition of the mean BMD, precision error could be significantly reduced at the total hip, the femoral neck, and the upper femoral neck. Contralateral femoral BMD was highly correlated at all measuring sites ( r = 0.879–0.964). For the male group and for the postmenopausal subgroup, no significant differences in contralateral femoral BMDs were found. In the postmenopausal women, the percentage of subjects with discordance in classification (i.e., normal, osteopenia, and osteoporosis) for the left and right femora declined from 16.9% to 8.1% with precision adjustment. From a population perspective, since there may still be a considerable number of misdiagnosed cases, we therefore suggest that bilateral femur measurements may be justified for postmenopausal Chinese women.

HANDEDNESS AND BILATERAL FEMORAL BONE DENSITIES IN MEN AND WOMEN

To examine the relation of hand preference to bilateral femoral bone mineral density (BMD), the right and left total and regional (neck, trochanter, intertrochanteric, and Ward's triangle) proximal femur BMDs (g/cm2) were measured using dual-energy X-ray absorbtiometry (DEXA) in 32 right- and 26 left-handed university students. The mean total BMD of the total right-handers and the mean trochanteric BMD of the right- handed males were greater in the left femur than the right femur. Contrarily, the total left-handers had higher mean intertrochanteric BMD in the right side than in the left side. There were negative correlations between R-L BMD differences and Geschwind scores of total, male, and female subjects. The results suggest that femur-BMD may be related to hand preference.