Bilateral Choroidal Melanoma Research Articles

Multiple Uveal Melanoma

Introduction: Multiple uveal melanoma is a rare occurrence and includes bilateral melanoma, unilateral multiple/multifocal melanoma, or melanoma with metastasis to the ipsilateral or contralateral eye. Methods: A chart review of patients diagnosed with uveal melanoma between January 2013 and January 2019 at the Duke University Eye Center Ophthalmic Oncology Service was performed. Results: Three patients with multiple, sequential melanoma were identified; patient 1 had bilateral choroidal melanoma and patients 2 and 3 had 2 choroidal melanomas occurring in the same eye. In all 3 patients, both the first and sequential choroidal melanomas were treated with I-125 radioactive plaque brachytherapy (PBT). Two patients were found to have developed secondary metastatic uveal melanoma as a presenting sign of systemic metastases. Patient 4, initially treated with PBT, was diagnosed with ipsilateral metastatic choroidal melanoma, also treated with PBT. Patient 5 had right eye enucleation for choroidal melanoma and developed vision-threatening metastasis in the left eye, which was treated with PBRT. None of the patients had history of cancer prior to their first diagnosis. Patients 1 and 5 were tested with a systemic melanoma panel; both were negative for BAP1, but patient 1 had a variant of unknown significance in BRCA2. Patient 3 had oculodermal melanocytosis, an established risk factor of uveal melanoma. Conclusion: Although rare, the possibility of multiple uveal melanoma does exist. Examination of the treated and contralateral eye on a regular basis is crucial, not only to identify local failure but also new metastases from the primary tumor and additional primary tumors.

Bilateral Choroidal Metastases from Primary Esophageal Melanoma

The purpose of this case report is to report a rare, bilateral, choroidal metastases from a primary esophageal melanoma. A 44-year-old white female presented to the ocular oncology clinic in February 2010 on urgent referral from her ophthalmologist for evaluation of an elevated mass in each eye. The patient presented with best-corrected visual acuities of 20/25 in both eyes. Fundus examination displayed creamy white choroidal infiltrates located in the superior temporal arcade of the right eye and temporally in the left eye. The patient was diagnosed with bilateral choroidal metastatic melanoma from known primary esophageal melanoma. External beam radiation therapy was administered and complete resolution of the lesions occurred. Final visual outcome was 20/20 in both eyes. Nine months after diagnosis of choroidal metastases, the patient died from complications related to the extensive systemic metastatic involvement. Choroidal metastases are the most common intraocular malignancy. However, metastatic melanoma is a rare finding and has only been reported from cutaneous and primary choroidal melanoma. Therefore, to the best of the authors' knowledge, this is the first reported case of bilateral choroidal metastasis from a primary esophageal malignant melanoma.

Bilateral choroidal melanoma a patient with bilateral melanocytosis

Abstract Purpose Ocular melanocytosis, is a congenital condition characterized by hyperpigmentation of the episclera and uvea.. There is a clear association between this condition and uveal melanoma in Caucasian populations. We report a case of a patient affect of bilateral ocular malanocytosis whom has recently been diagnosticated of bilateral choroidal melanoma. Methods Interventional Case report Results A 65‐years‐old man affected of bilateral ocular melanocytosis diagnosed of bilateral choroidal melanoma without systemic affection. In his right eye presented a melanotic choroidal mass with orange‐pigment in the surface measuring 10,63 mm in basal diameter and 3,74 mm in height. In the left eye, there was another melanotic choroidal mass with subretinal hemorrhage measuring 12,69 x 8,7 mm. The left eye was treated with (125)I brachytherapy. Conclusion Despite the fact that the uveal melanoma is the most frequent intraocular tumour, a bilateral choroidal melanoma is very uncommon. A few clinical conditions can predispose to or be associated with uveal melanoma, including ocular melanocytosis and oculodermal melanocytosis, neurofibromatosis type I, and familial atypical mole and melanoma syndrome. Patients with ocular melanocytosis and oculodermal melanocytosis sometimes do not have adequate follow‐up, which results in late diagnosis.

Trifocal Uveal Melanoma

To report the singular case of a patient who developed three noncontiguous uveal melanomas over a 30-year period. Case report. Systemic evaluation of a 50-year-old man with an iris melanoma and bilateral choroidal melanomas disclosed no evidence of metastases or other primary neoplastic disease. Although rare, the possibility of bilateral and multifocal uveal melanoma should be recognized.

Bilateral choroidal melanomas. Case report and incidence.

A 55-year-old woman had bilateral choroidal melanoma. To our knowledge, this is the second reported case in the United States. To calculate the incidence of bilateral cases, we determined the incidence of unilateral choroidal and ciliary body melanomas among the white population in Iowa. We also studied the incidence of these melanomas by different age and sex groups. One of 2,500 whites will develop a choroidal melanoma during his or her lifetime. Based on these values and those of life expectancy in patients harboring a choroidal melanoma, we calculated the risks of developing a second primary melanoma in the other eye. In a population of 50 million whites, 1 person will develop a bilateral choroidal melanoma during his or her lifetime. In other words, a bilateral case is expected to occur once every 18 years in the United States.