Reactive oxygen species (ROS) are widely used in environmental and health-related fields due to their high reactivity. Among them, hydrogen peroxide (H2O2) is the most mild, stable, and environmentally friendly oxidant with only H2O and O2 as the decomposition products. Therefore, it is widely used in bleaching, wastewater treatment, fuel cells, and medical which can using on sterilization or infective wound healing and so on. However, the traditional anthraquinone method for producing H2O2 requires precious metal catalysts、high energy consumption and produces a large amount of wastewater. In addition, the catalytic production of H2O2 is mainly achieved by photocatalysis, piezocatalysis, or electrocatalysis procresses, which limits the application environment. To solve this problem, thermocatalysis based on temperature difference by using thermoelectric materials is a promising solution. However, the current H2O2 production efficiency is still low, which limits the application scenarios. Therefore, we propose to use Au nanoparticles and MoS2 nanosheets with Bi2Te3 nanoplates as the thermocatalytic material. Bi2Te3 nanoplates have high Seebeck coefficient at room temperaturea and high specific surface area. Moreover, Au nanoparticles and MoS2 nanosheets are known as great photothermal property materials which can be used to increase the temperature difference of the material to improve the H2O2 production efficiency. The temperature difference is the most common environmental factor in daily life, which makes thermoelectric nanomaterials have great potential for practical applications in the field of thermalcatalysts.