Benign Proliferative Disease Research Articles

Some topological relationships in multisystems of n+3 phases, III; ternary systems

<h3>OBJECTIVE:</h3> The importance of benign proliferative and non-invasive breast lesions as a risk factor preceding the development of invasive mammary carcinoma is well established in the literature. The objective of this study is to estimate the magnitude of benign proliferative diseases as well as mammary intra-epithelial neoplasia in the Western region of the Kingdom of Saudi Arabia (KSA), in order to encourage nationwide breast cancer screening programs for early detection of the high risk proliferative and pre-invasive breast lesions. <h3>METHODS:</h3> We reviewed histopathology records (reports and slides of selected cases) of 2129 breast cases including mastectomies and breast biopsies from January 1985 to December 2002 in King Abdul-Aziz University Hospital and King Khalid National Guard Hospital, Jeddah, KSA. All the cases and diagnosis are listed and reclassified using systematized nomenclature of medicine (SNOMED) coding system and then regrouped based on the associated risk factors of developing breast carcinoma. <h3>RESULTS:</h3> Two thousand one hundred and twenty-nine reports were reviewed and 2343 diagnosis were identified as some cases had more than one diagnosis. The total of benign diagnosis were 1504 after exclusion of malignant diagnosis (558), normal breast tissue, gynecomastia, and non-mammary tissue (281). All diagnosis (1504) were reclassified based on anatomical prognostic indicators into non-proliferative (1283/1504), proliferative (140/1504), atypical hyperplasia (AH) (8/1504), and carcinoma in situ (CIS) (73/1504). We compare our findings with the literature and we found that the percentage of benign non-proliferative diagnosis was 85.3% that is higher than the literature 69.7%. Proliferative diseases were 9.3% and atypical hyperplasia was 0.5%, which was lower than the literature 26.2% and 3.6%. On the other hand, CIS diagnosis was 4.9%, which is much higher than the reported literature 1.7%. The study findings could be explained on the basis of higher prevalence of benign breast lesions in our population, or it is related to the number of cases studied, or to the diagnostic criteria followed initially. <h3>CONCLUSION:</h3> These findings should encourage us to refine our diagnostic criteria of proliferative diseases, AH and CIS (mammary intraepithelial neoplasia [MIN]). In addition, we strongly encourage a breast cancer screening program, nationwide.

Pattern of Fine Needle Aspiration Cytology of Superficially Palpable Lesions: One year hospital based study

Introduction: This is a retrospective study on fine need aspiration cytology (FNCA) of superficially palpable lesions done in Shree Birendra Hospital, Chhauni, over a period of one year from 14th April 2008 to 13th April 2009. Aim: The aim of this study was to review cytological diagnosis on superficially palpable lesions in various sites. Methods: A total of 323 cytological diagnoses of palpable lumps performed in one year by pathologists were retrieved. Sites of FNA and diagnoses were analyzed and correlated with age and sex of the patients. Results:This study has included 323 FNACs. Lymph node was the most common site for FNAC (32%), followed by breast (29%), thyroid (22%), and salivary gland (2%). Other site comprised 15% of cases. In lymph node, reactive lymphadenitis was the most common benign lesion (42.7%) and metastatic squamous cell carcinoma was the commonest malignant lesion(12.62%). In breast, benign proliferative breast disease was the most common(84.1%) and ductal carcinoma was commonest among malignant lesions(8.5%). Among thyroid lesions, benign proliferative thyroid disease was the commonest one (47.9%)followed by papillary carcinoma among malignant lesions(11.3%).Among salivary gland lesions, Chronic sialadenitis was common inflammatory lesion (37.5%) followed by pleomorphic adenoma among benign lesions(25%) and carcinoma comprised 25%. Lipoma was the commonest lesion ( 63%) from other sites. Conclusion: Wide range of lesions, both benign and malignant, can be diagnosed by FNAC thus restricting surgery to cases only requiring further histopathological evaluation. DOI: http://dx.doi.org/10.3126/mjsbh.v9i2.5022 Medical Journal of Shree Birendra Hospital Vol.9(2) 2010: 25-29