Benign Fibro-osseous Lesion Research Articles

Multiple osteosclerotic masses of the jaw

Florid osseous dysplasia is a peculiar reactive or developmental bone disease that is known to appear only in the jaws. It has an inexplicable decided predilection for occurrence in middle-aged, black women. Extent of the disease may vary from a few isolated periapical lesions to diffuse involvement of the mandibular and maxillary alveolar processes. Radiographically, it is characterized by multiquadrant, globular, radiolucent-radiopaque lesions. Histopathologically, it is a benign fibro-osseous lesion that must be differentiated from other benign fibro-osseous lesions such as fibrous dysplasia, ossifying fibroma, Paget's disease, and sclerosing osteomyelitis on the basis of combined clinical, radiographic, and histological features. Correctly identifying this disease is important because it requires no treatment unless a secondary osteomyelitis develops. Sequestrae and osteomyelitis are complications arising when teeth are removed and removable dental prostheses are supported by diseased bone.

A histopathologic study of 116 ameloblastomas with special reference to the desmoplastic variant

The histopathologic features of 116 ameloblastomas were reviewed with special reference to the incidence of the recently described desmoplastic variant. The series included 110 intraosseous lesions and 6 extraosseous ameloblastomas. Ninety-six (88%) of the intraosseous tumors were found in the mandible, and 61% involved the molar-ascending ramus area. Fourteen examples of the desmoplastic variant were identified, representing 13% of the intraosseous tumors. The lesions showed distinctive histologic features characterized by an extensive collagenized stroma containing small islands of tumor epithelium with scant tendency to form cystic structures. This histologic variant has a marked tendency to involve the anterior portions of the jaws with 7 of the 14 examples being located in the maxilla. These desmoplastic lesions also showed unusual radiographic findings, often more suggestive of a benign fibro-osseous lesion than of ameloblastoma.

顎骨に生ずる線維骨性病変の臨床病理学的検討 とくにＸ線所見と病理組織所見について

A clinico-pathological analysis on 54 cases of benign fibro-osseous lesions of the laws was made and Nomarski reflection microscopic and scanning electron microscopic findings of these lesions were added. These cases were classified according to WHO's classification, i. e. 35 cases of cementoma (including 2 cases of benign cementoblastoma, 8 of cementifying fibroma, 23 of periapical cemental dysplasia, 2 of gigantiform cementoma), 9 of ossifying fibroma, 3 of fibrous dysplasia, 2 of benign osteoblastoma, and 5 other cases which could not be classified as any other diagnosable disease. 13 cases were multiple lesions which were all cementomas.Nomarski reflection microscopy was useful to observe hard tissues and distinguish cementum from bone. The collagen fibers were found to be arranged more crowded than those of the bone and vertical to the cementum according to scanning electron microscopy.

The prevalence of benign fibro-osseous lesions of periodontal ligament origin in black women: A radiographic survey

A radiographic study was conducted to determine the prevalence of benign fibro-osseous lesions of periodontal ligament origin (BFOLPDLO) in black women. Of 491 black women with both a panoramic radiograph and a full or partial periapical series, thirty-eight or 7.7% (age-adjusted rate = 7.7%) exhibited BFOLPDLO. Of these thirty-eight patients, twenty-nine had what is clinically recognized as periapical cemental dysplasia, for a prevalence of 5.9% (age-adjusted rate = 5.5%). The combination of a panoramic radiograph and a full or partial periapical series appeared more sensitive in the detection of BFOLPDLO than a panoramic radiograph or full series alone.

Aggressive cementifying fibroma of the maxilla

The cementifying fibroma is a benign fibro-osseous lesion. Its usual location is in the mandible while rare sites of involvement have been the maxilla and ectopic locations. These tumors are generally believed to originate from the connective tissue of the periodontal ligament. Clinically, lesions are usually asymptomatic, slow-growing, and well-circumscribed. However, in very few cases, particularly in younger patients, these tumors have demonstrated and apparent aggressive course of development. We describe a case of an aggressive cementifying fibroma of the maxilla in a middle-aged male. The pathogenesis of the tumor is discussed, and the need for appropriate surgical management is emphasized.

Ossifying fibroma: A clinicopathologic study of sixty-four cases

Sixty-four cases of neoplastic benign fibro-osseous lesions are presented, with clinical and radiographic follow-up in 23 instances. A marked predilection for female patients was observed, with the majority or cases arising in the molar-premolar region of the mandible. Radiographically, these neoplasms are well demarcated and may be radiolucent, radiolucent with central opacification (target appearance), or multilocular radiolucent. A benign fibro-osseous histopathologic pattern is observed with osseous, cemental, and/or ovoid-curvoid calcified deposits. This feature, along with confinement to tooth-bearing regions, supports a periodontal ligament origin. It appears that the distinction between cementifying and ossifying variants is academic, as no behavioral differences exist. The recurrence rate following curettage was found to be 28%.

Familial hyperparathyroidism associated with cementifying fibromas of the jaws in two siblings

Two brothers affected by primary hyperparathyroidism, both with unusual jaw lesions, are described here. The atypical growth patterns of these lesions led to their surgical exploration, which revealed that they were histologically similar benign fibro-osseous lesions. The possible influence of long-standing metabolic alterations in hyperparathyroidism in the genesis of fibro-osseous lesions is discussed.

Pathologic studies on benign fibrous and fibro-osseous lesions of the jaws

Pathologic studies on benign fibrous and fibro-osseous lesions of the jaws

Pathologic studies on benign fibrous and fibro-osseous lesions of the jaws

Pathologic studies on benign fibrous and fibro-osseous lesions of the jaws

Fibroosseous tumors of the facial skeleton in association with primary hyperparathyroidism: An endocrine syndrome or coincidence?

In a retrospective study of 350 cases of primary hyperparathyroidism at the University of Toronto, 5 patients had associated benign fibroosseous lesions of the facial skeleton which did not regress after successful parathyroidectomy and restoration of normocalcemia. Two of these patients were siblings and an offspring of one of these patients was recently shown to have hyperparathyroidism, suggesting that this group of patients does represent a syndrome with familial and genetic implications. At present bone disease in patients with hyperparathyroidism should be viewed with some consideration of unrelated process, and appropriate biopsy and treatment should be undertaken after its recognition.

し骨どう原発と考えられるＯｓｓｉｆｙｉｎｇ Ｆｉｂｒｏｍａの一症例 Ｆｉｂｒｏｕｓ Ｄｙｓｐｌａｓｉａとの関連

The classification of benign fibro-osseous lesions is not unequivocal. It is especially difficult to distinguish ossifying fibroma from fibrous dysplasia. We report two cases of these benign fibro-osseous lesions here.The first case was a 37-year-old female complaining of right-sided exophthalmus and nasal obstruction. Radiographically, the border of the lesion was well defined. This lesion was totally removed while preserving the orbital contents and histo-pathologically was diagnosed as ossifying fibroma.The second case was a 15-year-old male complaining of painless swelling of the right cheek. Radiographically the border of the lesion was not well defined. He underwent curretting and histopathologically this lesion was diagnosed as fibrous dysplasia.These two lesions were analyzed with respect to clinical, surgical, radiographical and histopathological features. As a result of the analysis, we conclude that ossifying fibroma was not identical with fibrous dysplasia.

Ossifying fibroma — One disease or six?An analysis of 39 fibro-osseous lesions of the jaws

Thirty-nine cases of benign fibro-osseous lesions of the jaws of which ten cases were reported as central ossifying fibromata are reviewed. Such lesions usually present in young adults with the exception of classical fibrous dysplasia which is normally first diagnosed in the second decade of life. All the lesions appear to be more common in females and with the exception of the peripheral ossifying fibroma show a prediliction for the mandible. It is argued that as there is no absolute histological distinction between bone and cementum and as cementum-like areas of calcification are seen in fibro-osseous lesions of all membrane bones the distinction between ossifying and cementifying lesions should be discontinued. It is also suggested that the benign fibro-osseous jaw lesions may represent different stages in the evolution of a single disease process.

Sclerotic cemental masses of the jaws (so-called chronic sclerosing osteomyelitis, sclerosing osteitis, multiple enostosis, and gigantiform cementoma)

A series of thirty-eight cases of densely sclerotic lesions of the jaws was studied. The lesions were all at least 1.5 cm. in diameter. Pain, drainage, or localized expansion of the jaw was present in two thirds of the patients. Thirty-four of the thirty-eight patients were women, and twenty-five were negros. In fourteen instances, a radiographic survey of the entire jaws was available. Thirteen of these fourteen patients had multiple lesions which were usually symmetrically distributed throughout the jaws. In twenty-four patients radiographs of the lesional area only were available for review. In thirty-four of the thirty-eight cases (89 per cent), the sclerotic masses were interpreted as cementum. Although this condition has previously been described as chronic sclerosing osteomyelitis, sclerosing osteitis, multiple enostosis, or gigantiform cementoma, it appears more appropriate to consider these lesions as part of the spectrum of the benign fibro-osseous lesions of periodontal ligament origin. Four of the sclerotic lesions, which were radiographically indistinguishable from the cemental lesions, consisted only of bone. Two of these appeared to be examples of true chronic sclerosing osteomyelitis, and two may be appropriately designated as enostosis or osteomas.

Benign fibro-osseous lesions of the mandible and maxilla. A review of 35 cases.

AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract Thirty-five benign fibro-osseous lesions of the mandible and maxilla in the Bantu were reviewed. Their clinical and radiographic features are very similar, and it was impossible to make a definitive diagnosis on these grounds alone. Although there was some overlap in the pathologic picture in 3 cases, in the remainder it was possible to make a definitive pathologic diagnosis of fibrous dysplasia, ossifying fibroma, or giant cementoma. There were 6 instances of chronic osteomyelitis incorrectly diagnosed clinically, and at first pathologically, as either fibrous dysplasia or ossifying fibroma. References 1 Amies, A., and Fleming, W. E.: Central ossifying fibroma of the jaws. Oral Surg. 15: 1409– 1414, 1962. 2 Bernier, J. L., and Thompson, H. C.: The histogenesis of the cementoma. Amer. J. Orthodont. 32: 543– 555, 1946. 3 Bradlev, J. L.: Multiple cementoma. J. Oral Surg. 2: 278– 282, 1944. 4 Chaudhry, A. P., Spink, J. H., and Gorlin, R. J.: Periapical fibrous dysplasia (cementoma). J. Oral Surg. 16: 483– 488, 1958. 5 Fontaine, J.: Periapical fibro-osterima or cementoma. J. Canad. Dent. Ass. 21: 10– 20, 1955. 6 Garcia, A., Jr., and Grantham, S. A.: Haematogenous pyogenic vertebral osteomyelitis. J. Bone Joint Surg. 42-A: 429– 436, 1960. 7 Gorlin, R. J., Chaudhry, A. P., and Pindborg, J. J.: Odontogenic tumors. Cancer 14: 73– 101, 1961. 8 Hamner, J. E., Scofield, H. H., and Cornyn, J.: Benign fibro-osseous jaw lesions of periodontal membrane origin. Cancer 22: 861– 878, 1968. 9 Harris, W. H., Dudley, H. R., and Barry, R. J.: The natural history of fibrous dysplasia. J. Bone Joint Surg. 44-A: 207– 233, 1962. 10 Pepler, W. J.: Ossifying fibromas and their relation to fibrous dysplasia, and other tumours. J. Path. Bact. 79: 408– 412, 1966. 11 Rabhan, W. N., and Rosai, J.: Desmoplastic fibroma. J. Bone Joint Surg. 50-A: 487– 502, 1968. 12 Reed, R. J.: Fibrous dysplasia of bone, a review of 25 cases. Arch. Path. 75: 480– 495, 1963. 13 Smith, A. G., and Zavelata, A.: Osteoma, ossifying fibroma, and fibrous dysplasia of facial and cranial bones. AMA Arch Path. 54: 507– 537, 1952. Citing Literature Volume26, Issue2August 1970Pages 303-312 ReferencesRelatedInformation

Benign fibro-osseous jaw lesions of periodontal membrane origin. An analysis of 249 cases.

An analysis of the clinical, radiographic, histologic and follow-up data on 249 cases of lesions of periodontal membrane origin is presented. Such lesions may be cementoid, osteoid, mixed (cemento-osteoid) or fibrous. These tumors may be single or multiple and usually behave in a benign fashion. Occasionally they may act in an aggressive manner and attain giant size, although none metastasize. The benign fibro-osseous lesions of periodontal membrane origin are more prevalent in the jaws than fibro-osseous lesions of medullary bone origin. The use of polarized light was most helpful in distinguishing mature cementoid lesions from tumors with mature lamellar bone; the former have finer lines of parallel birefringence. Fibrous dysplasia has often been misused as a diagnostic term and was found not to be prevalent as a fibro-osseous jaw lesion. Fibrous dysplasia has its own particular histologic features, and the immature "woven" bone within the lesion polarizes in a random birefringent pattern.