Belt Electrode Research Articles

Electrical Stimulation-Based Twitch Exercise Suppresses Progression of Immobilization-Induced Muscle Fibrosis via Downregulation of PGC-1α/VEGF Pathway

This study aimed to determine whether electrical stimulation-based twitch exercise is effective in inhibiting the progression of immobilization-induced muscle fibrosis. 19 Wistar rats were randomly divided into a control group (n=6), an immobilization group (n=6; with immobilization only), and a Belt group (n=7; with immobilization and twitch exercise through the belt electrode device, beginning 2 weeks after immobilization). The bilateral soleus muscles were harvested after the experimental period. The right soleus muscles were used for histological analysis, and the left soleus muscles were used for biochemical and molecular biological analysis. As a result, in the picrosirius red images, the perimysium and endomysium were thicker in both the immobilization and Belt groups compared to the control group. However, the perimysium and endomysium thickening were suppressed in the Belt group. The hydroxyproline content and α-SMA, TGF-β1, and HIF-1α mRNA expressions were significantly higher in the immobilization and belt groups than in the control group. These expressions were significantly lower in the Belt group than in the immobilization group. The capillary-to-myofiber ratio and the mRNA expressions of VEGF and PGC-1α were significantly lower in the immobilization and belt groups than in the control group, these were significantly higher in the Belt group than in the immobilization group. From these results, Electrical stimulation-based twitch exercise using the belt electrode device may prevent the progression of immobilization-induced muscle fibrosis caused by downregulating PGC-1α/VEGF pathway, we surmised that this intervention strategy might be effective against the progression of muscle contracture. Keywords: Immobilization • Skeletal muscle • Fibrosis • Electrical stimulation-based twitch exercise • PGC-1α/VEGF pathway

Belt electrode tetanus muscle stimulation reduces denervation-induced atrophy of rat multiple skeletal muscle groups

Belt electrode-skeletal muscle electrical stimulation (B-SES) involves the use of belt-shaped electrodes to contract multiple muscle groups simultaneously. Twitch contractions have been demonstrated to protect against denervation-induced muscle atrophy in rats, possibly through mitochondrial biosynthesis. This study examined whether inducing tetanus contractions with B-SES suppresses muscle atrophy and identified the underlying molecular mechanisms. We evaluated the effects of acute (60 Hz, 5 min) and chronic (60 Hz, 5 min, every alternate day for one week) B-SES on the tibialis anterior (TA) and gastrocnemius (GAS) muscles in Sprague–Dawley rats using belt electrodes attached to both ankle joints. After acute stimulation, a significant decrease in the glycogen content was observed in the left and right TA and GAS, suggesting that B-SES causes simultaneous contractions in multiple muscle groups. B-SES enhanced p70S6K phosphorylation, an indicator of the mechanistic target of rapamycin complex 1 activity. During chronic stimulations, rats were divided into control (CONT), denervation-induced atrophy (DEN), and DEN + electrically stimulated with B-SES (DEN + ES) groups. After seven days of treatment, the wet weight (n = 8–11 for each group) and muscle fiber cross-sectional area (CSA, n = 6 for each group) of the TA and GAS muscles were reduced in the DEN and DEN + ES groups compared with that in the CON group. The DEN + ES group showed significantly higher muscle weight and CSA than those in the DEN group. Although RNA-seq and pathway analysis suggested that mitochondrial biogenesis is a critical event in this phenomenon, mitochondrial content showed no difference. In contrast, ribosomal RNA 28S and 18S (n = 6) levels in the DEN + ES group were higher than those in the DEN group, even though RNA-seq showed that the ribosome biogenesis pathway was reduced by electrical stimulation. The mRNA levels of the muscle proteolytic molecules atrogin-1 and MuRF1 were significantly higher in DEN than those in CONT. However, they were more suppressed in DEN + ES than those in DEN. In conclusion, tetanic electrical stimulation of both ankles using belt electrodes effectively reduced denervation-induced atrophy in multiple muscle groups. Furthermore, ribosomal biosynthesis plays a vital role in this phenomenon.

Muscle contractile exercise through a belt electrode device prevents myofiber atrophy, muscle contracture, and muscular pain in immobilized rat gastrocnemius muscle.

Immobilization of skeletal muscles causes muscle atrophy, muscle contracture, and muscle pain, the mechanisms of which are related to macrophage accumulation. However, muscle contractile exercise through a belt electrode device may mitigate macrophage accumulation. We hypothesized that such exercise would be effective in preventing myofiber atrophy, muscle contracture, and muscular pain. This study tested this hypothesis in immobilized rat gastrocnemius muscle. A total of 32 rats were divided into the following control and experimental groups: immobilization (immobilized treatment only), low-frequency (LF; immobilized treatment and muscle contractile exercise with a 2 s (do) /6 s (rest) duty cycle), and high-frequency (HF; immobilized treatment and muscle contractile exercise with a 2 s (do)/2 s (rest) duty cycle). Electrical stimulation was performed at 50 Hz and 4.7 mA, and muscle contractile exercise was applied to the lower limb muscles for 15 or 20 min/session (once daily) for 2 weeks (6 times/week). After the behavioral tests, the bilateral gastrocnemius muscles were collected for analysis. The number of macrophages, the Atrogin-1 and MuRF-1 mRNA expression, and the hydroxyproline content in the HF group were lower than those in the immobilization and LF groups. The cross-sectional area (CSA) of type IIb myofibers in the superficial region, the PGC-1α mRNA expression, and the range of motion of dorsiflexion in the HF group were significantly higher than those in the immobilization and LF groups. The pressure pain thresholds in the LF and HF groups were significantly higher than that in the immobilization group, and the nerve growth factor (NGF) content in the LF and HF groups was significantly lower than that in the immobilization group. Muscle contractile exercise through the belt electrode device may be effective in preventing immobilization-induced myofiber atrophy, muscle contracture, and muscular pain in the immobilized rat gastrocnemius muscle.

Efficacy of Belt Electrode Skeletal Muscle Electrical Stimulation in the Postoperative Rest Period in Patients with Diabetes who Have Undergone minor Amputations: A Randomized Controlled Trial.

This study aimed to investigate whether belt electrode skeletal muscle electrical stimulation (B-SES) would improve postoperative lower limb function and walking ability in patients with diabetes who have undergone minor amputations. Diabetic patients who had undergone minor amputations were assigned randomly to a B-SES or control group. The B-SES group underwent conventional physical therapy for 20 min and B-SES for 20 min. The control group underwent only the 20-min conventional physical therapy. In both groups, rehabilitation was introduced by the physical therapists for 14 days from postoperative day 1. The outcome measures were range of motion in the ankle joint, knee extension muscle strength, ambulation status, and quality of life score. All these were evaluated before the intervention and 2 and 4 weeks after the intervention. From the 84 patients initially assessed, 32 were assigned to either the B-SES (N = 16) or control (N = 16) group. Preoperatively, there were no significant differences in all endpoints. The B-SES group showed significant improvement in the ankle dorsiflexion angle at 2 weeks postoperatively and knee joint extension strength at 4 weeks postoperatively. Postoperative B-SES with standard physical therapy might improve the range of motion of dorsiflexion of the ankle joint and extensor strength of the knee joint in patients with diabetes who have undergone minor amputations. B-SES is a useful tool to improve postoperative physical function in diabetic patients who have undergone minor amputations. A multicenter study is needed to determine the effective B-SES combined with regular physiotherapy for minor amputation.

Effects of early post-transplant belt electrode skeletal muscle electrical stimulation therapy on an allogeneic hematopoietic stem cell transplant recipient: A case study

Effects of early post-transplant belt electrode skeletal muscle electrical stimulation therapy on an allogeneic hematopoietic stem cell transplant recipient: A case study

Efficacy of belt electrode skeletal muscle electrical stimulation on muscle flexibility of lower limbs: A randomized controlled pilot trial.

Background:Muscular contracture may be caused by immobility-induced muscle atrophy and skeletal muscle hypoxia. Belt electrode skeletal muscle electrical stimulation (B-SES) is a new type of neuromuscular electrical stimulation that can simultaneously contract the lower limb muscle groups, in contrast to the conventional pad-type electrodes. B-SES can suppress muscular atrophy and relieve hypoxia of the skeletal muscle and is considered an appropriate strategy for preventing muscular contracture. However, the effect of B-SES on muscle flexibility has not been verified. This study aimed to compare the immediate effects of B-SES on skeletal muscle flexibility using different stimulation modes before the clinical study.Methods:We conducted a randomized controlled pilot trial with cross-over analysis of 10 healthy subjects. The participants were subjected to three stimulus conditions (Disuse B-SES, Metabolic B-SES, and Control) with a minimal interval of 1 day between interventions, and the lower limb flexibility before and after the B-SES intervention was evaluated. Lower extremity flexibility was evaluated based on the hamstring muscle stiffness and sit-and-reach distance. For each endpoint, within-group comparisons were performed before and after the intervention and were compared between the groups using paired t-tests. Changes in each endpoint before and after the intervention were analyzed using repeated-measures analysis of variance and the Bonferroni method. The significance level was 0.05.Results:Ten healthy individuals participated in all three interventions with a washout period between each intervention. In the Metabolic B-SES group, the sit-and-reach distance after the intervention was significantly higher than that before the intervention (P < 0.05). A comparison of the change in the sit-and-reach distance among the three groups before subsequent tests showed that the Metabolic B-SES group had a significantly increased sit-and-reach distance compared with the control group (P < 0.05).Conclusion:Metabolic B-SES was effective for the immediate improvement of flexibility of the lower limb muscles. Therefore, Metabolic B-SES may be useful as a strategy for preventing muscular contracture.

Effect of belt electrode skeletal muscle electrical stimulation on psychological stress

Effect of belt electrode skeletal muscle electrical stimulation on psychological stress

Effect of belt electrode skeletal muscle electrical stimulation during hemodialysis on the endothelial function in hemodialysis patients

Effect of belt electrode skeletal muscle electrical stimulation during hemodialysis on the endothelial function in hemodialysis patients

Changes of blood myokine levels following human skeletal muscle contraction using belt electrode skeletal muscle electrical stimulation

Interleukin (IL)-6 is a myokine secreted from skeletal muscle fibers by the stimulation of muscle contraction. IL-6 then acts on skeletal muscle itself or on remote organs through the blood circulation, resulting in various health benefits. The quantity of mobilized muscle, exercise intensity, and exercise time are deeply involved in the rise of blood IL-6 levels. In this study, we investigated whether high sensitivity C-reactive protein, IL-6, and the anti-inflammatory cytokine, IL-10, were produced in humans by muscle contraction due to electrical stimulation . Six healthy men underwent 20 min of belt electrode skeletal muscle electrical stimulation. No time-dependent changes in IL-6, IL-10, and high sensitivity C-reactive protein were observed. These results suggest that blood myokines do not increase in response to standard electrical stimulation.

Efficacy of belt electrode skeletal muscle electrical stimulation on reducing the rate of muscle volume loss in critically ill patients: A randomized controlled trial.

Belt electrode skeletal muscle electrical stimulation can induce muscle contraction of the whole lower body. This study examined the efficacy of belt electrode skeletal muscle electrical stimulation on reducing loss of muscle volume in critically ill patients. Intensive care unit patients were randomly assigned to control and electrical muscle stimulation groups. In both groups, early rehabilitation was administered from day 2 of admission. In the electrical muscle stimulation group, belt electrode skeletal muscle electrical stimulation was administered. Femoral muscle volume was evaluated with computed tomography on days 1 and 10. Ninety-Four severely ill patients were included 47 patients were assigned to each group. Femoral muscle volumes of 16 control and 21 electrical muscle stimulation group patients were measured. For both groups, femoral muscle volume decreased significantly from day 1 to day 10 (p < 0.0001). The mean rate of muscle volume loss was 17.7% (standard deviation (SD) 10.8%) for the control group and 10.4% (SD 10.1%) for the electrical muscle stimulation group (p = 0.04). The score for stair-climbing of Barthel Index was significantly better in the electrical muscle stimulation group 3.9 (SD 4.0) than in the control group 1.5 (1.5) (p = 0.04). Belt electrode skeletal muscle electrical stimulation has the potential to inhibit muscle volume loss in critical care.

Medium-term effects of Belt Electrode Skeletal Muscle Stimulation (B-SES) on blood glucose and lipid control, body composition, muscular strength and muscular endurance in patients with type 2 diabetes

Medium-term effects of Belt Electrode Skeletal Muscle Stimulation (B-SES) on blood glucose and lipid control, body composition, muscular strength and muscular endurance in patients with type 2 diabetes

Electrical Stimulation in Addition to Passive Exercise Has a Small Effect on Spasticity and Range of Motion in Bedridden Elderly Patients: A Pilot Randomized Crossover Study

Purpose: Belt electrode skeletal muscle electrical stimulation (B-SES) can stimulate large portions of muscles including deep sites without localisation of the stimulation area. The purpose of this study is to investigate both immediate treatment effects of B-SES and long-term treatment effects of B-SES with passive exercise on range of motion (ROM) and muscle tone of lower extremities in bedridden elderly patients. Methods: Outcome measures before and after B-SES treatment alone (4 Hz, 20 min, both lower extremities) were examined for the immediate effect. Outcome measures were: ROM and Modified Ashworth scale (MAS) of hip flexion and adduction; knee flexion and extension; and knee joint distance at position of flexion abduction in hip (distance of knee). A randomized crossover trial was conducted to examine the long-term effect of adding B-SES to passive exercise on ROM and MAS. Results and Discussion: The immediate effect study had 18 patients. ROM and MAS of 4 joint angles in 2 joints and distance of knee significantly improved after B-SES treatment. The long-term effect study had 11 patients. Friedman test revealed ROM and MAS of 4 joint angles in 2 joints and distance of knee significantly improved during B-SES intervention but not control intervention. B-SES in addition to passive stretch has a more statistically significant effect on contracture and spasticity in large portions of the lower extremities of bedridden elderly patients than passive stretching alone. Conclusions: We consider B-SES a useful tool to improve the ROM in lower extremities of bedridden patients.

透析中ベルト電極式骨格筋電気刺激法が透析患者の身体機能に与える影響

透析中ベルト電極式骨格筋電気刺激法が透析患者の身体機能に与える影響

Belt-Type Corona-Electrostatic Separator for the Recovery of Conductive and Nonconductive Products From Micronized Wastes

The commercial roll-type corona-electrostatic separators, which are currently employed for the recovery of metals and plastics from millimeter-size granular mixtures, are inappropriate for the processing of finely grinded wastes. The aim of this paper is to demonstrate that a belt-type corona-electrostatic separator could be an appropriate solution for the selective sorting of conductive and nonconductive products contained in micronized wastes. The experiments are carried out on a laboratory-scale multifunctional electrostatic separator designed by the authors. The corona discharge is generated between a wire-type dual electrode and the surface of the metal belt conveyor. The distances between the wire and the belt and the applied voltage are adjusted to values that permit particles charging without having an electric wind that puts them into motion on the surface of the belt. The separation is performed in the electric field generated between a high-voltage roll-type electrode (diameter 30 mm) and the grounded belt electrode. The study is conducted according to the experimental design methodology, to enable the evaluation of the effects of the various factors that affect the efficiency of the separation: position of the roll-type electrode and applied high voltage. The conclusions of this study will serve at the optimum design of an industrial belt-type corona-electrostatic separator for the recycling of metals and plastics from the waste electric and electronic equipment.

Low-intensity electrical muscle stimulation induces significant increases in muscle strength and cardiorespiratory fitness

The aim of this study was to investigate the effect of low-intensity exercise training using belt electrode skeletal muscle electrical stimulation on muscle strength and cardiorespiratory fitness in healthy subjects. Nineteen healthy subjects were allocated into control or intervention groups; in both groups the participants kept regular physical activity while the intervention group underwent 30 min B-SES training at 3–4 METs for four weeks. Knee extensor muscle strength and cardiorespiratory endurance during incremental exercise test were measured at baseline and after four weeks for all participants. The relative change of knee extensor muscle strength in the intervention group was significantly higher than control group (p < .05). Also, oxygen uptake at ventilator threshold and peak oxygen uptake during incremental exercise test significantly increased in the intervention group when compared with control group (p < .05). This study showed that prolonged low-intensity B-SES training resulted in significant increases in muscle strength and cardiorespiratory fitness in healthy subjects. Our present work suggested that B-SES training could assist patients who might have difficulty performing adequate voluntary exercise because of excessive obesity, orthopaedic problems and chronic diseases such as cardiovascular disease and type 2 diabetes. An intervention study conducted for such patients is strongly recommended.

Beneficial effects of short-term Belt electrode Skeletal muscle Electrical Stimulation（B-SES）in a patient with lower limb muscle weakness followed by acute respiratory distress syndrome

Beneficial effects of short-term Belt electrode Skeletal muscle Electrical Stimulation（B-SES）in a patient with lower limb muscle weakness followed by acute respiratory distress syndrome

Effects of the belt electrode skeletal muscle electrical stimulation system on lower extremity skeletal muscle activity: Evaluation using positron emission tomography

BackgroundLower-extremity muscle weakness in athletes after lower limb trauma or surgery can hinder their return to sports, and the associated muscle atrophy may lead to deterioration in performance after returning to sports. Recently, belt electrode skeletal muscle electrical stimulation (B-SES) which can contract all the lower limb skeletal muscles simultaneously was developed. However, no study has evaluated skeletal muscle activity with B-SES. Since only superficial muscles as well as a limited number of muscles can be investigated using electromyography, we investigated whether positron emission tomography (PET) can evaluate the activity of all the skeletal muscles in the body simultaneously. The purpose of this study was to evaluate the effectiveness of the B-SES system using PET. MethodsTwelve healthy males (mean age, 24.3 years) were divided into two groups. The subjects in the control group remained in a sitting position for 10 min, and [18F] fluorodeoxyglucose (FDG) was intravenously injected. In the exercise group, subjects exercised using the B-SES system for 20 min daily for three consecutive days as a pre-test exercise. On the measurement day, they exercised for 10 min, received an injection of FDG, and exercised for another 10 min. PET-computed tomography images were obtained in each group 60 min after the FDG injection. Regions of interest were drawn in each lower-extremity muscle. We compared each skeletal muscle metabolism using the standardized uptake value. ResultsIn the exercise group, FDG accumulation in the gluteus maximus, gluteus medius, gluteus minimus, quadriceps femoris, sartorius, and hamstrings was significantly higher than the muscles in the control (P < 0.05). ConclusionExercise with B-SES increased the skeletal muscle activity of the gluteal muscles as well as the most lower-extremity muscles simultaneously.

Electrostatic separator for micronized mixtures of metals and plastics originating from waste electric and electronic equipment

In spite of their extensive use for processing mixtures of granules exceeding 1 mm in size, very few industrial electrostatic separators are capable of handling micronized metals and plastics originating from waste electric and electronic equipment. The aim of the present work is to validate the possibility of using a novel belt-type electrostatic separator for the selective sorting of such particulate mixtures, the dimensions of which are in the order of 0.1 mm. In this type of separator, the metal particles get charged by electrostatic induction in contact with the grounded metal belt electrode, while the plastics remain uncharged in the electric field and are collected separately. The experiments are performed with 2-g samples of a mixture composed in equal proportions (50% - 50%) of Aluminium and Acrylonitrile Butadiene Styrene (ABS) particles of average diameter ranging between 125 μm and 250 μm. They enabled the evaluation of the effects and the interaction of two control variables of the process: the angle of inclination of the roll-type electrode and the high voltage applied to it.

Optimisation of belt-type electrostatic separation of granular plastic mixtures tribocharged in a propeller-type device

Electrostatic separation has already proven its efficiency as a method to recover metals and plastics from granular waste electrical and electronic equipment (WEEE). Nevertheless, there still is some work to do regarding the sorting of the various sorts of plastics (ABS, ABS-PC, HIPS, PC) contained in information technology wastes. The main objective of this paper is to optimize the electrode configuration and the operation of a belt-type electrostatic separator employed in conjunction with a new tribo-aerodynamic charging device. This application is particularly designed for the recovery of granular materials issued from shredding of computer cases, which contain large quantities of ABS. The following control variables were considered for the optimization: (i) distance between the axis of the high-voltage electrode and the surface of the grounded belt electrode; (ii) angular position of the high-voltage electrode with respect to the horizontal plane; (iii) high-voltage level. Experimental design methodology was employed for determining the optimum value of each variable, using commercial software (MODDE, Umetrics, Sweden).

Development of Electrostatic Separator Equipped with Moving Belt Electrode

This paper presents the results of an experimental study of the performance of a novel electrostatic separator. The separator consists of a conductive belt conveyor equipped with a plate electrode. The separation tests were performed on a sample containing 50% polyvinylchloride (PVC) and 50 aluminum. The influence of electric field strength and belt speed on the separation efficiency was investigated. Numerical experiments have shown the feasibility of obtaining extract contents of aluminum and PVC in excess of 99.99% and 99.46%, respectively.