Battery Of Psychometric Tests Research Articles

Cognitive Impairment in Superficial Siderosis of the Central Nervous System: A Case Report

Superficial siderosis is a rare disease characterized by cerebellar ataxia and sensorineural deafness. So far, there are only few reports on cognitive dysfunctions associated with superficial siderosis. Using a comprehensive psychometric test battery, we describe the cognitive impairments in a 65-year-old woman fulfilling the clinical and magnetic resonance imaging criteria of superficial siderosis. The neuropsychological findings included deterioration of primary and episodic memory, behavioral and linguistic changes characterized by social disinhibition, and decreased verbal fluency. These findings may correspond to the "cerebellar cognitive affective syndrome" which was suggested to occur in patients with selective cerebellar lesions. Probable mechanisms leading to the characteristic cognitive impairment in superficial siderosis are discussed.

Sedation and antihistamines: an update. Review of inter‐drug differences using proportional impairment ratios

The use of antihistamines (AHs) has been associated with cognitive and psychomotor impairments, largely caused by the sedative properties of many of these drugs. Due to the ambulant nature of the population using AHs, it is important to evaluate these effects using standardised methodology and psychometric tests. A previous extensive review of the literature collated the results of studies of H(1) receptor antagonists to determine the extent to which a particular AH produced impairments on a battery of psychometric tests by calculating a proportional impairment ratio for each AH. In light of a number of major studies published following the previous review, and the development of the second and new-generation AHs, the present review aims to add to the database and update the review, using the same methodology. The newer generation AHs appear to be the least impairing, and the first generation, as expected, appear to be the most impairing. There are also differences within the AH drug generations. The review highlights the necessity to consider the sedating potential of AHs, along with other factors such as efficacy, when prescribing AHs to ambulant patients.

Working in Health Access Programme (WHAP): initial results

Academic achievement and social class are positively related and applications to medical schools reflect a class-based bias favouring middle-class candidates. Applying a measure that is class-free could be useful as an indicator of a potential good health professional may widen the pool of applicants. In the Working in Health Access Programme (WHAP), we report on the potential usefulness of such a measure. In addition, we describe a programme for raising awareness of higher education (HE) and careers in health care. Pupils attending schools with low HE participation rates sat a battery of psychometric tests assessing both cognitive and non-cognitive skills. A total of 2349 pupils sat the tests and 1000 of them took part in the subsequent activities. These pupils are being followed up and have obtained their Standard Grade (Year 11) examination results. Although social class influenced cognitive skills, it had no influence on non-cognitive abilities. Pupils with high levels of cognitive ability were found in all classes, including the most deprived. Both the testing and the awareness-raising programme were successful. Additional information was obtained on factors influencing the participants' choices of career. Psychometric assessment could act as an early indicator for identifying potential in young people. For pupils with both cognitive and non-cognitive attributes that might indicate they would be successful in veterinary or human medicine, appropriate advice regarding subject choices for school examinations and future careers could be provided.

Next‐day cognition, psychomotor function, and driving‐related skills following nighttime administration of eszopiclone

To evaluate next-day driving ability, as assessed by brake reaction time (BRT), and cognitive/psychomotor function following nighttime administration of 3 mg eszopiclone. Two randomized, double-blind, placebo-controlled, cross-over studies were performed in healthy volunteers (n = 32) and patients with primary insomnia (n = 32). Study participants received nighttime dosing of 3 mg eszopiclone or placebo. BRT and a psychometric test battery were used to assess the next-day effects of eszopiclone treatment. In both studies, driving ability and measures of cognitive and psychomotor function were not impaired the morning after eszopiclone, as compared to placebo. All eszopiclone subjects reported improved ease in getting to sleep and quality of sleep with no significant changes in behavior upon awakening. A significant increase in next-day feelings of sedation was reported in healthy volunteers, but not in patients with primary insomnia, following eszopiclone treatment relative to placebo. Sleep induction, maintenance, duration, and efficiency, as assessed by PSG, were significantly improved following eszopiclone treatment in patients with insomnia. Nighttime administration of 3 mg eszopiclone improved objective and subjective sleep measures in patients with insomnia (and subjective sleep measures in healthy patients) and did not impair next-day driving-related skills or measures of cognition in either study population relative to placebo.

Psychiatric comorbidity in different organic vertigo syndromes

A high degree of psychiatric disorders has repeatedly been described among patients with organic vertigo syndromes and attributed to vestibular dysfunction. Yet almost no investigations exist which differentiate between various organic vertigo syndromes with regard to psychiatric comorbidity. The following prospective, interdisciplinary study was carried out to explore whether patients with different organic vertigo syndromes exhibit different psychological comorbidities. 68 patients with organic vertigo syndromes (benign paroxysmal positioning vertigo (BPPV) n = 20, vestibular neuritis (VN) n = 18, Menière's disease (MD) n = 7, vestibular migraine (VM) n = 23) were compared with 30 healthy volunteers. All patients and control persons underwent structured neurological and neuro-otological testing. A structured diagnostic interview (-I) (SCID-I) and a battery of psychometric tests were used to evaluate comorbid psychiatric disorders. Patients with VM and MD showed significantly higher prevalence of psychiatric comorbidity (MD = 57%, VM = 65%) especially with anxiety and depressive disorders, than patients with VN (22%) and BPPV (15 %) compared to normal subjects (20 %). These elevated rates of comorbidities resulted in significantly elevated odds-ratios (OR) for the development of comorbid psychiatric disorders in general (for VM OR = 7.5, for MD OR = 5.3) and especially for anxiety disorders (for VM OR = 26.6, for MD OR = 38.7). As a consequence, a structured psychological and psychometric testing and an interdisciplinary therapy should be proceeded in cases with complex and prolonged vertigo courses, especially in patients with VM and MD. Possible reasons of these unexpected results in VM and MD are discussed.

Aggression, Impulsivity, Personality Traits, and Childhood Trauma of Prisoners with Substance Abuse and Addiction

Introduction: The aim of our study is then to analyze psychological and judicial features of a subgroup of inmates with substance abuse. Methods: Prisoners with substance abuse (n = 312) were compared to prisoners without substance abuse (n = 591). Recruited inmates completed a semistructured interview for collection of sociodemographic and judicial data and a battery of psychometric tests for assessement of aggression, impulsivity, depression, personality traits, hostility, resilience, and childhood trauma. Results: Substance abusers had on average multiple incarcerations (78.8%), more juvenile convictions (60.2%), more violent behaviors during detention (29.8%), and a history of one or more suicide attempts (20.8%). They also had higher scores on subscales for childhood trauma, higher scores for psychoticism and neuroticism, higher impulsivity levels, worse resilience, increased hostility, and prevalent suicidal ideation. Conclusion: Prisoners with substance abuse constitute a subgroup with increased judiciary and psychiatric issues, possibly due to early life history and psychological characteristics, such as high impulsivity and aggressiveness, poor resilience, and higher suicidal risk.

Relationship of anxiety and depression with cognitive Disorder after surgery in the elderly

目的 了解老年患者术后短期认知功能障碍与患者焦虑状况、抑郁状况的相关性.方法 选择105例60岁以上(ASAⅠ～Ⅲ)行腹部外科手术的老年患者,参加测试的患者术前均征得本人及家属的同意.精神测试包括韦氏成人智力量表(简明),韦氏记忆力量表(简明),简易智力状态检查表,焦虑自评量表,抑郁自评量表.比较术前1 d及术后1周的精神测试的结果.抑郁状况采用抑郁自评量表测量,限定大于41分.焦虑状况采用焦虑自评量表测量,限定大于40分.结果 术后1周与术前的认知功能测试的结果存在着统计学差异.术前及术后的抑郁状况与认知功能下降有相关性.结论 麻醉对老年患者认知功能的短期影响有显著性临床意义.术后短期认知功能障碍与患者抑郁状况有一定的相关性,可能有一定的临床意义。

Using Personal Quality Assessment for Selection of Social Work Students

The social work profession has long struggled to find fair and effective ways of selecting students into their education programs. A psychometric test battery, gathered together under the title “Personal Qualities Assessment” (PQA) has been developed at the University of Newcastle to identify a range of qualities in aspiring health professionals. Two of its components were used to determine whether there was a relationship between scores obtained by social work students in these tests and scores achieved in an empathic listening and critical review hurdle assessment prior to the first field placement. The results showed that social work students who were moderately empathic, not narcissistic, and moderately libertarian in their moral orientation performed better on the assessment than students who were less empathic, more narcissistic, or extreme in their moral orientation. These results suggest that measurement of these qualities could be useful in selecting the most suitable individuals for social work programs.

Markers of inflammation and cognitive decline in an African‐Caribbean population

Inflammatory processes may play an important role in cognitive decline and dementia. We investigated the prospective association between levels of three markers of inflammation, plasma interleukin-6 (IL-6), serum C-reactive protein (CRP), serum amyloid A (SAA), and cognitive decline in an African-Caribbean community population. Of 290 participants aged 55-75 years at baseline sampled from Primary Care registration lists in south London, 216 (75%) were re-interviewed after 3 years. Baseline plasma concentrations of IL-6, CRP and SAA were ascertained through immunoassays. A battery of psychometric tests was administered on both occasions and decline in both individual tests and a composite outcome was analysed. After adjustment for potential confounding factors, raised levels of IL-6 (>3.1 pg/ml) were associated with cognitive decline in the total sample (odds ratio 2.9, 95% CI 1.1-7.5), but no associations were found for CRP or SAA. Raised IL-6 was most strongly associated with decline in orientation and immediate verbal recall tasks, with weaker associations for delayed recall and psychomotor speed. Raised IL-6 but not CRP predicted cognitive decline in this population Inflammatory changes associated with cognitive decline may be specific to particular causal pathways.

Global Assessment Measures for Assessing Efficacy in Dementia Drug Trials

The use of judgment-based global measures of clinical treatment effects has a long history in the regulatory approval of drugs for the treatment of dementia. This paper reviews current use of these measures, noting several practical difficulties with their implementation. Importantly, global measures have usually yielded general estimates of drug effects similar to psychometric test batteries, even though correlations between global and psychometric measures at the individual patient level is modest. Like psychometric tests, global measures can tell us that some clinically detectable effect is present but often yield only limited evidence about what those effects might be. Steps should be taken to improve the specificity of treatment effect description and to incorporate patient/caregiver preferences in global measures about disease treatment in dementia.

Activation of soluble guanylate cyclase by nitric oxide in lymphocytes correlates with minimal hepatic encephalopathy in cirrhotic patients

Patients with liver cirrhosis with normal neurological and mental status examination may present minimal forms of hepatic encephalopathy, showing intellectual function impairment that cannot be detected through general clinical examination but can be unveiled using specific neuropsychological or neurophysiological examination. Evaluation of minimal hepatic encephalopathy (MHE) in cirrhotic patients would have prognostic value. The psychometric hepatic encephalopathy score (PHES) has been recommended as the "gold standard" in the diagnosis of MHE. Altered modulation of cyclic GMP (cGMP) levels in the brain seems to be responsible for the impairment of some types of cognitive function in liver disease. In animal models of liver disease, some of the alterations in modulation of cGMP levels in the brain are reproduced in lymphocytes. The aim of the present work was to assess whether there is a correlation between the alterations in different parameters involved in modulation of cGMP levels and the presence of MHE in patients with liver disease. We studied in 46 patients with liver cirrhosis and 26 controls the performance in the PHES battery of psychometric tests and the critical flicker frequency (CFF), the concentration of cGMP in plasma and lymphocytes, activation of guanylate cyclase by nitric oxide (NO) in lymphocytes, and several parameters likely involved in altered cGMP homeostasis in liver disease such as ammonia, NO metabolites, and atrial natriuretic peptide (ANP). Activation of guanylate cyclase by NO in lymphocytes and cGMP in plasma were higher and CFF lower in patients with MHE than in patients without MHE. Ammonia, ANP, and metabolites of NO were higher in patients than in controls but were no different in patients with or without MHE. Alteration in activation of guanylate cyclase by NO in lymphocytes correlates with PHES performance, CFF, and ammonia levels. This suggests that altered modulation of guanylate cyclase by NO in lymphocytes would reflect a parallel alteration in the brain occurring in patients with MHE that would be involved in their cognitive impairment.

Can we ignore minimal hepatic encephalopathy any longer?

Can we ignore minimal hepatic encephalopathy any longer?

Smooth pursuit eye movements and phonological processing in adults with dyslexia

The extent to which adults with dyslexia are characterized by concurrent smooth pursuit eye movement and phonological difficulties was investigated, as was the relationship between performance on these respective tasks and literacy skills. A total of 19 adults with dyslexia and 19 age- and IQ-matched controls undertook a comprehensive battery of psychometric, literacy, and phonological tests. Smooth pursuit initiation was measured quantitatively under both gap and nongap conditions. The results revealed that adults with dyslexia had longer smooth pursuit latencies; however, both groups showed a similar gap effect. Moreover, the group with dyslexia had poorer phonological skills than controls. The smooth pursuit impairments affected 37% of the group whereas the phonological difficulties—most notably phoneme deletion latency—were severe among participants with dyslexia, affecting 89% of the group. Phonological processing tasks, but not the smooth pursuit task, were strongly correlated with nonword- and word-decoding skills in the group with dyslexia. These results suggest a lower incidence of smooth pursuit problems than phonological difficulties in dyslexia, and that the latter tasks are more critical for word level decoding.

Amyloid, hypometabolism, and cognition in Alzheimer disease

To investigate the association between brain amyloid load in Alzheimer disease (AD) measured by [11C]PIB-PET, regional cerebral glucose metabolism (rCMRGlc) measured by [18F]FDG-PET, and cognition. Nineteen subjects with AD and 14 controls had [11C]PIB-PET and underwent a battery of psychometric tests. Twelve of those subjects with AD and eight controls had [18F]FDG-PET. Parametric images of [11C]PIB binding and rCMRGlc were interrogated with a region-of-interest atlas and statistical parametric mapping. [11C]PIB binding and rCMRGlc were correlated with scores on psychometric tests. AD subjects showed twofold increases in mean [11C]PIB binding in cingulate, frontal, temporal, parietal, and occipital cortical areas. Higher cortical amyloid load correlated with lower scores on facial and word recognition tests. Two patients fulfilling the clinical criteria for AD had normal [11C]PIB at baseline. Over 20 months this remained normal in one but increased in the cingulate of the other. Mean levels of temporal and parietal rCMRGlc were reduced by 20% in AD and these correlated with mini mental scores, immediate recall, and recognition memory test for words. Higher [11C]PIB uptake correlated with lower rCMRGlc in temporal and parietal cortices. [11C]PIB-PET detected an increased amyloid plaque load in 89% of patients with clinically probable Alzheimer disease (AD). The high frontal amyloid load detected by [11C]PIB-PET in AD in the face of spared glucose metabolism is of interest and suggests that amyloid plaque formation may not be directly responsible for neuronal dysfunction in this disorder.

Humour therapy in patients with late‐life depression or Alzheimer's disease: a pilot study

Of the disabling disorders of the elderly, depression is the most common affective disorder and Alzheimer's disease (AD) the most common neurodegenerative disorder. Pharmacological treatment strategies for these disorders are often accompanied with severe side effects. Therefore non-pharmacological treatment strategies are of great importance. The aim of the present study was to investigate the impact of humour therapy on quality of life in patients with depression or AD. Twenty patients with late-life depression and 20 patients with AD were evaluated. Ten patients in each group underwent a humour therapy group (HT) once in two weeks for 60 min in addition to standard pharmacotherapy, which was given as usual to the other group as standard therapy (ST). All patients completed a psychometric test battery at admission and before discharge from the clinic. The quality of life scores improved both in HT and ST groups for depressive patients but not for patients with AD irrespective of the therapy group. Depressive patients receiving HT showed the highest quality of life after treatment. In addition, patients with depression in both therapy groups showed improvements in mood, depression score, and instrumental activities of daily living. Although there was no significant effect of humour therapy comparing with standard therapy on quality of life, these findings suggest that humour therapy can provide an additional therapeutic tool. Further studies with higher frequently humour groups are required in order to investigate the impact of humour therapy in gerontopsychiatric treatment.

A double‐blind, placebo‐controlled investigation of the residual psychomotor and cognitive effects of zolpidem‐MR in healthy elderly volunteers

To assess residual psychomotor and cognitive effects of a modified-release formulation of zolpidem (zolpidem-MR), developed to provide sustained hypnotic efficacy during the whole night, compared with placebo and flurazepam. Twenty-four healthy elderly volunteers received four study treatments (zolpidem-MR 6.25 mg and 12.5 mg, placebo and flurazepam 30 mg) using a randomized, cross-over, double-blind design. Residual psychomotor and cognitive effects were assessed with a psychometric test battery. Quality of sleep and residual effects were evaluated subjectively with the Leeds Sleep Evaluation Questionnaire. Psychometric performance was significantly impaired with flurazepam but not with zolpidem-MR at either dose. Ease of falling asleep and sleep quality were significantly improved with both doses of zolpidem-MR and with flurazepam. Neither active drug modified perception of well-being on awakening. In elderly subjects, zolpidem-MR showed no residual functional impairment in psychometric or cognitive tests sensitive to flurazepam.

Tablas de normalidad de la población española para los tests psicométricos utilizados en el diagnóstico de la encefalopatía hepática mínima

Minimal hepatic encephalopathy (MHE) induces an impairment in the quality of life and has been found as the first stage in hepatic encephalopathy syndrome. Psychometric Hepatic Encephalopathy Score (PHES) is a psychometric test battery widely utilized in the diagnosis of MHE which requires correction by age and education. Eight-hundred and eighty four healthy people were included. Trailmaking test-A (TMT-A), TMT-B, digit symbol test (DST), serial dotting (SDT) and line drawing test (LDT) were performed. Age, education, gender, alcohol consumption and hospitalization were recorded. T-student and Pearson correlation were utilized in univariate analyses. A multiple linear regression was performed to detect independent variables associated with psychometric test score. Using the equation from the multiple linear regression, normality tables were built. Age and education were associated with all 5 tests. An alcohol consumption higher than 10 g per day was associated with a lower score in DST and SDT. A gender influence was seen in TMT-A and TMT-B. Moreover, some differences were found in SDT, TMT-B and LDT according to hospital procedence. In multivariate analyses using multiple linear regression, age and education were independently associated with all five tests. Normality tables of the PHES allow investigating MHE in cirrhotics avoiding local control groups. Taking in mind normality tables, PHES could become a gold standard test to analyze further diagnostic methods and to evaluate drugs efficacy in MHE. Normality tables are freely available at http://www.redEH.org.

Heritable risk factors associated with language impairments

There is a strong genetic contribution to children’s language and literacy impairments. The aim of this study was to determine which aspects of the phenotype are familial by comparing 34 parents of probands with language/literacy impairments and 33 parents of typically developing probands. The parents responded to questionnaires regarding previous history for language/reading impairment and participated in psychometric testing. The psychometric test battery consisted of tests assessing non-verbal IQ, short-term memory, articulation, receptive grammar, reading abilities and spelling. Self-report measures demonstrated a higher prevalence of language and literacy impairments in parents of affected probands (32%) compared with parents of unaffected probands (6%). The two groups of parents differed significantly in their performance on the non-word repetition, oromotor and digit span tasks. Non-word repetition gave the best discrimination between the parent groups even when the data from the parents who actually were impaired as ascertained by direct testing or self-report were removed from the analyses. This suggests that non-word repetition serves as a marker of a family risk for language impairment. The paper concludes with a discussion of issues associated with ascertainment of specific language impairment (SLI).

White matter integrity and cognition in childhood and old age

To test the hypothesis that white matter integrity, as measured by diffusion tensor and magnetization transfer MRI is significantly associated with cognitive ability measured in youth and old age. Forty, nondemented, surviving participants of the Scottish Mental Survey of 1932 underwent brain MRI and a battery of psychometric tests covering major cognitive domains and tests of information processing efficiency. IQ scores were available from age 11. Mean diffusivity, fractional anisotropy (FA), and magnetization transfer ratio (MTR) were measured in frontal and parieto-occipital white matter and centrum semiovale. Centrum semiovale FA correlated (r = 0.36 to 0.56; p < 0.02) with contemporaneous (age 83) scores on psychometric tests of nonverbal reasoning, working memory, executive function, and information processing efficiency. Centrum semiovale FA also correlated with IQ at age 11 (r = 0.37; p = 0.02). Controlling for IQ at age 11 and information processing at age 83 attenuated the association between centrum semiovale FA and general cognitive ability by approximately 85%. MTR, largely, did not show significant correlations with cognitive test scores. These data support the information processing efficiency hypothesis of cognitive aging and suggest one foundation for individual differences in processing efficiency. They also suggest that studies of imaging and cognition in the elderly should take into account prior mental ability rather than assuming that any associations between imaging parameters and cognitive test scores are the result of age-related changes.

Investigation into the suitability of a portable psychometric device to be used in the field: An illicit drugs field investigation

Rationale: Driving performance is easily disrupted as a direct consequence of the use of alcohol, licit and illicit drugs. The use of such drugs has a high degree of correlation with increased accident risk. Europe wide research projects into drugged driving have called for the development of a portable objective device capable of screening those impaired through drug use which can be used at the roadside. Objective: This study investigated the cognitive and psychomotor performance of a cohort of polydrug drug users in field conditions. Volunteers completed a psychometric test battery on a hand held device in music festival conditions. The test battery comprised a critical tracking task (CTT) and a sustained attention to response task (SART). Volunteers also took a breathanalyser and provided a saliva sample for a DOA screen. Results: On the CTT significance was observed for tracking error following response to a peripheral stimulus in the high alcohol (>80 mg/100 ml) illicit drug group ( p = 0.0090) and approached significance for the low alcohol (<80 mg/100 ml) illicit drug group ( p = 0.088). For the SART, incorrect presses to the target stimulus was impaired for volunteers in both the low (<80 mg/100 ml) alcohol illicit drug group ( p = 0.0080) and the high alcohol (>80 mg/100 ml) illicit drug group ( p = 0.0415). Discrimination analysis demonstrated that the impairment device was able to discriminate between those individuals who had consumed neither alcohol nor drugs (94.12%), those in the low alcohol drug group (46.67%) and those in the high alcohol drug group (60.00%). Conclusion: It is possible to derive an impairment ratio. Further research will demonstrate whether this device could significantly contribute to drug driving detection and road traffic safety.