In this work, we present a comprehensive analysis of the structure of six-derivative bosonic couplings in heterotic string theory. First, we determine the maximal covariant and Yang-Mills gauge invariant basis, which consists of 801 independent coupling constants. By imposing T-duality constraints on the circular reduction of these terms, we obtain 468 relations between the coupling constants at the six-derivative order and the known couplings at lower derivative orders. Through the use of field redefinitions, we are able to eliminate the remaining 333 coupling constants. Remarkably, we find that the Yang-Mills field strength only appears through the trace of two field strengths or their derivatives. Finally, we perform further field redefinition to rewrite the remaining couplings in a canonical form characterized by 85 independent couplings.
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