This paper collects into a medical waste plasma gasification, a cleaning system, a gas turbine, a syngas storage tank and a coal-fired power unit to establish the medical waste plasma hybrid peak shaving system. In this system, medical waste is transported into a plasma gasification furnace and prepared as syngas by reaction. Then, the syngas is delivered to the gas turbine after cooling and deacidification. Finally, the flue gas from the combustion of the gas turbine is used to heat the condensate of a coal-fired power unit. Compared to the coal-fired power unit, the system has a larger range of peak load capability. Establish the integrated regional power grid dispatching model. The paper selects five typical days, which combine the actual data to comprehensively consider many factors. Then analyze the optimal economy of the regional power grid and propose the optimal dispatch scheme for the regional power grid. After modification, the system energy efficiency is 37.38%, and system exergy efficiency is 36.19%. After the dispatching optimization, the average daily profit is 140.78 k$, the profitability can reach initial cost in 6.20 years, and the net present value generated by the medical waste plasma hybrid peak shaving system is 178,410.43 k$.