Au Nanocomposites Research Articles

Synthesis, Characterization and Anticancer Activity of Chitosan Schiff Base / PEG Blend Doped with Gold and Silver Nanoparticles in Treatment of Breast Cancer Cell Line MCF-7

In the present study, chitosan Schiff base has been prepared from chitosan reaction with the para chloro benzaldehyde. The AuNPs and AgNPs were manufacture by extract of onion peels as a reducing agent. The AuNPs and AgNPs that have been synthesized were characterized through UV-vis spectroscopy the XRD analyses and SEM microscopy. The polymer blends of the chitosan / PEG has been prepared through using the approach of solution casting. Chitosan Schiff base / PEG Au and Ag nano-composites were synthesized nano composites and polymer blends have been characterized by FTIR which confirm the formation of Schiff base by revealing a new band of absorption at 1693 cm-1 as a result of the (C=N) imine group. FESEM, DSC and TGA confirms the thermal stability of the prepared polymer blends and nanocomposites, nano composites have shown good results in inhibiting breast cancer cell line MCF-7, IC50 of nanocomposite = 19.44 µg / mL.

Raspberry-shaped ZIF-8/Au nanozymes with excellent peroxidase-like activity for simple and visual detection of glutathione.

Artificial enzymes with high stability, adjustable catalytic activity, controllable preparation, and good reproducibility have been widely studied. Noble metal nanozymes, particularly gold nanoparticles (Au NPs), exhibit good catalytic activity, but their stability is poor. In this study, zeolitic imidazolate framework-8 (ZIF-8) was used as a carrier for Au NPs, thus improving the utilization efficiency and conservation stability of the nanozymes. A ZIF-8/Au nanocomposite with peroxidase activity and a raspberry-shaped structure was synthesized. In the assay, ZIF-8/Au catalyzed the oxidation of 3,3',5,5'-tetramethylbenzidine (TMB) to a blue product oxidized TMB (oxTMB). Glutathione (GSH) selectively inhibited this reaction, with a detection limit of 0.28µM and linear range of 0.5-60µM. Using the photo and chromaticity analysis functions, we developed a portable analysis method using a smartphone equipped with a camera module as a detection terminal for a wide range of rapid screening techniques for GSH. Preparation of raspberry-shaped ZIF-8/Au improved the catalytic activity of Au NPs and good results were demonstrated in serum, which suggests their promising application under physiological conditions.

Zinc Oxide:Gold Nanoparticles (ZnO:Au NPs) Exhibited Antifungal Efficacy Against Aspergillus niger and Aspergillus candidus

Fungal pathogens are a major health issue that threatens the era of antifungal drugs commonly used in the treatment of infections. An effective approach of biosynthetic nanoparticles can be used as antifungal agents owing to their intrinsic features such as their simplicity, non-toxic, and physicochemical properties. Therefore, this study was aimed to molecularly ascertain Aspergillus species known to cause aspergillosis and investigate the potency of zinc oxide:gold nanoparticles (ZnO:Au NPs) against the fungal pathogens. Two Aspergillus strains retrieved with potato dextrose agar (PDA) culture media from commercial food products in South Africa were molecularly identified using calmodulin (CaM) gene region. DNA sequence phylogeny of the gene showed that the strains were A. niger and A. candidus. ZnO:Au (1%) NPs were synthesised and characterised using X-ray diffraction (XRD), scanning electron microscopy (SEM), and X-ray photoelectron spectroscopy (XPS). Two distinct peak plasmon bands for ZnO and ZnO:Au NPs were 390 nm and 565 nm, respectively. FE-SEM images demonstrated the presence of Au on the surface of ZnO nanoparticles in the ZnO:Au nanocomposites. The ZnO:Au NPs antifungal activity of 10 µg/mL and 50 µg/mL concentrations were evaluated against the two Aspergillus spp. ZnO:Au NPs at 50 µg/mL exhibited a maximum antifungal activity against A. candidus and A. niger, with zones of inhibition (ZoI) of 31.2 ± 0.15 mm and 25.0 ± 0.06, respectively. When the ZoI was observed by SEM, major morphological damages on the conidia were observed for both strains, indicating that the antifungal activity may have been enhanced by the ZnO:Au NPs. Therefore, due to these outstanding properties, ZnO:Au NPs can be utilised as potential antifungal agents to inhibit the proliferation of fungal pathogens.

Structural Properties and Photocatalytic Activity of TiO2/Au Nanocomposites Synthesized with Glucose

AbstractA one‐pot synthesis of plasmonic gold‐modified TiO2 nanocomposites is reported by using glucose reduction of HAuCl4 in presence of titanium tetraisopropoxide. The resulting nanocomposites are characterized by thermal‐gravimetric analyses, X‐ray diffraction combined with X‐ray fluorescence and photoelectron spectroscopies. A binary system of β‐TiO2 and anatase phases is obtained for low Au content while only anatase form is favored when the initial Au rate rises. This investigation also suggests the inclusion of gold in the TiO2 structure. Although the optical bandgap of the different nanocomposites remains around 3 eV, the increase of Au content induces a shift of both valence and conduction edge bands to lower energy levels. The photocatalytic activity of TiO2/Au nanocomposites is assessed through the decolorization of different cationic and anionic dyes as model compounds. Regarding rhodamine and methylene blue dyes, the sample TiO2 modified with 3.5 wt% of Au presents the best performance. The relation between the structure of the nanocomposites and their capacity to degrade pollutants is discussed.

1D ZnO–Au nanocomposites as label-free photoluminescence immunosensors for rapid detection of Listeria monocytogenes

In this study, we explore the potential of 1D ZnO–Au nanocomposites as innovative label-free photoluminescence (PL) immunosensors for rapidly detecting Listeria monocytogenes, a significant concern in food safety. We synthesized ZnO nanorods (ZnO_NR) and nanowires (ZnO_NW), followed by Au deposition to create ZnO_NR/Au and ZnO_NW/Au nanocomposites. Our analyses, including SEM, TEM, Raman spectroscopy, and photoluminescence (PL), revealed distinct structural and optical properties of these nanocomposites, especially noting the superior crystallinity and stability of ZnO_NR/Au. The biosensor performance was evaluated through PL sensitivity to Anti-Listeria antibodies, demonstrating that ZnO_NR with higher concentration of Au nanoparticles exhibited higher sensitivity and a lower limit of detection (LOD), attributed to a greater density of Listeria binding sites. The developed biosensor demonstrated a remarkable limit of detection (LOD) of 8.3 × 102 CFU/mL, rivaling or surpassing conventional culture-based methods and some molecular techniques. This research underscores the critical role of Au deposition duration in optimizing biosensor performance and presents a promising advancement in rapid and sensitive Listeria detection, with significant implications for enhancing food safety protocols.

Preparing and studying of Au Nanocomposites Synthesized with different polymer matrix

This work investigates the impact of several polymer matrix types, which are utilised as a capping layer around gold particles, on the optical properties. Nanocomposite materials consisting of gold and polymers such as polyethylene oxide, polyvinyl alcohol, and polyvinyl pyrrolidone were produced by a chemical reduction process. Tri sodium citrate was employed as the reducing agent. using the drop casting approach, nanocomposites based on gold were successfully put as a film on glass substrates.. An investigation was conducted to determine the influence of the polymer matrix type on the optical properties, including surface plasmon resonance, direct band gap, and indirect band gap. Furthermore, the absorption spectra of the materials that were synthesised demonstrated that the selection of the polymer that was utilised during the preparation process has a considerable impact on the location of the plasmonic absorption peak as well as the magnitude of the energy gap. Within the range of 1.9 to 2.3 electron volts (eV), the band gaps were found to be present.

Graphene Oxide-Coated Mach-Zehnder Interferometer Based Ammonia Gas Sensor

The presence of high levels of ammonia in the bloodstream can lead to unconsciousness and convulsions, making it a prime example of dangerous air pollution. The presence of certain gases in our environment can be quite discomforting. In light of these concerns, we present a contemporary approach to designing and developing an exceptionally sensitive ammonia gas sensor. This sensor utilizes a substrate composed of single-mode fiber (SMF), photonic crystal fiber (PCF), and SMF to create a Mach-Zehnder interferometer (MZI). The sensing mechanism involves the immobilization of an Au and GO nanocomposite. In this setup, the region of interference between the waves of the SMF and the solid crystal fiber creates a collapse zone that is utilized to excite the core and cladding modes of the PCF. This innovative technique ensures remarkably rapid response and recovery times.The reusable probe showcased in this study displays significant potential for achieving rapid, highly accurate, and reproducible ultratrace ammonia detection. This introduces a novel avenue for conducting online measurements and environmental monitoring. The intersection point of the SMF and the solid crystal specialty fiber generates a collapse zone that effectively excites the core and cladding modes of the PCF, resulting in the promised rapid response and recovery times.The reusable probe exhibits the capability to swiftly detect ultratrace amounts of ammonia, boasting good selectivity, consistent characteristics, and sensitivities of up to 18.65 nm/ppm. This development opens up new possibilities for environmental monitoring and real-time measurements, offering improved insights into our surroundings.

Influence of production method on the structure and photocatalytic activity of CeO<sub>2</sub>/Au nanocomposite

Two methods for preparing mesoporous CeO2/Au nanocomposites were compared: template synthesis and photochemical modification of fibrous cerium(IV) oxide with gold nanoparticles. The composition, structure, morphology of the obtained nanocomposites, as well as the specific surface area and pore size distribution were studied by a complex of physicochemical methods: X-ray phase analysis, X-ray spectral microanalysis, scanning electron microscopy, low-temperature nitrogen adsorption, and electron spectroscopy. The catalytic properties of the obtained nanocomposites were studied in methyl orange photodegradation reactions. It is shown that the CeO2/Au catalyst obtained by the photochemical modification method has the highest photocatalytic activity both under the action of UV and visible light.

Impact of photoinduced energy transfer and LSPR of Au nanoparticles prepared by pulsed laser ablation technique on nonlinear optical response of zinc tetraphenyl porphyrin

Nonlinear optical (NLO) response and optical limiting activity in zinctetraphenyporphyrine (ZnTPP)/Au nanocomposites are examined using z-scan experiment aiding pulsed laser that delivers 7 ns pulses at 532 nm wavelength. ZnTPP/Au nanocomposite is prepared by ablating Au target in ZnTPP solution using nanosecond laser pulses. Nanocomposite formation in ZnTPP with Au NPs is confirmed from the modification of absorption spectrum and quenching of fluorescent emission spectrum. When compared to the well-known pristine constituents, the nonlinear optical properties and optical limiting (OL) activity in ZnTPP/Au nanocomposites have been enhanced significantly, that accounts the photo-induced energy transference between ZnTPP and Au NPs along with the local field effect of Au NPs. The nanocomposite formation induces additional energy transfer pathways that are responsible for enhanced excited-state absorption. In addition, the augmentation will be supported by local field effects of the Au NPs, which significantly increase the interaction field strength on the surface of the NPs and in the surrounding medium. The excited state absorption is the major mechanism of NLA and optical limiting activity. The threshold value of the optical limiting of the compound is found to be superior to the values reported for many compounds under similar experimental conditions. We anticipate that the suggested method will be of great interest for the eventual implementation of optical limiting-based photonic devices suitable for integrated optics.

Facile fabrication and antibacterial properties of chitosan/acrylamide/gold nanocomposite hydrogel incorporated with Chaetomium globosium extracts from Gingko biloba leaves

Microorganisms are a unique part of our ecosystem because they affect the survival of living organisms. Although pathogenic microorganisms could be detrimental to the plants, animals, and humans, beneficial microbes have provided significant improvement in the growth and development of living organisms. In this study, the fungus Chaetomium globosium was isolated from the medicinal tree Gingko biloba, and then incorporated into a polymerization system to fabricate chitosan/acrylamide/gold (CS/Am/Au) nanocomposite hydrogels. The as-prepared hydrogel displayed increased mechanical strength due to the reinforcement of Au (gold) nanocomposites within the hydrogel matrix. Also, the equilibrium pH responsive swelling rates of the hydrogels gradually increased as the pH increases due to partial acid and basic hydrolysis occurring in the hydrogel as well as formation of hydrogen bond. In addition, the hydrogel demonstrated promising antibacterial activities against selected gram-positive (Staphylococcus epidermidis and Staphylococcus aureus) and gram-negative (Pseudomonas aeruginosa) bacterial strains with an average MIC90 of 0.125 mg/mL at a dosage of 1.0 mg/L. The obtained results are quite promising towards resolving several health challenges and advancing the pharmaceutical industries.

Rapid and sensitive electrochemical detection of oxidized form of glutathione in whole blood samples using Bi-metallic nanocomposites

We report a facile one-pot synthesis of bimetallic nickel-gold (Ni–Au) nanocomposite for ultra-sensitive and selective electrochemical detection of oxidized glutathione (GSSG) by electrochemical deposition on fluorine doped tin oxide (FTO) substrate. The electrodeposition of Ni–Au nanocomposite on FTO was confirmed by various characterization techniques such as field emission scanning electron microscopy (FE-SEM), X-ray diffractometer (XRD) and Fourier transform infra-red (FTIR) spectroscopy. The cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) was utilized for the electrochemical characterization of glutathione reductase (GR)/Ni–Au/FTO working electrode at each stage of modification. The GR enzyme immobilized on the Ni–Au/FTO working electrode via glutaraldehyde cross-linking exhibited excellent selectivity against GSSG in the presence of nicotinamide adenine dinucleotide phosphate (NADPH). The immobilized GR enzyme breaks down the GSSG to reduced glutathione (GSH) and converting NADPH to NADP+ whereby generating an electron for the electrochemical sensing of GSSG. The synergistic behavior of bimetals and good electro-catalytic property of the fabricated sensor provided a broad linear detection range from 1 fM to 1 μM with a limit of detection (LOD) of 6.8 fM, limit of quantification (LOQ) of 20.41 fM and sensitivity of 0.024 mA/μM/cm2. The interference with other molecules such as dopamine, glycine, ascorbic acid, uric acid and glucose was found to be negligible due to the better selectivity of GR enzyme towards GSSG. The shelf-life and response time of the fabricated electrode was found to be 30 days and 32 s, respectively. The real sample analysis of GSSG in whole blood samples showed average recovery percentage from 95 to 101% which matched well with the standard calibration plot of the fabricated sensor with relative standard deviation (RSD) below 10%.

Paper-based microfluidic device for selective detection of peanut allergen Ara h1 applying black phosphorus-Au nanocomposites for signal amplification

This paper developed a portable microfluidic paper-based analysis device (μ-PAD) combined with the electrochemical technique for efficient and sensitive detection of peanut allergen Ara h1. The proposed μ-PAD works based on the variation of differential pulse voltammetry (DPV) response current induced by peanut allergen Ara h1. Black phosphorus (BP)–Au nanocomposites were introduced both to improve the electron transfer rate at the electrode interface for signal amplification, and to immobilize the specific Ara h1 aptamers through Au–S bonding to recognize the target in food matrices. This μ-PAD had good specificity and detection stability for Ara h1 allergen and could complete the entire analysis process within 20 min, achieving a wide linear response range (25–800 ng mL−1) and a low detection limit (LOD, 11.8 ng mL−1). In the Ara h1 allergen detection applied to real peanut products (cookies, milk, and bread), the constructed μ-PAD obtained acceptable recoveries (93.50%–101.86%) with relative standard deviations (RSDs) of 0.36–2.97% (n = 3), with a good correlation with the ELISA results (R2 = 0.9956). Therefore, the portable μ-PAD based on BP-Au nanocomposites was demonstrated to provide an effective strategy for rapid analysis and screening of Ara h1 allergen in food, which has broad application prospects.

Octahedral Cu2O nanomaterials as electrochemical aptasensor for sensitive detection of tetracycline in milk

In this work, A novel label-free electrochemical biosensor based on octahedral Cu2O @ Au nanocomposites was developed for the detection of tetracycline. The gold nanoparticles (AuNPs) on the surface of Cu2O nanomaterials not only improve the electrochemical performance, but also can be used as a binding site for thiol-modified tetracycline aptamers, which can specifically bind to tetracycline. Cu2O @ Au nanocomposites provide a synergistic effect of electrochemical signal amplification and tetracycline recognition strategy. Under the optimal conditions, the proposed biosensor exhibited different electrochemical reactions for different concentrations of tetracycline, with a linear range of 1 nM-1000 μM and a detection limit of 0.16 nM. This work provides a new idea for rapid and sensitive detection of tetracycline by using a simple and economical tetracycline aptamer combined with Cu2O @ Au biosensor platform.

Supported gold nanoparticles on lignosulfonate coated magnetic nanoparticles: Investigation of its catalytic efficiency in the reductive formylation of nitroarenes

This article describes a biogenic synthesis towards the fabrication of Au NPs over sodium lignosulfonate (NaLS) modified Fe3O4 bio-nanocomposite and its catalytic and biological applications. The morphology and physicochemical characteristics of the material were determined over a number of analytical techniques like FT-IR, FE-SEM, TEM, EDS, XRD, ICP-OES and VSM. The prepared Fe3O4@NaLS/Au nanocomposite presented an excellent catalytic performance in the one-pot synthesis of N-formyl amines via reductive formylation of different nitrobenzene derivatives using NaBH4 as the hydride source and triethyl orthoformate [CH(OEt)3] as the formylating agent. Due to magnetic core, the nanocatalyst was retrieved magnetically with facile and recycled for 8 successive runs keeping its potential intact.

Plasmonic metal/doped-semiconductor nanocomposites for high-efficiency solar-driven clean water production

Despite their strong light absorption capacity, the narrow absorption bandwidth of plasmonic metal materials has impeded their application in solar-driven freshwater production. To address this limitation, we grew copper sulfide (Cu7S4) shell on gold nanorod (Au NR) core to construct a plasmonic nanocomposite Au NR@Cu7S4, which exhibited broad and intense absorption of solar radiation due to the integration of their individually visible (Au NR) and near-infrared (Cu7S4) plasmons, with this absorption being further broadened and enhanced by the coupling of these two plasmons. This strategy is conceptually distinct from aggregating plasmonic metal nanoparticles, which is subject to a trade-off between the breadth and intensity of their absorption. The Au NR@Cu7S4-impregnated hydrogel delivered an evaporation rate of 2.35 kg m−2 h−1 under 1 sun illumination despite having a Au areal density of only 28 μg cm−2. Moreover, it showed excellent volatile organic compound removal performance.

Sensitive detection of SARS-CoV-2 spike protein based on electrochemical impedance spectroscopy of Fe3O4@SiO2–Au/GCE biosensor

Highly contagious COVID-19 disease is caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which poses a serious threat to global public health. Therefore, the development of a fast and reliable method for the detection of SARS-CoV-2 is an urgent research need. The Fe3O4@SiO2–Au is enriched with a variety of functional groups, which can be used to fabricate a sensitive electrochemical biosensor by biofunctionalization with angiotensin-converting enzyme 2 (ACE2). Accordingly, we developed a novel electrochemical sensor by chemically modifying a glassy carbon electrode (GCE) with Fe3O4@SiO2–Au nanocomposites (hereafter Fe3O4@SiO2–Au/GCE) for the rapid detection of S-protein spiked SARS-CoV-2 by electrochemical impedance spectroscopy (EIS). The new electrochemical sensor has a low limit detection (viz., 4.78 pg/mL) and a wide linear dynamic range (viz., 0.1 ng/mL to 10 μg/mL) for detecting the EIS response signal of S-protein. The robust Fe3O4@SiO2–Au/GCE biosensor has high selectivity, stability, and reproducibility for the detection of S-protein with good recovery of saliva samples.

Synthesis, Characterization and Anticancer Activity of Chitosan Schiff Base / PVP Gold Nano Composite in Treating Esophageal Cancer Cell Line

In the present paper, chitosan Schiff base has been synthesized from chitosan’s reaction with the salicyldehyde. The AuNPs was manufacture by extract of onion peels as a reducing agent. The Au NPs that have been prepared were characterized through the UV-vis spectroscopy, XRD analyses and SEM microscopy. The polymer blends of the chitosan Schiff base / PVP has been prepared through using the approach of solution casting. Chitosan Schiff base / PVP Au nano-composites was prepared. Nano composites and polymer blends have been characterized by FTIR which confirm the formation of Schiff base by revealing a new band of absorption at 1651cm-1 as a result of the (C=N) imine group. SEM, DSC and TGA confirms the thermal stability of the prepared polymer blends and nanocomposites, nano composites have shown good results in inhibiting esophageal cancer cell lines, IC50 of nanocomposite = 21.56 µg / mL.

Mixed-Dimensional MXene Nanocomposites/Aramid Nanofibers-Based Flexible Pressure and Strain Sensor for Electronic Skin

The implementation of tactile functions in array sensors has created an urgent need for high-performance force sensors with both high linearity and sensitivity so as to ensure the uniformity and accuracy of acquisition of multiple sensing units in the array sensors. In addition, it still remains challenging to fabricate exquisite geometric constructions for integrating highly sensitive materials, extraordinary sensitivity, high stretchability, wide sensing range, and flexibility into a single type of pressure/strain sensor. Herein, a sensitive flexible sensor was fabricated that was composed of mixed-dimensional MXene-based nanocomposites as piezoresistive layers and Ecoflex layers as the encapsulation. The resultant sensors with MXene (Ti3C2Tx)-ANF (aramid nanofiber)-BP (black phosphorus)-gold (Au) nanocomposites exhibited excellent electrical conductivity, ultrahigh press sensitivity of 0.4986 kPa–1 (0–1 kPa), reliable linearity (R2 = 0.998), rapid response time of 12 ms, excellent durability over 4000 cycles, and ultrahigh tensile sensitivity of 9188.583. An 8 × 8 pixel electronic skin was fabricated by the as-prepared mixed-dimensional MXene-based sensors and tested in the identification of sliding movements and surface shape, and the good performance shows great potential applications in the fields of wearable devices, human–machine interaction, and robotics.

Triple-enzyme-mimicking AuPt3Cu hetero-structural alloy nanozymes towards cascade reactions in chemodynamic therapy

Inspired by unique enzyme-mimicking activities of Au and Pt nanocomposites and special roles of Cu components for native and artificial enzymes, we have designed the novel AuPt3Cu trimetallic hetero-structural nanozymes skillfully in this study. AuPt3Cu nanoparticles composed with Au-rich cores and Pt/Cu-rich outer shells with total size of 27.5 ± 3.1 nm are produced in aqueous solutions at 40 °C. Thanks to the alloyed Cu and special hetero structure, AuPt3Cu nanoparticles show excellent oxidase-, peroxidase-, and catalase-like activities. Catalyzed by AuPt3Cu, glucose and glutathione are oxidized by O2 (maximum reaction velocity, vmax, (5.65 ± 0.96) × 10-8, (9.82 ± 1.17) × 10-8 mol·L–1·s−1, respectively) and H2O2 is produced. Further, H2O2 is decomposed into O2 (vmax, 0.06 ± 0.003 mol·L–1·s−1) and reactive oxygen species (ROS, including ·OH, O2·–, 1O2). Then, O2 is decomposed into O2·– radicals. The catalytic reaction velocities of AuPt3Cu are higher than those of AuPt3 and PtCu0.4 counterparts. Because of the cascade reactions in tumor microenvironments, AuPt3Cu nanozymes own remarkable chemodynamic therapy (CDT) performance with IC50 of 50 µg·mL−1 towards cancerous MCF-7 cells. Starving and ROS therapy paths coexist. The tumors of mice bearing with MCF-7 disappeared completely on the 14th day after administering with 5 mg·kg−1 AuPt3Cu agents every 3 days. There are no damages to normal cells and organs, and liver and renal functions. Whether the synthetic strategy or CDT effects, AuPt3Cu nanozymes have unique advantages in cost, performance, and environmental conservation compared to noble metal-, transition metal oxide-, metal complex-, and polymer-relevant drugs.

Au decorated WO3-SnO2 nanocomposite for enhanced benzene vapors sensing performance

In this present work, we synthesized WO3-SnO2 and Au decorated WO3-SnO2 nanocomposite by hydrothermal method. The optical characterization has been done by UV/Vis spectroscopy to determine the band gap (Eg) of pure and gold (Au) decorated WO3-SnO2 which shows a reduction in Eg value from 3.56 to 3.03 eV after addition of Au in WO3-SnO2 which improves the crystallinity of WO3-SnO2 . Fourier transformed Infra red (FTIR) spectroscopy has been used to confirm the chemical bonding between Au and WO3-SnO2 nanocomposite. The x-ray Diffraction (XRD) technique was used to study the structural aspects of prepared materials which shows the decrease in crystallite size from 8 to 6.7 nm after addition of Au in pure sample. Field Emission Scanning Electron Microscopy (FESEM) has been used to investigate morphological characteristics of as prepared nanocomposite. The doping of Au was further confirmed by Energy-Dispersive x-ray spectroscopy (EDS) technique. The sensing properties have been studied from the I–V measurement of WO3-SnO2/Au nanocomposite for Benzene. The sensing parameters such as sensitivity (response), operating temperature and response and recovery time were calculated for benzene vapors. The addition of Au in WO3-SnO2 increases its response to 2.7 times for 100 ppm benzene with a reduction in response/recovery time from 18/50 s to 13/29 s. The operating temperature was 300 °C. Further, the material is highly selective for benzene as compared to cyclohexane, toluene and aniline.