Lipids in stratum corneum are largely responsible for skin barrier function. There have been numerous studies on skin barrier repairing and moisturizing effects of products containing occlusives, emollients and humectants. However, currently there are few studies systematically evaluating effect of moisturizers containing endogenous lipids on skin barrier properties. The objective of this study was to study the effect of products containing endogenous lipids on various barrier-related indicators. A total 89 subjects with dry skin were enrolled. To evaluate the effect of the test products on skin barrier function and hydration after 28 days of use on the face, this study combined clinical assessments of skin condition (skin redness, global appearance of dry line, skin roughness and radiance), instrumental assessments (transepidermal water loss, skin hydration and scaliness) and photo tracking (VISIA-CR,VC20 and 3D in-vivo Reflectance Confocal Microscope). Adverse reactions were also assessed. All test products showed significant improvement in all the attributes assessed by both clinical assessments and instrumental assessments after 28 days of treatment. In addition, the products containing skin-identical ceramides and niacinamide show improvement on TEWL and skin hydration. Two products containing exogenous lipids can improve skin hydration and barrier function which have demonstrated efficacy in improving dry skin condition.